UM SOM: Mucosal Biology Research Center (MBRC)

Abstracts

Adams D, Fang E, VOGEL SN, FASANO A. Zonulin Is Structurally and Functionally Related to the Mucosal Mast Cells-Derived Mast Cell Protease II. Gastroenterology 2004; 126A-520.

Angelini DJ, Grigoryev P, Garg S, Hyun SW, SINGH IS, GOLDBLUM SE. Tumor necrosis factor opens the pulmonary vascular endothelial paracellular pathway through fyn activing and increases tyrosine phosphorylation of zonula adherens proteins. 2004; 44th American Society for Cell Biology Annual Meeting, Washington, DC, December 4-8.

Atzmon G, Schechter C, Gabriely I, Das M, Greiner W, Davidson D, SHULDINER AR, Barzilai N. The valine 405 CEPT variant has pleiotrophic effects on lipoprotein particle size and insulin sensitivity which contribute to exceptional longevity. 2003; Annual Meeting of the American Diabetes Association, New Orleans, LA.

Atzmon G, Rabizadeh P, Gottesman R, SHULDINER AR, Barzilai N. Inherited pathway for exceptional longevity. 2003; Annual Meeting of the American Society of Human Genetics, Los Angeles, CA.

Bussiere F, Chaturvedi R, Gainor J, Scholz A, Fertel D, Yao M, Sloane D, Cheng Y, Xu H, WILSON KT. Suppression of Lymphocyte Apoptosis at Low Levels of H. pylori Infection. 2004; Gastroenterology 126: A404, Poster Presentation, AGA Annual Meeting, New Orleans, LA.

Catassi C, Louis-Jacques O, Kryszak DA, HORVATH K, Medeiros L, Hill I, Duekerson D, Crowe SE, Brown AR, Wolf A, Vitelli A, Robison W, Moreci J, Mally A, Colodny S, Hartley P, Saxena R, Parnam S, Bennett N, Palchick P, College D, Thomas V, Brooks C, Paulin C, Volk M, Bednarz-Volk A, Heald D, FASANO A. Celiac Disease Case-Finding in Primary Care in North America. Preliminary Results of a Multicenter, Prospective Study. Gastroenterology 2004; 126A-250.

Chaturvedi R, Bussiere F, Kim P, Cheng Y, Xu H, Casero RA, WILSON KT. L-arginine Uptake Regulates H. pylori-Induced Macrophage iNOS. 2004; Gastroenterology 126: A404, Poster Presentation, AGA Anual Meeting, New Orleans, LA.

Cheng Y, Chaturvedi R, Yao M, Potosky D, Xu H, Bussiere F, WILSON KT. H. pylori Urease Induces Macrophage Apoptosis by c-Myc-Mediated Activation of Ornithine Decarboxylase (ODC). 2004; Gastroenterology 126: A108, Oral Presentation, AGA Annual Meeting, New Orleans, LA.

Cheng K, RAUFMAN J-P. Deoxycholyltaurine (DCT)-induced proliferation of H508 colon cancer cells is mediated by transactivation of epidermal growth factor receptors (EGFR). 2004; Gastroenterology 126:A262, Poster Presentation at DDW, New Orleans, LA.

Clemente MG, De Virgilis S, Usai MP, Porqueddu P, Cicotto L, Massida C, FASANO A. Intestinal Proteinase-Activated Receptor (PAR) – 2 Is Up-regulated in Active Celiac Disease and Co-Localizes with Zot/Zonulin Receptor. Gastroenterology 2004; 126; A-249

Clemente MG, Musu MP, Troncone R, Ciacci C, Not T, Neri E, Strisciuglio P, Maggiore G, Cicotto L, Sole G, Gasbarrini G, Corazza GR, Volta U, FASANO A, De Virgiliis S. Detection of Autoantibodies against Enterocyte Actin Filaments as Serological Predictive Test for Intestinal Villous Atrophy in Celiac Disease: Results of a Polycentric Study. Gastroenterology 2003;124:A-660

Clemente MG, VOGEL SN, Hollenberg M, De Virgilis S, FASANO A. Involvement of the Proteinase-Activated Receptor 2 (PAR-2) in the Zot/zonulin-Medicated Regulation of Intestinal Tight Junctions. Gastroenterology 2004; 126A-519.

Cross RK, WILSON KT, Binion DG. High prevalence of polypharmacy in Crohn’s disease. 2003; Poster presentation, American College of Gastroenterology Annual Meeting.

