Bookmark and Share

Current Buzz

December 2014

Laurels

W. Jonathan Lederer, MD, PhD, professor in the Department of Physiology and director of the Center for Biomedical Engineering and Technology, is the co-recipient of the 2015 Peter Harris Distinguished Scientist Award from the International Society for Heart Research (ISHR). The award will be presented during an ISHR meeting in Bordeaux, France, in July 2015.

Events, Lectures and Workshops

Curt Civin, MD, Associate Dean for Research, Director, Center for Stem Cell Biology & Regenerative Medicine, and Professor, Departments of Pediatrics and Physiology, will present “MicroRNA (MIR) Regulation of Human Hematopoietic Stem-Progenitors (HSPCs)” at the Plenary Session during the 7th Annual Maryland Stem Cell Research Fund Symposium (MSCRF), to be held at the Silver Spring Civic Center on December 2.

Maryland Stem Cell Research Grant Fund Awardees

Investigator-Initiated Grant Awardees:

Curt Civin, MD, Professor, Department of Pediatrics, Director of the Center for Stem Cell Biology & Regenerative Medicine, and Associate Dean for Research—“Genetic Modification of Sickle Cell Disease in Hematopoietic Stem Cells” J Ke Ren, MD, PhD, Associate Professor, Department of Anatomy & Neurobiology (secondary appointment) and University of Maryland School of Dentistry—“Mesenchymal Stem Cells for Chronic Pain Therapy”

Exploratory Grant Awardees:

Curt Civin, MD, Professor, Department of Pediatrics, Director of the Center for Stem Cell Biology & Regenerative Medicine, and Associate Dean for Research, and Jonathan Dinman, University of Maryland, College Park—“Directed Delivery of Therapeutic RNAs into Hematopoietic Stem-Progenitor Cells” J Marta Lipinski, PhD, Assistant Professor, Department of Anesthesiology—“Modeling Parkinson’s Disease Function of the PARK10 Gene USP24 in Human iPS Cells” J A-Lien Lu-Chang, PhD, Professor, Department of Biochemistry & Molecular Biology—“The Effects of Histone Deacetylation and DNA Demethylation on Somatic Cell Reprogramming” J Feyruz Rassool, PhD, Associate Professor, Department of Radiation Oncology—“Efficiently Reprogramed Cells with a MYC Signature Display High Fidelity Repair of DNA Damage.” J Joseph Stains, PhD, Associate Professor, Department of Orthopaedics—“The Role of the Beta-Catenin Signaling Cascade in the Skeletal Phenotype of Hutchinson-Gilford Progeria Syndrome”

In the News

Curt Civin, MD, Associate Dean for Research, Director, Center for Stem Cell Biology & Regenerative Medicine, and Professor, Departments of Pediatrics and Physiology, was featured on the cover and in a feature story for the National Foundation for Cancer Research Progress Report. The interview was titled “Molecular Sawdust Holds The Key—The Power of microRNA.”

November 2014

Honors and Awards

W. Jonathan Lederer, MD, PhD, Professor, Department of Physiology, and Director of the Center for Biomedical Engineering and Technology (BioMET), has been se-lected as the co-recipient (with Dr. Roberto Bolli from the University of Louisville) of the 2015 Peter Harris Distinguished Scientist Award of the International Society for Heart Research (ISHR). The award will be bestowed during the 2015 ISHR European Section meeting in Bordeaux, France from July 2–5, 2015. As a recipient of this award, Dr. Lederer will present a major lecture and receive $3,000 and a plaque. An announcement of the Award, along with a photograph and a biosketch, will be pub-lished in Heart News and Views and posted on the ISHR website. Dr. Lederer will also prepare a review article based on his lecture that will be published in the Journal of Molecular and Cellular Cardiology, published by the ISHR. The full details of the award are available on the ISHR website at www.ishrworld.org.

October 2014

Grants and Contracts

Thomas Blanpied, PhD, Associate Professor, Department of Physiology, received a five-year, $335,850 subcontract from the University of Pittsburgh as part of a three-investigator, multi-PI R01 grant from the National Institute of Neurological Disorders and Stroke for “CRCNS: Transmitter Release Site Organization in Plasticity and Disease at the NMJ.”

Mark Rizzo, PhD, Associate Professor, Department of Physiology, received a five-year, $1,822,815 grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) for a competing renewal of “Regulatory Mechanisms of Insulin Secretion.”

Publications

Andrea Meredith, PhD, Associate Professor, Department of Physiology, was among the co-authors on “Nuclear BK channels Regulate Gene Expression Via the Control of Nuclear Calcium Signaling” in Nature Neuroscience, 2014 Aug;17(8):1055-63.

Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, was among the co-authors on “An Unsuspected Cause of Diarrhoea and Gastrointestinal Bleeding During Corticosteroid Therapy” in Acta Gastro-Enterologica Belgica, 2014 Jun;77:259–261.

September 2014

Grants and Contracts

W. Jonathan Lederer, MD, PhD, Professor, Department of Physiology, and Director of The Center for Biomedical Engineering and Technology (BioMET), received a $3.55 million grant from NIH/NHLBI for “Multi-scale Spatiotemporal Modeling of Cardiac Mitochondria.” The grant combines advanced computer modeling with state-of-the-art imaging and electrophysiology.

