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Rezwanul  Wahid

Rezwanul Wahid M.B.B.S., Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Pediatrics
Location: HSF II, 330
Phone: 410-706-1848
Fax: 410-706-6205
Lab: 410-706-7376

Personal History:

  • 1987 Bachelor of Medicine & Surgery (MBBS)
    Dhaka Medical College, Bangladesh
  • 1996 Ph.D.
    Kagoshima University School of Medicine, Japan

Research Interests:

Dr. Wahid studies T and B cell mediated host-immune responses and induction immune memory by immunization with licensed or candidate vaccines in humans. He primarily utilizes the clinical samples obtained from volunteers participating in various vaccine trials. His ultimate goal is to enhance the endeavors of developing efficient vaccines, especially against enteric pathogens by understanding the immune correlate of protection against those diseases in humans.


Selected Publications 2011-Present

  1. Tapia MD, Sow OS,  Lyke KE et al.  Safety and immunogenicity trials in Malian (Phase 1b) and U.S. (Phase 1) adults of non-replicating chimpanzee adenovirus vector expressing Zaire ebolavirus glycoprotein and a nested randomized, double-blind, placebo-controlled trial to assess the effect of boosting Malian participants with heterologous live vector MVA-BN®-Filo or saline. The Lancet Infectious Diseases. 2015  (in press)
  2. Wahid R, Fresnay S, Levine MM and Sztein MB.  Immunization with Ty21a live oral typhoid vaccine elicits cross-reactive multifunctional CD8+ T cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A and S. Paratyphi B in humans. Mucosal Immunology. 2015. [Epub ahead of print] PMID: 25872480
  3. Wahid R, Zafar SJ, McArthur MA, Pasetti MF, Levine MM, Sztein MB. Live oral Salmonella enterica serovar Typhi vaccines Ty21a and CVD 909 induce opsonophagocytic functional antibodies in humans that cross-react with S. Paratyphi A and S. Paratyphi B. Clin Vaccine Immunol. 2014 Mar;21(3):427-34. PMC3957674
  4. Wahid R*, Simon JK*, Picking WL, Kotloff KL, Levine MM, Sztein MB (*equal contributing first author). Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a. Clin Immunol. 2013:148:35-43
  5. Davis CL, Wahid R, Toapanta FR, Jakub K. Simon JK, Sztein MB and Levy D. Applying Mathematical Tools to Accelerate Vaccine Development: Modeling Shigella Immune Dynamics. PloS One: 2013. 8(4):e59465
  6. Ramirez K*, Wahid R *, Richardson C, Bargatze RF, El-Kamary SS , Sztein MB and Pasetti MF (*equal contributing first author). Intranasal vaccination with an adjuvanted Norwalk virus-like particle vaccine elicits antigen-specific B memory responses in human adult volunteers: Clin Immunol. 2012:144(2):98
  7. Wahid R, Simon R, Zafar SJ, Levine MM, Sztein MB Live oral typhoid vaccine Ty21a induces cross reactive humoral immune responses against S. Paratyphi A and S. Paratyphi B in humans. Clin Vaccine Immunol. 2012:19(6):825
  8. Ruiz-Perez F, Wahid R, Faherty CS, Kolappaswamy K, Rodriguez L, Santiago A, Murphy E, Cross A, Sztein MB and Nataro JP. Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins: PNAS 2011:108(31):12881-6
  9. Simon JK, Maciel M Jr, Weld ED, Wahid R, Pasetti MF, Picking WL, Kotloff KL, Levine MM, Sztein MB. Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates. Clin Immunol. 2011:139(2):185-92
  10. Wahid R, Pasetti MF, Maciel M Jr., Simon JK, Tacket CO, Levine MM, Sztein MB. Oral priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+ IgD- S. Typhi specific IgA and IgG B memory cells in humans. Clinical Immunology: 2011: 138(2):187-200