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HP-STAR Research Mentors List

Availability for Summer 2014
Baumgarten, Mona, PhD  EPH Epidemiologic studies of elderly populations, both in the community and hospital and nursing home settings. She has an ongoing research program on the study of pressure ulcer risk factors and prevention; studies of risk factors for pressure ulcers in elderly medical patients and in elderly hip fracture patients; research project on health disparities, parkinsonian signs, and disability among community-dwelling elders in Baltimore; epidemiologic research in aging, includes planning, protocol development, pilot studies, data collection, data analysis, and publication. (Updated on 12/16/10)  
Beamer, Brock, MD  MED
Resistance training to improve balance and prevent falls; quantitative measures to assess change in physical traits with aging; genetic associations with the rate of decline in strength in older adults. (Updated on 11/15/11)  
Bernstein, Steven L., MD, PhD  OPHT Age-associated vascular eye diseases are a leading cause of visual loss in the United states. These include age-related macular degeneration, optic nerve stroke, glaucoma, and type 2-associated diabetic retinopathy. We are critically interested in the physiological changes in the CNS that increase susceptibility to these diseases. The lab has developed the first clinically relevant models of non-arteritic optic nerve stroke (NAION). We utilize both molecular, immunological, microscopic, and electrophysiological methods to dissect the mechanisms of resistance to stroke, and are critically evaluating specific approaches to early and delayed treatment for age-related eye disease. (Updated on 1/18/11)  
Bever, Jr., Christopher T., MD, MBA  NEUR Causes and treatment of multiple sclerosis, including clinical trials of disease modifying and symptomatic treatments of MS on motor control and upper extremity robotics for rehabilitation in disability; sensorimotor outcomes of rehabilitation research, including gait biomechanics, upper extremity motor control and functional assessments of chronic disability. (Updated on 11/17/11)  
Blumenthal, Jacob, MD  MED
Effects of aging, AEX and WL on the relationship of cytokine production and circulating cytokine levels to insulin resistance, obesity and the metabolic syndrome. He is actively involved in clinical and teaching activities in gerontology, conduct of clinical exercise and metabolism research, glucose clamps, and the biology of aging and age-associated diseases.  
Cole, John, MD  NEUR Research focuses on understanding stroke etiology through epidemiologic and genetic approaches that lead to development of new preventive strategies; development of new drugs for stroke prevention, as well as using genetic testing to identify high-risk individuals for personalized stroke risk factor modification; research also focuses upon stroke risk as mediated through genetic predisposition and environmental factors, including cigarette smoking and infectious etiologies. (Updated on 11/15/11)  
deFilippi, Christopher, MD  MED
Currently, multi-center studies are being conducted to establish novel uses for several established blood based cardiac biomarkers and evaluating the utility of several new cardiac markers. The focus of a research experience will be to identify if cardiac biomarker levels that identify a poor cardiac prognosis in the elderly or other asymptomatic populations can be modulated by lifestyle and other potentially modifiable factors that will predict improvements in prognosis. Ultimately, the research is aimed at identifying a blood test that could track the efficacy of an intervention. The focus will be on "at-risk" asymptomatic people for cardiovascular events including those with chronic renal disease and the elderly. (Updated on 11/30/11)  
Gambert, Steven R., MD  MED
Goldberg, Andrew P., MD  MED
I conduct patient oriented clinical research examining the functional declines and cardiometabolic risk associated with aging that are due to physical deconditioning and obesity, and conduct clinical research interventions in exercise physiology and weight loss to examine the mechanisms by which they affect cardiovascular disease risk factors, body composition and VO2max, regional fat distribution, endocrine-metabolic function, glucose and lipid metabolism, and adipose tissue metabolism. Students would learn methods for the conduct of clinical research, receive hands on training in studies of the physiology of age-associated diseases and functional limitations that can improved by aerobic and resistive exercise training. (Updated on 11/15/11)  
