Ayse  L Mindikoglu
 

Ayse L Mindikoglu M.D., M.P.H.

Academic Title: Assistant Professor
Primary Appointment: Medicine
Additional Title(s): Director of Clinical Hepatology
amindiko@medicine.umaryland.edu
Location: UMH N3W50
Phone: (410) 328-1358
Fax: (410) 328-1897

Personal History

Education and Training

1989-1995: M.D., University of Istanbul, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
1995-1998: Resident in General Surgery, University of Istanbul, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
1998-2001: Resident in Internal Medicine, Bronx-Lebanon Hospital Center, New York, New York
2001-2004: Fellow in Gastroenterology and Hepatology, Loyola University Medical Center, Maywood, Illinois
2004-2005: Fellow in Advanced Hepatology, Center for Liver Diseases, University of Miami Leonard M. Miller School of Medicine, Miami, Florida
2005-2007: M.P.H. (Track: Epidemiology and Biostatistics), University of Maryland, Baltimore, Baltimore, Maryland

Positions and Employment

2005-Present: Attending Physician, Baltimore VA Medical Center, Baltimore, Maryland
2005-Present : Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland
2007- Present:  OPTN/UNOS approval as the primary transplant physician for the liver transplant program at the University of Maryland Medical System
2007- Present:  Director of Liver Transplantation, Baltimore VA Medical Center, Baltimore, Maryland
2009- Present: Director of Clinical Hepatology, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland
2010- Present:  OPTN/UNOS Approval - primary transplant physician for the living donor liver transplant program, University of Maryland Medical Center, Baltimore, Maryland

Honors and Awards

1995: Graduation with "Highest Honors," corresponding to Summa Cum Laude, 5th out of 385 graduates in the Medical School
2002: Third Place Abstract Presentation in Annual Research Prize Competition of the Chicago Society for Gastroenterology
2002: Winner of the Biannual Chicago Academic Debate entitled "Liver Disease: Controversies on the New Millennium". Argued the "Con" of the statement "Measuring portal pressure to measure the efficacy of beta blockers"
2004: American Association for the Study of Liver Diseases (AASLD) Advanced Hepatology Fellowship Award

Board Certifications (American Board of Internal Medicine)

* Certified as a Diplomate in Internal Medicine
* Certified as a Diplomate in Gastroenterology
* Certified as a Diplomate in Transplant Hepatology  

Research Interests

Dr. Mindikoglu's current research is focused on outcomes of patients on the liver transplant waiting list and after liver transplantation. Her prior research involved coagulation and fibrinolysis in patients with advanced liver disease, non-alcoholic fatty liver disease and metabolic syndrome on progression of fibrosis in patients with recurrent hepatitis C after liver transplantation.

Clinical Speciality

Dr. Mindikoglu's clinical interests are cirrhosis and its complications (e.g. acute kidney injury, ascites, encephalopathy, hepatocellular carcinoma), viral hepatitis, drug-induced hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, liver diseases in pregnancy and liver transplantation.

Publications

Selected Peer-Reviewed Publications

Mindikoglu AL, Anantharaju A, Villanueva J, Shah N, Van Thiel DH. Pericardiocentesis and pancreatic aspiration needle biopsy in coagulopathic and thrombocytopenic cirrhotic patient. Chest 2003; 123:956-958.

Mindikoglu AL, Anantharaju A, George M, Shah N, Villanueva J, Van Thiel DH. Acute intracranial hemorrhage in a coagulopathic cirrhotic controlled with recombinant human factor VIIa. Dig Dis Sci 2003; 48:1130-1135.

Van Thiel DH, Anantharaju A, Mindikoglu AL, Shah N, Leone N, Bejna J, Tarasuk G, Todo A, Mobarhan S, George M. Modulation of endothelial cell inflammatory integrins and stress markers with rh-Factor VIIa in patients with advanced chronic hepatitis C. J Viral Hepat 2003; 10:310-317.

Anantharaju A, Mehta K, Mindikoglu AL, Van Thiel DH. Use of activated recombinant human factor VIIa (rhFVIIa) for Colonic polypectomies in patients with cirrhosis and coagulopathy. Dig Dis Sci 2003; 48:1414-1424.

Mindikoglu AL, Anantharaju A, Hartman GG, Li SD, Villanueva J, Van Thiel DH. Prochlorperazine-induced cholestasis in a patient with alpha-1 antitrypsin deficiency. Hepato-Gastroenterol 2003; 50: 1338-1340.

Mindikoglu AL, Anantharaju A, George M, Leone N, Bejna J, Van Thiel DH. Splenic embolization in a jehovah’s witness: role of recombinant human factor VIIa. Hepato-Gastroenterol 2003; 50: 1697-1699.

