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Carol L. Greene
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Carol L. Greene M.D.

Academic Title: Professor
Primary Appointment: Pediatrics
Secondary Appointments: Obstetrics, Gynecology and Reproductive Sciences, Pathology
Location: 737 W. Lombard St., 199
Phone: (410) 328-3335
Fax: (410) 328-5484

Personal History:


1971-1974: B.S. (biology), Stanford University, Palo Alto, California
1974-1977: M.D., Albert Einstein College of Medicine, Bronx, N.Y.


1977-1980: Pediatric Internship and Residency, Children's Hospital of Los Angeles, Los Angeles, California
1980-1983: Fellow in Genetics, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California

Research Interests:

Policy in genetics, inborn errors of metabolism and newborn screening

Clinical Speciality:

Genetics (Pediatrics and Adult) and Inborn Errors of Metabolism


Book Chapters

Greene CL, Thomas J and Goodman SI: "Inborn Errors of Metabolism". In: Current Pediatric Diagnosis and Treatment, 10th, 11th, 12th, 13th, 14th, 15th, 16th and 17th Editions, Ed. Hay et al, 1014-1038, Appleton and Lange Publishers, 2005.

Yannicelli S and Greene CL: "Nutrition Therapies for Inborn Errors of Metabolism". In: Neonatal Nutrition and Metabolism, 507-542, Mosby Year Book Medical Publisher, 1991.

Greene CL: "Inborn Errors of Metabolism in the Neonate". In: Pediatric Decision Making 2nd, 3rd and 4th Editions, Ed. S. Berman, 504-505, Mosby, 2003.

Greene CL: "Inborn Errors of Metabolism". In: Pediatric Decision Making, 3rd and 4th Editions, Ed. S Berman, 506-509, Mosby, 2003.

Thomas J, Greene CL and Cohn R: “Lysosomal Storage, Peroxisomal and Glycosylation Disorders and Smith Lemli Opitz Presenting in the Neonate”. In: Avery's Diseases of the Newborn, WB Saunders Co, Eds. Taeusch, Ballard and Gleason, 7th and 8th Editions, 258-288, 2004.

Greene CL and Yudkoff M: “Disorders of Lysosomal Storage”. In: Saunders Manual of Pediatric Practice, ed. L. Finberg, 1st and 2nd edition (2nd edition with M Yudkoff), 245-253, WB Saunders, 2002

Thomas J and Greene CL: “Newborn Screening”. In: Pediatric Decision Making, 4th Edition, Ed. S Berman, 510-515, Mosby, 2003.

Greene C: “Evaluating for Genetic Disease”. In: Pediatric Decision Making, 4th Edition, Ed. S Berman, 486-489, Mosby, 2003.

Tsai A and Greene C: “Birth Defects and Dysmorphic Features”. In: Pediatric Decision Making, 4th Edition, Ed. S Berman, 490-497, Mosby, 2003.

Journals (Peer Reviewed)

Gibson KM, Sweetman L, Nyhan WL, Page TM, Greene CL and Cann HM: 3 Hydroxy-3-methylglutaric aciduria: A new assay of 3-hydroxy-3-methylglutaryl-CoA lyase using high performance liquid chromatography. Clin Chim Acta 126:171-181, 1982.

Greene CL, Cann HM, Robinson BH, Gibson DM, Sweetman L, Holm J and Nyhan WL: 3-hydroxy-3-methyl-glutaric aciduria. J Neurogenet 1:165-173, 1984.

Greene CL, Pitts W, Rosenfeld R and Luzzatti L: Sex reversal in the Smith-Lemli-Opitz syndrome: Pathologic and endocrine evaluation. Clin Gent 25:366-372, 1984.

Greene CL, Wilson A and Shapira E: Prune belly syndrome and heart defect in one of monozygotic twins following exposure to Tigan and Bendectin. Acta Genet Med Genello (Roma) 34:1010-104, 1985.

Gregory P, Greene CL, Shapira E and Wang N: Alterations in the time of X chromosome replication induced by 5-azacytidine in a patient with 48 XXXY/47 XXY. Cytogenet Cell Genet 39:234-236, 1985.

Amendt B, Greene CL, Sweetman L, Cloherty J, Shih V, Moon A, Teel L and Rhead W: Short-chain acyl-CoA dehydrogenase deficiency: Clinical and biochemical studies in two patients. J Clin Invest 79:1303-1309, 1987.

Greene CL, Blitzer MG and Shapira E: Inborn errors of metabolism and Reye syndrome: Differential diagnosis. J Pediatric 113(1):156-159, 1988.

Gibson KM, Brea J, Kaiser K, Nyhan WL, McCoy EE, Ferreira P, Greene CL, Blitzer MG, Shapira E, Reverte F, Conde C, Bagnell P and Cole DEC: 3-Hydroxy-3-methylgulatryl-coenzyme A lyase deficiency: Report of five new patients. J Inher Metab Dis 11:76-87, 1988.

Luder AL, Davidson AD, Goodman SI and Greene CL: Transient nonketotic hyperglycinemia in neonates. J Pediatric 114:(6):1013-1015, 1989.

Luder AL, Yannicelli S, Greene CL: Normal growth and development with unrestricted protein intake after severe infantile propionic acidemias. J Inher Metab Dis 12:307-311, 1989.

Luder AL and Greene CL: Maternal phenylketonurea and hyperphenylalaninemia: Implications for medical practice in the United States. Am J of Ob Gyn 161(5):1102-1105, 1989.

