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Thomas G Blanchard Ph.D., J.D.

Academic Title: Associate Professor
Primary Appointment: Pediatrics
tblanchard@peds.umaryland.edu
Location: BRB, 13-043
Phone: (410) 706-1772
Fax: (410) 328-1072
Lab: (410) 706-8777

Publications:

Blanchard, T.G., S.J. Czinn, J.G. Nedrud, and R.W. Redline. Helicobacter-associated gastritis in SCID mice. Infection and Immunity. 1995; 63(3):1113-1115.

Blanchard, T.G., S.J. Czinn, R. Maurer, W.D. Thomas, S. Golapoli, and J.G. Nedrud. Urease-specific monoclonal antibodies protect mice from infection with Helicobacter felis. Infection and Immunity 1995; 63(4):1394-1399.

Czinn, S.J., J.C. Bierman, T.G. Blanchard, R.W. Diters, and R.D. Leunk. Characterization and therapy of experimental infection by Helicobacter mustelae in ferrets. Helicobacter 1996; 1(1): 43-51.

Cuenca, R., T.G. Blanchard, S.J. Czinn, T.P. Monath, C.K. Lee, and R.W. Redline. Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets. Gastroenterology. 1996; 110:1770-1775.

Blanchard, T.G., N. Lycke, S.J. Czinn, and J.G. Nedrud. Cholera toxin B subunit is not an adjuvant for oral immunization against Helicobacter felis in mice. Immunology 1998; 93:22-27.

Blanchard T.G., J.G. Nedrud, E.S. Reardon, and S.J. Czinn. Qualitative and quantitative analysis of the local and systemic antibody response in mice and humans with Helicobacter immunity and infection. Journal of Infectious Diseases. 1999; 179:725-8.

Blanchard T.G., S.J. Czinn, R.W. Redline, N. Sigmund, G. Harriman, and J.G. Nedrud. Antibody-independent protective mucosal immunity to gastric Helicobacter infection in mice. Cellular Immunology. 1999; 191:74-80.

Blanchard, T.G., J.G. Nedrud, S.J. Czinn. Local and systemic antibody responses in humans with Helicobacter pylori infection. Canadian Journal of Gastroenterology. 1999; 13(7): 591-594.

J.K. Robinson, T.G. Blanchard, A.D. Levine, S.N. Emancipator, and M.E. Lamm. A mucosal IgA-mediated excretory immune system functions in vivo. Journal of Immunology. 2001; 166(6):3688-3692.

Gottwein, J.M., T.G. Blanchard, O.S. Targoni, J. Eisenberg. B.M. Zagorski, R.P. Trezza, R.W. Redline, J.G. Nedrud, M. Tary-Lehmann, P.V. Lehmann, and S.J. Czinn. Systemic vaccination with aluminum hydroxide induces protective immunity against Helicobacter pylori infection in mice. Journal of Infectious Disease. 2001; 184:308-314.

K.J. McGovern, T.G. Blanchard, J.A. Gutierrez, S. Czinn, S. Krakowka, and P. Youngman. Gamma-glutamyl transpeptidase is a Helicobacter pylori virulence factor but is not essential for colonization. Infection and Immunity 2001; 69(6):4168-4173.

Eisenberg, J.C., S.J. Czinn, C.A. Garhart, R.W. Redline, W.C. Bartolomae, J.M. Gottwein, J.G. Nedrud, S.E. Emancipator, B.B. Boehm, P.V. Lehmann, and T.G. Blanchard. Protective anti-Helicobacter pylori immunity following systemic immunization of neonatal mice. Infection and Immunity 2003; 71:1820-7.

Blanchard, T.G., F. Yu, C.-L. Hsieh, and R.W. Redline. Lack of phagocyte oxidase activity results in severe inflammation and a reduced bacterial load in murine Helicobacter pylori and felis infection. Journal of Infectious Diseases 2003; 187:1609-15.

Blanchard, T.G., J.C. Eisenberg, and Y. Matsumoto. Clearance of Helicobacter pylori infection through immunization: The site of T cell activation contributes to vaccine efficacy. Vaccine 2004; 22:888-97.

Busiello, I., R. Acquaviva, A. Di Popolo, T.G. Blanchard, V. Ricci, M. Romano, and R. Zarrilli. Helicobacter pylori gamma-glutamyltranspeptidase upregulates COX-2 and EGF-related peptide expression in human gastric cells. Cellular Microbiology 2004; 6:255-267.

Drakes, M., T. Blanchard, and S. Czinn. Enhanced cytokine release by probiotic-stimulated dendritic cells. Infection and Immunity 2004; 72:3299-3309.

Drakes, M.L., S.J. Czinn, and T.G. Blanchard. Isolation and purification of colonic lamina propria dendritic cells. Cytotechnology 2004; 151-161.

Basu, M., S.J. Czinn, and T.G. Blanchard. Absence of catalase reduces long-term survival of Helicobacter pylori in macrophage phagosomes. Helicobacter 2004; 9:211-216.

Rahn, W., R.W. Redline, and T.G. Blanchard. Molecular analysis of Helicobacter pylori-associated gastric inflammation in chronically infected and immune mice. Vaccine 2004; 23:807-818.

Matsumoto, Y., T.G. Blanchard, M.L. Drakes, M. Basu, R.W. Redline, A.D. Levine, and S.J. Czinn. 2004. Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10 deficient mice. Helicobacter 2005; 10:407-415.

Drakes, M.L., T.G. Blanchard, and S.J. Czinn. Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis. Journal of Leukocyte Biology 2005; 78: 1291-1300.

Anderson, K., S.J. Czinn, R.W. Redline, and T.G. Blanchard. Induction of CTLA-4 mediated anergy contributes to persistent colonization in the murine model of gastric H. pylori infection. Journal of Immunology 2006;176:5306-5313.

Drakes, M.L., S.J. Czinn, and T.G. Blanchard. Regulation of murine dendritic cell immune responses by Helicobacter felis antigen. Infection and Immunity. 2006; 74:4624-4633.

Chintalacharuvu, S.R., M. Yamashita, N. Bagheri, T.G. Blanchard, J.G. Nedrud, M.E. Lamm, Y. Tomino, and S.N. Emancipator. T cell cytokine polarity as a determinant of IgA glycosylation and the severity of experimental IgA nephropathy. Clinical and Experimental Immunology 2008; 153: 456-462.

Stuller, K.M., H. Ding, R.W. Redline, S.J. Czinn, and T.G. Blanchard. CD25+ T cells induce H. pylori-specific CD25- T cell anergy but are not required to maintain persistent hyporesponsiveness. European Journal of Immunology 2008; 38(12):3426-35.

DeLyria, E.S., R.W. Redline, and T.G. Blanchard. Protective immunity against Helicobacter pylori in mice is neutrophil-dependent and associated with local IL-17. Gastroenterology 2009; 136:247-256.

Drakes, M.L. and T.G. Blanchard. Inverse relationship between dendritic cell CCR9 expression and maturation state. Immunology 2009; 127:466-76.