Sarah Ransom, BS, a PhD student in the Department of Physiology working in the lab of Thomas Blanpied, PhD, Associate Professor, received a two-year, $74,584 NIH Ruth L. Kirschstein National Research Service Award (NRSA) F31 individual training grant from the National Institute of Mental Health for “Regulation of NMDA Receptor Activation by Postsynaptic Nanostructure.”

August 2014

Events, Lectures and Workshops

Andrea Meredith, PhD, Associate Professor, Department of Physiology, presented “Beyond Transcription: Identification of Novel Biophysical Mechanisms That Generate Daily Differences In SCN BK Currents” at the Society for Research on Biological Rhythms (SRBR) Annual Meeting in Big Sky, MT, on June 15.

Honors and Awards

Curtis Gallagher, Graduate Student, Department of Physiology, was awarded the 2014 Glaser Prize in Imaging for his image of a hippocampal neuron in cell culture expressing cyan fluorescent protein. This prize was established to honor Dr. Edmund Glaser upon his retirement from the Department of Physiology in 1997. Dr. Glaser and his colleague, Dr. Hendrick Van der Loos, made a seminal contribution in the 1960s by creating the first computer-assisted neuron reconstruction system—Neurolucida. Dr. Glaser went on to found a company, MBF Bioscience, to further develop and market software for neuroscience imaging. The Glaser prize is awarded for the most visually attractive scientific image submitted by a student working in the laboratory of a faculty member in the Department of Physiology. All of the 2013 and 2014 submitted images are currently on display in the second-floor lobby of the SMC Campus Center.

The article “Anatomy of Success: The Top 100 Cited Scientific Reports Focused on Hypertension Research” in Hypertension 63:641-647, 2014), cited three articles from the University of Maryland School of Medicine’s Department of Physiology, chosen from a field of more than 380,000 articles. It included a review and hypothesis by Mordecai Blaustein, MD, in the American Journal of Physiology, 1977, 232:C165-C173 (#27; 1294 citations), and a research article by John Hamlyn, PhD, et al. in Nature, 1982, 300:650-652 (#92, 614 citations). Furthermore, Young and Galis’ “List of Top 100 ‘Original’ Articles in Hypertension Research” includes the aforementioned Hamlyn et al. article (#73) and another Hamlyn et al article from Proceedings of the National Academy of Sciences, USA, 88:6259-6263, 1991 (# 89; 561 citations). The three articles describe, respectively, the hypothesis that a novel ‘ouabain-like’ hormone plays a role in hypertension (1977); preliminary evidence for the hormone in human plasma (1982); and the purification, from human plasma, and identification of ‘endogenous ouabain’ (1991). Drs. Hamlyn and Blaustein, both professors in the Department of Physiology, are the only authors with two basic research studies on the latter list.

July 2014

Publications

Chunsik Lee, PhD, Research Associate; Anguo Liu, PhD, Research Associate; Alba Miranda-Ribera, PhD, Research Associate; and Sang Hyun, PhD, Research Associate, all from the Department of Medicine; along with Erik Lillehoj, PhD, Associate Professor, Department of Pediatrics; Alan Cross, MD, and Simeon Goldblum, MD, both Professors, Department of Medicine; Antonino Passaniti, PhD, Associate Professor, Department of Pathology; and Bo-Young Kim, Research Specialist, and Paul Welling, MD, Professor, both from the Department of Physiology, were among the co-authors on “NEU1 Sialidase Regulates the Sialylation State of CD31 and Disrupts CD31-Driven Capillary-like Tube Formation in Human Lung Microvascular Endothelia” in the Journal of Biological Chemistry, 2014 Mar 28;289(13):9121-9135.

Honors and Awards

Steven Fisher, MD, Professor, Department of Medicine, has been awarded the 2014 Distinguished Service Award by the Physiological Genomics Group of the American Physical Society (APS).

Michael Lai, a PhD Student in the Fischell Department of Bioengineering of the University of Maryland, College Park, who is performing his research in the School of Medicine’s Department of Physiology, in the laboratory of Andrea Meredith, PhD, Assistant Professor, was awarded the first annual Hugo Gonzalez-Serratos Scientific Presentation Award for the best presentation at the joint Annual Retreat of the training programs in Integrative Membrane and Interdisciplinary Muscle Research. The award was established to honor the memory of Hugo Gonzalez-Serratos, PhD, who was a professor in the Department of Physiology until his death in 2011. Michael’s research concerns the role of BK-type potassium channels in the sinoatrial node of the heart, where he shows that they strongly influence the pacemaker of the heart.

Rick Matteson, PhD, Associate Professor, Department of Physiology, and Director of Student Research Education and Dual Degree Programs, and Susan Wolfsthal, MD, the Celeste Lauve Woodward, MD Professor in Humanism and Ethical Medical Practice, Department of Medicine, Internal Medicine Residency Program Director, and Associate Chair for Education in the Department of Medicine, were inducted into the Carolyn J. Pass, MD ’66 and Richard M. Susel, MD ’66 Academy of Educational Excellence, which was established in 2008 to honor faculty members past and present who demonstrate exceptional innovation in, and dedication to, medical education; who embody the highest ideals of the medical and/or science professions; and who display a singular commitment to the best interests of medical students.

