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Ikwunga  Wonodi
 

Ikwunga Wonodi M.B.B.S.

Academic Title: Clinical Associate Professor
Primary Appointment: Psychiatry
Additional Title(s): Program in Human Genetics and Genomic Medicine
iwonodi@mprc.umaryland.edu
Location: MPRC - Tawes, P.O. Box 21247, Baltimore, MD 21228
Phone: (410) 402-6820
Fax: (410) 402-6023

Personal History:

1986: Bachelor of Science in Comparative Anatomy, College of Health Sciences, University of Port Harcourt, Nigeria
1989: Medicine (M.B.B.S), College of Health Sciences, University of Port Harcourt, Nigeria
1997 – 2003: Research Track Residency Training and Post-doctoral Fellowship
2003 – Present: Faculty, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine

Research Interests:

Neurogenetics and genomics: Endophenotype-based candidate gene association studies in schizophrenia. Gene expression studies in post-mortem cortical tissue, and in animal models of neuropsychiatric diseases. Pharmacogenomics.

Medication-induced motor disorders: Identification, prevention, and management of antipsychotic-induced motor disorders, consultation and application of novel treatment strategies.

Combined genetic and Positron Emission Tomography (PET) imaging studies: Current interests in sequence variations that affect dopamine-related candidate receptor gene association with endophenotypes in clinical samples, expression in post-mortem cortical tissue, and receptor density in clinical samples using receptor-specific radioligand.

Pharmacological probe studies and experimental therapeutics: Using novel compounds to treat neurocognitive deficits related to poor functional outcome in schizophrenia. Current interests in improving social and emotional cognition in schizophrenia by modulation of oxytocin receptors, and treatment of positive and negative symptoms with an adenosinergic agent.

Lab Techniques and Equipment:

Prism 7900HT Fast Sequence Detection System and ancillary equipments; Microarray platforms; Genome Wide Association Studies (GWAS); Molecular gene expression of candidate genes and perturbed biochemical pathways in post-mortem tissue; Combined genetic-endophenotypic-PET imaging studies using receptor-specific ligands.

Laboratory Personnel 
* Shan Li

Publications:

Ghannoum MA, Okogbule-Wonodi I, Bhat N, Sanati H .Antifungal activity of voriconazole (UK-109,496), fluconazole and amphotericin B against hematogenous Candida krusei infection in neutropenic guinea pig model. J. Chemother.11(1):34-9, 1999.

Wonodi I, Stine OC, Mitchell BD, Buchanan RW and Thaker GK. Association Between Val108/158 Met polymorphism of the COMT Gene and Schizophrenia. American J. of Med. Genet.120B: 47-50, 2003.

Wonodi I, Adami H, Sherr J, Avila MT, Hong LE and Thaker GK. Naltrexone Treatment of Tardive Dyskinesia in Patients With Schizophrenia. J Clin Psychopharmacol. 24(4): 441-445, 2004.

Wonodi I, Adami HM, Cassady SL, Sherr JD, Avila MT, and Thaker GK. Ethnicity and the Course of Tardive Dyskinesia in outpatients presenting to the Motor Disorders Clinic at the Maryland Psychiatric Research Center. J Clin Psychopharmacol. 24: 592-598. 2004.

Thaker GK, Wonodi I, Avila MT, Hong LE, and Stine OC. Catechol-O-Methyltransferase Polymorphism and Eye Tracking in Schizophrenia: A Preliminary Report. The American Journal of Psychiatry, 161:2320-2333, 2004.

Wonodi I, Hong LE, Avila MT, Buchanan RW, Carpenter WT Jr, Stine OC, Mitchell BD, Thaker GK. Association between polymorphism of the SNAP29 gene promoter region and schizophrenia. Schizophr Res. 2005 May 19

Hong LE, Wonodi I, Avila MT, Buchanan RW, McMahon RP, Mitchell BD, Stine OC, Carpenter WT Jr, Thaker GK. Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 27

Hong LE, Tagamets M, Avila MT, Wonodi I, Holcomb H, Thaker GK: Specific motion processing pathway deficit during eye tracking in schizophrenia: a performance-matched fMRI study. Biol Psychiatry. 2005 Apr 1;57(7):726-32

Hong LE, Avila MT, Wonodi I, McMahon RP, Thaker GK. Reliability of a portable head-mounted eye tracking instrument for schizophrenia research. Behav Res Methods. 2005;37(1): 133–8.