Cross RK, WILSON KT, Binion DG. Narcotic use in patients with Crohn’s disease. 2003; Poster presentation, American College of Gastroenterology Annual Meeting.

Drago S, El Asmar R, De’Agate C, Lacono G, Di Pierro M, Catassi C, FASANO A. Gliadin Induces Increased Intestinal Permeability, Zonulin Release, and Occludin Down-Regulation in an Ex-Vivo Human Intestinal Model of Celiac Disease. Gastroenterology 2003;124: A-658

Drago S, Di Pierro M, Bizzarri B, Sapone A, Kryszak D, Catassi C, FASANO A. HLA A*0201 Allele Accounts DQ2/DQ8 Negative Genome Screening in Celiac Disease Patients. Gastroenterology 2003;124:A-658

FASANO A, Clemente M, DeVirgillis S, Musu M, Usai P, Porqueddu P, Cicotto L, Massidda C. Intestinal Zot/Zonulin Receptor is Up-Regulated in Active Celiac Disease and Co-Localizes with Proteinase-Activated Receptor (Par)-2. J Pediatr Gastroenterol Nutr 39:1: 2004;P0005PP-S57.

FASANO A, Adams D, Fang E. Structural and Functional Relationship Between Zonulin and the Mucosal Mast Cells-Derived Mast Cell Protease II. J Pediatr Gastroenterol Nutr 39:1: 2004;P0064PP-S80.

FASANO A, Clemente M, VOGEL SNl, Hollenberg M. Zot/Zonulin-Mediated Regulation of Intestinal Tight Junctions Involves the Proteinase-Activated Receptor 2 (PAR-2). J Pediatr Gastroenterol Nutr 39:1: 2004;P0517PP-S253.

FASANO A, Catassi C, Kryszak D, M. Abu-Zakry. Prevalence of Celiac Disease Among School Children in Egypt: Results of a Pilot Study.J Pediatr Gastroenterol Nutr 39:1: 2004;P0438PP-S222.

FASANO A, Watts T, Sapone A, Zielke R. Zonulin-Dependent Increased Intestinal Permeability is Involved in the Pathogenesis of Type 1 Diabetes and Can Be Blocked to Prevent The Onset of the Disease. J Pediatr Gastroenterol Nutr 39:1: 2004;P0086PP-S89.

Fu M, Damcott C, Sabra M, Ott J, Lee J, Pollin TI, Garant M, O’Connell J, Mitchell BD, SHULDINER AR. Association of calsequestrin on 1q21 with type 2 diabetes mellitus (T2DM) in the Old Order Amish. 2003; Annual Meeting of the American Society of Human Genetics, Los Angeles, CA.

Garg P, Angelini DJ, Pallero MA, Mosher DF, Murphy-Ullrich JE, GOLDBLUM SE. Thrombospondin-1 increases the tyrosine phosphorylation of VE-cadherin and ?-catenin and opens the endothelial paracellular pathway through activation of EGFR/ErbB2. 2004; American Society for Cell Biology Annual Meeting, Washington, DC, December 4-8.

Gong P, Angelini DJ, VOGEL SN, FENTON MJ, GOLDBLUM SE. Bacterial lipopolysaccharide increases tyrosine phosphorylation of zonula adherens (ZA) proteins and opens the pulmonary vascular endothelial paracellular pathway. 2004; 44th American Society for Cell Biology Annual Meeting, Washington, DC, December 4-8.

Hyun SW, Sui X, Del Vecchio RL, Tonks NK, PASSANITI A, GOLDBLUM SE. Protein tyrosine phosphatase (PTP) ? regulates endothelial cell (EC) proliferation, adhesion and migration. 2004; 44th American Society for Cell Biology Annual Meeting, Washington, DC, December 4-8.

Liu X, Fallin MD, Yang RZ, Coresh J, SHULDINER AR, Bray MS, Brancati FL, Kao WHL. Tests for gene-environment interaction on risk of Type 2 diabetes in African Americans: the Atherosclerosis Risk in Communities (ARIC) study. 2004; Annual Meeting of the American Heart Association CVD Meeting, San Francisco, CA.

Mitchell BD, Beck TJ, Streeten EL, McBride DJ, Lodge AL, Uusi-Rasi K, SHULDINER AR. Reduced mechanosensitivity is associated with fractures in the Old Order Amish. 2003; Annual Meeting of the Society for Bone and Mineral Research, Minneapolis, MN.