Matthew Trudeau, PhD, Associate Professor, Department of Physiology, received the Cranefield Award for his paper “Direct Interaction of EAG Domains and Cyclic Nucleotide-Binding Homology Domains Regulate Deactivation Gating in hERG Channels,” which was published in the Journal of General Physiology in 2013. The Paul F. Cranefield Award was created by the Council of the Society of General Physiologists to honor Paul F. Cranefield, MD, PhD, who for 30 years served as Editor of the Journal of General Physiology. The Award is meant to recognize an independent young investigator who in the preceding calendar year has published an outstanding article in the journal. It further was stipulated that the Award need not be given every year; that it should be reserved for a truly noteworthy paper. This award comes with a $2,000 cash prize, to be issued at the Society of General Physiologists meeting in September 2014. Elena Gianulis, BS, Graduate Student, won the Graduate Student Cranefield Award for the same paper.

Paul Welling, MD, Professor, Department of Physiology, received the Steven Hebert Award from the American Physiological Society and was honored to deliver the Steven Hebert Distinguished Lecture at the Experimental Biology Meeting in San Diego, CA, in April 2014. This award from the Epithelial Transport Group honors Dr. Steven Hebert, former chair and C.N.H. Long Professor of Cellular and Molecular Physiology and Professor of Medicine at the Yale University School of Medicine, who was a pioneer in developing a genetic and molecular understanding of renal ion transport mechanisms. Dr. Welling’s lecture highlighted his laboratory’s efforts to elucidate the molecular underpinnings of sodium-potassium balance, and blood-pressure control. Dr. Welling joins the illustrious company of former awardees such as Richard P. Lifton (Yale); Ernest M. Wright (UCLA); William Guggino (Johns Hopkins); and Gerardo Gamba (Universidad Nacional Autonoma de Mexico) in this honor.

Events, Lectures and Workshops

Steven Fisher, MD, Professor, Department of Medicine, was an invited speaker and presented “Regulation and Function of Myosin Light Chain Phosphatase” at “Symposium on Regulatory Circuits in Cell Motility: A Celebration of Dave Hartshorne’s Career,” sponsored by The Physiological Society of Philadelphia. He also presented on “Smooth Muscle Cell Biology and Mechanobiology” at the International Society for Applied Cardiovascular Biology in April.

John McLenithan, PhD, Assistant Professor, Departments of Medicine and Physiology, gave a lecture on “Adipokines and Inflammatory Mediators: The Link Between Obesity and GDM” at the 13th Annual Meeting of the Diabetes in Pregnancy Study Group of North America, and “Adipose Tissue in Health and Disease” in a lecture at Howard University’s Department of Nutrition.

Media Spotlight

Stephen Davis, MBBS, FRCP, FACP, the Theodore E. Woodward Professor of Medicine and Chairman, Department of Medicine, was quoted in the Baltimore Sun article “Officials Urge Consumers to Cut Back on Sugar” on March 21, and was featured in a WJZ-TV interview on March 25 at the opening of the Expanded Diabetes Center at the University of Maryland Midtown Campus.

June 2014

Publications

Terez Shea-Donohue, PhD, Professor, and Aiping Zhao, MD, Associate Professor, both from the Department of Radiation Oncology, were among the co-authors on “SerpinB2 Mediated Regulation of Macrophage Function During Enteric Infection” in Gut Microbes, 2014 Feb 5;5(2) [Epub ahead of print].

May 2014

Events, Lectures & Workshops

Scott Thompson, PhD, Professor and Chair, Department of Physiology; Elyse Sullivan, PhD student, Program in Neuroscience; and Emma Rose, PhD, Visiting Assistant Professor, Department of Psychiatry, were on Capitol Hill on March 26 on behalf of the Society for Neuroscience, lobbying congress on the need for increased funding for the National Institutes of Health (NIH) and the National Science Foundation (NSF). The three met with healthcare and science policy staffers in the offices of both Maryland senators and Maryland representatives to describe their personal experiences with the drastic consequences of sequestration on the research enterprise and to make the case for a full restoration of funding for the NIH and NSF.

Grants & Contracts

Robert Bloch, PhD, Professor, Department of Physiology, received a new five-year, $1,688,500 grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for his research on “Role of Dysferlin In T-Tubules of Skeletal Muscle.”

Mark Rizzo, PhD, Associate Professor, and Withrow Wier, PhD, Professor, both from the Department of Physiology, received a new two-year, $422,125, Multi-PI R21 research grant from the Office of the Director, National Institutes of Health, for their research on “Development of RhoA Optical Sensor Mice for Novel Vascular Smooth Muscle Studies.”

April 2014

Grants & Contracts

Robert Bloch, PhD, Professor, Department of Physiology, received a one-year $250,000 contract from the Jain Foundation for “Analyzing the Role of Dysferlin in Skeletal Muscle in Vitro and in Vivo.”

Honors & Awards

Mordecai Blaustein, MD, Professor, Department of Physiology, will receive the American Physiological Society’s (APS) 2014 Annual Reviews Award for Scientific Reviews at the Experimental Biology Meeting on April 29 in San Diego, CA.

Publications

Terez Shea-Donohue, PhD, Professor, and Aiping Zhao, PhD, Associate Professor, both from the Department of Radiation Oncology, were among the co-authors on “Role of Macrophages in the Altered Epithelial Function During a Type 2 Immune Response Induced by Enteric Nematode Infection” in PLoS One, 2014 Jan 23;9(1):e84763.

