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David A Zimrin
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David A Zimrin M.D.

Academic Title: Associate Professor
Primary Appointment: Medicine
Additional Title(s): Director, Cardiac Catheterization Laboratory & Director, Interventional Cardiology Fellowship Program
dzimrin@medicine.umaryland.edu
Location: UMH Room S3B08
Phone: (410) 328-3244
Fax: (410) 328-3826

Research Interests:

In collaboration with our cardiac surgery colleagues we are designing and testing “hybrid” approaches to coronary revascularization.  In the cardiac catheterization lab we are investigating coronary plaque characteristics in patients with end stage renal disease using intracoronary ultrasound and biomarkers.  In addition, we are in the early stages of a project which will examine differential gene expression in atherosclerosis prone and atherosclerosis resistant human arteries.  This latter project is being carried out in collaboration with the Center for Vascular and Inflammatory Diseases and cardiac surgery.

Clinical Speciality:

My major clinical focus is interventional cardiology.  Our lab provides invasive diagnostic and interventional therapeutic care for the entire range of clinical cardiac pathology, most prominently ischemic heart disease and congestive heart failure with an expanding focus on structural and valvular heart disease.  I also have an active outpatient consultative practice in general cardiology with a focus on ischemic heart disease.  

Teaching:

The cardiac catheterization lab and outpatient practice setting are geared toward teaching students, residents and fellows the practical and theoretical aspects of cardiology including observational, hands on, and didactic instruction.

Publications:

Journal Articles (Peer Reviewed)

Reichek N, Priest C, Zimrin D, Chandler T, St. John Sutton, M: Antianginal Effects of Nitroglycerin Patches. Am J Cardiology, 54:1-7, 1984.

Zimrin D, Reichek N, Bogin K, Aurigemma G, Douglas P, Berko B, Fung H. Antianginal Effects of Intravenous Nitroglycerin over 24-Hours. Circulation, 77:1376-1384, 1988.

Zimrin D, Reyes P, Reicher B, Poston R.  A Hybrid Alternative for high risk left main disease. Catheterization and Cardiovascular Interventions, 69:123-127, 2007.

Kon ZN, Brown EN, Tran R, Joshi A, Reicher B, Grant MC, Kallam S, Burris NS, Connerney I, Zimrin D, Poston R. Simultaneous Hybrid Coronary Revascularization Reduces Postoperative Morbidity Compared to Conventional Off-Pump Coronary Artery Bypass. J Thoracic Cardiovasc Surg. 2008;135:367-75.

Zimrin D, Reyes P, Miller KL, Fisher SD, Griffith BP, Gammie JS. Staged Balloon Aortic Valvuloplasty and Aortic Valve Bypass for “Inoperable” Aortic Stenosis. Congestive Heart Failure. 2008;14:211-213.

Mehra M, Reyes P, Benitez M, Zimrin D, Gammie J. Surgery for Severe Mitral Regurgitation and Left Ventricular Failure: What Do We Really Know? J Card Fail. 2008 Mar;14(2):145-50.

Reicher B, Poston RS, Mehra MR, Joshi A, Odonkor P, Kon Z, Reyes PA, Zimrin D. Simultaneous “hybrid” percutaneous coronary intervention and minimally invasive surgical bypass grafting: Feasibility, safety, and clinical outcomes. Am Heart J 2008;155:661-7

Poston RS, Tran R, Collins M, Reynolds M, Connerney I, Reicher B, Zimrin D, Griffith BP,   Bartlett ST. Comparison of Economic and Patient Outcomes with Minimally Invasive vs. Traditional Off-Pump CABG Techniques. Annals of Surgery 2008;248(4):638-46

Rehman A, Garcia J, Deshpande S, Fitzpatrick M, Odonkor P, Zimrin D, Griffith B, Bonatti J. Poor left ventricular function is not a contraindication for robotic totally endoscopic coronary artery bypass grafting. Heart Surg Forum 2009;12(3):E152-4

