George F Wittenberg
 

George F Wittenberg M.D., Ph.D., PhD

Academic Title: Associate Professor
Primary Appointment: Neurology
Secondary Appointments: Physical Therapy and Rehabilitation Science
gwittenb@grecc.umaryland.edu
Location: VAMC/GRECC 4B-193
Phone: (410) 605-7000, Ext. 5413
Fax: (410) 605-7913

Personal History

Dr. George F. Wittenberg is Assistant Professor in the Department of Neurology at the University of Maryland. Previously, he was Director of the Rehabilitation Program within the Department of Neurology at Wake Forest University in Winston-Salem, North Carolina. He obtained his doctorate degree in Biology at the University of California, San Diego, in 1991 and completed medical school in 1993 at the same university. Dr. Wittenberg had further clinical and research training at Washington University, St. Louis and the National Institutes of Health (NIH). His clinical interests are in neurorehabilitation, stroke, and movement disorders. He sees both inpatients and outpatients at the VA Medical Center and Kernan Hospital.

Research Interests

Dr. Wittenberg's ongoing research interests presently lie in using transcranial magnetic stimulation (TMS) and functional imaging to understand motor cortical reorganization following stroke and in designing testing new methods for neurorehabilitation. He is the principal investigator in a study of motor map plasticity after constraint-induced therapy, where TMS and functional MRI are used to detect changes in motor representation and task-specific activation. He is investigating the correlation between motor map abnormalities and functional ability in children with cerebral palsy. He is the site principal investigator in VA Cooperative Study #558, “Robotic Assisted Upper-Limb Neurorehabilitation in Stroke Patients”, and will be pursuing new lines of research combining robotics with non-invasive studies of the human motor system.

Publications

Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG, Hallett M. Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 2006;129:791-808

Hancox JG, Wittenberg GF, Yosipovitch G. A patient with nasal ulceration after brain surgery. Arch Dermatol. 2005;141:796-798.

Wittenberg GF, Werhahn KJ, Wassermann EM, Herscovitch P, Cohen LG. Functional connectivity between somatosensory and visual cortex in early blind humans. European Journal of Neuroscience 2004: 20:1923–1927

Wittenberg GF, Chen R, Ishii K, Bushara KO, Eckloff S, Croarkin E, Taub E, Gerber LH, Hallett M, Cohen LG. Constraint-Induced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabilitation and Neural Repair 2003; 17:111-119.

Muellbacher W, Richards C, Ziemann U, Wittenberg G, Weltz D, Boroojerdi B, Cohen L, Hallett M. Improving hand function in chronic stroke. Arch Neurol. 2002;  59: 1278-82.

Ziemann U, Wittenberg GF, Cohen LG. Stimulation-induced within-representation and across-representation plasticity in human motor cortex. J. Neurosci. 2002; 22: 5563-71

Wittenberg GF, Bastian AJ, Dromerick AW, Thach WT, Powers WJ. Mirror movements complicate cerebral activation changes during recovery from subcortical infarction. Neurorehabilitation and Neural Repair 2000; 14:213-221

Wittenberg GF, Bushara K, Werhahn KJ, Wassermann EM, Horwitz B, Herscovitch P, Cohen LG. Cortical somatosensory-visual connections in the blind revealed by repetitive transcranial magnetic stimulation during PET. Soc. for Neurosci. Abstr. 2000; 26, Part 2, 686.1.

Cohen LG, Wittenberg G. Study of anatomical connectivity with TMS-PET in intact humans. Biol Psychiat 2000; 47: 65S-65S

Wittenberg G, Kristan WB Jr. Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech: I. Motor output pattern. J. Neurophysiol. 1992;  68: 1693-1707.

Wittenberg G, Kristan WB Jr. Analysis and modeling of the multisegmental coordination of shortening behavior in the medicinal leech: II. Role of identified interneurons. J. Neurophysiol. 1992;  68: 1693-1707.

Wittenberg G, Loer CM, Adamo SA, & Kristan WB Jr.  Segmental specialization of neuronal connectivity in the leech. Journal of Comparative Physiology A 1990; 167: 453-459.

Lockery SR, Wittenberg G, Kristan WB Jr., Cottrell GW:  Function of identified interneurons in the leech elucidated using neural networks trained by back-propagation. Nature 1989; 340: 468-471.




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