Mitchell BD, Post W, Peyser PA, Bielak L, Lodge A, Rumberger J, SHULDINER AR Correlates of coronary and aortic calcification in the Old Order Amish. 2003; Annual Meeting of the American Society of Human Genetics, Los Angeles, CA.

Neri E, Not T, Kryszak D, Tommasini A, Zamuner E, HORVATH K, Ventura A, FASANO A. High Prevalence of Diabetes and Thyroiditis Related Antibodies in First Degree Relatives of Celiac Patients. J Pediatr Gastroenterol Nutr 39:1: 2004;P0425PP-S217.

Neri E, Not T, Kryszak S, Zamuner E, Medeiros L, HORVATH K, FASANO A, Ventura A. Follow Up in an USA Adult Celiac Population: The Role of the Gluten in Autoimmunity. J Pediatr Gastroenterol Nutr 39:1: 2004;P0442PP-S224.

Phares DA, Halverstadt AA, SHULDINER AR, Ferrell RE, Ryan AB, Goldberg AP, Hagberg JM. Collective effects of three adrenergic receptor (AR) polymorphisms are associated with body fat response to training. 2003. Meeting of the American College of Sports Medicine.

Pollin TI, Agarwala R, Schaffer AA, SHULDINER AR, Mitchell BD, O’Connell JR. Investigations of male founder structure and the Y chromosome in the Old Order Amish. 2003; Annual Meeting of the American Society of Human Genetics, Los Angeles, CA.

Pollin TI, Mitchell BD, Hsueh W-C, Tanner K, SHULDINER AR, McLenithan JC Adiponectin and cardiovascular risk in the Old Order Amish. 2004; Annual Meeting of the International Genetic Epidemiology Society, Noordwijkeihout, The Netherlands.

Ruse CI, Kinter M, and BOND, ML. Analysis of the human phosphoproteome. 2003; Biophysical Society Annual Meeting, San Antonio, TX.

Ruse CI, Kinter M , BOND ML, Analysis of the human cardiac phosphoproteome. 2003; 47th Annual Meeting of the Biophysical Society, San Antonio, TX.

Ruse CI, Kinter M and BOND ML. Integrated analysis of human cardiac proteome and phosphoproteome. 2003; 51st Annual Conference on Mass Spectrometry and Allied Topics.

Rutherford S, Imumorin IG, Steinle NE, Mitchell BD, SHULDINER AR. Localization of a gene influencing blood pressure variation on chromosome 2q31-q34 in the Amish. 2003; Annual Meeting of the Endocrine Society, Philadelphia.

Rutherford S, Green J, Steinle NI, Mitchell BD, SHULDINER AR. Effects of thiazide-sensitive sodium-chloride co transporter (NCCT) mutations on blood pressure in the Amish. 2003; Annual Meeting of the American Society of Human Genetics, Los Angeles, CA.

Sabra M, Fu M, Damcott CM, Ott S, O’Connell JR, Mitchell BD, SHULDINER AR. The search for type 2 diabetes loci on chromosome 1q21-q24: Results of linkage disequilibrium mapping in the Old Order Amish. 2003; Diabetes 52: A35.

Sabra M, Ott, S, Lee J, O’Connell JO, Mitchell BD, SHULDINER AR. Vesicle-associated membrane protein 4 (VAMP4), a positional candidate gene on 1q21-q24, is not associated with type 2 diabetes in the Old Order Amish. 2003; Annual Meeting of the Endocrine Society, Philadelphia, PA.

Sabra M, Fu M, Damcott C, O’Connell J, Mitchell B, SHULDINER AR. Rho guanine nucleotide exchange factor 11, a candidate gene on chromosome 1q21, is associated with impaired glucose homeostasis in the Amish. 2004; American Diabetes Association Annual Meeting, Orlando, FL.

Sapone A, Watts T, Counts D, Zielke R, Bizzari B, FASANO A. Inhibition of the Zonulin-Dependent Increased Intestinal Permeability Prevents the Onset of Type 1 Diabetes In BB/Wor Rats. Gastroenterology 2004; 126A-518.

Snitker S, Watanabe R, Ani I, Xiang A, Marroquin A, Ochoa C, Goico J, SHULDINER AR, Buchanan T. Subjects with and without the common, functional PPAR-g-2 Pro12Ala variant are similarly responsive to thiazolidinedion. 2003; Diabetes 52: A144.

