I received my undergraduate degree in mechanical and aerospace engineering from Cornell University in 1994. After working in information technology industry I resumed my formal education at the University of Maryland. I completed my doctoral work in epidemiology focusing on genetic epidemiology and aging.
My primary academic research interests are in new inferential methods applied to go beyond correlation to causation. My approach to causal inference is at the crossroads of statistics, epidemiology and practical application.
Through my affiliation with the Program in Personalized and Genomic Medicine, I work together with a team to advance so-called personalized medicine into the real clinics to direct effect patient outcomes.
As the Associate Director of Research for the Maryland Center on Problem Gambling, I work towards the single goal of the Center: to minimize the problems associate with gambling. I oversee research in this area and take a direct leadership role in maintaining research resources across the State.
McArdle PF, Pollin TI, O'Connell JR, Sorkin JD, Agarwala R, Schaeffer AA, Streeten EA, King TM, Shuldiner AR, Mitchell BD. Does having children extend lifespan? A genealogical study of parity and longevity in the Amish. J Gerontol A Biol Sci Med Sci. 2006 Feb;61(2):190-5. PMID: 16510865
Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ. Phosphodiesterase 4d Polymorphisms And The Risk Of Cerebral Infarction In A Biracial Population: The Stroke Prevention In Young Women Study. Hum Mol Genet. 2006 Aug 15;15(16):2468-78. Epub 2006 Jul 11. PMID: 16835261
McArdle PF, O'Connell JR, Pollin TI, Baumgarten M, Shuldiner AR, Peyser PA, Mitchell BD. Accounting for relatedness in family-based genetic association studies. Hum Hered 2007;64:234-242. PMID: 16510865
Rampersaud E, Damcott CM, Fu M, Shen H, McArdle PF, Shi X, Shelton J, Yin J, Chang CY, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR. Identification of novel candidate genes for type-2 diabetes from a genome-wide association scan in the Old Order Amish: Evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes. Publish Ahead of Print September 10, 2007 DOI: 10.2337/db07-0457
McArdle PF, Dytch H, O'Connell JR, Shuldiner AR, Peyser PA, Mitchell BD, Abney M. Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture. BMC Genetics 2007, 8:66 (1 October 2007).
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