Bookmark and Share

1990s Publications

A.I. FADEN. Opioid and non-opioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury. Ann Neurol 27: 67-74, 1990.

R. Bakshi and A.I. FADEN. Competitive and non-competitive NMDA antagonists limit dynorphin A-induced rat hindlimb paralysis. Brain Res 507: 1-5, 1990.

S.S. Panter, S.W. Yum, and A.I. FADEN. Alteration in extracellular amino acids after traumatic spinal cord injury. Ann Neurol 27: 96-99, 1990.

M. Lemke, B. Frei, B.N. Ames, and A.I. FADEN. Decreases in tissue levels of ubiquinol-9 and -10, ascorbate and alpha-tocopherol following spinal cord impact trauma in rats. Neurosci Lett 108: 201-206, 1990.

S. Yum and A.I. FADEN. Comparison of the neuroprotective effects of the Nï·“methyl-D-aspartate antagonist MK801 and the opiate-receptor antagonist nalmefene in experimental spinal cord ischemia. Arch Neurol 47: 277ï·“281, 1990.

M. Lemke and A.I. FADEN. Edema development and ion changes in rat spinal cord after impact trauma: Injury dose-response studies. J Neurotrauma 7: 41ï·“54, 1990.

R. Bakshi and A.I. FADEN. Blockade of the glycine modulatory site of NMDA receptors modifies dynorphin-induced behavioral effects. Neurosci Lett 110: 113-117, 1990.

S.H. Graham, K. Shiraishi, S.S. Panter, R.P. Simon, and A.I. FADEN. Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia. Neurosci Lett 110: 124-130, 1990.

R. Vink, V.A. Head, P.J. Rogers, T.K. McIntosh, and A.I. FADEN. Mitochondrial metabolism following traumatic brain injury in rats. J Neurotrauma 7: 21-27, 1990.

A.I. FADEN, J.A. Ellison, and L.J. Noble. Effects of competitive and noncompetitive NMDA antagonists in spinal cord injury. Eur J Pharmacol 175:165-174, 1990.

A.I. FADEN, S.W. Yum, M. Lemke, and R. Vink. Effects of TRH-analog treatment on tissue cations, phospholipids and energy metabolism after spinal cord injury. J Pharmacol Exp Ther 255: 608-614, 1990.

A.I. FADEN, R. Shirane, L.-H. Chang, T.L. James, M. Lemke, and P.R. Weinstein. Opiate-receptor antagonist improves metabolic recovery and limits neurochemical alterations associated with reperfusion after global brain ischemia in rats. J Pharmacol Exp Ther 255: 451-458, 1990.

R. Bakshi, A.H. Newman, and A.I. FADEN. Dynorphin A-(1-17) induces alterations in free fatty acids, excitatory amino acids, and motor function through an opiate receptor-mediated mechanism. J Neurosci 10: 3793-3800, 1990.

M. Lemke, S.W. Yum, and A.I. FADEN. Lipid alterations correlate with tissue magnesium decrease following impact trauma in rabbit spinal cord. Molec Chem Neuropath 12(3):147-165, 1990.

R. Vink, T.K. McIntosh, R. Romhanyi, and A.I. FADEN. Opiate antagonist nalmefene improves intracellular free Mg2+, bioenergetic state and neurologic outcome following traumatic brain injury in rats. J Neurosci 10: 3524ï·“3530, 1990.

R. Vink, P. S. Portoghese and A.I. FADEN. Kappa-opioid antagonist improves cellular bioenergetics and recovery after traumatic brain injury. Am J Physiol 261:R1527-1532,1991.

A.I. FADEN and S. Salzman. Pharmacological strategies in CNS trauma. Trends in Pharmacol Sci 13(1):29-35, 1992.

A.I. FADEN. Dynorphin increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism. J Neurosci 12(2):425-429, 1992.

Panter, S. and A.I. FADEN. Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury. Neurosci Lett 136:165-168. 1992.

Bakshi, R., R. Ni and A.I. FADEN. N-methyl-D-aspartate and opioid receptors mediate dynorphin-induced spinal cord injury. Brain Res 580:255-264, 1992.

A.I. FADEN and P. Halt. Platelet-activating factor reduces spinal cord blood flow and causes behavioral deficits after intrathecal administration in rats through a specific receptor mechanism. Jour Pharm Exp Ther 261(3):1064-1070, 1992.

Widmer, H. Abiko, A.I. FADEN, T. L. James and P. R. Weinstein. Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. J Cereb Blood Flow Metab 12:456-468, 1992.

L.H. Chang, H. Shimizu, H. Abiko, R.A. Swanson, A.I. FADEN, T.L. James, and P.R. Weinstein. Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. J Cereb Blood Flow Metab 12:1030-1038, 1992.

A.I. FADEN and P.A. Tzendzalian. Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma. Am J Physiol 263:R909-R914, 1992.

P.Halt, R. Swanson and A.I. FADEN. Alcohol exacerbates behavioral and neurochemical effects of rat spinal cord trauma. Arch Neurol 49:1178-1184, 1992.

