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Buzz Archive

December 2013

Publications

Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, was among the authors on “Combined Blockade of IL-17A and IL-17F May Prevent the Development of Experimental Colitis,” in Immunotherapy, 2013 Sep;5:923–925. Dr. Shea-Donohue was also among the co-authors on “Selenium Status Alters the Immune Response and Expulsion of Adult Heligmosomoides bakeri Worms in Mice” in Infection and Immunity, 2013 Jul;81:2546–2553; and “Gut Microbiota, Tight Junction Protein Expression, Intestinal Resistance, Bacterial Translocation and Mortality Following Cholestasis Depend on the Genetic Background of the Host” in Gut Microbes, 2013 Jul-Aug;4:292–305.

November 2013

Events, Lectures & Workshops

Alan Shuldiner, MD, the John Whitehurst Professor in the Department of Medicine, Associate Dean for Personalized Medicine, and Director of the Program in Genetics and Genomic Medicine, hosted a conference at the SMC Campus center on September 3. The topic was “Regulatory Issues in Next-Generation Medicine and Pharmacogenomics.” This one-day meeting was part of the FDA-funded University of Maryland Center of Excellence in Regulatory Science and Innovation (MCERSI).

Joseph Stains, PhD, Assistant Professor, Department of Orthopaedics, presented “Both the Connexin 43-Specific Channel and C Terminus Are Required for the Regulation of Runx2 Activity and Osteoblast Gene Expression” at the International Gap Junction Conference in Charleston, SC, in July.

Grants & Contracts

Tuo Peter Li, BS, a MD/PhD Student in the Department of Physiology, received a five-year, $204,939 MD/PhD F30 individual training grant renewal from the National Institute of Mental Health for research on “The Influence of Binding and Crowding on Synaptic Protein Mobility.” This individual training grant was awarded with three years of PhD and two years of MD support. F30 grants are highly competitive and only a fraction of those MD/PhD students who apply receive funding. The purpose of the F30 is to support promising pre-doctoral applicants who have the potential to become highly productive researchers in their fields.

Scott Thompson, PhD, Professor and Chair, Department of Physiology, received a five-year, $1,177,808 training grant renewal from the National Institute of General Medical Sciences for the “Training Program in Integrative Membrane Biology.” This training grant was awarded with six pre-doctoral training slots.

Owen Woodward PhD, Research Associate, Department of Physiology, received a one-year, $40,000 research grant from the National Kidney Foundation of Maryland for his research work entitled “Urate Secretion, ABCG2 and Human Disease.”

Honors & Awards

Mark Kvarta, Graduate Student, won the Graduate Program in Life Sciences’ (GPILS) 2013 PhD Scholar Award. Mark is in the Neuroscience Program, and his mentor is Scott Thompson, PhD, Professor and Chair, Department of Physiology. Aparna Kishor, PhD, now a MS-IV, won the 2013 GPILS PhD Thesis Project Award. She completed her PhD in the Molecular Medicine Program, where her mentor was Gerald Wilson, PhD, Associate Professor, Department of Biochemistry and Molecular Biology.

Publications

Curt Civin, MD, Professor of Pediatrics and Physiology, Associate Dean for Research, and director of the Center for Stem Cell Biology & Regenerative Medicine, was among the co-authors on “Investigation of the Role of Interleukin-6 and Hepcidin Antimicrobial Peptide in the Development of Anemia with Age” in Haematologica, 2013 Oct;98(10):1633-1640.

October 2013

Appointments

Matthew Trudeau, PhD, Associate Professor, Department of Physiology, has been appointed as a Special Emphasis Panel Member to the NIH’s Biological Chemistry & Macromolecular Biophysics IRG.

Events, Lectures & Awards

Alan Shuldiner, MD, the John L. Whitehurst Professor of Medicine, Director of the Program in Pharmacogenomics and Genomic Medicine, and Associate Dean for Personalized and Genomic Medicine presented “Pharmacogenomics: Real-Work Challenges in Translation to Clinical Practice” at the Up Close and Personalized meeting in Paris, France on July 27; “Genetic Diseases in the Amish Adult Population” at the Genomic Medicine and the Plain Populations of North America conference in Lancaster, PA on July 17; “Genomic Management of Anti-Platelet Therapeutics” at the Keystone Symposia in Stockholm, Sweden on June 20; and “Amish Participation in Medical Research: A Partnership of Trust and Mutual Benefit” at the World International Conference at Elizabethtown College on June 8.

Grants & Contracts

Matthew Trudeau, PhD, Associate Professor, Department of Physiology, received a two-year, $154,000 Grant-in-Aid from the American Heart Association’s Mid-Atlantic division for his current research work “Gating in hERG K Channels.”