Rehman A, Garcia J, Deshpande S, Odonkor P, Reicher B, Vesely M, Zimrin D, Griffith B, Bonatti J. Totally endoscopic coronary artery bypass grafting is feasible in morbidly obese patients. Heart Surg Forum 2009;12(3):E134-6

Bonatti J, Garcia J, Rehman A, Odonkor P, Haque R, Zimrin D, Griffith B. On-pump beating heart with axillary artery perfusion: a solution for robotic totally endoscopic coronary artery bypass grafting? Heart Surg Forum 2009 12(3):E131-3

Bonatti J, Schachner T, Bonaros N, Oehlinger A, Wiedemann D, Ruetzler E, Weidinger F, Kilbitsch C, Feuchtner G, Zimrin D, Friedrich G, Pachinger O, Laufer. Effectiveness and Safety of Total Endoscopic Left Internal Mammary Artery Bypass Graft to the Left Anterior Descending Artery. Am J Cardiol 2009;104(12):1684-8

Lehr E, Zimrin D, Vesely M, Odonkor P, Grifffith B, Bonatti J. Axillary-Coronary Sequential Vein Graft for Total Endoscopic Triple Coronary Artery Bypass. Annals of Thoracic Surgery 2010; 90:e79-81

Bonatti J, Lehr E, Vesely M, Friedrich G, Bonaros N, Zimrin D. Hybrid Coronary Revascularization – Which Patients, When, How. Curr Opin Cardiol 2010;25(6):568-74

Zimrin D, Bonatti J, Vesely MR, Lehr EJ. Hybrid Coronary Revascularization:  An overview of options for anticoagulation and platelet inhibition. Heart Surg Forum 2010;13(6):E405-8

Kon ZN, Lehr E, Odonkor P, Fitzpatrick M, Zimrin D, Griffith B, Bonatti J. Is an intraaortic balloon pump a contraindication to robotic totally endoscopic coronary artery bypass? Heart Surg Forum 2010;13(6):E399-401

Bonatti J, Rehman A, Schwartz K, Kon Z, Lehr E, Zimrin D, Griffith B. Robotic Totally Endoscopic Triple Coronary Bypass Grafting on the Arrested Heart – Report of the First Successful Clinical Case. Heart Surg Forum 2010;13(6)E394-6

Zimrin D, Friedrich G, Griffith B, Bonati J. ICR 2010: Fifth Workshop on Integrated Cardiac Repair. Heart Surg Forum 2010;13(6):E381-2

Bonatti J, Zimrin D. Simultaneous Hybrid Revascularization Versus Off-pump Coronary Artery Bypass for Multivessel Coronary Artery Disease (Commentary). Annals of Thoracic Surgery (In Press)

Schachner T, Bonaros N, Wiedemann D, Lehr E, Weidinger F, Feuchtner G, Zimrin D, Bonatti J. Predictors, Causes and Consequences of Conversions in Robotically Enhanced Totally Endoscopic Coronary Bypass Surgery. Annals of Thoracic Surgery (In Press)    

Abstracts

Reichek N, Priest C, Zimrin D, Chandler T, Raichlen J, St. John Sutton, M. Antianginal Effects of Nitroglycerin Patches Do Not Last 24-Hours. Circulation, 68:III-407, 1983.
 
Reichek N, Priest C, Zimrin D, Chandler T, Berger N, Douglas P, St. John Sutton, M. Antianginal Effects of Nitroglycerin Over 24-Hours: Role of Method of Administration. Circulation, 70:II-190, 1984.
 
Zimrin D, Reichek N, Bogen C, Cameron S, Douglas P, Fung H. Antianginal Efficacy of IV Nitroglycerin. Circulation, 72:III-46, 1985.
 
Zimrin D, Reichek N, Bogen C, Cameron S, Douglas P, Fung H. IV Nitroglycerin: Infusion Rate, Plasma Concentration and Hemodynamic Effects. J of the Am Coll of Card, 7:181A, 1986.
 
