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Young  Kwok
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Young Kwok M.D.

Academic Title: Associate Professor
Primary Appointment: Radiation Oncology
ykwok@umm.edu
Location: UMMC/Gudelsky, GGJ85
Phone: (410) 328-9134 - office
Phone: (410) 328-6080 - appointments
Fax: (410) 328-5279

Personal History:

Dr. Kwok received his BA in Psychology from Johns Hopkins University in 1995. He received his MD from Albert Einstein College of Medicine (New York) in 1999. He completed an internship in Internal Medicine at Beth Israel Medical Center (New York) in 2000, before commencing his residency in Radiation Oncology at the University of Maryland Medical Center, which he completed in 2004. Dr. Kwok then joined the Department of Radiation Oncology at the University of Maryland School of Medicine as an Assistant Professor in 2004. He became an Associate Professor in 2011.

Clinical Speciality:

Dr. Kwok’s clinical specialty includes brain and base-of-skull tumors, pediatric malignancies, genito-urinary tumors, such as prostate and bladder cancer.


Current Grant Support/Investigator Initiated Trials:

Phase II Study Evaluating Bone Marrow-Sparing, Image-Guided Pelvic Intensity-Modulated Radiotherapy (IMRT) with Cesium-131 Brachytherapy Boost, Adjuvant Chemotherapy, and Long-Term Hormonal Ablation in Patients with High Risk, Non-Metastatic Prostate Cancer.
Role: Principal Investigator

Phase II Trial of Low-Dose Whole Brain Radiotherapy with Concurrent Temozolomide and Adjuvant Temozolomide in Patients with Newly-Diagnosed Glioblastoma Multiforme
Role: Principal Investigator


Active Clinical Trials:

Dr. Kwok has offers a range full clinical trials. These include trials initiated through the Greenebaum Cancer Center, as well as national cooperative group trials such as NRG, Alliance, RTOG, CALGB and COG.


Publications:

Peer-Reviewed Journal Articles:

Kwok Y, DiBiase S, Amin P, Naslund M, Jacobs S.  Risk group stratification in patients undergoing permanent I-125 prostate brachytherapy as monotherapy.  International Journal of Radiation Oncology Biology Physics 2002, 53(3), 588-594.

Flannery T, Suntharalingam M, Kwok Y, Koffman B, Amin P, Chin L, Nicol B, Fowler B, Young AB, Regine W.  Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer.  Lung Cancer 2003, 42, 327-333.

Thomas L, Kwok Y, Edelman M.  Management of paraneoplastic syndromes in lung cancer.  Current Treatment Options in Oncology 2004, 5(1), 51-62.

Herman JM, Petit JH, Amin P, Kwok Y, Dutta P, Chin LS. Repeat gamma knife radiosurgery for refractory or recurrent trigeminal neuralgia: Treatment outcomes and quality of life assessment.  International Journal of Radiation Oncology Biology Physics 2004, 59(1), 126-133.

Garofalo M, Kwok Y, Regine WF.  The Evolving Role of Adjuvant Postoperative Radiation Therapy.  Surgical Oncology Clinics of North America 2004 Oct;13(4):589-604, viii.

Patel AB, Edelman MJ, Kwok Y, Krasna M, Suntharalingam M.  Predictors of acute esophagitis in patients with non-small cell lung carcinoma treated with concurrent chemotherapy and hyperfractionated radiation therapy followed by surgery.  International Journal of Radiation Oncology Biology Physics 2004 Nov;60(4),1106-12.

DiBiase S, Kwok Y, Yovino S, Arena C, Temple R, Regine W, Amin P, Chin L. Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas.  International Journal of Radiation Oncology Biology Physics 2004 Nov 15;60(4):1106-12.

Kwok Y, Regine WF, Patchell RA.  Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quo.  Journal of Clinical Oncology  2005 May 20;23(15):3308-10. Epub 2005 Feb 28.]

Yovino S, Kwok Y, Krasna M, Bangalore M, Suntha M.  An association between preoperative anemia and decreased survival in early-stage non-small cell lung cancer treated with surgery alone.  International Journal of Radiation Oncology Biology Physics 2005 Aug 1;62(5):1438-4.

Ma L, Kwok Y, Chin LS, Simard JM, Regine WF.  Concomitant GRID boost for Gamma Knife radiosurgery.  Medical Physics 2005 Nov;32(11):3419-23.

