Personal History:I graduated from Virginia Polytechnic Institute with a BS in biology. Being interested in human genetics, I completed my Ph.D. training in human genetics and molecular biology at the Johns Hopkins University School of Medicine under the co-mentorship of Kirby Smith, PhD, and George Dover, MD. I worked on the genetics underlying fetal hemoglobin production as a possible way to provide better treatment for patients with sickle cell disease and beta-thalassemia. After spending 6 years working in Italy with Licinio Contu, M.D., again on genetic factors that modify clinical severity of beta thalassemia, I returned to the Baltimore in 2001. While working under Aravinda Chakravarti, Ph.D. I switched my research focus to the genetics of complex diseases such as hypertension. I became an assistant professor at UMB in 2005.
Research Interests:* Genetics of hypertension and other complex disorders
* Pharmacogenetics of thiazide diuretics
* Bioinformatics tools for function prediction
* Regulatory elements (non-protein coding) in the human genome
G.J. Dover, K.D. Smith, Y.C. Chang, S. Purvis, A. Mays, D.A. Meyers, C. Shells, and G. Serjeant: Fetal Hemoglobin Levels in Sickle Cell Disease and Normal Individuals are Partially Controlled by an X-Linked Gene Located at Xp22.2, Blood, 80(3):816-824, 1992
Y.C. Chang, K.D. Smith and G.J. Dover: Dinucleotide Repeat Polymorphisms at the DXS85, DXS16 and DXS43 loci, Human Molecular Genetics, 3:1029, 1994
Y.C. Chang, K.D. Smith, R. Moore, G. Serjeant, and G.J. Dover: An Analysis of Fetal Hemoglobin Variation in Sickle Cell Disease: The Relative Contribution of the X-linked Factor, alpha-globin Haplotypes, alpha-globin Gene Number, Sex and Age, Blood, 85(4):1111-1117,1995
Y.C. Chang, M. Maier-Redelsperger, K.D. Smith, G.J. Dover, L. Contu, J. Elion, R. Ducrocq, M. de Montalembert, M. Bellory, and R. Girot: The Relative Importance of the X-Linked FCP Locus and beta-globin Haplotype in Determining Hemoglobin F Levels: A Study of SS Patients Homozygous for beta-S Haplotypes. British Journal of Haematology. 96(4): 806-814, 1997
Y.C. Chang, R. Littera, R. Garau, K.D. Smith and G.J. Dover, S. Iannelli, E. Cacace, and L. Contu: The Role of Hereditary Persistence of Fetal Hemoglobin in ï? ï¢0-thalassemia Intermedia, British Journal of Haematology.114(4): 899-906, 2001
X. Zhu, Y. C. Chang, D. Yan, A. Weder, R. Cooper, A. Luke, D. Kan, and A. Chakravarti. Associations between Hypertension and Genes in the Renin-Angiotensin System. Hypertension. 41:1027-1034, 2003
M. Armanios, J.L. Chen, Y.C. Chang, R.A. Brodsky, A. Hawkins, C.A. Griffin, J.R. Eshleman, A. Chakravarti, A. Hamosh, C.W. Greider. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenital. Proc Natl Acad Sci U S A. 102(44):15960-4, 2005
J.H. Young, Y.C. Chang, J-P Chretien, D.J. Kim, M.J. Klag, M.A. Levine, C.B. Ruff, A. Chakravarti. Differential susceptibility to hypertension is due to selection during the out-of-Africa expansion. PLoS Genetics. 1(6):e82, 2005
C.C. Gu, Y.C. Chang, K. Schwander, J. Eckfelt, D. Arnett, L. Djousse, G. Heiss, A. Oberman, J-M. Lalouel, M. Province, A. Chakravarti, D.C. Rao: Haplotype Association Analysis of AGT Variants with Secondary Clinical and Physiological Traits of Hypertension: The HyperGen Study. Human Heredity. 60(3):164-176, 2005
Y.C. Chang, D.J. Kim, K. Schwander, D.C. Rao, M. Miller, A. Weder, R. Cooper, N. Schork, M. Province, S. Kardia, T. Quertermous, A. Morrison, A. Chakravarti. The impact of data quality on the identification of complex disease genes: experience from the Family Blood Pressure Program. European Journal of Human Genetics, 14(4):467-477, 2006
Y.C. Chang, M.A. Ikeda, D.J. Kim, X. Liu, M. Layton, A. Weder, R. Cooper, S. Kardia, D.C. Rao, S. Hunt, A, Luke, E. Boerwinkle, A. Chakravarti. Multiple Essential Hypertension Susceptibility Genes On Chromosome 1q. American Journal of Human Genetics, 80(2):253-264, 2007
P.F. McArdle, A. Parsa, Y.C. Chang, M.R. Weir, J.R. O'Connell, B.D. Mitchell, A.R. Shuldiner. A common non-synonymous variant in GLUT9 is a determinant of serum uric acid levels in Old Order Amish, Arthritis & Rheumatism, 58(9):2878, 2008
Y. Wang, P.F. McArdle, J.B. Wade, J. O'Connell, S.E. Dorff, S. Shah, X. Shi, L. Pan, E. Rampersaud, H. Shen, J.D. Kim, A.R. Subramanya, N.I. Steinle, C. Ober, P.A. Welling, A. Chakravarti, A.B. Weder, R.C. Cooper, B.D. Mitchell, A.R. Shuldiner, Y.C. Chang.. PNAS, 106(1):226-231, (Cover story, Epublished Dec 29, 2008)
Y. Wang, JF Samuels, Y.C. Chang, M.A. Grados, B.D. Greenberg, J.A. Knowles, J.T. McCracken, S.L. Rauch, D.L. Murphy, S.A. Rasmussen, B. Cullen, R. Hoehn-Saric, A. Pinto, A.J. Fyer, J. Piacentini, D.L. Pauls, O.J. Bienvenu, M. Riddle, Y.Y. Shugart, K.Y. Liang, G. Nestadt. Gender differences in Genetic Linkage and Association on 11p15 in Obsessive-Compulsive Disorder families, American Journal of Medical Genetics, 150B(1):33-40, 2009
P.A. Welling, Y. C. Chang, E. Delpire and J. B. Wade. Multigene Kinase Network, Kidney Transport and Salt in Essential Hypertension, Kidney International, 77(12):1063-9, 2010 (e-published April 14, 2010).
Hypertrophy-Associated Polymorphisms Ascertained in a Founder Cohort Applied to Heart Failure Risk and Mortality, A. Parsa, Y. C. Chang, R. J. Kelly, M. C. Corretti, K. A. Ryan, S. W. Robinson, S. S. Gottlieb, S. L.R. Kardia, A. R. Shuldiner, S.B. Liggett, Clin Transl Sci. 4(1):17-23, 2011
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk. The International Consortium for Blood Pressure Genome-wide Association Studies, Nature, in press Whole genome association study identifies STK39 as a novel hypertension susceptibility gene
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