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2000-2009 Publications

Albensi BC, Knoblach SM, Chew BGM, O'Reilly MP, FADEN AI, Pekar JJ. Diffusion and high resolution MRI of traumatic brain injury in rats: time course and correlation with histology. Exp Neurol 162(1):61-72, 2000.

Eldadah BA, Ren RF, FADEN AI. Ribozyme-mediated inhibition of Caspase-3 protects cerebellar granule cells from apoptosis induced by serum/potassium deprivation. J Neurosci 20(1):179-186, 2000.

Allen JW, Knoblach SM, FADEN AI. Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro. Cell Death Diff 7(5):470-476,2000.

Knoblach SM, FADEN AI. Cortical interleukin-1 beta elevation after traumatic brain injury in the rat: no effect of two selective antagonists on motor recovery. Neurosci Lett 289(1):5-8, 2000.

Eldadah BA, FADEN AI. Caspase pathways, neuronal apoptosis, and CNS injury. J Neurotrauma 17(10):811-29, 2000.

Toman RE, Spiegel S, Faden AI. Role of ceramide in neuronal cell death and differentiation. J Neurotrauma 17(10):891-8, 2000.

O'Leary DM, Movsesyan V, Vicini S, FADEN AI. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131(7):1429-37, 2000.

Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PG, Knoblach SM, FADEN AI. mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 296(1):41-7, 2001.

Movsesyan VA, Yakovlev AG, Fan L, FADEN AI. Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis. Exp Neurol 167(2):366-75, 2001.

FADEN AI, O'Leary DM, Fan L, Bao W, Mullins PG, Movsesyan VA. Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma. Exp Neurol 167(2):435-44, 2001.

Yakovlev AG, Di X, Movsesyan VA, Mullins PG, Wang G, Boulares H, Zhang J, Xu M, and FADEN AI. Presence of DNA fragmentation and lack of neuroprotective effect in DFF45 knockout mice subjected to traumatic brain injury. Mol Med 7:205-216, 2001.

Allen JW, Eldadah BA, Huang X, Knoblach SM, FADEN AI. Multiple caspases are involved in b-amyloid-induced neuronal apoptosis. J Neurosci Res 65:45-53, 2001.

Allen JW, Vicini S, and FADEN AI. Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors: role of NMDA receptors and arachidonic acid release. Exp Neurol 169:449-460, 2001.

FADEN AI. Neuroprotection and traumatic brain injury: the search continues. Arch Neurol 58:1553-1555, 2001.

Lea P.M. IV and AI FADEN. Traumatic brain injury: developmental differences in glutamate receptor response and the impact on treatment. Special Issue: The glutamate signalling in developmental and in neonatal brain injury. Mental Retardation & Developmental Disabilities Research Reviews 7:235-248, 2001.

Yakovlev AG and AI FADEN. Caspase-dependent apoptotic pathways in CNS injury. Mol Neurobiol 24:131-144, 2001.

Bao WL, Williams AJ, FADEN AI, and Tortella FC. Selective mGluR receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. Brain Res 922:173-179, 2001.

Yakovlev AG, Ota K, Wang G, Movsesyan V, Bao WL, Yosihara K, and FADEN AI. Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. J Neurosci 21:7439-7446, 2001.

Vink R, Mullins PG, Temple MD, Bao W, and FADEN AI. Small shifts in craniotomy position in the lateral fluid percussion injury model are associated with differential lesion development. J Neurotrauma 18:839-847, 2001.

Toman RE, Movsesyan V, Murthy SK, Milstien S, Spiegel S, and FADEN AI. Ceramide-induced cell death in primary neuronal cultures: Upregulation of ceramide levels during neuronal apoptosis. J Neurosci, in press.

Lea PM IV, Custer SJ, Vicini S, and FADEN AI. Neuronal and glial mGluR5 modulation prevents stretch-induced enhancement of NMDA receptor current. Pharmacol Biochem Behav, in press.