Publications

Matthew Trudeau, PhD, Associate Professor, Department of Physiology, was a co-author on “The eag Domain Regulates hERG Channel Inactivation Via a Direct Interaction” in The Journal of General Physiology, 2013, Feb;141(2):229-241, and “Structure of the C-terminal Region of an ERG Channel and Functional Implications” in Proceedings of the National Academy of Sciences, USA, 2013 Jul;110(28):11648-11653.

September 2013

Grants & Contracts

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology; Associate Dean for Research; and Director, Center for Stem Cell Biology & Regenerative Medicine, was awarded the Leukemia and Lymphoma Society (LLS) Translational Research Grant for research on “Artemisinins for Treatment of Acute Leukemias.” The $600,000 grant has been approved for a three-year period starting October 1.

Joseph Stains, PhD, Assistant Professor, Department of Orthopaedics, was recently awarded a five-year, $1.1 million NIH R01 research grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for his research on “Regulation of Osteoblast Differentiation and Function by Connexin 43.”

Loren Thompson, PhD (pictured), Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, and Bhanu Telugu, PhD, Assistant Professor, Department of Animal Science, UMCP, received a one-year, UMB/UMCP Seed Grant Award for $75,000 to research “Development of a Novel Animal Model for Human Preeclampsia.”

Publications

Charles Chaffin, PhD, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was a co-author on “Follicle Growth, Ovulation, And Luteal Formation In Primates And Rodents: A Comparative Perspective” in Experimental Biology and Medicine, 2013 May 1;238(5):539-48.

Joseph Stains, PhD, Assistant Professor, and Carla Hebert, Research Assistant, both from the Department of Orthopaedics, were among the co-authors on “Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43” in Calcified Tissue International, 2013 Jun 11 [Epub ahead of print].

August 2013

Appointments

Mordecai Blaustein, MD, Professor, Department of Physiology, has been elected as an honorary member of the Physiological Society by their Council of Trustees. He was formally welcomed at the Physiological Society 2013 annual meeting.

Curt Civin, MD, Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine; and Professor, Departments of Pediatrics and Physiology, was inducted into the Baltimore Jewish Hall of Fame at the Gordon Jewish Community Center in Baltimore on June 12. The Jewish Hall of Fame celebrates Jewish Baltimoreans who have a made a difference in the fields of medicine, science, politics, law, education, business, community service, arts & entertainment, and beyond. Dr. Civin was honored for his contributions in the field of medicine for his work with stem cells, specifically his groundbreaking research that led to the development and implementation of both clinical bone marrow stem-cell transplantation and leukemia diagnosis. Created in 2008, the Baltimore Jewish Hall of Fame now has 38 members, including this year’s nine honorees. Dr. Civin is one of six physician members.

Events, Lectures & Workshops

Charles Chaffin, PhD, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, presented “How the Sugars That Fuel the Oocyte Are Regulated” to the Department of Biology at Loyola University Chicago in March. Also in March, Dr. Chaffin lectured on ovarian follicle growth at the “Frontiers in Reproductive Medicine” course sponsored by the University of Medicine and Dentistry of New Jersey.

Curt Civin, MD, Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine; and Professor, Departments of Pediatrics and Physiology, presented “The Progress and Vision of Stem Cell Research in Maryland” to the TEDCO Board of Directors in Columbia, MD, on May 16.

Grants and Contracts

Eugene Albrecht, PhD, Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, received a four-year $2.43 million R01 research grant from the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) in April for “Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth.” Dr. Albrecht and his team will study the impact of estrogen deprivation during primate pregnancy on the development of insulin insensitivity in offspring after birth. The study highlights the consequences of estrogen deprivation in human pregnancy (i.e. premature birth or exposure to endocrine disruptors), in increasing the risk of developing type 2 diabetes in offspring after birth.

Publications

Charles Chaffin, PhD, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was among the co-authors on “EGF-Like Ligands Mediate Progesterone’s Anti-Apoptotic Action on Macaque Granulosa Cells” in Biology of Reproduction, 2013 Jan 25;88(1):18.

Curt Civin, MD, Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine; and Professor, Departments of Pediatrics and Physiology, was among the co-authors on “Artemisinin-Derived Dimer Phosphate Esters as Potent Anti-Cytomegalovirus (Anti-CMV) and Anti-Cancer Agents: A Structure-Activity Study” in Bioorganic & Medicinal Chemistry, 2013, April [Epub ahead of print]; and “FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm” in Cell Stem Cell, 2013, 11(3):346-58.

