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Division of Infectious Disease & Tropical Pediatrics

The mission of the Division of Infectious Diseases and Tropical Pediatrics is to improve the health of children by promoting excellence in diagnosis, management and prevention of infectious diseases through clinical care, education, research, advocacy and training.

Our clinical service provides offers comprehensive inpatient and outpatient consultative services for children with proven or suspected infections. We assist in the development and interpretation of diagnostic evaluations and in the formulation of management plans, including recommendations for type and duration of antimicrobial therapy. We evaluate children who present with uncertain diagnoses, recurrent or persistent infections, or who are found to have complicated infections.

Clinical Services

Specialized Evaluations

Travel Clinic

  • Provides vaccinations, pre-travel counseling and other preventive measures against infectious diseases and travel-related illnesses for children and adults traveling outside the United States
  • Provides evaluation of children with infections acquired abroad
  • Services to Physicians
  • Consultations
  • Second opinions
  • Diagnostic and management plans for complicated cases

Research

Research efforts of the Division of Infectious Diseases and Tropical Pediatrics occur within the University of Maryland Center for Vaccine Development (CVD), a world-renowned multi-disciplinary research center that focuses on development and implementation of vaccines to prevent infections of global significance. In addition, we study strategies to prevent infections that occur among children living in the United States, such as influenza and methicillin-resistant Staphylococcus aureus (MRSA).

  • Vaccine Testing and Evaluation Units (VTEU): As one of the nine NIAID-funded VTEU sites in the U.S., we conduct clinical trials of vaccines and therapeutics in adults and children. The VTEUs have played a key role in the NIH's effort to develop new and improved vaccines and therapies against infectious diseases for over 40 years.
  • University of Maryland, Baltimore Cooperative Center for Translational Research on Human Immunology and Biodefense (UMB-CCHI): Funded by NIAID to support translational research in human immunology, we perform in-depth studies to further our understanding of the protective immunological mechanisms that can be elicited in the GI microenvironment of humans.  Moreover, because the normal GI flora (microbiota) is certain to influence the host immune response, we are conducting pioneering studies on the interactions between the local intestinal microbiota and the host immune response in humans.
  • CVD-Mali: In collaboration with investigators in the Malian Ministry of Health, we conduct epidemiologic and intervention studies with a focus on vaccine-preventable infectious diseases in children.
  • Malaria project field sites (Bandiagara Malaria Project in Mali, West Africa and Blantyre Malaria Project in Malawi, Central Africa): These sites comprise multidisciplinary teams that study malaria molecular epidemiology, antimalarial drug resistance, malaria in pregnancy, and malaria-HIV interactions, and conduct candidate malaria vaccine trials.
  • CVD Pediatric Clinical Studies Group: We conduct pediatric vaccine trials in private practices and in the University of Maryland Pediatrics at the Harbor (PATH) clinic sponsored by NIH and industry.
  • The Global Enterics Multi-Center Study (GEMS): a study of the cause and sequelae of diarrhea among children younger than 5 years of age living in seven developing countries

Education

  • NIH Vaccinology Training Grant: Each year we accept 1-2 pediatricians into our Pediatric Infectious Disease Fellowship Program. The Vaccinology Training Grant supports fellows who pursue research projects related to vaccine development, immunology, or clinical trials.

Faculty

Clinical Faculty

  • Andrea Berry M.D.
    Academic Title: Assistant Professor of Pediatrics
    Administrative Title: Head, Pediatric Clinical Studies Group, Center for Vaccine Development.

    Dr. Berry conducts clinical trials designed to evaluate new and improved pediatric vaccines among children in Baltimore. In addition, she is conducting research on immune responses to malaria infection and vaccination.  

  • James D. Campbell M.D., M.S.
    Academic Title: Associate Professor of Pediatrics

    Dr. Campbell's research interests include the performance of clinical trials of vaccines in all age groups, the investigation of the epidemiology of vaccine-preventable diseases, and HIV prevention.  

  • Karen L. Kotloff M.D.
    Academic Title: Professor of Pediatrics and Medicine
    Administrative Title: Head, Division of Infectious Disease and Tropical Pediatrics, Associate Director for Clinical Research and Chief, Community Studies Section, Center for Vaccine Development.