Wonodi I, Cassady SL, Adami H, Avila MT, and Thaker GK. Effects of Repeated Amphetamine Administration on Antisaccades in Schizophrenia Spectrum Personality. Psychiatry Research, 2006 Mar 30;141(3):237-45.

Wonodi I, Hong LE, Thaker GK. Psychopathological and cognitive correlates of tardive dyskinesia in patients treated with neuroleptics. Adv Neurol. 2005;96:336-49. Review.

Avila MT, Robles O, Hong LE, Blaxton TA, Myers CS, Wonodi I, Gold J, Thaker GK: Deficits on the Continuous Performance Test (CPT) within the Schizophrenia Spectrum and the Mediating Effects of Family History of Schizophrenia. Journal of Abnormal Psychology, 2006 Nov;115(4):771-8.

Wonodi I, Mitchell BD, Stine OC, Hong LE, Elliott A, Kirkpatrick B, Carpenter WT Jr, Thaker GK, Buchanan RW. Lack of association between COMT gene and deficit/nondeficit schizophrenia. Behav Brain Funct. 2006 Dec 15;2:42.

Hong LE, Summerfelt A, Wonodi I, Adami H, Buchanan RW, Thaker GK. Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval. Am J Psychiatry. 2007 Jan;164(1):61-5.

Wonodi I, Reeves G, Carmichael D, Verovsky I, Avila M, Elliott A, Hong LE, Adami HM, Thaker GK. Tardive Dyskinesia in Children treated with Atypical Antipsychotic Medications. Mov Disord. 2007 Sep 15;22(12):1777-82.

Hong LE, Wonodi I, Mitchell BD, Stine OC & Thaker GK. Evidence of Missense Mutations on the Neuregulin 1 Gene Affecting Function of Prepulse Inhibition. Biol Psychiatry. 2008 Jan 1;63(1):17-23.

Hong LE, Turano KA, O'neill H, Hao L, Wonodi I, McMahon RP, Elliott A, Thaker GK. Refining the Predictive Pursuit Endophenotype in Schizophrenia. Biol Psychiatry. 2008 Mar 1;63(5):458-64.

Hong LE, Wonodi I, Lewis J, Thaker GK. Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients. Neuropsychopharmacology. 2008 Aug; 33(9): 2167-74.

Wonodi I, Hong LE, Stine OC, Mitchell BD, Elliott A, Roberts RC, Conley RR, McMahon RP, Thaker GK. Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 13. [Epub ahead of print]

Hong LE, Summerfelt A, Mitchell BD, McMahon RP, Wonodi I, Buchanan RW, Thaker GK. Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate. Arch Gen Psychiatry 2008 Sep;65(9):1008-16.

Hong LE, Turano KA, O'Neill HB, Hao L, Wonodi I, McMahon RP and Thaker GK. Is Motion Perception Deficit in Schizophrenia a Consequence of Eyetracking Abnormality? Biological Psychiatry, 2008 Dec 1. [Epub ahead of print]

Sathyasaikumar,K.V., Stachowski,E.K., Wonodi,I., Roberts,R.C., Rassoulpour,A., McMahon,R.P., Schwarcz,R. Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia. Schizophrenia Bulletin 2010 Oct 29. [Epub ahead of print]

Weiner E, Conley RR, Ball MP, Feldman S, Gold JM, Kelly DL, Wonodi I, McMahon RP, Buchanan RW. Adjunctive risperidone for partially responsive people with schizophrenia treated with clozapine. Neuropsychopharmacology. 2010 Oct;35(11):2274-83. Epub 2010 Jul 21.

Wonodi I, Schwarcz R. Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia.
Schizophrenia Bulletin 2010 Mar:36(2):211-8. Epub 2010 Feb 10.