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Personal History
Education/Training
* BS, Life Sciences (Emphasis in Biochemistry), Arizona State University
* ScM, Toxicology, Johns Hopkins University, Bloomberg School of Hygiene and Public Health
* PhD, Toxicology, University of Maryland, Baltimore
Research Interests
* Alzheimers disease* Mitochondrial dysfunction and neurodegenerative disease
* Environmental exposure (specifically pesticide exposure) and neurodegenerative disease
* Environmental exposure and mitochondrial dysfunction
Lab Techniques and Equipment
* Mitochondrial bioenergetics* Fluorescent measurements of cell death
* Confocal microscopy (laser and CARV)
* PCR
* Western blotting and immunohistochemical staining
* Organotypic hippocampal slice cultures
* Enzyme activity measurements
* ELISA Spectrofluorometry
Publications
Schuh RA, Lein PJ, Beckles RA, and Jett DA. (2002). Noncholinesterase Mechanisms of Chlorpyrifos Neurotoxicity: Altered Phosphorylation of Ca2+/cAMP Response Element Binding Protein in cultured Neurons. Toxicol Appl Pharmacol 182 (2), 176-185. Schuh RA, Kristin T, and Fiskum G. (2005) Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB). J Neurochem 92 (2), 388-394.
Schuh RA, Kristin T, Gupta RK, Flaws JA, and Fiskum G. (2005). Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol. Sci. 88 (2), 495-504.
Gupta RK, Schuh RA, Fiskum G, and Flaws JA. (2006). Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. Toxicol Appl Phar 216, 436-445.
Soane L, Siegel ZT, Schuh RA, and Fiskum G. (2008). Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J. Neurosci. Res. 86, 1267-1276.
Schuh RA, Matthews CC, and Fishman PS. (2008). Interaction of mitochondrial respiratory inhibitors and excitotoxins potentiate cell death in hippocampal slice cultures. J. Neurosci. Res. 86 (15), 3306-3313.
Schuh RA, Richardson JR, Gupta RK, Flaws JA and Fiskum G. (2009). Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. Neurotoxicology (In press).
Faculty members:
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