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|-?-celiac sprue||autoimmune-mediated intolerance of gliadin leading to steatorrhea|
|-?-gout||more common in men; treatment is allopurinol, probenecid, colchicines, & NSAIDs|
|-?-rheumatoid arthritis||classic presentation: morning stiffness improving with use, symmetric joint involvement, & systemic symptoms (fever, fatigue, pleuritis, pericarditis)|
|-?-pseudogout||usually affects large joints (classically the knee); >50 yrs old; both sexes equally affected; no treatment|
|-?-rheumatoid arthritis||inflammatory disorder affecting synovial joints, with pannus formation in joints (MCP, PIP), subcutaneous rheumatoid nodules, ulnar deviation, subluxation|
|-?-celiac sprue||associated with people of northern European descent; findings include blunting of villi, lymphocytes in the lamina propria, and abnormal D-xylose test|
|-?-osteoarthritis||Mechanical wear and tear of joints leads to destruction of articular cartilage, subchondral bone formation, sclerosis, osteophytes, eburnation, Heberden's nodes (DIP), & Bouchard's nodes (PIP)|
|-?-Sjögren's syndrome||classic triad: dry eyes, dry mouth, arthritis; predominantly affects females b/t 40 & 60 yrs of age|
|osteoarthritis rheumatoid arthritis Sjögren's syndrome gout pseudogout celiac sprue|
Systemic lupus erythematosus:90% are -?-female and b/t ages 14 & 45; symptoms are fever, fatigue, weight loss, joint pain, malar rash, and -?-photosensitvity; may also occur with pleuritis, pericarditis, nonbacterial verrucous endocarditis, -?-Raynauds phenomenon; -?-wire loop lesions kidney with immune complex deposition; death from -?-renal failure & infections.
Sarcoidosis:immune-mediated widespread noncaseating granulomas and elevated serum -?-ACE levels; common in black females; associated with restrictive -?-lung disease, bilateral hilar lymphadenopathy, erythema nodosum -?-Bells palsy, epithelial granulomas containing microscopic Schaumann & asteroid bodies, uveoparotitis, and hypercalcemia.
|-?-Ankylosing spondylitis:||chronic inflammatory disease of spine & sacroiliac joints → stiff spine, uveitis & aortic regurgitation|
|-?-Reiters syndrome:||classic triad of urethritis, conjunctivitis & anterior uveitis, and arthristis|
Schleroderma (progressive systemic sclerosis-PSS): Summarize the CREST syndromeC -?-Calcinosis
R -?-Raynauds phenomenon
E -?-Esophageal dysmotility
Matching: Skin disorders
|-?-psoriasis||nonpruritic chronic inflammation of the skin, particularly knees & elbows; associated with HLA-B27, HLA-13, and HLA-17|
|-?-dermatitis||a group of inflammatory pruritic skin disorders; etiology: allergy, chemical injury, infection|
|-?-pemphigus vulgaris||potentially fatal autoimmune skin disorder; intradermal bullae involving the oral mucosa & skin; findings: acantholysis (breakdown of epithelial cell-to-cell junctions), IgG antibody against epidermal cell surface|
|-?-bullous pemphigoid||autoimmune disorder with IgG antibody against epidural basement membrane (linear immunofluorescence); similar to but less severe than pemphigus vulgaris-affects skin but spares oral mucosa|
|dermatitis psoriasis bullous pemphigoid pemphigus vulgaris|