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Cardiovascular & Renal Physiology Research Group

Faculty in the Department of Physiology are internationally recognized for their research into the cellular and molecular aspects of cardiovascular and kidney function. We employ an interdisciplinary approach, using molecular, cell biological, electrophysiological, transgenic, functional genomic and optical techniques to understand how the cardiovascular-renal system works. Many of our graduate students, post-doctoral fellows and faculty are focused on elucidating the mechanisms of human disease, including hypertension, heart failure, cardiac arrhythmias and inherited disorders of salt and water balance.

Cardio Myocyte Ma Cell

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Faculty

  • Toni Antalis, membrane serine proteases
  • Robert Bloch, The structure and function of the membrane systems in muscle, and the effects of muscular dystrophy and other myopathies
  • Mordecai Blaustein, Mechanisms of calcium signaling
  • Steven Fisher, Regulation of gene expression in vascular smooth muscle in hypoxia and heart morphogenesis 
  • Vera Golovina, Understanding the mechanisms of regulation of Ca2+ signaling in glial and vascular smooth muscle cells and its role in physiological and pathophysiological processes
  • John Hamyln, Endogenous ouabain and mechanisms of hypertension
  • Pedro Jose, The role of dopamine and adrenergic receptors in the pathogenesis of genetic hypertension
  • Joseph P. Y. Kao, Molecular Mechanisms of Calcium signaling
  • H. Moo Kwon 
  • W. Jon Lederer, Molecular models of cardiac dysfunction
  • Andrea L. Meredith, Regulation of sino-atrial node firing and in vivo modulation of heart rate
  • Ben Prosser, How mechanical stress affects intracellular calcium homeostasis and ROS/redox signaling in heart muscle
  • Shawn Robinson, Pathophyisology of hypertensive heart disease, heart failure
  • Alan Shuldiner, Molecular genetics of type 2 (adult) onset diabetes, obesity, and hypertension
  • Marc Simard, Cerebral circulation, stroke
  • Dudley Strickland, LDL receptor proteins in inflammation 
  • Matthew Trudeau, The molecular specializations underlying ion channel function in potassium channels activated by voltage and cation channels activated by intracellular cyclic nucleotides
  • James Wade, Membrane traffic of epithelial transporters
  • W. Gil Wier, Calcium signaling in heart and vascular smooth muscle
  • E. J. Weinman, Molecular mechanisms of salt balance, PDZ based protein-protein interactions
  • Paul Welling, Molecular mechanisms of ion channels in salt balance and blood pressure control
  • Jin Zhang, How the vascular smooth muscle-specific sodium/calcium exchanger affects arterial contraction and blood pressure
  • Li Zhang, The role of leukocytes in adaptive immune responses and the development of atherosclerosis, myocardial infarction, and stroke
  • Guiling Zhao, How the IP3 receptor works in heart and smooth muscle