March 2014

Honors & Awards

Shannon Salyer, Administrative Analyst, Department of Physiology, received the distinction of making the Dean’s List for her undergraduate studies at the University of Maryland University College. This is the second such distinction in a row for Ms. Salyer. Shannon was the 2012/2013 recipient of the James T. Hill Scholarship for University of Maryland Baltimore Staff and has put her scholarship to good use by receiving this back-to-back recognition for her hard work.

February 2014

Appointments

Andrea Meredith, PhD, Associate Professor, Department of Physiology, has been elected to serve as a Councilor of the Society of General Physiologists, for a three-year term ending in 2016. The Society, founded in 1948, has a rich history in the field of physiology, and is headquartered at the Marine Biological Lab in Woods Hole, MA.

Events, Lectures & Workshops

Colin Mackenzie, MB, ChB, Clinical Professor, Department of Anesthesiology, was one of three international guests invited to give Plenary Lectures at the Australian Society of Anesthesiologists’ Annual Scientific Meeting in Canberra, Australia, from September 26–29, 2013 and in Perth and Freemantle, Western Australia, from October 1–3, 2013, as part of the Australian Society of Anesthesiologists’ CME outreach program. His lectures were entitled: “New ‘Big Data’ Approaches to Trauma Outcome Prediction”; “Current and Future Interventions for Acute Cervical Spine Trauma”; “Video Task Analysis in Healthcare and Anesthesia Crisis Events”; and “HBOC’s: Myths, Reality and the Future.”

January 2014

Appointments

Scott Thompson, PhD, Professor and Chair, Department of Physiology, became the Chair of the Public Education and Communication Committee of the Society for Neuroscience last November. This strong international professional organization has 42,000 members, supporting scientists and physicians devoted to understanding the brain and nervous system. Dr. Thompson’s committee oversees many programs focused on educating the public, policy makers, and educators about neuroscience, including the dissemination of neuroscience information through press releases and web-based content.

Paul Welling, MD, Professor, Department of Physiology, was appointed by the Federation of American Societies for Experimental Biology (FASEB) to serve on its Finance Committee for a three-year term starting in July 2013.

Grants and Contracts

Owen Woodward, PhD, Research Associate, Department of Physiology, received a four-year, $308,000 Scientist Development research grant from the American Heart Association’s National Center for “Regulation of Uric Acid Transporter ABCG2 in the Kidney.”

Publications

Andrea Meredith, PhD, Associate Professor; Chris Shelly, PhD, Postdoctoral Fellow; Joshua Whitt, Program in Neuroscience Graduate Student; and Jenna Montgomery, PhD, Postdoctoral Fellow, all from the Department of Physiology, were among the co-authors on “Phosphorylation of a Constitutive Serine Inhibits BK Channel Variants Containing the Alternate Exon ‘SRKR’” in The Journal of General Physiology, 2013 Nov 25; 142(6): 585-598. The article was accompanied by a commentary, “Multilevel Regulation: Controlling BK channels in Central Clock Neurons” in the same issue, pages 579-583.

December 2013

Publications

Terez Shea-Donohue, PhD, Professor, Department of Radiation Oncology, was among the authors on “Combined Blockade of IL-17A and IL-17F May Prevent the Development of Experimental Colitis,” in Immunotherapy, 2013 Sep;5:923–925. Dr. Shea-Donohue was also among the co-authors on “Selenium Status Alters the Immune Response and Expulsion of Adult Heligmosomoides bakeri Worms in Mice” in Infection and Immunity, 2013 Jul;81:2546–2553; and “Gut Microbiota, Tight Junction Protein Expression, Intestinal Resistance, Bacterial Translocation and Mortality Following Cholestasis Depend on the Genetic Background of the Host” in Gut Microbes, 2013 Jul-Aug;4:292–305.

November 2013

Events, Lectures & Workshops

Alan Shuldiner, MD, the John Whitehurst Professor in the Department of Medicine, Associate Dean for Personalized Medicine, and Director of the Program in Genetics and Genomic Medicine, hosted a conference at the SMC Campus center on September 3. The topic was “Regulatory Issues in Next-Generation Medicine and Pharmacogenomics.” This one-day meeting was part of the FDA-funded University of Maryland Center of Excellence in Regulatory Science and Innovation (MCERSI).

Joseph Stains, PhD, Assistant Professor, Department of Orthopaedics, presented “Both the Connexin 43-Specific Channel and C Terminus Are Required for the Regulation of Runx2 Activity and Osteoblast Gene Expression” at the International Gap Junction Conference in Charleston, SC, in July.

Grants & Contracts

Tuo Peter Li, BS, a MD/PhD Student in the Department of Physiology, received a five-year, $204,939 MD/PhD F30 individual training grant renewal from the National Institute of Mental Health for research on “The Influence of Binding and Crowding on Synaptic Protein Mobility.” This individual training grant was awarded with three years of PhD and two years of MD support. F30 grants are highly competitive and only a fraction of those MD/PhD students who apply receive funding. The purpose of the F30 is to support promising pre-doctoral applicants who have the potential to become highly productive researchers in their fields.