Sorkin JD, SHULDINER AR, Pollin TI, Hsueh W-C, Mitchell BD. Low birth weight is associated with the metabolic syndrome in the Old Order Amish. 2003; Diabetes 52:A229.

Steinle NI, Mitchell BD, SHULDINER AR. Variants in the ghrelin gene are associated with glucose, lipids, insulin and leptin levels in the Old Order Amish. 2003; Annual Meeting of the Endocrine Society, Philadelphia, PA.

Streeten EL, McBride DJ, O’Connell JR, Pollin TI, Beck TJ, Uusi-Rasi K, SHULDINER AR, Mitchell BD. Heritability of hip structural phenotypes in the Old Order Amish. 2003; Annual Meeting of the Society for Bone and Mineral Research, Minneapolis, MN.

Sui X, Hyun SW, Kiser TD, Del Vecchio RL, Tonks NK, PASSANITI A, GOLDBLUM SE. Receptor protein tyrosine phosphatase (PTP) ? regulates the endothelial paracellular pathway. 2004; 44th American Society for Cell Biology Annual Meeting, Washington, DC, December 4-8.

Tan FL, Dai Y, Ruse CI, Skacel M, Pettay JD, Tubbs RR, Francis G, Young JB, McCarthy PM, Moravec C, and BOND M. Identification of a Novel Gene That is Highly Cardiac-specific and Up-regulated in Heart Failure, From Genome to Disease: 2003; A Symposium for High Throughput Biology, National Institutes of Health, July 23-24.

Weiss EP, Kulaputana IA, Ghiu DA, Phares DA, SHULDINER AR, Hagberg JM. Effects of PPARg genotype on endurance training-induced changes in insulin response to oral glucose. 2003. Meeting of the American College of Sports Medicine.

Weiss EP, Ghin IA, Brandauer J, Wong CR, Kulaputana O, Phares DA, SHULDINER AR, Hagberg JM. FABP2 genotype and exercise training as determinants of glucoregulatory function and postprandial lipemia. 2004; American College of Sports Medicine Annual Meeting, Indianapolis, IN.

Wolfe AF, Wolfe AE, Reider-Demer M, Monarch E, Gerarduzzi T, FASANO A, Pietzak MM. Celiac Disease Antibodies in Patients with Sjogren’s Syndrome. Gastroenterology 2003;124:A-660.

Xie G, Yamada M, Wess J, RAUFMAN J-P. Studies using muscarinic receptor knockout mice indicate that cholinergic agonist-induced gastric pepsinogen secretion is mediated by M1 and M3 receptors. Gastroenterology 126:A31, 2004. Oral presentation at DDW, New Orleans, LA.

Xu H, Chaturvedi R, Cheng Y, Fertel D, Bussiere F, Asim M, Peek RM, Rhee J, WILSON KT. H. pylori-induced Gastric Epithelial Cell Apoptosis and DNA Damage is Caused by Polyamine Oxidation. 2004; Gastroenterology 126: A59, Oral Presentation, AGA Annual Meeting, New Orleans, LA.

Yang R, McLenithan JC, Xu M, Hong H, Jadhao SB, Hansen BC, SHULDINER AR, Gong DW. Cloning of omentin, a new adipocytokine from omental fat tissue in humans. 2003; Diabetes 52:A1.

Yang R, Huang Q, Xu A, McLenithan J, SHULDINER AR, Gong, D-W. Comparative studies of resistin expression and phylogenomics in human and mouse. 2003; International Diabetes Federation Meeting, Paris, France.

Yang R-Z, McLenithan J, Lee M-J, Hu H, Hansen BC, Fried SK, SHULDINER AR, Gong D-W. Omentin enhances insulin-stimulated glucose transport in adipocytes. 2003; Adipose tissue secretory function and its role in Obesity-associated co-morbidities, National Institutes of Health, Washington DC.

Yang R-Z, Lee M-J, Hu H, Pollin T, Nicklas B, Goldberg AP, SHULDINER AR, Fried SK, Gong D-W. Serum amyloid protein A, an adipocytokine in humans. 2003; Adipose tissue secretory function and its role in Obesity-associated co-morbidities, National Institutes of Health, Washington, DC.

Zhou J, Milner CM, PASSANITI A, CROSS AS, GOLDBLUM SE. Endothelial cell expression of sialidases. 2004; 44th American Society for Cell Biology Annual Meeting, Washington, DC, December 4-8.