Ma L, Kwok Y, Chin LS, Yu C, Regine WF.  Comparative analyses of linac and Gamma Knife radiosurgery for trigeminal neuralgia treatments. Phys Med Biol 2005 Nov 21;50(22):5217-27. Epub 2005 Oct 24.

D’Souza W, Kwok Y, DeYoung C, Zacharapoulos N, Pepelea M, Klahr P, and Yu CX.  Gated CT imaging using a free-breathing respiration signal from flow-volume spirometry. Medical Physics 2005 Dec;32(12):3641-49.

Kwok Y, DeYoung C, Garofalo M, Dhople A, and Regine W.  Radiation Oncology Emergencies.  Hematology/Oncology Clinics of North America April 2006;20(2):505-522.

Kwok Y, Tibbs PA, Patchell RA.  Clinical approach to metastatic epidural spinal cord compression. Hematology/Oncology Clinics of North America Dec 2006;20(6):1297-1305.

D’Souza W, Nazareth D, Zhang B, Deyoung C, Suntharalingam M, Kwok Y, Yu CX, and Regine W. The use of gated and 4D CT imaging in planning for stereotactic body radiation therapy.  Medical Dosimetry 2007 Summer;32(2):92-101.

Dhople A, Kwok L, Chin L, Shepard D, Slawson R, Amin P, and Regine W.  Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery. Int J Radiat Oncol Biol Phys 2007;69(2):397-403. Epub 2007 Apr 30.

Flannery TW,Suntharalingam M, Regine WF, Chin LS,  Krasna MJ, Shehata MK, Edelman MJ, Kremer M, Patchell RA, and Kwok Y.  Long-term survival in patients with synchronous, solitary brain metastasis from non-small cell lung cancer treated with radiosurgery. Int J Radiat Oncol Biol Phys 2008 Sept 1;72(1):19-23. Epub 2008 Feb 13.

Dhople AA, Adams JR, Maggio WW, Naqvi SA, Regine WF, and Kwok Y.  Long Term Outcomes of Gamma-Knife Radiosurgery for Classic Trigeminal Neuralgia:  Implications of Treatment and Critical Review of the Literature.  J Neurosurg 2009: 1-8. Epub 2009 March 27.

Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Carter K, Ord R, Zimrin A, Strome S, and Suntharalingam M.  Race impacts outcome in stage III/IV squamous cell carcinomas of the head and neck after concurrent chemoradiation therapy. Cancer 2009; 115(8):1744-52.

Yovino S, Settle K, Taylor R, Wolf J, Kwok Y, Cullen K, Ord R, Zimrin A, Strome S,and  Suntharalingam M. Patterns of failure among patients with squamous cell carcinoma of the head and neck who obtain a complete response to chemoradiotherapy. Head Neck 2010;32(1):46-52. Epub 2009 May 29.

Kwok Y, Yovino S.  Radiation-based therapies for prostate cancer. Curr Opin Oncol 2010 May;22(3):257-62.

DiBiase SJ, Hussain A, Kataria R, Amin P, Bassi S, Dawson N, and Kwok Y.  Long-term results of a prospective, phase II study of long-term androgen ablation, pelvic radiotherapy, brachytherapy boost and adjuvant docetaxel in patients with high-risk prostate cancer.  International Journal of Radiation Oncology Biology Physics 2010 Oct 30. [Epub ahead of print].

Hussain A, Wu Y, Mirmiran A, DiBiase S, Goloubeva O, Bridges, Mannuel H, Engstrom C, Dawson N, Amin P and Kwok Y.  Long-term follow-up of a prospective trial of trimodality therapy of weekly paclitaxel, radiation and androgen deprivation in high risk prostate cancer with or without prior prostatectomy.  International Journal of Radiation Oncology Biology Physics 2010 Oct 30. [Epub ahead of print].

Szerlip N, Rutter C, Ram N, Yovino S, Kwok Y, Maggio W, Regine W.  Factors impacting volumetric white matter changes following whole-brain radiation therapy. Journal of Neuro-Oncology 2010 Aug 20. [Epub ahead of print]

Koshy M, Rich SE, Mahmood U, Feigenberg S, and Kwok Y. The Declining Utilization of Radiation Therapy in Stage I and II Hodgkin's Disease and its Impact on Survival and Secondary Malignancies. In Press. International Journal of Radiation Oncology Biology Physics 2011.

