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Gauri J Sabnis
 

Gauri J Sabnis Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Pharmacology
gsabn001@umaryland.edu
Location: BRB, 4-002
Phone: (410) 706-5885
Fax: (410) 706-0032

Personal History:

Education

Bachelor of Pharmacy (1997- 2001): Bharti Vidyapeeth’s Poona College of Pharmacy, University of Poona, Pune- 411038, Maharashtra, India.

Doctor of Philosophy (2001- 2005): University of Maryland, Baltimore, Department of Pharmacology and Experimental Therapeutics, Baltimore, MD, USA.
Advisor: Angela M. H. Brodie, Ph.D.

Post Graduate Education and Training

June 2000-July 2000: Internship at German Remedies Ltd. Andheri (East), Mumbai - 400099, India

January 2002-March 2005: Graduate Research Assistant, Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore

March 2005-March 2008: Post-Doctoral Fellow, Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore.

Certifications

Registered with Maharashtra State Board of Pharmacy, Maharashtra, India (Registered Pharmacist).

Employment History

January 2002-March 2005: Graduate Research Assistant, Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore.

March 2005-March 2008: Post-Doctoral Fellow, Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore.

March 2008-July 2010: Research Associate, Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore.

July 2010-Present: Assistant Professor, Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore.

August 2010-Present: Adjunct Faculty, Dental Hygiene Program, Community College of Baltimore County, Dundalk, Maryland.

Research Interests:

Breast Cancer - Hormonal Therapy Resistance


Honors and Awards:

April 2004: Awarded “Second Place” for Poster Presentation in Cancer Research Category at 26th Annual Graduate Research Conference, University of Maryland Baltimore County, MD.

April 2006: Awarded “AACR-AstraZeneca Scholar-in-Training” Award for the AACR 97th Annual Meeting, Washington, D.C.

December 2006: Awarded “SABCS Basic Science Scholars” award for the 29th Annual San Antonio Breast Cancer Symposium, San Antonio, TX.

December 2007: Awarded “SABCS Basic Science Scholars” award for the 30th Annual San Antonio Breast Cancer Symposium, San Antonio, TX.

June 2008: Awarded “Endocrine Trainee” award for the 90th Annual Endocrine Society Meeting, San Fransico, CA.

June 2008: Awarded “Best Poster Award” for the Breast Cancer Program Retreat at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

October 2008: “Travel Award” for the 9th International Aromatase Meeting, Shanghai, China.

June 2009: “Travel Award” for the 91st Annual Meeting for Endocrine Society, Washington, DC.

June 2009: “First Place in Clinical/Translational Research” at the Breast Cancer Program Retreat at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

Publications:

Gauri J Sabnis; Olga G. Goloubeva; Saranya Chumsri; Nguyen Nguyen; Saraswati Sukumar; Angela M.H. Brodie. “Functional reactivation of the estrogen receptor-α and aromatase by the HDAC inhibitor, entinostat, increases sensitivity of ER-negative tumors to letrozole.” Cancer Research (Manuscript Accepted)

Adam Schayowitz; Gauri Sabnis; Vincent C.O. Njar; Angela M.H. Brodie; “Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR” British Journal of Cancer. September 28th 2010; 103(7): 1001-7.

Lodish MB, Gartner LA, Albini P, Gauri Sabnis, Brodie A, Meck JM, Meloni-Ehrig AM, Hill S, Tsilou E, Valera VA, Walter BA, Merino MJ, Stratakis CA. “Intrauterine growth retardation associated with precocious puberty and sertoli cell hyperplasia” Hormone and Metabolism Research. August 2010; 42(9): 682-8.

Gauri Sabnis; Olga Goloubeva; Rabia Gilani; Luciana Macedo and Angela M. H. Brodie. “Sensitivity to the aromatase inhibitor letrozole is prolonged after a “break” in treatment” Molecular Cancer Therapeutics. January 2010; 9(1): 46-56.

Lalji K Gediya; Aakanksha Khandelwal; Jyoti Patel; Aashvini Belosay; Gauri Sabnis; Jhalak Mehta; Puranik Purushottamachar; and Vincent C. O. Njar. "Design, Synthesis and Evaluation of Novel Mutual Prodrugs (Hybrid Drugs) of All-trans retinoic acid and Histone Deacetylase Inhibitors with Enhanced Anticancer Activities in Breast and Prostate Cancer Cells In Vitro." Journal of Medicinal Chemistry July 10th,2008; 51 (13): 3895-3904

Gauri Sabnis; Luciana Macedo; Olga Goloubeva; Adam Schayowitz; Angela M. H. Brodie; "Stopping treatment can reverse acquired resistance to letrozole." Cancer Research June 15th, 2008; 68 (12):4518-24.