Andrea Meredith, PhD, Associate Professor, Department of Physiology, was among the co-authors on “mitoBKCa is Encoded By the Kcnma1 Gene, and a Splicing Sequence Defines Its Mitochondrial Location” in the Proceedings of the National Academy of Sciences, 2013 Jun 10 [Epub ahead of print]. She was also among the co-authors on “Quantitative Localization of Cav2.1 (P/Q-type) Voltage-Dependent Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic Co-clustering with Calcium-Activated Potassium Channels” in the Journal of Neuroscience, 2013; Feb 20;33(8):3668-78; and “Olivocochlear Suppression of Outer Hair Cells In Vivo: Evidence for Combined Action of BK and SK2 Channels Throughout the Cochlea” in the Journal of Neurophysiology, 2013; Mar;109(6):1525-34.

July 2013

Events, Lectures & Workshops

Thomas Blanpied, PhD, Associate Professor, Department of Physiology, was invited to present “Single-Molecule Imaging Reveals Protein Position and Dynamics in the Synapse of Living Neurons” at the International Society for Neurochemistry’s Satellite meeting “Emerging Topics in Synapse Function: Molecular Mechanisms, Circuit Function, and Disease,” held April 20–24 in Cancun, Mexico.

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology, Associate Dean for Research, and Director, Center for Stem Cell Biology & Regenerative Medicine, presented “How to Develop a Funding Plan for Your Research and Lab: Role of NIH Funding, Other Sources of Funding (Advantages, Disadvantages)” at the Scientific Leadership & Professional Development Symposium for Basic Science and Translational Researchers, held here on campus on April 24.

Stephen Davis, MBBS, FRCP, FACP, the Theodore E. Woodward Professor and Chair, Department of Medicine, gave the Albert & Miriam Weinstein Lecture at Vanderbilt University Medical Center on April 18. His topic was “Novel Mechanisms Implicated in Hypoglycemia-Associated Autonomic Failure.”

Alan Shuldiner, MD, the John L. Whitehurst Professor of Medicine, Director of the Program in Genetics and Genomic Medicine, and Associate Dean for Personalized and Genomic Medicine, presented “Genomics of the Metabolic Syndrome: Lessons Learned from Engaging the Amish Community as a Founder Population” at the Rockefeller University Clinical Research Seminar on March 27.

Honors & Awards

Shannon Salyer, Budget Analyst, Department of Physiology, was the recipient of the James T. Hill Scholarship from the University of Maryland, Baltimore. At the 2012/2013 Employee Service Recognition Luncheon on April 18, Shannon received a check for $2,000 to help her continue her education. She is currently working toward an undergraduate degree in Business Administration.

Publications

Harold MacGillavry, PhD, Postdoctoral Fellow, and Thomas Blanpied, PhD (pictured), Associate Professor, both from the Department of Physiology, were among the co-authors on “Nanoscale Scaffolding Domains Within the Postsynaptic Density Concentrate Synaptic AMPA Receptors,” published in Neuron, 2013 May;78: 1-8.

June 2013

Events, Lectures & Workshops

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology; Associate Dean for Research; and Director, Center for Stem Cell Biology & Regenerative Medicine, presented “The Ethical Issues Surrounding Non-Financial Conflicts of Interest” at the AAMC Forum on Conflict of Interest in Academe (FOCI) Meeting in Baltimore on March 21.

Alan Shuldiner, MD, the John Whitehurst Professor, Department of Medicine, and Associate Dean for Personalized & Genomic Medicine, was the Plenary Speaker for Washington University School of Medicine’s Diabetes Day, where he presented “Genetics of Diabetes: Lessons from a Founder Population.”

Grants & Contracts

Michael Quon, MD, PhD, Professor, Department of Medicine, received a three-year, $345,000 award from the American Diabetes Association for “Phosphorylation of Ser24 in IRS-1 By IRAK-1 Promotes Insulin Resistance in Mice.”

May 2013

Events, Lectures & Workshops

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology; Associate Dean for Research; and Director, Center for Stem Cell Biology & Regenerative Medicine, presented a lecture on “MicroRNA Maestros of Hematopoiesis and Leukemia” at the Genetics Branch Seminar Series, National Cancer Institute/National Institute of Health in Bethesda, MD, on February 21. 

Grants and Contracts

Robert Bloch, PhD, Professor, Department of Physiology, received a one-year, $250,000 grant extension from the Jain Foundation for his current research work “Analyzing the Role of Dysferlin in Skeletal Muscle in Vitro and in Vivo.”

Michele Vitolo, PhD, Research Associate, Department of Physiology, received a five-year, $525,000 NCI K01 Research Scientist Development Award for “PTEN Loss Increases Efficiency of Breast Tumor Metastasis.” She will investigate the role of PTEN in maintenance of the actin cortex and how the loss of this tumor suppressor increases microtentacles, tumor cell reattachment, and metastasis. Stuart Martin, PhD, Associate Professor, Department of Physiology, serves as the mentor of her research program. 

