My primary research interests relate to the clinical epidemiology of chronic kidney disease and end-stage renal disease. Specifically, I am interested in the relation between chronic kidney disease (CKD) and ischemic brain disease and its consequences, dementia, cognitive dysfunction, and physical impairment. We are studying brain structure and cerebral blood flow in patients with CKD to identify risk factor and correlates of cognitive and physical dysfunction in this high-risk population, and testing the effect of aerobic exercise training on cognitive and physical performance.
SELIGER SL, Longstreth WT, Katz R, Manolio T, Fried LF, Shlipak M, Stehman-Breen CO, Sarnak M, Gillen DL, Bleyer A, Siscovick DS. “Cystatin C and Subclinical Brain Infarction”. J Am Soc Nephrol, 2005; 16(12): 3721-7.
Shlipak M, Sarnak MJ, Katz R, Fried LF, SELIGER SL, Newman AB, Siscovick DS, Stehman-Breen C. “Cystatin C and the Risk of Death and Cardiovascular Events among Elderly Persons.” New Engl J Med, 2005: 352(20): 2049-60.
SELIGER SL, Katzel LI, Fink JC, Weir MR, Waldstein SR. “Renal function and cardiovascular response to mental stress.” Am J Nephrol 2008; 28(2):304-10.
SELIGER SL, Zahn M, Hsu VD, Walker LD, Fink JC. “Chronic kidney disease adversely influences patient safety.” J Am Soc Nephrol, 2008; 19(12):2414-9.
SELIGER SL*, Longstreth WJ#. “Lessons about brain vascular disease from that other pulsatile organ, the kidney”. Stroke 2008 Jan;39(1):5-6 [Invited Editorial]
SELIGER SL, Fox KM, Gandra SR, Bradbury B, Hsu VD, Walker L, Chang C-F, Fink JC. “Timing of Erythropoiesis-stimulating agent (ESA) initiation and adverse outcomes in non-dialysis CKD: a propensity-matched observational study.” Clin J Am Soc Nephrol 2010 May; 5(5):882-8.
deFilippi CR, deLemos JA, Christenson RH, Gottdiener JS, Kop WJ, SELIGER SL. “Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults.” JAMA 2010; 304(22):2494-2502.
SELIGER SL, Zhang AD, Weir MR, Walker L, Hsu VD, Parsa A, Diamantidis CJ, Fink JC. “Erythropoiesis-stimulating agents increase the risk of acute stroke in patients with chronic kidney disease.” Kidney Int 2011; 80(3):288-94.
deFilippi CR, de Lemos JA, Tkazcuk AT, Christenson RH, Carnethon M, Siscovick DS, Gottdiener JS, SELIGER SL. “ Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults”. J Am Coll Cardiology, 2012 Dec 18;60(24):2539-47
SELIGER , SL. “Physical Activity in ESRD – time to get moving”. Clin J Am Soc Nephrol, 2012 Dec;7(12):1927-9 [Invited Editorial]