Suntharalingam M, Kwok Y, Goloubeva O, Parekh A, Taylor R, Wolf J, Zimrin A, Strome S, Ord R, and Cullen K.  A Phase II Study Evaluating the Addition of Cetuximab to the Concurrent Delivery of Weekly Carboplatin, Paclitaxel and Daily Radiotherapy for Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck. In Press. International Journal of Radiation Oncology Biology Physics 2011.

Koshy M, Rich S, Merchant E, Mahmood U, Regine W, and Kwok Y. Post-operative Radiation Improves Survival in Children Younger Than 3 Years with Intracranial Ependymoma.  Journal of Neuro-oncology 2011 June 3. [Epub ahead of print]

Husain ZA, Regine WF, Kwok Y and Feigenberg SJ. Brain Metastases: Contemporary Management and Future Directions. The European Journal of Clinical & Medical Oncology. June 2011, 3(3). 38-45.

Koltz MT, Polifka AJ, Saltos A, Slawson RG, Kwok Y, Aldrich EF, and Simard JM.  Long-Term Outcome of Gamma Knife Stereotactic Radiosurgery for Arteriovenous Malformations Graded by the Spetzler-Martin Classification.  Journal of Neurosurgery 2012;Oct 19. [Epub ahead of print].

Diss E, Nalabothula N, Nguyen D, Chang E, Kwok Y, and Carrier F. Vorinostat SAHA Promotes Hyper-Radiosensitivity in Wild Type p53 Human Glioblastoma Cells. JSM Clin Oncol Res 2014; 2(1): 1004.

Tye K, Engelhard HH, Slavin KV, Nicholas MK, Chmura SJ, Kwok Y, Ho DS, Weichselbaum RR, Koshy M. An analysis of radiation necrosis of the central nervous system treated with bevacizumab.  J Neurooncol 2014; Feb 7. [Epub ahead of print].

Non-refereed:

Kwok Y, Patchell RA.  Commentary on: “The role of radiation in the management of brain metastases from renal cell carcinoma.” Doh, Amato, Paulino et al.  Oncology May 2006;20(6):619-625.

Book Chapters:

Kwok Y, Garofalo M, Regine WF.  Postoperative Adjuvant Therapy for Pancreatic Cancer.  In: Pancreatic Cancer.  Von Hoff DD, Evans DB, and Hruban RH (ch.27, p395-404). Sudbury, MA: Jones and Barlett, 2005.

Kwok Y, Patchell RA, Regine WF.  Palliation of Brain and Spinal Cord Metastases.  In: Principles and Practice of Radiation Oncology (ch.91, p1974-1985).  Lippincott Williams & Wilkins; 5th edition.  2007.

Miker-Zabel S, Kwok Y, Debus J.  Skull Base Tumors.  In: Principles and Practice of Stereotactic Radiosurgery (ch.37, p383-392).  Springer; 1st edition.  2008

Chin LS, Patel S, Mattingly T, Kwok Y.  Trigeminal Neuralgia.  In: Principles and Practice of Stereotactic Radiosurgery (ch.52, p519-526).  Springer; 1st edition.  2008

Kwok Y, Patchell RA, Regine WF.  Management of Overt CNS Metastases: Brain and Spinal Cord.  Lung Cancer: Principles and Practice.  Lippincott Williams & Wilkins; 4th edition.  April 2010.

Yovino S, Kwok Y, Regine WF. Brain and Cranial Nerves. In: ALERT: Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. Rubin P, Constine L, Marks L, Williams J, Hansen J. New York, NY: Springer-Verlag, 2012.

Nichols E, Patchell RA, Regine WF, Kwok Y. Palliation of Brain and Spinal Cord Metastases.  In: Principles and Practice of Radiation Oncology.  Lippincott Williams & Wilkins; 6th edition. 2013

Other Brief Communications:

Kwok Y, Regine W, Dibiase SJ. In reply to Dr. Rogers et al. International Journal of Radiation Oncology Biology Physics 2005 Jun 1;62(2):618-9.

Kwok Y, Patchell RA, Regine W.  In reply to Dr. Macbeth et al and Dr. Maranzano et al. Journal of Clinical Oncology 2005;23(32):8272-8275.

Kwok Y, Patchell RA.  Commentary on: “The role of radiation in the management of brain metastases from renal cell carcinoma.” Doh, Amato, Paulino et al.  Oncology May 2006;20(6):619-625.

Mahmood U, Kwok Y, Regine WF, and Patchell RA.  Whole brain irradiation for patients with brain metastasis: still the standard of care.  Lancet Oncol 2010;11(3):221-2.