April 2013

Events, Lectures & Workshops

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology, Associate Dean for Research, and Director, Center for Stem Cell Biology & Regenerative Medicine, presented a lecture on “How Stem Cells are Transforming Medicine” and a panel discussion on “Stem Cell Science—Cancer” at the 2012 World Stem Cell Summit in Palm Beach, FL on December 3, 2012. He also presented “MicroRNA Maestros of Hematopoiesis and Leukemia” at the Brown Foundation Institute of Molecular Medicine Seminar Series at the University of Texas Health Science Center in Houston, TX, on January 25.

W. Jonathan Lederer, MD, PhD, Professor, Department of Physiology and director of the Center for Biomedical Engineering and Technology, gave the Dirk L. Brutsaert Lecture, entitled “Elementary Ca2+ Events: From Discovery to Their Implication for the Physiology and Pathology of the Heart,” at the European Society for Cardiology Meeting in Les Diablerets, Switzerland on January 24.

Grants & Contracts

Colin Mackenzie, MBChB, FRCA, FCCM, Clinical Professor, Department of Anesthesiology has received a three-year, $2,077,553 grant from the U.S. Air Force for “Continuous Non-Invasive Monitoring and the Development of Predictive Triage Indices for Outcome Following Trauma”; a 30-month, $398,422 grant from the Office of Naval Research for “Autonomous Critical Care Systems- Athena GTX”; a two-year, $824,552 grant from the U.S. Air Force for “Predicting Casualty Blood Product Needs Using Pre-Hospital Vital Signs”; and a three-year, $2 million grant from the U.S. Army for “Use of Performance Measure to Evaluate, Document Competence and Deterioration of ASSET Surgical Skills.”

Publications

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology, Associate Dean for Research, and Director, Center for Stem Cell Biology & Regenerative Medicine, was a co-author on “Hematopoietic Stem Cells” in The Biomedical Engineering Handbook, Fourth Edition (Fischer, ed.), Boca Raton: CRC pp 9.1-9.13. 2012. Dr. Civin; Weh-Chih Cheng, PhD, Postdoctoral Fellow; and Tami Kingsbury, PhD, Assistant Professor, Department of Physiology, were among the co-authors on “A Simple High-Throughput Technology Enables Gain-of-Function Screening of Human MicroRNAs” inBioTechniques—International Journal of Life Science Methods, 2013 Feb;54(2):77-86. Dr. Civin and Iain Farrance, PhD, former Assistant Professor, Department of Biochemistry & Molecular Biology, were among the co-authors on “Biochemistry of Signaling in Stem Cells, and Vice Versa” inBiophysica Acta, 2013 Feb; 1830(2):2267.

March 2013

Publications

Cristina Linde, PhD, postdoctoral fellow; John Hamlyn, PhD, professor; and Vera Golovina, PhD (pictured), associate professor, all from the Department of Physiology, were among the co-authors on “Activation of c-SRC Underlies the Differential Effects of Ouabain and Digoxin on Ca2+ Signaling in Arterial Smooth Muscle Cells” in the American Journal of Physiology—Cell Physiology, 2012 Nov 28 [Epub ahead of print]. Drs. Linde and Golovina, along with Mordecai Blaustein, MD, professor, Departments of Physiology and Medicine, were among the co-authors on “Nanomolar Ouabain Increases NCX1 Expression and Enhances Ca2+ Signaling in Human Arterial Myocytes: A Mechanism that Links Salt to Increased Vascular Resistance?” in theAmerican Journal of Physiology—Heart and Circulatory Physiology, 2012 Oct 1;303(7):H784-94. Drs. Hamlyn and Blaustein were also co-authors on “Salt Sensitivity, Endogenous Ouabain and Hypertension” in Current Opinion in Nephrology and Hypertension, 2013 Jan;22(1):51-8.

February 2013

Grants & Contracts

Curt Civin, MD, professor, Departments of Pediatrics and Physiology, associate dean for Research, and director of the Center for Stem Cell Biology & Regenerative Medicine, received a one-year, CRF Pilot grant award of $62,500 for “Interplay of miR-34, S100, and Artemesinins in Leukemias and Melanomas.”

Stuart Martin, PhD, associate professor, Department of Physiology, received a new, five-year, $1.55 million R01 grant from the National Cancer Institute for “Targeting Microtubule Stabilization to Reduce Breast Tumor Metastasis.”

Honors & Awards

Andrea Meredith, PhD, assistant professor, Department of Physiology, was one of the top three fundraisers for the University of Maryland, Baltimore (UMB) team at the 2012 American Heart Association Stroke Walk in Baltimore. In thanks for her efforts, she was treated to lunch with UMB President Jay Perman, MD.

