Teodor T Postolache
M.D.
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| Academic Title:
Associate Professor |
| Primary Appointment:
Psychiatry |
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tpostola@psych.umaryland.edu |
| Location:
701 W. Pratt St.,
388 (MPRC) |
| Phone:
(410) 706-2323 |
| Fax:
(410) 706-0751 |
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Personal History
Education
1976-1982: Medical School, Bucharest, Cluj-Napoca School of Medicine, Romania (Years I-III, pre-clinical; Years IV- VI, clinical)
1982: MD, Cluj-Napoca School of Medicine, Romania
Post Graduate Education
1982-1985: Postgraduate, Medicine, Coltea Hospital and the Bucharest School of Medicine, Romania.
1990-1991: Postgraduate, Cardiology, University of Vienna, Austria
1991-1992: Residency, Internal Medicine, Broussais Hospital, Paris, France (INSERM Hypertension Unit)
1992-1996: Residency, Psychiatry, Beth Israel Medical Center, New York, NY; PGY I-II, Mount Sinai School of Medicine, New York, NY
1996-1998: Fellowship, Clinical Research in Psychiatry, NIMH, Bethesda MD
Employment History
1982-1985: Postgraduate training in Medicine, Coltea Hospital, Bucharest, Romania
1985-1990: Practice in a remote rural area, Bruiu Medical Unit, Romania
1990-1991: Cardiology postgraduate training, General Hospital, Vienna, Austria
1991-1992: Internal Medicine/Hypertension, Broussais Hospital, Paris, France
1992- 1996: Residency, Department of Psychiatry, Beth Israel Medical Center, New York, NY
1995- 1999: Emergency psychiatry and consultation-liaison, St. Mary's Hospital, Waterbury, CT, affiliated with Yale University Medical School
1996-1998: Fellowship in Clinical Research in Psychiatry, Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD
- Clinical experience: management of rapid cycling bipolar disorder patients, seasonal affective disorder patients and patients with circadian rhythm sleep disorders
- Assistant Clinical Professor of Psychiatry, Georgetown University School of Medicine, Washington, D.C.
1998-2003: Special Volunteer, Section on Biological Rhythms, NIMH
1999-present: Part-time private practice, National Center for the Treatment of Phobias, Anxiety and Depression, Washington, D.C.
- Pharmacotherapy of Anxiety and Mood Disorders
- Treatment of seasonal and circadian rhythms disorders
1998-2001: Attending psychiatrist, St. Elizabeth’s Hospital, Washington, D.C.
- Psychopharmacology in the elderly and medically ill patients with cognitive disorders, psychotic disorders and severe refractory mood disorders
2001-2003: Director, Psychopharmacology Consultation Service, St. Elizabeth Hospital, Department of Mental Health, Washington, D.C.
2003: Clinical Associate Professor, Department of Psychiatry, University of Maryland, Baltimore
2003-present: Associate Professor of Psychiatry, Director, Mood and Anxiety Program, Department of Psychiatry, University of Maryland, Baltimore
Current Grant Support:
2007-2010: Principal Investigator
"Light treatment for winter-SAD: Improvement after 1 hour and clinical response at 4 weeks"
National Institute Mental Health, R34
Direct costs: $ 450,000
Total costs: $675,000
The goal of this project is to evaluate the predictive value of the response to the first session of bright light treatment on response after a full course of treatment, and to investigate the potential of bright light treatment to reduce cardiovascular risk in depressed SAD patients.
2007-2009: Principal Investigator
"Seasonality of suicide and airborne allergens"
National Institute Mental Health, R01
Direct costs: $893.759.00
Total costs: $1,189.080.00
The goal of this study is to investigate epidemiologically the association between peaks in airborne allergens and seasonal peaks in suicide, and between suicide and allergy.
2006-2008: Principal Investigator
"Mood worsening in spring in women with depression and tree-pollen allergy"
National Institute Mental Health, R21
Direct costs: $247,500
Total costs: $367,538
The aim of this project is to investigate the association between IgE antibody, tree pollen and mood worsening in spring in women with major mood disorders.
2006-2008: Principal Investigator
"Allergy and suicide history in patients with mood disorders"
NARSAD, Independent investigator award
Direct costs: $92,540
Total costs: $99,944
To compare history of suicide attempts in patients with and without positive IgE antibody against common allergens.
2006-2008: Co-Investigator; Principal Investigator: L. Tonelli
"Intranasal immune challenge, brain cytokines and gender differences in depression"
National Institute Mental Health, R21
Direct costs: $247,500
Total costs: $367,538
To evaluate the behavioral and molecular effects of intranasal immune challenge, differentially, in female vs. male rats.
Publications
Peer-Reviewed Articles
Postolache T.T., S. Gautier, B. Laloux, M. Safar and A. Benetos: Positive correlation between the blood pressure and heart rate response to the cold pressor test and the environmental temperature in older hypertensives. American Journal of Hypertension, 6: 376-381, 1993
Postolache T.T., Londono J.H., Halem R.G. Newmark M.D. (1995). Electroconvulsive therapy in tardive dystonia. Convuls Ther 11:275-9.