A.I. FADEN. Comparison of single and combination drug treatment strategies in experimental brain trauma. J Neurotrauma 10(2):91-100, 1993.

A.I. FADEN, V.M. Labroo and L.A. Cohen. Imidazole-substituted analogues of TRH limit behavioral deficits after experimental brain trauma. J Neurotrauma 10(2):101-108, 1993.

Shimizu, S.H. Graham, L.-H. Chang, J. Minotovitch, T.L. James, A.I. FADEN and P.R. Weinstein. Relationship between extracellular neurotransmitter amino acids and energy metabolism during cerebral ischemia in rats monitored by microdialysis and in vivo magnetic resonance spectroscopy. Brain Res 605:33-42, 1993.

A.I. FADEN. Experimental neurobiology of central nervous system injury. Crit Rev Neurobiol 7:175-186, 1993.

S.H. Graham, H. Shimizu, A. Newman, P. Weinstein, and A.I. FADEN. Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia. Brain Res 632:346-350, 1993.

T.K. McIntosh, S. Fernyak, R.L. Hayes and A.I. FADEN. Beneficial effect of the nonselective opiate antagonist Naloxone hydrochloride and the thyrotropin-releasing hormone (TRH) analog YM-14673 on long-term neurobehavioral outcome following experimental brain injury in the rat. J Neurotrauma 10:373-384, 1993.

C.C. Hanstock, A.I. FADEN, M.R. Bendall and R. Vink. Diffusion-weighted imaging differentiates ischemic tissue from traumatized tissue. Stroke, 25:843-848, 1994.

T.K. McIntosh, S. Fernyak, I. Yamakami, and A.I. FADEN. Centrally and systemically-administered kappa opioid agonists exacerbate cardiovascular and neurobehavioral response to traumatic brain injury in the rat. Am J Physiol 267:R665-R672, 1994.

J.P. Headrick, M.R. Bendall, A.I. FADEN and R. Vink. Dissociation of adenosine levels from bioenergetic state in experimental brain trauma: potential role in secondary injury. J Cereb Blood Flow Metab 14:853-861, 1994.

F.Y. Sun and A.I. FADEN. High and low affinity NMDA receptor-binding sites in rat spinal cord: effects of traumatic injury. Brain Res 664:63-69, 1994.

A.G. Yakovlev and A.I. FADEN. Sequential expression of c-fos protooncogene, TNF-alpha and dynorphin genes in spinal cord following experimental traumatic injury Molec & Chem Neuropathol, 186:179-190, 1994.

A.I. FADEN and V.A. Sharpe. Iatrogenic neurological complications. Arch Neurol 51:1184-1185, 1994.

F.Y. Sun and A.I. FADEN. N-methyl-d-aspartate receptors mediate posttraumatic increases of protein kinase C in rat brain. Brain Res 661:63-69, 1994.

Yamakami, R. Vink, A.I. FADEN, T.A. Gennarelli, R. Lenkinski and T.K. McIntosh. Effects of acute ethanol intoxication on experimental brain injury in the rat: neurobehavioral and phosphorus-31 nuclear magnetic resonance spectroscopy studies. J Neurosurg 82:813-821, 1995.

J.P. Headrick, A.I. FADEN and R. Vink. Intrathecal dynorphin-A infusion in rat spinal cord causes energy depletion, edema and neurologic dysfunction. Neurochem Int 26(5):489-495, 1995.

D. Sappey-Marinier, L. Chileuitt, M.W. Weiner, A.I. FADEN, and P.R. Weinstein. Hypoglycemia prevents increase in lactic acidosis during reperfusion after temporary cerebral ischemia in rats. NMR Biomed 8:171-178, 1995.

F.Y. Sun and A.I. FADEN. Neuroprotective effects of 619C89, a use-dependent sodium channel blocker, in rat. Brain Res 673:133-140, 1995.

A.Y. Yakovlev, K. Krueger and A.I. FADEN. Structure and expression of a rat kappa opioid receptor gene. J Biological Chem 270:6421-6424, 1995.

Pitts L, Ross A, Chase GA, and FADEN AI. Treatment with thyrotropin releasing hormone (TRH) in patients with traumatic spinal cord injuries. J Neurotrauma 12:235-243, 1995.

F.Y. Sun and A.I. FADEN. Pretreatment with antisense oligodeoxynucleotides directed against the NMDA-R1 receptor enhances survival and behavioral recovery following traumatic brain injury in rats. Brain Res 693:163-168, 1995.

A.G. Yakovlev and A.I. FADEN. Molecular strategies in CNS injury. J Neurotrauma 12(5):767-777, 1995.

S.P. Moore, D.M. Zapple, S.M. Smith, and A.I. FADEN. Georgetown MedNetwork: A New Software Tool for Research Administration and Oversight. SRA Journal 27:7-20, 1995.

V.A. Sharpe and A.I. FADEN. Appropriateness in patient care: a new conceptual framework. Milbank Quarterly 74:115-138, 1996.

A.I. FADEN. Pharmacological treatment of central nervous system trauma. Pharmacology and Toxicology 78:12-17, 1996.