George M, Li SD, Mindikoglu AL, Baluch MH, Dhillon S, Farr D, Van Thiel DH. Platelet sparing effect of COX II inhibition used with pegylated interferon alfa-2a for the treatment of chronic hepatitis C: short term pilot study. Cytokine 2004; 27:159-165.

Van Thiel DH, George M, Mindikoglu AL, Baluch MH, Dhillon S. Coagulation and fibrinolysis in individuals with advanced liver diseases. Turk J Gastroenterol 2004; 15: 67-72.

Karasu Z, Mindikoglu AL, Van Thiel DH. Cardiovascular problems in cirrhotic patients. Turk J Gastroenterol 2004; 15: 126-132.

Mindikoglu AL, George M, Ion-Nedelcu N, Farr D, Van Thiel DH. Hepatic and plasma leptin levels in chronic hepatitis C. In: 12th International Congress of Endocrinology- 12th ICE. Italy: Medimond S.r.l. International Proceedings Division, 2004: Volume ISBN 88-7587-071-3, pages 557-569.

Mindikoglu AL, Miller JS, Borge MA, Van Thiel DH. Post transplant IVC occlusion and thrombosis treated with tPA, heparin and sharp recanalization. J Gastroenterol 2005; 40:302-305.

Van Thiel DH, Farr D, Mindikoglu AL, Todo A, George M. Recombinant human factor VIIa induced alterations in tissue factor and thrombomodulin in patients with advanced liver cirrhosis. J Gastroenterol Hepatol 2005; 20:882-889.

Mindikoglu AL, Regev A, Levi JL, Casillas J, Schiff ER. Focal nodular hyperplasia in identical twins. Am J Gastroenterol 2005; 100:1616-1619.

Bayraktar Y, Mindikoglu AL, Van Thiel DH. Postoperative infections in cirrhotic patients. Hepato-Gastroenterol 2005; 52:1240-1243.

Mindikoglu AL, Regev A, O’Sullivan MJ, Schiff ER. Multiple normal deliveries in a woman with severe portal hypertension due to congenital hepatic fibrosis: the importance of preserved hepatocellular function. Am J Gastroenterol 2005; 100: 1-3.

Mindikoglu AL, Regev A, Schiff ER. Epithelioid hemangioendothelioma of the liver. Clin Gastroenterol Hepatol 2005; 3: (7).

Mindikoglu AL, Regev A, Casanova-Romero P, Bejarano PA, Martinez EJ, Tzakis AG, Schiff ER. The impact of nonalcoholic fatty liver disease and the metabolic syndrome on progression of fibrosis in patients with recurrent HCV after liver transplantation. Transplantation Proceedings 2006; 38: 1440-1444.

Mindikoglu AL, Regev A, Schiff ER. Hepatitis B reactivation following cytotoxic chemotherapy: the disease and its prevention. Clin Gastroenterol Hepatol 2006; 4: 1076-1081.

Mindikoglu AL, Li SD, Yong SL, Borge MA, Brems J, Van Thiel DH. HELLP syndrome complicated bile duct injury and subsequent left lobe atrophy. Dig Dis Sci 2006; 51: 1206-1212.

Mindikoglu AL, Regev A, Bejarano PA, Martinez EJ, Jeffers LJ, Schiff ER. Imatinib mesylate (gleevec) hepatotoxicity. Dig Dis Sci 2007; 52: 598-601.

Mindikoglu AL, Regev A, Magder LS. Impact of human immunodeficiency virus on survival after liver transplantation. Analysis of United Network for Organ Sharing database. Transplantation 2008; 85:359-368.

Mindikoglu AL, Miller RR. Hepatitis C in the Elderly: Epidemiology, natural history and treatment. Clin Gastroenterol Hepatol 2008; 7:128-134.

Mindikoglu AL, Magder LS, Regev A. Outcome of Patients with Drug Induced Acute Liver Failure after Liver Transplantation: Analysis of the United Network for Organ Sharing Database. Liver Transplantation 2009; 15:719-729.

Bhagat V, Mindikoglu AL, Nudo CG, Schiff ER, Tzakis AG, Regev A. Outcomes of Liver Transplantation in Patients with Cirrhosis due to Nonalcoholic Steatohepatitis compared to Alcoholic Liver Disease. Liver Transpl 2009; 15: 1814-1820.

Hosseini-Aslinia F, Mindikoglu AL. Radiofrequency Ablation of Hepatocellular Carcinoma (Letter to the Editor). Hepatology 2009; 50: 2053
.


Book Chapter

Van Thiel DH, Mindikoglu AL, Anantharaju A, Baluch M, Dhillon S, George MM, Brems J, Li SD, Mobarhan S. Unusual indications for liver transplantation. In: Busuttil R, Klintmalm G. Transplantation of the Liver, 2nd Edition, W. B. Saunders, 2005: 275-284.




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