Dudley Strickland, PhD, professor, Department of Surgery, was named The American Heart Association’s Sol Sherry Distinguished Lecturer in Thrombosis at the AHA Scientific Sessions conference in Los Angeles, CA, in November 2012, in recognition of his seminal contributions to the field of thrombosis research. Dr. Strickland, who is also director of the Center for Vascular and Inflammatory Diseases and Assistant Dean for Graduate and Postdoctoral Studies, delivered the lecture “Role of LRP1 in Protecting the Vasculature.” His laboratory was one of two that discovered and identified the LDL receptor-related protein (LRP1) as a receptor for protease-inhibitor complexes.

In the News

Benjamin Prosser, PhD, assistant professor, Department of Physiology, was the subject of the section “Postdoc Spotlight” in the December 2012 Newsletter of the Biophysical Society. The Society has nearly 10,000 members worldwide.

Publications

Andrea Meredith, PhD (pictured), assistant professor, Department of Physiology, was a co-author with postdoctoral fellow, Jenna Montgomery, PhD, on “Genetic Activation of BK Currents In Vivo Generates Bidirectional Effects on Neuronal Excitability” in Proceedings of the National Academy of Sciences of the United States of America, 2012, Nov 13;109(46):18997-9002. Drs. Meredith and Montgomery also co-authored “Mis-expression of the BK K+ Channel Disrupts Suprachiasmatic Nucleus Circuit Rhythmicity and Alters Clock-Controlled Behavior” in the American Journal of Physiology-Cell Physiology, 2012, Nov 21 [Epub ahead of print] with Josh Whitt, Program in Neuroscience graduate student; Breanne Wright, UMBC undergraduate student; and Michael Lai, Bioengineering graduate student at UMCP, all also from the Department of Physiology.

January 2013

Events, Lectures & Workshops

Mordecai Blaustein, MD, professor, Departments of Physiology & Medicine, presented “Role of Endogenous Ouabain in Salt-Sensitive Hypertension” at a workshop on “Unifying Theories of Hypertension: Past, Present and Emerging” in September 2012 in Washington, DC.

Joseph Stains, PhD, assistant professor, Department of Orthopaedics, presented “The Inositol Polyphos-phate/Protein Kinase C-delta Signaling Cascade Is Required for the Connexin43-dependent Amplification of Runx2 Activity” at the 2012 Annual Meeting of the American Society for Bone and Mineral Research in Minneapolis, MN, in October 2012.  

Grants & Contracts

Curt Civin, MD, professor, Departments of Pediatrics and Physiology, associate dean for Research, and director of the Center for Stem Cell Biology & Regenerative Medicine, was awarded two one-year, $75,000 grants from GPB Scientific, LLC, one for “High Efficiency Microfluidic Purification of Stem Cells to Improve Transplants” and the other for “Microfluidic Processing of Leukocytes for Molecular Diagnostic Testing.”

Joseph Stains, PhD, and Eugene Koh, MD, PhD, both assistant professors, Department of Orthopaedics, have been awarded a two-year, $229,412 grant from the Maryland Technology Development Corporation (TEDCO) for “Using Gap Junctions to Enhance Stem Cell Therapies in Osteoarthritis.” Dr. Stains will serve as the PI on this project, and Dr. Koh will be the Co-PI.  

Publications

Charles Chaffin, PhD, associate professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was among the co-authors on “Rhesus Monkey Cumulus Cells Revert to a Mural Granulosa Cell State After an Ovulatory Stimulus” in Endocrinology, 2012 Nov;153(11):5535-45.

Curt Civin, MD, professor, Departments of Pediatrics and Physiology, associate dean for Research and director of the Center for Stem Cell Biology & Regenerative Medicine, was among the co-authors on “Generation and Genetic Engineering of Human Induced Pluripotent Stem Cells Using Designed Zinc Finger Nucleases” in Stem Cells and Development, 2012 Oct 19 [Epub ahead of print].

Loren Thompson, PhD, associate professor, and Yazan Al-Hasan, PhD, former postdoctoral fellow, Department of Obstetrics, Gynecology & Reproductive Sciences, were co-authors on “Impact of Oxidative Stress in Fetal Programming” in the Journal of Pregnancy, 2012;2012:582748.

See more in the Buzz Archive.  

December 17, 2012: The President’s Message

Laurels

University researchers led by J. Marc Simard, MD, PhD, professor, have discovered a new ion channel, the NC(Ca-ATP) channel, on certain cells in the central nervous system. A newly issued Japanese patent is directed toward a method of treating spinal cord injury by administering a drug that inhibits the NC(Ca-ATP) channels.