Gruber-Baldini, Ann L., PhD  EPH Research interests are in gerontology, cognitive functioning, psychological functioning, and the impact of chronic conditions on functioning. Dr. Gruber-Baldini is currently investigating the interaction of cognition (including dementia and delirium) and health among hip fractures patients and also examining longitudinal quality of life, functioning, and self-efficacy beliefs among Parkinson's Disease and other movement disorders; I have access to large, longitudinal datasets and ongoing research projects that will provide opportunities for students to conduct research, analyze data, and write publications. (Updated on 11/17/11)  
Hafer-Macko, Charlene E., MD   NEUR
Effects of diabetes, stroke and exercise rehabilitation on skeletal muscle structure, function and metabolism; research that examines 1) the cellular mechanisms by which exercise impacts sarcopenia, shifts in skeletal muscle phenotype, and alters contractile proteins in aging and neurological disability conditions; 2) the mechanisms by which exercise improves systemic insulin sensitivity in skeletal muscle in aging and disability, and 3) the effects of exercise on inflammation and oxidative injury pathways in skeletal muscle in older people with chronic stroke. (Updated on 11/17/11)  
Harris, Anthony D., MD, MPH   EPH Research interests include emerging pathogens, antimicrobial-resistant bacteria, infection control interventions, epidemiologic methods in infectious diseases and medical informatics; antibiotic resistance and hospital epidemiology. (Updated on 12/13/2011)  
Hochberg, Marc C., MD, MPH   MED
Dr. Hochberg's research focuses on the clinical epidemiology of musculoskeletal disorders, particularly osteoarthritis and osteoporosis. He is the Principal Investigator of the Baltimore Clinical Center of the Osteoarthritis Initiative and Co-Principal Investigator of the Baltimore Hip Studies. His research is funded by the National Institutes of Health. (Updated on 11/15/11)  
Horenstein, Richard, MD   MED
Genetics of Lipid Disorders (Dyslipidemia); Genetics of Type 2 Diabetes and Obesity; Management of Type 2 Diabetes, Thyroid Disorders, and Thyroid Cancer; Cardiovascular Disease Prevention.  
Ivey, Frederick M., PhD   NEUR
Training in exercise physiology, exercise rehabilitation, and metabolic research in stroke survivors. (Updated on 12/18/10)  
Katzel, Leslie MD, PhD  MED
Research examines the effects of 1) exercise and weight loss on insulin resistance and CVD risk (metabolic syndrome), 2) hypertension, metabolic syndrome, and chronic kidney disease on neurocognitive function, and 3) the examination of associations of candidate gene polymorphisms to lipid, glucose metabolism, and blood pressure responses to AEX and WL interventions in older people.  
Kittner, Steven J., MD, MPH  NEUR Research on the identification of novel risk factors and candidate genes for stroke and the development of effective strategies to prevent stroke and reduce its disability in younger people; case-control epidemiologic studies; and clinical trials of stroke prevention and treatment. (Updated on 11/15/11)  
Macko, Richard F., MD  NEUR
Develops models of task-oriented training that combine motor learning with exercise rehabilitation to improve motor function, fitness and cardiometabolic health in individuals aging with chronic disability of stroke; research program develops customized exercise rehabilitation interventions for stroke and chronic disease conditions associated with aging, validates and applies quantitative and disease specific human performance outcomes to establish functional intervention efficacy, and determines exercise-mediated cardiometabolic and neuromuscular adaptations to rehabilitation.  
Magaziner, Jay, PhD, MS Hyg  EPH The consequences of hip fracture, psychosocial aspects of health and long-term care, and methods for studying older populations. The major focus of this work has been to identify ways of enhancing functioning and improving the quality of life of older persons; hip fracture recovery, and is also leading studies of bone metabolism and hormonal changes with exercise after hip fracture, a study of body composition changes after hip fracture, and a population-based study of dementia and its medical, functional, and economic consequences.  