Scott Thompson, PhD, Professor and Chair, Department of Physiology, received a five-year, $1,177,808 training grant renewal from the National Institute of General Medical Sciences for the “Training Program in Integrative Membrane Biology.” This training grant was awarded with six pre-doctoral training slots.

Owen Woodward PhD, Research Associate, Department of Physiology, received a one-year, $40,000 research grant from the National Kidney Foundation of Maryland for his research work entitled “Urate Secretion, ABCG2 and Human Disease.”

Honors & Awards

Mark Kvarta, Graduate Student, won the Graduate Program in Life Sciences’ (GPILS) 2013 PhD Scholar Award. Mark is in the Neuroscience Program, and his mentor is Scott Thompson, PhD, Professor and Chair, Department of Physiology. Aparna Kishor, PhD, now a MS-IV, won the 2013 GPILS PhD Thesis Project Award. She completed her PhD in the Molecular Medicine Program, where her mentor was Gerald Wilson, PhD, Associate Professor, Department of Biochemistry and Molecular Biology.

Publications

Curt Civin, MD, Professor of Pediatrics and Physiology, Associate Dean for Research, and director of the Center for Stem Cell Biology & Regenerative Medicine, was among the co-authors on “Investigation of the Role of Interleukin-6 and Hepcidin Antimicrobial Peptide in the Development of Anemia with Age” in Haematologica, 2013 Oct;98(10):1633-1640.

October 2013

Appointments

Matthew Trudeau, PhD, Associate Professor, Department of Physiology, has been appointed as a Special Emphasis Panel Member to the NIH’s Biological Chemistry & Macromolecular Biophysics IRG.

Events, Lectures & Awards

Alan Shuldiner, MD, the John L. Whitehurst Professor of Medicine, Director of the Program in Pharmacogenomics and Genomic Medicine, and Associate Dean for Personalized and Genomic Medicine presented “Pharmacogenomics: Real-Work Challenges in Translation to Clinical Practice” at the Up Close and Personalized meeting in Paris, France on July 27; “Genetic Diseases in the Amish Adult Population” at the Genomic Medicine and the Plain Populations of North America conference in Lancaster, PA on July 17; “Genomic Management of Anti-Platelet Therapeutics” at the Keystone Symposia in Stockholm, Sweden on June 20; and “Amish Participation in Medical Research: A Partnership of Trust and Mutual Benefit” at the World International Conference at Elizabethtown College on June 8.

Grants & Contracts

Matthew Trudeau, PhD, Associate Professor, Department of Physiology, received a two-year, $154,000 Grant-in-Aid from the American Heart Association’s Mid-Atlantic division for his current research work “Gating in hERG K Channels.”

Publications

Matthew Trudeau, PhD, Associate Professor, Department of Physiology, was a co-author on “The eag Domain Regulates hERG Channel Inactivation Via a Direct Interaction” in The Journal of General Physiology, 2013, Feb;141(2):229-241, and “Structure of the C-terminal Region of an ERG Channel and Functional Implications” in Proceedings of the National Academy of Sciences, USA, 2013 Jul;110(28):11648-11653.

September 2013

Grants & Contracts

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology; Associate Dean for Research; and Director, Center for Stem Cell Biology & Regenerative Medicine, was awarded the Leukemia and Lymphoma Society (LLS) Translational Research Grant for research on “Artemisinins for Treatment of Acute Leukemias.” The $600,000 grant has been approved for a three-year period starting October 1.

Joseph Stains, PhD, Assistant Professor, Department of Orthopaedics, was recently awarded a five-year, $1.1 million NIH R01 research grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for his research on “Regulation of Osteoblast Differentiation and Function by Connexin 43.”

Loren Thompson, PhD (pictured), Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, and Bhanu Telugu, PhD, Assistant Professor, Department of Animal Science, UMCP, received a one-year, UMB/UMCP Seed Grant Award for $75,000 to research “Development of a Novel Animal Model for Human Preeclampsia.”

Publications

Charles Chaffin, PhD, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was a co-author on “Follicle Growth, Ovulation, And Luteal Formation In Primates And Rodents: A Comparative Perspective” in Experimental Biology and Medicine, 2013 May 1;238(5):539-48.

Joseph Stains, PhD, Assistant Professor, and Carla Hebert, Research Assistant, both from the Department of Orthopaedics, were among the co-authors on “Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43” in Calcified Tissue International, 2013 Jun 11 [Epub ahead of print].

August 2013

Appointments

Mordecai Blaustein, MD, Professor, Department of Physiology, has been elected as an honorary member of the Physiological Society by their Council of Trustees. He was formally welcomed at the Physiological Society 2013 annual meeting.

Curt Civin, MD, Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine; and Professor, Departments of Pediatrics and Physiology, was inducted into the Baltimore Jewish Hall of Fame at the Gordon Jewish Community Center in Baltimore on June 12. The Jewish Hall of Fame celebrates Jewish Baltimoreans who have a made a difference in the fields of medicine, science, politics, law, education, business, community service, arts & entertainment, and beyond. Dr. Civin was honored for his contributions in the field of medicine for his work with stem cells, specifically his groundbreaking research that led to the development and implementation of both clinical bone marrow stem-cell transplantation and leukemia diagnosis. Created in 2008, the Baltimore Jewish Hall of Fame now has 38 members, including this year’s nine honorees. Dr. Civin is one of six physician members.