Inventors at the University, including Paul Welling, MD, professor, have been issued a U.S. patent for their discovery of a novel potassium channel (ROMK) internalization sequence and its corresponding binding partner—the autosomal recessive hypercholesterolemia (ARH) gene—which removes ROMK from the membrane, leading to decreased potassium loss. The invention could be used in the treatment of heart disease or Addison’s disease, or for patients receiving diuretics, ACE inhibitors, or chemotherapy for cancer. Also, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) issued Welling a four-year, $1,062,608 research grant—part of a National Institutes of Health (NIH) multi-PI grant with collaborator Eric Delpire, PhD, of Vanderbilt University—for “Kinase Modulation of Na+-Dependent Cl-Coupled Transporters in Mouse Kidney.” Welling also received a five-year, $1,669,315 NIH competing-renewal grant from the NIDDK for “Molecular Basis of Potassium Channels in the Kidney.”

December 2012

Events, Lectures & Workshops

Curt Civin, MD, professor, Departments of Pediatrics and Physiology, associate dean for research at the School of Medicine and director of the Center for Stem Cell Biology & Regenerative Medicine, served as a panelist for the 2012 Mid-Atlantic Bio Conference held in September in Bethesda, MD.

Alan Shuldiner, MD, the John L. Whitehurst Endowed Professor, Department of Medicine, and director of the Program in Personalized and Genomic Medicine, gave the Jack Mulholland Memorial Lecture, entitled “Knitting Needles, Lancaster Haystacks and the Search for Genes for Common Diseases and Their Treatment and Prevention” at Union Memorial Hospital in Baltimore, MD, on September 6.

The faculty of the Department of Physiology held a Mini-Med School at the Edenwald Retirement Community in Towson earlier this year. Led by Ted Carski, ’56, the faculty gave monthly lectures to the residents highlighting on-going research in the department, with emphasis on the health concerns of the elderly. It obviously had an impact—in the weeks following the lecture by Scott Thompson, PhD, professor and interim chair of the department, regarding depression in the elderly and the beneficial effects of physical exercise, Dr. Carski said use of the Edenwald Fitness Center increased by more than 50 percent.  

Grants & Contracts

Maureen Shanks, PhD, former research associate, along with Joseph Mauban, PhD, academic fellow, both from the Department of Physiology, and Linda Lund, PhD, research associate, Department of Biochemistry & Molecular Biology, were among the co-authors on “Chromodomain Helicase Binding Protein 8 (Chd8) Is a Novel A-Kinase Anchoring Protein Expressed during Rat Cardiac Development” in PLoS ONE, 2012;7(10): e46316.

Loren Thompson, PhD, associate professor, and Yazan Al-Hasan, PhD, former postdoctoral fellow, both from the Department of Obstetrics, Gynecology & Reproductive Sciences were among the co-authors on “Impact of Oxidative Stress in Fetal Programming” in the Journal of Pregnancy, 2012 July [Epub ahead of print].  

November 2012

Appointments

Alan Shuldiner, MD, the John Whitehurst Professor in the Department of Medicine, associate dean for Personalized Medicine, and director of the Program in Personalized & Genomic Medicine, has been appointed as Chair of the Observational Monitoring Board for the NHLBI Life After Linkage Consortium.

Grants & Contracts

Joseph Roche, PhD, assistant professor, Department of Physiology, received a one-year, $56,511 grant from the Jain Foundation for his research “Targeting Mitochondrial Mediated Apoptosis for Effectively Treating Dysferlinopathies.”

William Stanley, MD, professor, Department of Medicine, received a two-year, $351,000 R21 grant for “Mitochondrial Proteome Dynamics in Heart Failure Assessed with Heavy Water.” It started on August 1.

Paul Welling, MD, professor, Department of Physiology, received a four-year, $1,062,608 research grant (as part of an NIH, Multi-PI grant with collaborator Dr. Eric J. Delpire and Vanderbilt University) from the National Institute of Diabetes and Kidney Diseases (NIDKD) for “Kinase Modulation of Na+-Dependent Cl-Coupled Transporters in Mouse Kidney.” He also received a five-year, $1,669,315 NIH competing-renewal grant from the NIDKD for “Molecular Basis of Potassium Channels in the Kidney.”

Publications

Charles Chaffin, PhD, associate professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was a co-author on “Of the Many Secrets of Steroidogenesis” in Biology of Reproduction, 2012;86(1):1-2.

Alan Shuldiner, MD, the John Whitehurst Professor in the Department of Medicine, associate dean for Personalized Medicine, and director of the Program in Personalized & Genomic Medicine, was a co-author on “A Genome-Wide Approach Accounting for Body Mass Index Identifies Genetic Variants Influencing Fasting Glycemic Traits and Insulin Resistance” in Nature Genetics, 2012, May 13;44(6):659-69; a co-author on “Clopidogrel: A Case for Indication-Specific Pharmacogenetics” in the Journal of Clinical and Pharmacologic Therapeutics, 2012 May;91(5):774-6; a co-author on “Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women” in PLoS Genetics, 2012;8(5):e1002695 [Epub ahead of print]; a co-author on “Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits” in Diabetes, 2012 Aug;61(8):2176-86; and a co-author on “The C Allele of ATM rs11212617 Does Not Associate With Metformin Response in the Diabetes Prevention Program” in Diabetes Care, 2012 Sep;35(9):1864-1867.