McArdle, Patrick, PhD  MED
My research interests focus on the epidemiology of aging, particularly in the genetics of aging and the interaction with environmental or social factors and especially in epidemiological design and statistical issues as they are related to longitudinal study designs. I conduct the analysis for several genome wide association studies and have experience in data management and analysis of large genotype and phenotype databases. He has published on analytic techniques in genetic epidemiology and will contribute to study design and analytic decision making. (Updated on 12/17/10)  
Miller, Michael MD  MED
Examine the relationship of monounsaturated versus a polyunsaturated fat enriched diets on lipids and lipoproteins, biomarkers of inflammation and endothelial vasoreactivity; lipid metabolism and aging. (Updated on 11/17/11)  
Mitchell, Braxton D., PhD, MPH  EPH Study the genetic epidemiology of common age-related complex diseases, including osteoporosis, osteoarthritis, and cardiovascular disease. Trainee would conduct data analysis. (Updated on 11/30/2011)  
Mullins, C. Daniel, PhD  PHAR PHSR Research focuses on pharmacoeconomics, comparative effectiveness research (CER), and health disparities research. (Updated on 11/15/11)  
Ortmeyer, Heidi K., PhD  MED
Studies the mechanisms by which obesity, type 2 diabetes, HIV and various interventions (e.g. weight loss, aerobic exercise training, yoga, etc.) affect lipid and glucose metabolism in skeletal muscle and adipose tissue, examines the effects of PPAR agonists, aging and physical deconditioning on insulin action and mitochondrial fatty acid oxidation. She teaches trainees to 1) measure enzyme activities and protein levels in lyophilized, microdissected muscle and adipose tissues, 2) isolate mitochondria, 3) measure fatty acid oxidation in adipose tissue and muscle, and 4) determine intramuscular triglyceride and oxidative enzyme activity. (Updated on 11/28/11)  
Oursler, Kris Ann, MD, ScM  MED
Investigate the skeletal muscle mechanism by which exercise improves functional performance in older HIV-infected patients by examining oxidative dysfunction and metabolic effects of antiretroviral therapy in muscle. She will mentor trainees in areas of the conduct of clinical research, cardiometabolic risk and muscle metabolism in HIV.  
Polster, Brian, PhD  ANES Investigations center on two key pathways of injury, apoptotic programmed cell death and excitotoxic cell death initiated by excess release of the neurotransmitter glutamate. Current objectives include: 1) determining how mitochondrial protease activities contribute to bioenergetic dysfunction and reactive oxygen species production, 2) elucidating the roles and targets of calcium-dependent calpain proteases in neurotoxicity, and 3) improving our understanding of the roles that multi-functional apoptosis-related proteins such as Bax, AIF, and Htra2/Omi play in mitochondrial maintenance and injury. (Updated on 12/16/10)  
Quinn, Charlene, PhD, RN  EPI
Experience in geriatrics, research management, and policy analysis. As a geriatric clinician, Dr. Quinn is recognized for her expertise in studies of chronic diseases (particularly diabetes, depression, and dementia) as well as in mobile health monitoring. Her current funded research focuses on the application of mobile technology to the management of diabetes. Trained at the Johns Hopkins School of Public Health, Dr. Quinn applies expertise in health services research to understanding clinical outcomes in the context of long-term care services (community-based and institutional) for the elderly and disabled. She has experience in the design and conduct of clinical epidemiologic studies that have been funded by NIH, the VHA and private foundations. (Updated on 11/15/11)  
Resnick, Barbara, PhD  NURS
Research on optimizing function, time spent in physical activity and preventive behaviors in older adults across all levels of care and clinical conditions; projects utilize a comprehensive social ecological model approach with interpersonal interventions strongly based in social cognitive theory to change behavior in challenging areas such as exercise, diet and medication adherence; students will be involved in clinical issues with regard to aging, health care systems issues, as well as specific research skills. We are doing some descriptive work in Geriatric Trauma, measurement work in areas of physical activity and resilience, and genetic work as it is related to functional recovery, resilience, and recovery after hip fracture. Lastly, we have studies focused on dissemination of function focused care approaches across 20 long term care settings and dissemination of regular exercise among residents in low income housing centers. (Updated on 11/15/11)  
Rodgers, Mary, PhD, PT  PHYS THER Interdisciplinary training for fellows pursuing studies of exercise models for aging and disability, and human performance outcome measures; quantitative measures of gait biomechanics and evaluation of rehabilitation outcomes. (Updated on 1/3/11)  
Rogers, Mark, PhD, PT  PHYS THER Studies the use of movements of the limbs, such as during stepping and grasping of nearby objects to identify the link between aging associated impairments in hip joint force generation and lateral instability as a critical factor in the genesis of falls among older adults; study of motor control of postural balance and locomotion, and the implementation of interventions to enhance balance and functional mobility.  