Events, Lectures & Workshops

Charles Chaffin, PhD, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, presented “How the Sugars That Fuel the Oocyte Are Regulated” to the Department of Biology at Loyola University Chicago in March. Also in March, Dr. Chaffin lectured on ovarian follicle growth at the “Frontiers in Reproductive Medicine” course sponsored by the University of Medicine and Dentistry of New Jersey.

Curt Civin, MD, Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine; and Professor, Departments of Pediatrics and Physiology, presented “The Progress and Vision of Stem Cell Research in Maryland” to the TEDCO Board of Directors in Columbia, MD, on May 16.

Grants and Contracts

Eugene Albrecht, PhD, Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, received a four-year $2.43 million R01 research grant from the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) in April for “Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth.” Dr. Albrecht and his team will study the impact of estrogen deprivation during primate pregnancy on the development of insulin insensitivity in offspring after birth. The study highlights the consequences of estrogen deprivation in human pregnancy (i.e. premature birth or exposure to endocrine disruptors), in increasing the risk of developing type 2 diabetes in offspring after birth.

Publications

Charles Chaffin, PhD, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was among the co-authors on “EGF-Like Ligands Mediate Progesterone’s Anti-Apoptotic Action on Macaque Granulosa Cells” in Biology of Reproduction, 2013 Jan 25;88(1):18.

Curt Civin, MD, Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine; and Professor, Departments of Pediatrics and Physiology, was among the co-authors on “Artemisinin-Derived Dimer Phosphate Esters as Potent Anti-Cytomegalovirus (Anti-CMV) and Anti-Cancer Agents: A Structure-Activity Study” in Bioorganic & Medicinal Chemistry, 2013, April [Epub ahead of print]; and “FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm” in Cell Stem Cell, 2013, 11(3):346-58.

Andrea Meredith, PhD, Associate Professor, Department of Physiology, was among the co-authors on “mitoBKCa is Encoded By the Kcnma1 Gene, and a Splicing Sequence Defines Its Mitochondrial Location” in the Proceedings of the National Academy of Sciences, 2013 Jun 10 [Epub ahead of print]. She was also among the co-authors on “Quantitative Localization of Cav2.1 (P/Q-type) Voltage-Dependent Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic Co-clustering with Calcium-Activated Potassium Channels” in the Journal of Neuroscience, 2013; Feb 20;33(8):3668-78; and “Olivocochlear Suppression of Outer Hair Cells In Vivo: Evidence for Combined Action of BK and SK2 Channels Throughout the Cochlea” in the Journal of Neurophysiology, 2013; Mar;109(6):1525-34.

July 2013

Events, Lectures & Workshops

Thomas Blanpied, PhD, Associate Professor, Department of Physiology, was invited to present “Single-Molecule Imaging Reveals Protein Position and Dynamics in the Synapse of Living Neurons” at the International Society for Neurochemistry’s Satellite meeting “Emerging Topics in Synapse Function: Molecular Mechanisms, Circuit Function, and Disease,” held April 20–24 in Cancun, Mexico.

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology, Associate Dean for Research, and Director, Center for Stem Cell Biology & Regenerative Medicine, presented “How to Develop a Funding Plan for Your Research and Lab: Role of NIH Funding, Other Sources of Funding (Advantages, Disadvantages)” at the Scientific Leadership & Professional Development Symposium for Basic Science and Translational Researchers, held here on campus on April 24.

Stephen Davis, MBBS, FRCP, FACP, the Theodore E. Woodward Professor and Chair, Department of Medicine, gave the Albert & Miriam Weinstein Lecture at Vanderbilt University Medical Center on April 18. His topic was “Novel Mechanisms Implicated in Hypoglycemia-Associated Autonomic Failure.”

Alan Shuldiner, MD, the John L. Whitehurst Professor of Medicine, Director of the Program in Genetics and Genomic Medicine, and Associate Dean for Personalized and Genomic Medicine, presented “Genomics of the Metabolic Syndrome: Lessons Learned from Engaging the Amish Community as a Founder Population” at the Rockefeller University Clinical Research Seminar on March 27.

Honors & Awards

Shannon Salyer, Budget Analyst, Department of Physiology, was the recipient of the James T. Hill Scholarship from the University of Maryland, Baltimore. At the 2012/2013 Employee Service Recognition Luncheon on April 18, Shannon received a check for $2,000 to help her continue her education. She is currently working toward an undergraduate degree in Business Administration.

Publications

Harold MacGillavry, PhD, Postdoctoral Fellow, and Thomas Blanpied, PhD (pictured), Associate Professor, both from the Department of Physiology, were among the co-authors on “Nanoscale Scaffolding Domains Within the Postsynaptic Density Concentrate Synaptic AMPA Receptors,” published in Neuron, 2013 May;78: 1-8.

June 2013

Events, Lectures & Workshops

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology; Associate Dean for Research; and Director, Center for Stem Cell Biology & Regenerative Medicine, presented “The Ethical Issues Surrounding Non-Financial Conflicts of Interest” at the AAMC Forum on Conflict of Interest in Academe (FOCI) Meeting in Baltimore on March 21.

