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Virology

Research in virology at the University of Maryland School of Medicine is conducted by a number of investigators with primary and secondary faculty appointments in the Department of Microbiology & Immunology.

The focus of several investigators at the Institute of Human Virology (IHV), including Drs. DeVico, Gallo, Garzino-Demo, Kamin-Lewis, Lewis, Pauza, Guan and Latinovic is retroviruses, including HIV, SIV and rodent retroviruses. Research topics of these investigators include the molecular mechanisms of retroviral infection, the role of chemokines in the pathogenesis of AIDS, and the development of new vaccine candidates. Arenaviruses such as Lassa Fever are the focus of research by Drs. Salvato and Lukashevich, including virus-host interactions and vaccine development. Dr. Frieman is investigating the pathogenesis and host response of the SARS coronaviruses.  Dr. Feldman investigates mechanisms of oncogenesis by RNA tumor viruses and has also developed novel animal models that allow specific targeting of genes to stem cells in vivo, cells in the context of an intact animal. (See the Cell Biology section of this website.) Dr. A. Schmaljohn joined the Department after a distinguished career at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) at Fort Detrick, MD where he investigated immune responses to and developed vaccines and immunotherapeutics for a variety of hazardous and emerging viruses including poxviruses, Marburg, Ebola, and hantaviruses. The research focus of Dr. Zhao in the Department of Pathology is HIV-1 Vpr protein interactions with host cellular responses. Dr. Aurelian, Professor of Pharmacology, studies mechanisms of viral latency and pathogenesis of Herpes Simplex virus, and is developing HSV vaccines.