Reichek N, Zimrin D, Bogin K, Douglas P, Berko B, Aurigemma G, Fung H.  Tolerance to Antianginal Effects of Nitroglycerin. Clin Res, 34:338A, 1986.
 
Aurigemma G, Bogin K, Zimrin D, Douglas P, Berko B, Reichek N. Silent Ischemia During Submaximal Exercise and Anginal Threshold: Effects of Nitroglycerin. Clin Res, 35:259A, 1987.
 
Reicher B, Poston R S, Reyes P, Scaffidi R, Zimrin D. A Novel Strategy of Simultaneous Hybrid Minimally Invasive Coronary Artery Bypass Surgery/Drug Eluting Stents for Multivessel Coronary Artery Disease. Cardiovascular Revascularization Medicine, 7:2, 2006.
 
Reyes P, Poston R, Reicher B, Scaffidi R, Zimrin D. Simultaneous Hybrid MIDCAB/Stent for Multivessel CAD. Catheter Cardiovasc Interv, 67:793-794, 2006.
 
Levine JC, Feseha H, Miller KL, Reyes PA, Reicher B, Joshi A, Poston RS, Zimrin D. Safety and Efficacy of Platelet Inhibition During Coronary Hybrid Revascularization. Cardiovascular Research Medicine, 8:2, 2007.
 
Feseha H, Levine JC, Poston RS, Reicher B, Reyes P, Kon Z, Zimrin D. Platelet Function and Hybrid Coronary Revascularization. Catheter Cardiovasc Interv, 69:S78-79, 2007.
 
Kon Z, Joshi A, Reicher B, Kallam S, Burris NS, Zimrin D, Poston R. Simultaneous Hybrid Coronary Revascularization Reduces Postoperative Morbidity Compared to Conventional Off-Pump Coronary Artery Bypass. Oral presentation at AATS, 5/07, Washington , DC.

Bonaros N,  Schachner T, Friedrich G, Wiedemann D, Weidinger F, Lehr E, Rehman A, Zimrin D, Griffith,B, Bonatti J.  Totally endoscopic treatment of multivessel coronary artery disease using hybrid revascularization – two centers experience with 130 patients ICR Workshop. March 2010.  Baltimore, MD

Kon Z, Bonatti J, Lehr E, Zimrin D, Griffith B.  Can Totally Endoscopic Coronary Artery Bypass Reduce the Risk of Major Infection Compared to Conventional Coronary Artery Bypass. ICR Workshop. March 2010.  Baltimore, MD

Lehr E, Zimrin D, Vesely M, Odonkor P, Griffith B, Bonatti J.  Axillary-Coronary sequential vein graft for robotically assisted total endoscopic triople coronary artery bypass grafting.  ICR Workshop. March 2010.  Baltimore, MD

Pollock J, Perrin P, Lakin C, Grant M, Vesely M, Poston R, Zimrin D.  Five-year Mortality for Hybrid Coronary Revascularization vs CABG. ICR Workshop March 2010.  Baltimore, MD

Lehr EJ, Bonaros N, Schachner T, Wiedemann D, Weidinger F, Vesely M, Zimrin D, Griffith B, Bonatti J.  Hybrid treatment of multivessel coronary artery disease using robotic surgical techniques. Canadian Cardiovascular Conference 2010.  Montreal, Canada, October 2010.

Lakin C, Perrin P, Pollock J, Grant M, Vesely M, Poston R, Zimrin D.  Hybrid Coronary Revascularization versus CABG:  Five Year Mortality.  Annual Capital Cardiology Symposium and Scientific Exchange (American College of Cardiology Maryland, District of Columbia and Virginia Annual Regional Meeting) 2010. ACC Heart House Washington DC.

Weidinger F, Schachner T, Bonaros N, Hofauer B, Lehr E, Vesely M, Zimrin D, Bonatti J. Causes and consequences of postoperative atrial fibrillation in robotic totally endoscopic coronary bypass surgery. International Society for Minimally Invasive Cardiothoracic Surgery Annual Meeting Washington DC. June 2011.