Postolache T.T., J. Londono, H. Pinsker, S. Luccerini, L. Augustin, J. Chris Muran: A study of religion and psychotherapy. Psychiatric Services, 48: 1592, 1997
Aeschbach D., Matthews J.R., Postolache T.T., Jackson M.A., Giesen H.A., Wehr T.A. (1997). Dynamics of the human EEG during prolonged wakefulness: evidence for frequency-specific circadian and homeostatic influences. Neurosci. Lett 239: 121-4.
Neumeister A, Turner E.H., Matthews J.R., Postolache T.T., Barnett R.L., Rauh M., Vetticad R.G., Rosenthal N.E.(1998). Effects of tryptophan depletion versus cathecholamine depletion in patients with seasonal affective disorder remitted on light therapy. Archives of General Psychiatry 55: 524-534.
Postolache T.T., Hardin T.E., Meyers F., Turner E.H., Yi L.Y., Barnett R.L., Matthews J.R., Rosenthal N.E.(1998).Greater improvement in summer than with light treatment in winter in patients with seasonal affective disorder. American Journal of Psychiatry 155: 1614-1616.
Aeschbach D., Matthews J.R., Postolache T.T., Jackson M.A., Giesen H.A., Wehr T.A. (1999). Two circadian rhythms in the human electroencephalogram during wakefulness. Am J Physiol. 27:R1771-9.
Postolache T.T., Doty R., Wehr T., Turner E., Mathews J., Jimma L., Han L., No C., Kruger H., Rosenthal N. (1999). Olfactory acuity and smell identification in patients with seasonal affective disorder. Journal of Affective Disorders 56: 27-32.
Aeschbach D, Postolache T.T., Sher L., Matthews J.R., Jackson M.A., Wehr T.A. (2001). Evidence from the waking electroencephalogram that short sleepers live under higher homeostatic sleep pressure than long sleepers. Neuroscience 102: 493-502.
Sher,L., Matthews J.R., Turner E.H., Postolache T.T., Katz K.S., Rosenthal N.E. (2001). Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder. J. Psychiatry Neurosci 26(4):336-8.
Wehr T.A., Duncan W.C., Sher L., Aeschbach D., Schwartz P.E., Turner E.M., Postolache T.T., Rosenthal N.E. (2001). A circadian signal of change of seasons in patients with seasonal affective disorder. Archives of General Psychiatry 58:1093-1208.
Postolache T.T., Wehr T.A., Doty R.L., Sher L.,Turner E.H., Bartko J.J., Rosenthal N.E.(2002). Patients with seasonal affective disorder have lower odor detection thresholds than control subjects. Archives of General Psychiatry 59:1119-1122.
Aeschbach D., Sher L., Postolache T.T., Matthews J.R., Jackson M.A., Wehr T.A. (2003). A longer biological night in long sleepers than in short sleepers. J.Clin.Endocrinol Metab 88(1):26-30.
Agumadu C.O.,Yousufi S.M., Malik I., Nguyen M.T., Jackson M.A., Soleymani K., Thrower C.M., Niemtzoff M.J., Peterman M.J., Walters G., Postolache T.T. (2004). Seasonality of mood in African-American college students living in Washington, D.C. metropolitan area. Am. J. Psychiatry 161:1084-1089.
Tonelli L.H., Postolache T.T., Sternberg E.M. (2005). Inflammatory genes and neural activity: involvement of immune genes in synaptic function and behavior. Frontiers in Bioscience 10:675-680.
Komarow H.D., Postolache T.T. (2005). Seasonal allergy and seasonal decrements in athletic performance. Clin Sports Med 24(2):e35-50.
Postolache T.T., Stiller J.W., Herrell R., Goldstein M.A., Shreeram S.S., Zebrak R.,Thrower C.M., Volkov J., No M.J., Volkov I., Rohan K.J., Redditt J., Parmar M., Mohyuddin F., Olsen C., Moca M., Tonelli L.H., Merikangas K., Komarow H.D. (2005). Tree pollen peaks are associated with increased suicide in women. Molecular Psychiatry 10:232-5.
Tonelli L.H, Postolache T.T. (2005). Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge. Neurol Res 27(7):679-84.
Postolache T.T., Oren D.A. (2005). Circadian phase shifting, alerting, and antidepressant effects of bright light treatment. Clin Sports Med 24:381-413.
Stiller J.W., Postolache T.T. (2005). Sleep-wake and other biological rhythms: functional neuroanatomy. Clin Sports Med 24:205-35, vii.
Guzman A., Zebrak R., Rohan K.J., Sumar I.A., Savchenko S., Stiller J.W., Valadez-Meltzer A., Olsen C., Lapidus M., Soriano J.J., Postolache T.T. (2007). A prospective longitudinal study of seasonality in African students living in the greater Washington, D.C. metropolitan area. ScientificWorldJournal 7:577-83.
