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Ikwunga Wonodi
M.B.B.S.
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| Academic Title:
Associate Professor |
| Primary Appointment:
Psychiatry |
| Additional Title(s):
Program in Human Genetics and Genomic Medicine |
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iwonodi@mprc.umaryland.edu |
| Location:
MPRC - Tawes, P.O. Box 21247,
Baltimore, MD 21228 |
| Phone:
(410) 402-6820 |
| Fax:
(410) 402-6023 |
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Personal History
1986: Bachelor of Science in Comparative Anatomy, College of Health Sciences, University of Port Harcourt, Nigeria
1989: Medicine (M.B.B.S), College of Health Sciences, University of Port Harcourt, Nigeria
1997 – 2003: Research Track Residency Training and Post-doctoral Fellowship
2003 – Present: Faculty, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine
Research Interests
Neurogenetics and genomics: Endophenotype-based candidate gene association studies in schizophrenia. Gene expression studies in post-mortem cortical tissue, and in animal models of neuropsychiatric diseases. Pharmacogenomics.
Medication-induced motor disorders: Identification, prevention, and management of antipsychotic-induced motor disorders, consultation and application of novel treatment strategies.
Combined genetic and Positron Emission Tomography (PET) imaging studies: Current interests in sequence variations that affect dopamine-related candidate receptor gene association with endophenotypes in clinical samples, expression in post-mortem cortical tissue, and receptor density in clinical samples using receptor-specific radioligand.
Pharmacological probe studies and experimental therapeutics: Using novel compounds to treat neurocognitive deficits related to poor functional outcome in schizophrenia. Current interests in improving social and emotional cognition in schizophrenia by modulation of oxytocin receptors, and treatment of positive and negative symptoms with an adenosinergic agent.
Lab Techniques and Equipment
Prism 7900HT Fast Sequence Detection System and ancillary equipments; Microarray platforms; Genome Wide Association Studies (GWAS); Molecular gene expression of candidate genes and perturbed biochemical pathways in post-mortem tissue; Combined genetic-endophenotypic-PET imaging studies using receptor-specific ligands.
Laboratory Personnel
* Shan Li
Publications
Thaker GK, Wonodi I, Avila MT, Hong LE, Stine OC. Catechol-O-Methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary report. Am J Psychiatry. 2004 Dec;161(12):2320-2.
Wonodi I, Adami HM, Sherr J, Avila MT, Hong LE, Thaker GK. Naltrexone treatment of tardive dyskinesia in patients with schizophrenia. J Clin Psychopharmacol. 2004 Aug;24(4):441-5.
Hong LE, Tagamets M, Avila MT, Wonodi I, Holcomb H, Thaker GK: Evidence of specific motion processing pathway deficit during pursuit eye movement in schizophrenia: a performance-matched fMRI study. Biol Psychiatry. 2005;57:726.
Wonodi I, Hong LE, Thaker GK. Psychopathological and cognitive correlates of tardive dyskinesia in patients treated with neuroleptics. Adv Neurol. 2005;96:336-49.
Wonodi I, Hong LE, Avila MT, Buchanan RW, Carpenter WT Jr., Stine OC, Mitchell BD & Thaker GK. Association between Polymorphism of the SNAP29 Gene Promoter Region and Schizophrenia. Schizophr Res. 2005 15;78:339-41
Wonodi I, Reeves G, Carmichael D, Verovsky I, Avila MT, Elliott A, Hong LE, Adami HM, Thaker GK. Tardive dyskinesia in children treated with atypical antipsychotic medications. Mov Disord. 2007 Sep 15;22(12):1777-82
Wonodi I, Mitchell BD, Stine OC, Hong LE, Elliott A, Kirkpatrick B, Carpenter WT Jr, Thaker GK, Buchanan RW. Lack of association between COMT gene and deficit/nondeficit schizophrenia. Behav Brain Funct. 2006 Dec 15;2:42.
Hong LE, Wonodi I, Stine OC, Mitchell BD, Thaker GK. Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biol Psychiatry. 2008 Jan 1;63(1):17-23.
Hong LE, Wonodi I, Lewis J, Thaker GK. Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients. Neuropsychopharmacology. 2008 Aug;33(9):2167-74.
Wonodi I, Hong LE, Stine OC, Mitchell BD, Elliott A, Roberts RC, Conley RR, McMahon RP, Thaker GK. Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):282-9.
Wonodi I, Hong LE, Thaker GK. Molecular Psychiatry. In: The Year in Schizophrenia 2nd edition. Edited by Thaker GK and Carpenter WT. Atlas Medical Publishing, Ltd, 2008
Wonodi I, Adami HM, Cassady SL, Sherr JD, Avila MT, Thaker GK. Ethnicity and the course of tardive dyskinesia in outpatients presenting to the motor disorders clinic at the Maryland psychiatric research center. J Clin Psychopharmacol. 2004 Dec;24(6):592-8.
Wonodi I, Cassady SL, Adami H, Avila M, Thaker GK. Effects of repeated amphetamine administration on antisaccade in schizophrenia spectrum personality. Psychiatry Res. 2006 Mar 30;141(3):237-45.
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