 Loren Thompson, PhD, associate professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was among the co-authors on “Chronic Hypoxia Increases Peroxynitrite, MMP9 Expression, and Collagen Accumulation in Fetal Guinea Pig Hearts” in Pediatric Research, 2012;71(1):25-31.

October 2012

Publications

William Stanley, PhD, professor, Department of Medicine, Division of Cardiology, published an article with postdoctoral fellow Tatiana Galvao, MD, PhD, entitled “High Saturated Fat Intake Improves Survival in Heart Failure Compared to a High Polyunsaturated Fat or Low Fat Diet Despite Persistent Mitochondrial Defects” in Cardiovascular Research, 93:24-32, 2012.

Grants & Contracts

Robert Bloch, PhD, professor, Department of Physiology, received a one-year subcontract renewal for $43,890 from the Boston Biomedical Research Institute for contract work entitled “Developing and Testing Mouse Models of FSHD.”

Joseph Stains, PhD, assistant professor, Department of Orthopaedics, has received a two-year, $200,000 grant from the Maryland Stem Cell Research Fund.

September 2012

Publications

Curt Civin, MD, professor, Departments of Pediatrics and Physiology; associate dean for research, University of Maryland School of Medicine; and director, Center for Stem Cell Biology & Regenerative Medicine, co-authored “Late-Stage Erythroid Precursor Production is Impaired in Mice with Chronic Inflammation” in the journal Haematologica, 2012 May 11 [Epub ahead of print].

Events, Lectures & Workshops

Curt Civin, MD, professor, Departments of Pediatrics and Physiology; associate dean for research, University of Maryland School of Medicine; and director, Center for Stem Cell Biology & Regenerative Medicine, lectured on April 23 at Grand Rounds for the Department of Pathology at the Johns Hopkins University School of Medicine. His topic was “CD34 Stem Cell Stories and Lessons from the CD34 Wars.” On May 3, he presented “Toward Clinical Therapies Using Stem Cells: Lessons from Hematopoietic Stem Cells” at the STEP Forum at the NIH Center for Scientific Review in Bethesda, MD. And on May 9 he served as a panelist on The A. Alfred Taubman Forum on Public Policy: Innovation in Health Care, in the session on “Bringing Health Care Into the 21st Century,” at the Brookings Institute, Washington, DC.

Grants & Contracts

Tami Kingsbury, PhD, assistant professor, Department of Physiology and Center for Stem Cell Biology & Regenerative Medicine (PI), and Curt Civin, MD, professor, Departments of Pediatrics and Physiology; associate dean for research, University of Maryland School of Medicine; and director, Center for Stem Cell Biology & Regenerative Medicine, were awarded a two-year, $230,000 grant for their research entitled “MicroRNA and Control of Quiescence and Pluripotency” from the Maryland Stem Cell Research Fund. Dr. Civin, along with Kara Scheibner, PhD, assistant professor, Center for Stem Cell Biology and Regenerative Medicine, and Feyruz Rassool, PhD, associate professor, Department of Radiation Oncology and interim director of Radiobiology, were awarded a two-year, $230,000 grant for their research entitled “Regulation of DNA Double Strand Break Repair in Human Hematopoietic Stem Cells by MicroRNAs” from the Maryland Stem Cell Research Fund. Dr. Civin; Steven Zhan, PhD, professor, Department of Pathology and the Center for Vascular and Inflammatory Diseases; and Srujana Cherukuri, PhD, research associate, Department of Pediatrics and the Center for Stem Cell Biology & Regenerative Medicine, were awarded a two-year, $230,000 grant entitled “Modulation of Homing and Engraftment of Hematopoietic Stem Cells by I-BAR Proteins” from the Maryland Stem Cell Research Fund as well.

May 2012

Publications

Mordecai Blaustein, MD, professor, Joseph Kao, PhD, professor, and Donald Matteson, PhD, associate professor, all from the Department of Physiology, recently published the textbook Cellular Physiology and Neurophysiology, 2nd Edition (2012) as part of the Mosby Physiology Monograph Series, Elsevier Mosby, Philadelphia, 337 pages.