Roghmann, Mary-Claire, MD, MS  EPH Projects focus on understanding the transmission of methicillin-resistant S. aureus (MRSA) and other bacteria in the long term care setting; opportunities to work on patient-oriented research studies of the human microbiome in older adults from the community and nursing home environments. (Updated on 11/17/11)  
Ryan, Alice S., PhD  MED
Patient-oriented translational research examining the mechanisms by which diet and exercise interventions affect skeletal muscle and adipose tissue metabolism, inflammation, insulin signaling, gene expression, and in vivo insulin action in sedentary, older individuals and chronic stroke survivors. She mentors trainees in the assessment of body composition, exercise capacity, energy expenditure, glucose homeostasis, laboratory techniques, and the conduct of metabolic studies of exercise and weight loss in aging and disability. (Updated on 11/17/11)  
Shuldiner, Alan, MD  MED
Genetics of complex age-related diseases and traits, including diabetes, obesity, cardiovascular disease, osteoporosis, longevity and the pharmacogenomics of antiplatelet agents including aspirin and clopidogrel (Plavix). Trainees work in the Amish Research Clinic to learn skills of patient-oriented genetics research, and in the laboratory to apply high-throughput molecular genetic analysis and sophisticated statistical approaches to search for genes that influence susceptibility to these diseases and traits. (Updated on 11/30/11)  
Smith, Gordon S., MB, ChB, MPH  EPH    
Sorkin, John D., MD, PhD  MED
Examine age related changes in carbohydrate and lipid metabolism, obesity, and body fat distribution and their relationship to the development of T2DM, CVD, and mortality; principles of statistics, epidemiology, genetics and clinical investigation.  
Stuart, Bruce C., PhD  PHAR PHSR
Evaluating the impact of Medicare Part D drug benefit design (coverage, cost sharing, utilization management tools) on patient outcomes and costs. (Updated on 11/15/11)  
Sztalryd (Woodle), Carole, PhD  MED
Dr Sztalryd's research focuses on the molecular mechanisms regulating cellular lipid homeostasis in adipose and non adipose tissues in the pathogenesis of obesity and its metabolic complications. Fellows working in her laboratory learn a variety of methods including -Live cell imaging technology using confocal microscopic methods (FRAP, AFRET, FLIP) - Biochemistry methodologies, co-immunoprecipitation, lipid thin layer chromatography, cellular organelles isolation -Gene gain and lost of function using viral and non viral delivery of plasmids and siRNA in primary and cell line cultures-Analytical assays for lipid metabolism, lipolysis, lipase activities and b-oxidation (seahorse instrumentation), generating transgenic mice models ( overexpression and knock out genes) and phenotypic characterisation . Main projects in her laboratory examine 1) The molecular mechanisms for the regulation of lipolysis at the lipid droplet surface by studying trafficking and protein/protein interactions of known major players, perilipin proteins, lipases, co-lipases and using 2) The link between ectopic fat and development of insulin resistance by using in vitro and in vivo manipulation of perilpin protein expression (gain and loss of function) 3) The lipid droplet functional genomics: To advance understanding of LD cell biology, identify biological processes that regulated lipid droplet function and discover potential therapeutic targets using hi throughput RNAi and small drug screening 4) to study the effects of gene polymorphisms for key players in the lipolytic pathway on cardiovascular and diabetes phenotypes 5) to study the physical and metabolic interactions between mitochondria and lipid droplets using already generated transgenic mice models and cell biology. In addition as director of the Adipose Biology core from the Nutrition Obesity Research Center (NORC, NIH funded) to provide trainees with training in adipocyte biology and basic mechanisms, Dr Sztalryd plans seminars, mini-symposia, and journal clubs to enrich the trainee*s knowledge of obesity and its metabolic complications. (Updated on 11/15/11)  
Waldstein, Shari R., PhD  UMBC
Examines relations of cardiovascular risk factors, cardiovascular diseases, and cardiovascular psychophysiology to neurocognitive function, and evaluates potential underlying brain mechanisms using structural and functional neuroimaging procedures. Investigates biopsychosocial predictors of cardiovascular risk factors, subclinical vascular disease, and individual differences in the magnitude and patterning of stress-induced cardiovascular responses. (Updated on 12/16/10)  
Whitall, Jill, PhD  PHYS THER Research on how to improve the rehabilitation of walking in patients with either Stroke or Parkinson’s Disease. We are exploring a new device that will eventually be used in the community. (Updated on 12/16/10)  
Wittenberg, George, MD, PhD  NEUR
Technological approaches to rehabilitation, using non-invasive biological techniques to predict functional improvements and determine their substrates. His research investigates recovery of motor function after stroke and other types of neurological injury, focusing on the effect of task-oriented practice on motor cortical representations; opportunities to pursue cross-disciplinary training in neuroscience of exercise rehabilitation in aging and disability and the neurophysiology of motor control using near-infrared spectroscopy, EEG, fMRI and transcranial magnetic stimulation. (Updated on 12/13/2011)