Alan Shuldiner, MD, the John Whitehurst Professor, Department of Medicine, and Associate Dean for Personalized & Genomic Medicine, was the Plenary Speaker for Washington University School of Medicine’s Diabetes Day, where he presented “Genetics of Diabetes: Lessons from a Founder Population.”

Grants & Contracts

Michael Quon, MD, PhD, Professor, Department of Medicine, received a three-year, $345,000 award from the American Diabetes Association for “Phosphorylation of Ser24 in IRS-1 By IRAK-1 Promotes Insulin Resistance in Mice.”

May 2013

Events, Lectures & Workshops

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology; Associate Dean for Research; and Director, Center for Stem Cell Biology & Regenerative Medicine, presented a lecture on “MicroRNA Maestros of Hematopoiesis and Leukemia” at the Genetics Branch Seminar Series, National Cancer Institute/National Institute of Health in Bethesda, MD, on February 21. 

Grants and Contracts

Robert Bloch, PhD, Professor, Department of Physiology, received a one-year, $250,000 grant extension from the Jain Foundation for his current research work “Analyzing the Role of Dysferlin in Skeletal Muscle in Vitro and in Vivo.”

Michele Vitolo, PhD, Research Associate, Department of Physiology, received a five-year, $525,000 NCI K01 Research Scientist Development Award for “PTEN Loss Increases Efficiency of Breast Tumor Metastasis.” She will investigate the role of PTEN in maintenance of the actin cortex and how the loss of this tumor suppressor increases microtentacles, tumor cell reattachment, and metastasis. Stuart Martin, PhD, Associate Professor, Department of Physiology, serves as the mentor of her research program. 

April 2013

Events, Lectures & Workshops

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology, Associate Dean for Research, and Director, Center for Stem Cell Biology & Regenerative Medicine, presented a lecture on “How Stem Cells are Transforming Medicine” and a panel discussion on “Stem Cell Science—Cancer” at the 2012 World Stem Cell Summit in Palm Beach, FL on December 3, 2012. He also presented “MicroRNA Maestros of Hematopoiesis and Leukemia” at the Brown Foundation Institute of Molecular Medicine Seminar Series at the University of Texas Health Science Center in Houston, TX, on January 25.

W. Jonathan Lederer, MD, PhD, Professor, Department of Physiology and director of the Center for Biomedical Engineering and Technology, gave the Dirk L. Brutsaert Lecture, entitled “Elementary Ca2+ Events: From Discovery to Their Implication for the Physiology and Pathology of the Heart,” at the European Society for Cardiology Meeting in Les Diablerets, Switzerland on January 24.

Grants & Contracts

Colin Mackenzie, MBChB, FRCA, FCCM, Clinical Professor, Department of Anesthesiology has received a three-year, $2,077,553 grant from the U.S. Air Force for “Continuous Non-Invasive Monitoring and the Development of Predictive Triage Indices for Outcome Following Trauma”; a 30-month, $398,422 grant from the Office of Naval Research for “Autonomous Critical Care Systems- Athena GTX”; a two-year, $824,552 grant from the U.S. Air Force for “Predicting Casualty Blood Product Needs Using Pre-Hospital Vital Signs”; and a three-year, $2 million grant from the U.S. Army for “Use of Performance Measure to Evaluate, Document Competence and Deterioration of ASSET Surgical Skills.”

Publications

Curt Civin, MD, Professor, Departments of Pediatrics and Physiology, Associate Dean for Research, and Director, Center for Stem Cell Biology & Regenerative Medicine, was a co-author on “Hematopoietic Stem Cells” in The Biomedical Engineering Handbook, Fourth Edition (Fischer, ed.), Boca Raton: CRC pp 9.1-9.13. 2012. Dr. Civin; Weh-Chih Cheng, PhD, Postdoctoral Fellow; and Tami Kingsbury, PhD, Assistant Professor, Department of Physiology, were among the co-authors on “A Simple High-Throughput Technology Enables Gain-of-Function Screening of Human MicroRNAs” inBioTechniques—International Journal of Life Science Methods, 2013 Feb;54(2):77-86. Dr. Civin and Iain Farrance, PhD, former Assistant Professor, Department of Biochemistry & Molecular Biology, were among the co-authors on “Biochemistry of Signaling in Stem Cells, and Vice Versa” inBiophysica Acta, 2013 Feb; 1830(2):2267.

March 2013

Publications

Cristina Linde, PhD, postdoctoral fellow; John Hamlyn, PhD, professor; and Vera Golovina, PhD (pictured), associate professor, all from the Department of Physiology, were among the co-authors on “Activation of c-SRC Underlies the Differential Effects of Ouabain and Digoxin on Ca2+ Signaling in Arterial Smooth Muscle Cells” in the American Journal of Physiology—Cell Physiology, 2012 Nov 28 [Epub ahead of print]. Drs. Linde and Golovina, along with Mordecai Blaustein, MD, professor, Departments of Physiology and Medicine, were among the co-authors on “Nanomolar Ouabain Increases NCX1 Expression and Enhances Ca2+ Signaling in Human Arterial Myocytes: A Mechanism that Links Salt to Increased Vascular Resistance?” in theAmerican Journal of Physiology—Heart and Circulatory Physiology, 2012 Oct 1;303(7):H784-94. Drs. Hamlyn and Blaustein were also co-authors on “Salt Sensitivity, Endogenous Ouabain and Hypertension” in Current Opinion in Nephrology and Hypertension, 2013 Jan;22(1):51-8.