Guzman A., Rohan K.J., Yousufi S.M., Nguyen M., Jackson M.A., Soriano J.J., Postolache T.T. (2007). Mood sensitivity to seasonal changes in African college students living in the greater Washington, D.C. metropolitan area. ScientificWorldJournal 7:584-91.
Soriano J.J., Ciupagea C., Rohan K.J., Neculai D.B., Yousufi S.M., Guzman A., Postolache T.T. (2007). Seasonal variations in mood and behavior in Romanian postgraduate students. ScientificWorldJournal 7:870-879.
Volkov J., Rohan K.J., Yousufi S.M., Nguyen M., Jackson M.A. Thrower C.M., Stiller J.W., Postolache T.T. (2007). Seasonal changes in sleep duration in African American and African college students living in Washington, D.C. ScientificWorldJournal 7:880-887
Guzman A., Tonelli L.H., Roberts D., Stiller J.W., Jackson M.A., Soriano J.J., Yousufi S., Rohan K.J., Komarow H., Postolache T.T. (2007) Mood-worsening with high-pollen counts and seasonality: A preliminary report. J Affect Disord 101:269-274.
Reeves G.M., Tonelli L.H., Anthony B.J., Postolache T.T. (2007) Precipitants of adolescent suicide: possible interaction between allergic inflammation and alcohol intake. Int J Adolesc Med Health 19(1): 37-43.
Scrandis D, Sheikh T., Niazi R., Postolache TT: Depression after delivery: risk factors, diagnostic and therapeutic considerations (2007). ScientificWorldJournal 7, 1670–1680
Tonelli L.H., Holmes A., Postolache T.T. (2007) Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain. Neuropsychopharmacology 1-11. E-published ahead of print
Postolache T.T., Lapidus M., Sander E.R., Langenberg P., Hamilton R.G, Soriano J.J., McDonald J.S., Furst N. , Bai J., Scrandis D.A., Cabassa J.B., Stiller J.W., Guzman A., Togias A. Tonelli, L.H. Allergy Symptoms are Related to the Severity of Depression Scores in Patients with Recurrent Mood Disorders: A Preliminary Report. ScientificWorldJournal (2008), In press
McCloskey D. J., Postolache T.T., Vittone B.J., Nghiem K.L., Monsale J., Wesley R.A., Rick M.E. Selective Serotonin Reuptake Inhibitors (SSRIs): Effect on Platelet Function: Translational Research (2008), In press.
Postolache T.T., Roberts D., Langenberg, P. , Muravitskaja O., Stiller J.W., Hamilton R.G., Tonelli L.H. Allergen specific IgE: No relationship with prior history of suicide attempts and instability in patients with recurrent mood disorders. Int J C Health Hum Dev (2008), In press.
Tonelli L.H. , Stiller J., Rujescu, D., Giegling I., Schneider B, Maurer K, Schnabel A., Möller H-J, Postolache TT: Elevated TH2 cytokines in the orbitofrontal cortex of victims of suicide. Acta Psychiatrica Scandinavica (2008), In press
Books and Book Chapters
Postolache T.T. (editor): Sports Chronobiology, Saunders, New York, 2005
Postolache T.T., Oren D.A. (2005): Circadian phase shifting, alerting, and antidepressant effects of bright light treatment. In: Postolache T.T., editor, Sports Chronobiology, Saunders, New York, 2005
Stiller J.W., Postolache T.T. (2005). Sleep-wake and other biological rhythms: functional neuroanatomy. In: Postolache T.T., editor, Sports Chronobiology, Saunders, New York, 2005
Postolache T.T., Hung TM, Rosenthal RN, Soriano JJ, Montes F, Stiller JW. Sports Chronobiology: from the lab to the arena in . In: Postolache T.T., editor, Sports Chronobiology, Saunders, New York, 2005
Postolache T.T.: (collaborative author): Sleep and Biological Rhythms. In: F.K. Goodwin and K.R. Jamison, Manic-Depressive Illness-Bipolar Disorders and Recurrent Depression, second edition, Oxford University Press, London, 2007.
Reeves G.M., Tonelli L.H., Anthony B.J., Postolache T.T. (2007) Possible interaction between allergic inflammation and alcohol intake. In: Sher L, Kandel I, Merrick J. Alcohol and suicide: Research and clinical perspectives. Int Acad Press, Victoria, BC, 2007
Postolache T.T., Merick J (editors) Time and environment in mood disorders: Nova Science, New York. 2008 (invited)
Guzman A, Postolache TT: Suicide and suicide risk factors in Hispanics. Time and environment in mood disorders: Nova Science, New York. 2008 (invited)
Tonelli LN, Postolache TT: Molecular mediators of the allergy depression interaction. Time and environment in mood disorders: Nova Science, New York. New York 2008 (invited)
Postolache TT: Sports Chronobiology: Chapter for DeLee and Drez Orthopedic Sports Medicine, Third Edition, Saunders, New York, NY 2008
Faculty members:
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