Cristina Linde, PhD, postdoctoral fellow; Eiji Karashima, MD, PhD, former postdoctoral fellow; Hema Raina, MD, PhD, postdoctoral fellow; Alessandra Zulian, PhD, former postdoctoral fellow; W. Gil Wier, PhD, professor; John Hamlyn, PhD, professor; Mordecai Blaustein, MD, professor; and Vera Golovina, PhD, associate professor, all from the Department of Physiology, co-authored “Increased Arterial Smooth Muscle Ca2+ Signaling, Vasoconstriction, and Myogenic Reactivity in Milan Hypertensive Rats” in the American Journal of Physiology-Heart and Circulatory Physiology, 2012 Feb;302(3):H611-20. Drs. Golvina and Hamlyn, along with Brandiese Jacobs, BS, doctoral student; Yong Liu, PhD, postdoctoral fellow; and Maria Pulina, PhD, former postdoctoral fellow in the department, also published “Normal Pregnancy: A Ouabain Resistant State with Elevated Endogenous Ouabain, Suppressed Arterial Sodium Calcium Exchange and Low Blood Pressure” in the American Journal of Physiology-Heart and Circulatory Physiology, 2012 Jan 13 [Epub ahead of print].

In the News

Mordecai Blaustein, MD, professor, Departments of Physiology and Medicine and director, Maryland Center for Heart, Hypertension & Kidney Disease, was interviewed for an invited podcast entitled “Molecular Mechanisms Linking Salt to Hypertension,” which was broadcast by AJP-Heart and Circulatory Physiology. This podcast interview was related to his American Journal of Physiology-Heart and Circulatory Physiology review “How NaCl Raises Blood Pressure: A New Paradigm for the Pathogenesis of Salt-Dependent Hypertension.” 

Andrea Meredith, PhD, assistant professor, Department of Physiology, was quoted in a March 8, 2012, Baltimore Sun article “Making Up for Lost Daylight Savings Time,” regarding the negative impact of the “spring forward” time change.

Grants and Contracts

Mordecai Blaustein, MD, professor, Departments of Physiology and Medicine, and director, Maryland Center for Heart, Hypertension & Kidney Disease, received a four-year, $383,750 grant from the National Heart, Lung, and Blood Institute for “Alpha-2 Na+ Pumps, Ca2+, Arterial Contraction & Hypertension,” which focuses on acute and chronic ouabain-Na+ pump interactions and the specific role of Na+ pumps in the Ca2+ signaling pathway in the pathogenesis of salt-dependent hypertension.

Robert Bloch, PhD, professor, Department of Physiology, received a one-year, $350,000 research grant from the Jain Foundation for his work “Analyzing the Role of Dysferlin in Skeletal Muscle In Vitro and In Vivo.”

Elizabeth Powell, PhD, associate professor, Department of Anatomy & Neurobiology, and Bruce Krueger, PhD, professor, Department of Physiology, received a five-year, $1,592,565 Dual-PI grant from the National Institutes of Health’s Eunice Kennedy Shriver National Institute of Child Health and Human Development for their work entitled “Mechanisms of Valproic Acid-Induced Neurodevelopmental and Behavioral Defects.”

April 2012

Publications

Matthew Trudeau, PhD, assistant professor, Department of Physiology, published "hERG1a N-terminal Eag Domain-Containing Polypeptides Regulate Homomeric hERG1b and Heteromeric hERG1a/hERG1b Channels: A Possible Mechanism for Long QT Syndrome” in the Journal of General Physiology, 2011 Dec;138(6):581-92. He, along with graduate student Elena Gianulis, also from the Department of Physiology, published "Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-Go-Go-Related Gene Potassium Channels” in the Journal of Biological Chemistry, 2011 Jun 24;286(25):22160-9.

February 2012

Events, Lectures and Workshops

Mordecai Blaustein, MD, professor, Departments of Physiology and Medicine and director, Maryland Center for Heart, Hypertension & Kidney Disease, presented an invited conference banquet lecture entitled “Livin with NCX—and Lovin’ It: A 45-Year Romance” at the 6th International Conference on Sodium Calcium Exchanger in Ischia, Naples, Italy on October 4, 2011. At the same conference, Vera Golovina, PhD, associate professor, Department of Physiology, presented an invited talk entitled “Cross-Talk Between Plasma Membrane Na+/Ca2+ Exchanger-1 and TRPC/Orai-Containing Channels: Key Players in Arterial Hypertension” and Jin Zhang, MD, PhD, assistant professor, Department of Physiology, presented an invited talk entitled “NCX: A Key Player in the Regulation of Arterial Contraction and Blood Pressure.”

Honors and Awards

Ben Prosser, PhD, postdoctoral fellow, Department of Physiology and Center for Biomedical Engineering & Technology (BioMET), was named the GPILS Outstanding Postdoctoral Scholar for 2011. The formal award was given to Dr. Prosser at the GPILS Award Ceremony held on November 7, 2011.