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Nirav G. Shah

Nirav G. Shah M.D.

Academic Title: Assistant Professor
Primary Appointment: Medicine
Administrative Title: Co-Director Of The Dc-Baltimore Critical Care Educational Consortium
Location: 110 S. Paca Street, 2N-144
Phone: (410) 328-8141
Fax: (410) 328-0177

Personal History:

Dr. Shah graduated from the University of North Carolina in Chapel Hill, North Carolina with a BS in Biology with Honors and a minor in Chemistry and then went on to pursue his medical education at St. George's University School of Medicine in Grenada, West Indies. Upon graduating from St. George's University with Honors, he did his internship and residency in Internal Medicine at the Washington Hospital Center in Washington, D.C. He completed his fellowship in Critical Care Medicine at the National Institutes of Health and his fellowship in Pulmonary Diseases at the University of Maryland Medical Center. Dr. Shah is board certified in Internal Medicine, Pulmonary Medicine, and Critical Care Medicine. He has received multiple teaching awards and enjoys focusing on medical education. He is the program director for the Pulmonary and Critical Care Fellowship program at the University of Maryland Medical Center.

Research Interests:

Dr. Shah's research interest lies in the field of thermal molecular biology and acute lung injury. In particular, he is interested in lung inflammation, injury, and repair and in particular his focus is on the molecular mechanisms through which febrile-range hyperthermia and therapeutic hypothermia exert their immunomodulatory effects on human microvascular endothelial cells in the lung.

Clinical Speciality:

Dr. Shah's clinical and teaching interests have continued to focus on acute lung injury, ARDS, and critical illness as well as consultative pulmonary medicine including advanced fiberoptic bronchoscopy. This includes CT-guided bronchoscopy, transbronchial needle aspiration endobronchial ultrasound, and navigational bronchoscopy. He focuses on complex pulmonary issues in his outpatient clinic including interstitial lung disease, advanced COPD, sarcoidosis, and asthma.


  1. M. Longtine, A. McKenzie, D. Demarini, N. Shah, A. Wach, A. Brachat, P. Philippsen, J. Pringle. “Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae.” Yeast 1998; 14:953-61.
  2. J. Bahler, J. Wu, M. Longtine, N. Shah, A. McKenzie, A. Steever, P. Philippsen, J. Pringle.“Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe.” Yeast 1998; 14:943-51.
  3. Nagarsekar, R. Greenberg, N. Shah, I. Singh, J. Hasday. “Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils.” Journal of Immunology 2008; 181:2636-2643.
  4. N. Shah, M. Tularpurkar, I. Singh, J. Shelhamer, M. Cowan, J. Hasday. “Prostaglandin E2 Potentiates Heat Shock-Induced Heat Shock Protein 72 Expression in A549 Cells.” Prostaglandins and Other Lipid Mediators 2010; 93(1-2):1-7.
  5. A. Choi, H. Reynolds et al. “NHLBI Workshop: Respiratory Medicine-Related Research Training for Adult and Pediatric Fellows.” Lung 2009; 187:347-366.
  6. J. Hasday, N. Shah, P. Mackowiak, M. Tulapurkar, A. Nagarsekar, I. Singh. “Fever, hyperthermia, and the lung: it’s all about context and timing.” Trans Am Clin Climatol Assoc, 2010; 122:34-37.
  7. H. Sareh, M. Tulapurkar, N. Shah, I. Singh, J. Hasday. “Response of Mice to Continuous 5-day Passive Hyperthermia Resembles Human Heat Acclimation.” Cell Stress and Chaperones, 2011; 16(3):297-307.
  8. T. Maity, M. Henry, M. Tulapurkar, N. Shah, J. Hasday, I. Singh. “Distinct, gene-specific effect of heat shock and heat shock factor-1 recruitment and gene expression on CXC chemokine genes.” Cytokine 2011; 54:61-7.
  9. N. Shah, J. Hasday. “Does temperature make a difference? It depends on how hot (or cold), for how long, and in what clinical context.” Crit Care Med 2012; 40:326-7.
  10. M. Tulapurkar, E. Almutairy, N. Shah, J. He, A. Puche, P. Shapiro, I. Singh, J. Hasday. “Febrile-range Hyperthermia Modifies Endothelial and Neutrophil Functions to Promote Extravasation.” Am J Respir Cell Mol Biol 2012; 46:807-14.
  11. N. Shah, M. Tulapurkar, M. Damarla, I. Singh, S. Goldblum, P. Shapiro, J. Hasday. "Febrile-range Hyperthermia Augments Reversible TNFa-induced Hyperpermeability in Human Lung Microvascular Endothelial Cells" Int J Hyperthermia 2012; 28(7):627-35.
  12. N. Shah, M. Cowan, E. Pickering, H. Sareh, M. Afshar, D. Fox, J. Marron, J. Davis, K. Herold, C. Shanholtz, J. Hasday. “Nonpharmacologic Approach to Minimizing Shivering During Surface Cooling: A Proof of Principle Study.” Journal of Critical Care 2012; 27(6):746e1-8.
  13. A. Nagarsekar, M. Tulapurkar, I. Singh, S. Atamas, N. Shah, J. Hasday. “Hyperthermia Promotes and Prevents Respiratory Epithelial Apoptosis through Distinct Mechanisms.” Am J Respir Cell Mol Biol; 2012; 47(6):824-33.
  14. T. Bridges, M. Tulapurkar, N. Shah, I. Singh, J. Hasday. “Tolerance for chronic heat exposure is greater in female than male mice.” Int J Hyperthermia 2012; 28(8):747-55.
  15. G. Netzer, D. Dowdy, T. Harrington, S. Chandolu, V. Dinglas, N. Shah, E. Colantuoni, P. Mendez- Tellez, C. Shanholtz, J. Hasday, D. Needham. “Fever is Associated with Delayed Ventilator Liberation in Acute Lung Injury.” Annals ATS 2013; 10(6):608-15.