Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB. Full-genome sequence and analysis of a novel human Rhinovirus strain within a divergent HRV-A clade. ArchVirol 155:83-87, 2010.
Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. An a2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the β-blocker bucindolol in chronic heart failure. Circ Heart Fail 3:21-28, 2010.
Wang WCH, Mihlbachler KA, Brunnett AC, Liggett SB. Targeted transgenesis reveals discreet attenuator functions of GRK and PKA in airway β2-adrenergic receptor physiologic signaling. Proc Nat Acad Sci 106:15007-15012, 2009.
Dorn GW II, Liggett SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Mol Pharmacol 76:466-480, 2009.
Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, Rathe JA, Fraser-Liggett CM, Liggett SB. Sequencing and analyses of all known human rhinovirus genomes reveals structure and evolution. Science 324:55-59, 2009.
Petrashevskaya N, Gaume BR, Mihlbachler KA, Dorn GW II, Liggett SB. Bitransgenesis with β2-adrenergic receptors or adenylyl cyclase fails to improve b1-adrenergic receptor cardiomyopathy. Clinical and Translational Science 1:221-227, 2008.
Kardia SLR, Kelly RJ, Keddache MA, Aronow BJ, Grabowski GA, Hahn HS, Case KL, Wagoner LE, Dorn GW II, Liggett SB. Multiple interactions between the a2C- and b1-adrenergic receptors influence heart failure survival. BMC Medical Genetics 9:93, 2008
Swift SM, Gaume BR, Small KM, Aronow BJ, Liggett SB. Differential coupling of Arg- and Gly389 polymorphic forms of the β1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. Physiol Genomics 35:123-131, 2008.
Wang WCH, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB. A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of β2-adrenergic receptors. Pharmacogenet Genomics 18(8):729-732, 2008.
Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SLR, Dorn GW II. A G-protein coupled receptor kinase-5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure. Nature Medicine 14:510-517, 2008.
Liggett SB, Kelly RJ, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SLR, Dorn GW II. A functional polymorphism of the Gaq (GNAQ) gene is associated with accelerated mortality in African American heart failure. Hum Mol Genet 16:2740-2750, 2007.
Einstein R, Jordan H, Zhou W, Brenner M, Moses EG, Liggett SB. Alternative splicing of the G-protein coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors. Proc Nat Acad Sci 105(13):5230-5235, 2008.
Small KM, Mialet-Perez J, Liggett SB. Genetic variation within the β1-adrenergic receptor gene results in haplotype-specific expression phenotypes. J Cardiovasc Pharmacol 51:106-110, 2008.
Panebra A, Schwarb MR, Glinka CB, Liggett SB. Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 293:L453-L462, 2007.
McGraw DW, Elwing JM, Fogel KM, Wang WCH, Glinka CB, Mihlbachler KA, Rothenberg ME, Liggett SB. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. J Clin Invest 117:1391-1398, 2007.
Swift SM, Schwarb MR, Mihlbachler KA, Liggett SB. Pleiotropic b-agonist-promoted receptor conformations and signals independent of intrinsic activity. Am J Respir Cell Mol Biol 36:236-243, 2007.
McGraw DW, Fogel KM, Kong S, Kranias EG, Aronow BJ, Liggett SB. Transcriptional response to persistent β2-adrenergic receptor signaling reveals regulation of phospholamban which alters airway contractility. Physiol Genomics 27:171-177, 2006.
Liggett SB, Mialet-Perez J, Thaneemit-Chen S, Weber SA, Greene SM, Hodne D, Nelson B, Morrison J, Domanski MJ, Wagoner LE, Abraham WT, Anderson JL, Carlquist JF, Krause-Steinrauf HJ, Lazzeroni LC, Port JD, Lavori PW, Bristow MR. A polymorphism within a conserved β1-adrenergic receptor motif alters cardiac function and b-blocker response in human heart failure. Proc Nat Acad Sci 103(30):11288-11293, 2006.
McGraw DW, Mihlbachler KA, Schwarb MR, Rahman FF, Small KM, Almoosa KF, Liggett SB. Airway smooth muscle prostaglandin-EP1 receptors directly modulate b2-adrenergic receptors within a unique heterodimeric complex. J Clin Invest 116(5):1400-1409, 2006.
Small KM, Schwarb MR, Glinka C, Theiss CT, Brown KM, Seman CA, Liggett SB. a2A- and a2C adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and b-arrestin recruitment. Biochemistry 45:4760-4767, 2006.
Small KM, Brown KM, Seman CA, Theiss CT, Liggett SB. Complex haplotypes derived from non-coding polymorphisms of the intronless a2A-adrenergic gene diversify receptor expression. Proc Nat Acad Sci 103:5472-5477, 2006.
Tantisira KG, Small KM, Litonjua AA, Weiss ST, Liggett SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase 9 in asthma: interaction between b-agonist and corticosteroid pathways. Hum Mol Genet 14:1671-1677, 2005.
Small KM, Mialet-Perez J, Seman CA, Theiss CT, Brown KM, Liggett SB. Polymorphisms of the cardiac presynaptic a2Cadrenergic receptors: diverse intragenic variability with haplotype-specific functional effects. Proc Nat Acad Sci 101:13020-13025, 2004.
Mialet-Perez J, Green SA, Miller WE, Liggett SB. A primate-dominant third glycosylation site of the β2-adrenergic receptor routes receptors to degradation during agonist regulation. J Biol Chem 279:38603-38607, 2004.
Perez JM, Rathz DA, Petrashevskaya NN, Hahn HS, Wagoner LE, Schwartz A, Dorn GW II, Liggett SB. β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature Medicine 9:1300-1305, 2003.
McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by b-adrenergic receptors of Gq-receptor signaling via phospholipase-C underlies the airway b-agonist paradox. J Clin Invest 112:619-626, 2003.
Rathz DA, Gregory KN, Fang Y, Brown KM, Liggett SB. Hierarchy of polymorphic variation and desensitization permutations relative to β1- and β2-adrenergic receptor signaling. J Biol Chem 278:10784-10789, 2003.
Reviews of Interest
Liggett SB. Long-distance affair with adrenal GRK2 hangs up heart failure. Nature Medicine 13:246-248, 2007.
Liggett SB. Genetic variability of the β2-adrenergic receptor and asthma exacerbations. Thorax 61:925-927, 2006.
Liggett SB. Cardiac 7-TM receptor portfolios: diversify, diversify, diversify. J Clin Invest 116:875-877, 2006.
Liggett SB, Hall IP. β2-adrenergic receptor polymorphisms and asthmatic phenotypes. In: Genetics of Asthma and COPD. Edited by Postma DS and Weiss ST. Informa Healthcare, New York/London, 299-316, 2006.
Liggett SB. Genetically modified mouse models for pharmacogenomic research. Nature Reviews Genetics 5:657-663, 2004.
Liggett SB. The two-timing thyroid. Nature Medicine 10(6):582-583, 2004.
Small KM, McGraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol 43:381-411, 2003.
Liggett SB. β-adrenergic receptors in the failing heart: the good, the bad, and the unknown. J Clin Invest 107:947-948, 2001.