Luciana Macedo; Gauri Sabnis; Olga Goloubeva; Angela Brodie; "Combination of anastrozole with fulvestrant in intratumoral aromatase xenograft model." Cancer Research May 1st, 2008; 68 (9):3516-22.

Adam Schayowitz; Gauri Sabnis; Vincent C.O. Njar; and Angela M.H. Brodie; "The synergistic effect of a novel anti-androgen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in-vitro." Molecular Cancer Therapeutics, January 2008;7(1):121-32.

Gauri J Sabnis; Luciana Macedo; Olga Goloubeva;, Adam Schayowitz;, Yue Zhu; Angela Brodie; "Toremifene & Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model." Journal of Steroid Biochemistry and Molecular Biology. January 2008; 108 (1-2): 1-7.

Gauri Sabnis; Olga Goloubeva; Danijela Jelovac; Adam Schayowitz; Angela M. H. Brodie; "Inhibition of the PI3K/Akt Pathway Improves Response of Long Term Estrogen Deprived Breast Cancer Xenografts to Antiestrogens." Clinical Cancer Research. May 1st, 2007; 13 (9) p: 2151-2157

Jyoti B. Patel; Jhalak Mehta; Aashvini Belosay; Gauri Sabnis; Aakansha Khandelwal; Angela M. H. Brodie; Dianne Soprano; Vincent C. O. Njar; "Novel Retinoic Acid Metabolism Blocking Agents (RAMBAs) Have Potent Inhibitory Activities on Human Breast Cancer Cells and Tumor Growth." British Journal of Cancer. March 27th, 2007; 96(8) p:1204 - 1215.

Luciana F. Macedo, Zhiyong Guo, Syreeta L. Tilghman, Gauri J. Sabnis, Yun Qiu, Angela Brodie; "The Role of Androgens on MCF-7 Breast Cancer Cell Growth and on The Inhibitory Effect of Letrozole." Cancer Research; August 1st 2006; 66 (15) p 7775-7782.

Danijela Jelovac; Gauri Sabnis; Brian Long; Olga Goloubeva; Angela M. H. Brodie Ph.D. "Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole." Cancer Research. June 15th, 2005; 65(12) p: 5380-5389.

Gauri Sabnis; Danijela Jelovac; Brian Long and Angela M. H. Brodie; "Role of Growth Factor Receptor Pathways in Adaptation of MCF-7Ca Human Breast Cancer Cells to Long Term Estrogen Deprivation." Cancer Research; May 1st, 2005; 65(9) p. 3903-3910.

Luciana Macedo; Gauri Sabnis; Angela Brodie; "Preclinical Modeling of Endocrine Response and Resistance: Focus on Aromatase Inhibitors." Cancer. December 2007;12(S3):679-688.

Angela Brodie; Gauri Sabnis; Danijela Jelovac; "Xenograft Models For Aromatase Inhibitor Studies." Journal of Steroid Biochemistry and Molecular Biology, 2007 Aug-Sep;106 (1-5):119-24.

Angela Brodie; Gauri Sabnis; Danijela Jelovac;. "Aromatase and breast cancer." Journal of Steroid Biochemistry and Molecular Biology. December 1st, 2006; 102 (1-5), p:97-102.

Angela Brodie; Danijela Jelovac; Gauri Sabnis; Brian Long; Luciana Macedo; Olga Goloubeva. "Model systems: Mechanisms Involved in the Loss of Sensitivity to Letrozole." Journal of Steroid Biochemistry and Molecular Biology. June 17th, 2005; (95) p 41-48.

Angela Brodie, Danijela Jelovac; Luciana Macedo; Gauri Sabnis; Syreeta Tilghman and Olga Goloubeva "Therapeutic Observations in MCF-7 Aromatase Xenografts." Clinical Cancer Research, January 15th, 2005 (11) p 884s-888s.

Constantine A. Stratakis MD; Dalia Batista MD; Gauri Sabnis PhD; Angela Brodie PhD; "Prepubertal Gynecomastia Caused by Medications or the Aromatase Excess Syndrome." Clinical Endocrinology, December 2004; 61(6) p 779-80. (letters to editor)

Gauri Sabnis and Angela Brodie; "Aromatase and its inhibitors." Encyclopedia of Cancer, 2nd Edition, M. Schwab (Ed.)