D.M. Basso, M.S. Beattie, J.C. Breshnahan, D.K. Anderson, A.I. FADEN, J.A. Gruner, T.R. Holford, C.Y. Hsu, L.J. Noble, R. Nockels, P.L. Perot, S.K. Salzman, and W. Young. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. J Neurotrauma 13(7):343-359, 1996.

Mukhin A, Fan L, and FADEN A.I. Activation of metabotropic glutamate receptor subtype mGluR1 contributes to posttraumatic neuronal injury. J Neurosci 16(19):6012-6020, 1996.

B.A. Eldadah, A.G. Yakovlev, and A.I. FADEN. A new approach for the electrophoretic detection of apoptosis. Nucleic Acids Res 24(20):4092-4093, 1996.

A.I. FADEN. Pharmacologic treatment of acute traumatic brain injury. JAMA 276(7): 569-570, 1996.

Mukhin AG, Ivanova SA, and AI FADEN. mGluR modulation of post-traumatic neuronal death: Role of NMDA receptors. Neuroreport 8:2561-2566, 1997.

Mukhin AG, SA Ivanova, SM Knoblach, and AI FADEN. New in vitro model of traumatic neuronal injury: Evaluation of secondary injury and glutamate receptor mediated neurotoxicity. J Neurotrauma 14:651-663, 1997.

Eldadah BA, Yakovlev AG, and FADEN AI. The role of Ced-3-related cysteine proteases in apoptosis of cerebellar granule cells. J Neurosci 17(16):6105-6113, 1997.

Yakovlev, A.G., Knoblach, S.M., Fan, L., Fox, G.B., Goodnight, R., and FADEN, A.I. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci 17(19):7415-7424, 1997.

FADEN, A.I., Ivanova, S.A., Yakovlev, A.G., and Mukhin, A.G. Neuroprotective effects of group III mGluR in traumatic neuronal injury. J Neurotrauma 14(12);885-895, 1997.

Beattie MS, Bresnahan JC, Komon J, Tovar CA, Van Meter M, Anderson DK, Faden AI, Hsu CY, Noble LJ, Salzman S, Young W. Endogenous Repair after Spinal Cord Contusion Injuries in the Rat. Exp Neurology 148, 453-463, 1997.

A.G Mukhin, S.A. Ivanova, J.W. Allen, and A.I. FADEN. Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death. J Neurosci Res, 51:748-758, 1998.

G.B. Fox, L. Fan, R.A. LeVasseur and A.I. FADEN. Sustained sensory/motor and cognitive deficits associated with neuronal apoptosis following controlled cortical impact brain injury in the mouse. J Neurotrauma, Vol. 15: 599-614, 1998.

G.B. Fox and A.I. FADEN. Traumatic Brain Injury Causes Delayed Motor and Cognitive Impairment in a Mutant Mouse Strain Known to Exhibit Delayed Wallerian Degeneration. J Neurosci Res 53:718-727, 1998.

S. Knoblach and A.I. FADEN. Interleukin-10 Improves Outcome and Alters Proinflammatory Cytokine Expression after Experimental Traumatic Brain Injury. Exp Neurol 153:143-151, 1998.

G.B. Fox, L. Fan, R.A. LeVasseur and A.I. FADEN. Effect of traumatic brain injury on mouse spatial and non-spatial learning in the Barnes Circular Maze. J Neurotrauma 15:1037-1046, 1998.

L Fan, AG Yakovlev, AI FADEN. Site-specific cleavage of 28S rRNA as a marker of traumatic brain injury. J Neurotrauma 16: 357 - 364, 1999.

GB Fox, RA LeVasseur, AI FADEN. Behavioral responses of C57BL/6, FVB/N and 129/SvEMS mouse strains to traumatic brain injury: implications for gene targeting approaches to neurotrauma. J Neurotrauma 16: 377 -389, 1999.

JW Allen, BA Eldadah, AI FADEN. Beta-amyloid-induced apoptosis of cerebellar granule cells and cortical neurons: exacerbation by selective inhibition of group I metaobtropic glutamate receptors. Neuropharmacology 38:1243-1252, 1999.

JW Allen, SA Ivanova, L Fan, MG Espey, AS Basile, AI FADEN. Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury. J Pharmacol Exp Ther 290:112-120, 1999.

S. Knoblach, L. Fan, and A.I. FADEN. Early neuronal expression of tumor necrosis factor-a after experimental brain injury contributes to neurological impairment. J Neuroimmunol 95; 115-125, 1999.

JW Allen, SM Knoblach, AI FADEN. Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor-dependent neuronal cell death and caspase-3 dependent apoptosis. FASEB J 13 (13):1875-1882, 1999.

AI FADEN, GB Fox, L Fan, GL Araldi, L Qiao, Swang, AP Kozikowski. Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents. Amer J Physiol 27:R1196-104, 1999.

FADEN AI, Fox G, Fan L, Knoblach S, Araldi GL, Kozikowski AP. Neuroprotective and cognitive enhancing effects of novel small peptides. Ann N Y Acad Sci 890:120, 1999.