Department of Microbiology and Immunology
Cell Biology
Research in the Cell Biology Tract encompasses studies on diverse aspects of the host-microbe interface in normal and pathologic conditions, and complements traditional microbiology disciplines in the Program.
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For example, Dr. Feldman studies the molecular events that regulate normal hematopoietic stem cell development and its subversion by chromosomal translocations (i.e. AML1-ETO, Bcr-Abl), which convert normal stem cells into leukemic stem cells. The laboratory has developed transgenic animal models that allow retroviral-based delivery of genes in vivo, specifically to hemangioblasts, which give rise to the hematopoietic and vascular endothelial systems.
Dr. Schulze’s research focuses on divalent cation transport in eucaryotic and procaryotic systems; specifically, his work addresses the functional roles of tissue-specific isoforms of the Na/Ca exchange protein. Understanding regulation of Na/Ca exchanger transcription, splicing, and RNA stability in conjunction with protein-protein interaction provide mechanisms for regulation of calcium homeostasis.in cells. Interferons are pleiotropic cytokines that serve critical functions in the host immune response and in the control of cell proliferation.
Dr. Kalvakolanu studies interferon-induced signal transduction and gene expression. This work has identified novel mediators of cell death that are implicated in human cancers.
Dr. Hassel’s work focuses on the posttranscriptional regulation of gene expression in the anti-viral and anti-tumor activities of interferon. Protein modification by the ubiquitin-like protein, ISG15, and the control of RNA stability by the 2-5A-dependent endoribonuclease, RNase-L, are his specific areas of interest.
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