February 2013

Grants & Contracts

Curt Civin, MD, professor, Departments of Pediatrics and Physiology, associate dean for Research, and director of the Center for Stem Cell Biology & Regenerative Medicine, received a one-year, CRF Pilot grant award of $62,500 for “Interplay of miR-34, S100, and Artemesinins in Leukemias and Melanomas.”

Stuart Martin, PhD, associate professor, Department of Physiology, received a new, five-year, $1.55 million R01 grant from the National Cancer Institute for “Targeting Microtubule Stabilization to Reduce Breast Tumor Metastasis.”

Honors & Awards

Andrea Meredith, PhD, assistant professor, Department of Physiology, was one of the top three fundraisers for the University of Maryland, Baltimore (UMB) team at the 2012 American Heart Association Stroke Walk in Baltimore. In thanks for her efforts, she was treated to lunch with UMB President Jay Perman, MD.

Dudley Strickland, PhD, professor, Department of Surgery, was named The American Heart Association’s Sol Sherry Distinguished Lecturer in Thrombosis at the AHA Scientific Sessions conference in Los Angeles, CA, in November 2012, in recognition of his seminal contributions to the field of thrombosis research. Dr. Strickland, who is also director of the Center for Vascular and Inflammatory Diseases and Assistant Dean for Graduate and Postdoctoral Studies, delivered the lecture “Role of LRP1 in Protecting the Vasculature.” His laboratory was one of two that discovered and identified the LDL receptor-related protein (LRP1) as a receptor for protease-inhibitor complexes.

In the News

Benjamin Prosser, PhD, assistant professor, Department of Physiology, was the subject of the section “Postdoc Spotlight” in the December 2012 Newsletter of the Biophysical Society. The Society has nearly 10,000 members worldwide.

Publications

Andrea Meredith, PhD (pictured), assistant professor, Department of Physiology, was a co-author with postdoctoral fellow, Jenna Montgomery, PhD, on “Genetic Activation of BK Currents In Vivo Generates Bidirectional Effects on Neuronal Excitability” in Proceedings of the National Academy of Sciences of the United States of America, 2012, Nov 13;109(46):18997-9002. Drs. Meredith and Montgomery also co-authored “Mis-expression of the BK K+ Channel Disrupts Suprachiasmatic Nucleus Circuit Rhythmicity and Alters Clock-Controlled Behavior” in the American Journal of Physiology-Cell Physiology, 2012, Nov 21 [Epub ahead of print] with Josh Whitt, Program in Neuroscience graduate student; Breanne Wright, UMBC undergraduate student; and Michael Lai, Bioengineering graduate student at UMCP, all also from the Department of Physiology.

January 2013

Events, Lectures & Workshops

Mordecai Blaustein, MD, professor, Departments of Physiology & Medicine, presented “Role of Endogenous Ouabain in Salt-Sensitive Hypertension” at a workshop on “Unifying Theories of Hypertension: Past, Present and Emerging” in September 2012 in Washington, DC.

Joseph Stains, PhD, assistant professor, Department of Orthopaedics, presented “The Inositol Polyphos-phate/Protein Kinase C-delta Signaling Cascade Is Required for the Connexin43-dependent Amplification of Runx2 Activity” at the 2012 Annual Meeting of the American Society for Bone and Mineral Research in Minneapolis, MN, in October 2012.  

Grants & Contracts

Curt Civin, MD, professor, Departments of Pediatrics and Physiology, associate dean for Research, and director of the Center for Stem Cell Biology & Regenerative Medicine, was awarded two one-year, $75,000 grants from GPB Scientific, LLC, one for “High Efficiency Microfluidic Purification of Stem Cells to Improve Transplants” and the other for “Microfluidic Processing of Leukocytes for Molecular Diagnostic Testing.”

Joseph Stains, PhD, and Eugene Koh, MD, PhD, both assistant professors, Department of Orthopaedics, have been awarded a two-year, $229,412 grant from the Maryland Technology Development Corporation (TEDCO) for “Using Gap Junctions to Enhance Stem Cell Therapies in Osteoarthritis.” Dr. Stains will serve as the PI on this project, and Dr. Koh will be the Co-PI.  

Publications

Charles Chaffin, PhD, associate professor, Department of Obstetrics, Gynecology & Reproductive Sciences, was among the co-authors on “Rhesus Monkey Cumulus Cells Revert to a Mural Granulosa Cell State After an Ovulatory Stimulus” in Endocrinology, 2012 Nov;153(11):5535-45.

Curt Civin, MD, professor, Departments of Pediatrics and Physiology, associate dean for Research and director of the Center for Stem Cell Biology & Regenerative Medicine, was among the co-authors on “Generation and Genetic Engineering of Human Induced Pluripotent Stem Cells Using Designed Zinc Finger Nucleases” in Stem Cells and Development, 2012 Oct 19 [Epub ahead of print].

Loren Thompson, PhD, associate professor, and Yazan Al-Hasan, PhD, former postdoctoral fellow, Department of Obstetrics, Gynecology & Reproductive Sciences, were co-authors on “Impact of Oxidative Stress in Fetal Programming” in the Journal of Pregnancy, 2012;2012:582748.

See more in the Buzz Archive.