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Phillip A. Mackowiak, MD
Professor and Vice Chairman of Medicine
Chief, Medical Service, Baltimore VA Medical Center
MD: University of Maryland, 1970
Phone: (410) 605-7199
Fax: (410) 605-7849
E-mail: Philip.Mackowiak@med.va.gov
Address:
Medical Services 5D143
VA Medical Center
10 North Greene St.
Baltimore, MD 21201
RESEARCH INTERESTS
Mechanisms, clinical characteristics and consequences of fever and its treatment.
Dr. Mackowiak studies mechanisms, clinical characteristics and consequences of fever and its treatment. He has edited two editions of a monograph devoted to fever. His research has provided the first modern characterization of normal temperature in humans. He and his collaborators, have also published the most comprehensive description of the clinical characteristics of drug-induced fever, characterized the effects of physiological variations in temperature on bacteria growth and susceptibility, studied the relationship between the height of fever and the severity of the infections causing fever, examined the effect of interferon ß on regional cerebral blood flow, and demonstrated prolongation of illness due to experimental influenza A by antipyretic therapy. He is currently conducting an investigation to identify mechanisms responsible for diurnal fluctuations in fever during bacterial endocarditis.
RECENT PUBLICATIONS
Mackowiak, P, LeMaistre, F, Drug Fever: A critical appraisal of conventional concepts. Ann Intern Med 1987; 106: 728-733.
Mackowiak, P, Wasserman, S.S, Levine, M.M.: A critical appraisal of 98.6°F, the upper limit of the normal body temperature, and other legacies of Carl Reinhold August Wunderlich. JAMA 1992; 268: 1578-1580.
Mackowiak, P, Wasserman S.S, Levine M.M.:An analysis of the quantitative relationship between oral temperature and severity of illness in experimental shigellosis. J Infect Dis. 1992; 166:1181-4.
Mackowiak, P.A., Siegel, E. Wasserman, S, Cameron E, Nessaiver M.S., Bever, CT: Effects of IFN-ß on human cerebral blood flow distribution: J of Interferon Cytokine Res 1998; 18: 393-397.
Mackowiak, P, Wasserman, S.S., Tacket, C.O., Vaughn, D.W., Eckels, K.H., Dubois, D. R., Hoke, C., Edelman, R: Quantitative relationship between oral temperature and severity of illness following inoculation with candidate attenuated Dengue virus vaccines. Clin Infect Dis 1994; 19:948-950.
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To contact us:
Phone: 410-706-7560
Fax: 410-706-4619
E-mail: kvardjan@ihv.umaryland.edu
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