Nord A, vanDoorninck WJ and Greene CL: Developmental Profile of Patients with Maple Syrup Urine Disease. J Inher Metab Dis, 14, 881-889, 1991.

Davidson-Mundt A, Luder AS, Greene CL: Hyperuricemia in Medium Chain Acyl-CoA Dehydrogenase Deficiency. J Peds, 120:444-6, 1992.

Mazzocco MMM, Yannicelli SY, Nord AN, Davidson-Mundt AJ, Greene CL, Pennington BB: Cognition and Tyrosine Supplementation Among School Age Children with Phenylketonuria. Am J Dis Child, 146:1261-1264, 1992.

Friedman JM, Birch P, Greene CL, NNFF International Database Participants. National Neurofibromatosis Foundation International Database. Am J Med Gen, 45:88-91, 1993.

Acosta PB, Greene CL, Yannicelli S, Korson M, Rohr F, Hooper L, Williams J and Mofidi S. Nutrition Studies in Treated Infants with Phenylketonuria Int Peds, 8:63-73, 1993.

Mazzocco MMM, Nord A, Kovar C, Greene CL, vanDoorninck WJ, Pennington B. Cognitive Development Among Children with Early Treated Phenylketonuria. Devel Neuropsych, 10:133-151, 1994.

McDowell G, Blitzer MJ and Greene CL. Variable Expression in Siblings with Hurler Syndrome and San Filipo A Syndrome: Implications for Evaluation of Treatment. Am J Med Gen 47:1092-1095, 1993.

Citron BA, Kaufman S, Milstein S, Naylor EW, Greene CL and Davis MD. Mutation in the Carbinolamine Dehydratase Gene Leads to Mild Hyperphenylalaninemia with Deficient Co-factor Metabolism. Am J Hum Gen 53:768-774, 1993.

Arnold GL, Greene CL and Goodman SI. Molybdenum Co-factor Deficiency. J Peds 123:595-598, 1993.

Alderman BW, Bradley CM, Greene CL, Fernbach S, Baron AE. Increased Risk of Craniosynostosis with Maternal Cigarette Smoking During Pregnancy. Teratology 50:13-18, 1994.

Bradley CM, Alderman BW, Williams MA, Chectsoway H, Fernbach SK, Greene CL, Bigelow PL and Reif JS. Parental Occupations as Risk Factors for Craniosynostosis in Offspring. Epidemiology :306-310, 1995.

Alderman BW, Zamudo S, Baron AE, Joshua SC, Fernbach SK, Greene CL, Mangione EJ. Increased Risk of Craniosynostosis with Higher Antenatal Maternal Attitude. Inter Journal of Epidemiology. 24(2):420-426, 1995.

Alderman BW, Fernbach SK, Greene CL, Mangione EJ, Steslien AI, Ferguson WF. Diagnostic Practice and the Prevalence of Craniosynostosis in Colorado. Arch Ped and Adol Med. 151(2):159-164, 1997.

Irons M, Elias ER, Abuelo D, Bull MJ, Greene CL, Johnson VP, Keppen L, Schananen C, Tint GS, Salen G. Treatment of Smith-Lemli-Opitz syndrom: results of a multicenter trial. Am J Med Gen 68(3): 311-4, 1997.

Gardner JS, Guyard Boileau B, Alderman BW, Fernbach SK, Greene CL and Mangione EJ. Maternal exposure to prescription and non-prescription pharmaceuticals and drugs of abuse and risk of craniosynostosis. Int J of Epidemiology 27(1): 64-7, 1998.

Chamberlin ME, Ubagai T, Mudd SH, Thomas J, Pao VY, Nguyen TK, Levy HL, Greene C, Freehauf C, and Chou JY. Methionine Adenosyltransferase I/III Deficiency: Novel Mutations and Clincal Variations. Am J Hum Gen. 66(2): 347-55, 2000.

Thomas JA, Bernstein LE, Greene CL and Koeller DM. Apparent decreased caloric requirements in children with organic acidemias: preliminary observations. J Amer Dietetic Assoc. 100(9): 10074-6, 2000.

Wolf B, Freehauf CL, Thomas JA, Gordon PL, Greene CL and Ward JC. Markedly elevated serum biotinidase activity helps diagnose Glycogen Storage Disease Type Ia. J Inher Metab Dis 26: 805-809, 2003.

Chen B and total of 36 authors including Greene CL as a middle author. Developing a Sustainable Process to Provide Quality Control Material for Genetic Testing. Genetics In Medicine 7(8): 534-549, 2005.

Grosse SD, Khoury MJ, Greene CL, Crider, KS and Politt, RJ. The Epidemiology of Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD): An Update. Genetics in Medicine, 8(4):205-212, April 2006.

Kemper AR, Boyle CA, Aceves J, Dougherty D, Figge J, Hinman AR, Greene CL, Kus C, Miller J, Therrell B, Lloyd-Puryear M, van Dyck PC, Howell RR. Long-Term Follow-Up After Diagnosis Resulting From Newborn Screening: Statement of the US Secretary of Health and Human Services Advisory Committee on Heritable Disorders and Genetic Diseases in Newborns and Children. Genetics in Medicine 10(4): 259-261, April 2008.

Barshop, BA and Greene, CL. Laboratory Referral Practices in Biochemical Genetics in the United States. Molecular Genetics and Medicine [IEM Digest] 98(1-2): 149-151, 2009

Chen B and Greene C. Promoting Quality of Genetic Testing with Guidelines for Good Laboratory Practice. Molecular Genetics and Medicine [IEM Digest] 99(3); 238-243, 2010