    Dr. Kotloff is Principal Investigator of the NIAID-sponsored Vaccine Testing and Evaluation Unit, for which she led two of the nation’s first studies of the 2009 H1N1 influenza virus vaccine in both children and adults (see videos here and here). She also performs pediatric clinical trials and epidemiologic studies in developing countries.

     
  • Miriam K. Laufer M.D.
    Academic Title: Associate Professor of Pediatrics, Epidemiology and Public Health, and Medicine
    Administrative Title: Director, Pediatric Infectious Disease Fellowship Program and Head, Malaria Treatment and Prevention Studies Unit, Center for Vaccine Development.

    Dr. Laufer conducts clinical trials in Malawi focusing on the epidemiology of drug-resistant malaria, malaria-HIV interactions, and the interaction between malaria and pregnancy.
     
  • Matthew Laurens M.D., MPH
    Academic Title: Assistant Professor of Pediatrics and Medicine

    Dr. Laurens’ research interests include malaria-HIV interactions, malaria vaccine trials, malaria challenge studies, and correlates of protection against malaria infection and disease.
     
  • Milagritos Tapia M.D.
    Academic Title: Assistant Professor of Pediatrics
    Administrative Title: Clinical Director, Division of Infectious Disease and Tropical Pediatrics.

    Dr. Tapia conducts epidemiologic studies and vaccine trials at CVD-Mali.

     
  • Mark Travassos, M.D.
    Academic Title: Instructor, Pediatrics

    Dr. Travassos’ research interest is malaria. He is using molecular techniques to assess the role of variant antigen switching in the development of symptomatic malaria. 

Research Faculty

  • Myron M. Levine M.D., D.T.P.H.
    Academic Title: Simon and Bessie Grollman Distinguished Professor of Medicine, Epidemiology and Public Health, Microbiology and Immunology, and Pediatrics
    Administrative Title: Head, Division of Geographic Medicine and Director, Center for Vaccine Development.

    Dr. Levine’s world-renowned research involves studies of pathogenesis and vaccine development and the assessment of a variety of vaccines in adults and children in Baltimore, as well as in many developing countries. He conducted pivotal trials leading to licensure of vaccines to prevent typhoid fever and cholera. He is the recipient of the Albert B. Sabin Gold Medal Award for lifetime achievement in the area of vaccine development and implementation. 

  • Monica A. McArthur M.D., Ph.D.
    Academic Title: Instructor, Pediatrics

    Dr. McArthur's primary research interests are the interactions between pathogens and the human immune system. She is primarily involved in studies investigating human T cell responses to infectious diseases, particularly those that affect children in the developing world. 

  • Rosangela Mezghanni Ph.D.
    Academic Title: Assistant Professor, Pediatrics

    Dr. Mezghanni performs research to detail the different types of immune responses that occur after exposure to infection and vaccination, and the cellular signals that regulate these responses. She is developing an organotypic model of the human intestinal mucosa.
     
  • Marcela Pasetti Ph.D.
    Academic Title: Professor, Pediatrics and Microbiology and Immunology
    Administrative Title: Chief, of the Applied Immunology Section at the Center for Vaccine Development.

    Dr. Pasetti’s research focuses on characterizing immune responses to vaccination in young infants and children and evaluating the humoral immune responses to vaccination in clinical trials.
     
  • Marcelo B. Sztein M.D.
    Academic Title: Professor, Pediatrics and Microbiology and Immunology
    Administrative Title: Associate Director for Immunologic Research; Leader, Immunology Group; and Chief, Cellular Immunology and Flow Cytometry Section, Center for Vaccine Development.

    Dr. Sztein’s research focuses on understanding the immunologic correlates of protection in the context of vaccine development.
     


  • Rezwanul Wahid M.B.B.S., Ph.D.
    Academic Title: Assistant Professor, Pediatrics

    Dr. Wahid studies T and B cell mediated host-immune responses and induction immune memory by immunization with licensed or candidate vaccines in humans. He primarily utilizes the clinical samples obtained from volunteers participating in various vaccine trials.
     

Contact Information

Division of Infectious Diseases and Tropical Pediatrics
University of Maryland School of Medicine
685 W. Baltimore Street, HSF 480
Baltimore, Maryland 21201
Telephone: (410) 706-8695
Fax: (410) 706-6205

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