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Role of Personal Genomes in Medicine - MEDC 540


Successful completion of Year 1 curriculum


School of Medicine

Description and Goals:

This course will expose trainees to the use of personal genetic and genomic information in clinical medicine. It will cover principles of advanced medical genetics and genomics, complex disorders, laboratory design and execution, as well as ethical, legal, and social issues associated with decision-making, consent, and individualized genomic testing. The laboratory component will afford hands-on experience to allow an appreciation of genomic testing and bioinformatics. This will include exposure to DNA extraction and quantitation, microarray technology using a drug metabolism panel (on their own or an anonymous sample of DNA); and an opportunity to see ‘next-generation’ DNA sequencing using a panel for cancer and/or other common adult conditions. The data will be used to discuss how identification of specific mutations can impact the choice of treatment for cancer patients, but also challenge students to investigate how information about an individual’s genome will profoundly change how a physician may manage health and disease in the near future.

Number of Students:

5-15 (MSIII and MSIV students)

Time of Year Available:

4 weeks, (academic weeks 29-32, although can be flexible)


Monday-Friday – yes
Evenings – no
Weekends – no
Call – no

Faculty Responsible:

Miriam G. Blitzer, PhD

Alan R. Shuldiner, MD

Last Revision: October 22, 2013