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Yun Qiu
Ph.D.
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| Academic Title:
Associate Professor |
| Primary Appointment:
Pharmacology and Experimental Therapeutics |
| Secondary Appointments:
Pathology |
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yqiu@som.umaryland.edu |
| Location:
BRB
4-002 |
| Phone:
(410) 706-4535 |
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Research Interests
The overall theme of research in my laboratory is to study signal transduction within eukaryotic cells. We are particularly interested in elucidating the functions of several protein kinases which are believed to serve as the intracellular signaling integrators. Studying the mechanisms by which these kinases regulate their downstream signaling effectors in cancer models will allow us to design new effective drugs against cancer in the future.
Lab Techniques and Equipment
Techniques: Cell culture and transfection; Molecular cloning and site mutagenesis; PCR, Immunoprecipitation and Western blot; Immunocytochemistry; Transgenic mice; In vivo tumor models; Yeast two-hybrid; Microarrays.
Training History:
• Ph.D., Rutgers University, 1995
• Postdoc, Case Western Reserve University School of Medicine, 1995-1997
Recent Trainees:
Postdoctoral Trainees
Riyan Chen, Ph.D.,(1999-2001), Research Associate, McGill University, Canada
Jianbo Yang, MD., Ph.D., (2000-2002), Research Associate, University of Minnesota
Oekyung Kim, Ph.D.,(2000-2002), Assistant Professor, Pohang University of Science & Technology, Korea
Tianyun Jiang, MD. Ph.D., 2002-present
Ying-qiu Xie, Ph.D., 2002-present
Zhiyong Guo, MD., Ph.D., 2003-present
Bojie Dai, Ph.D., 2003-present
Predoctoral Trainees
Miyoung Kang, MS
Issa Neshiewat, MS
Kexin Xu, BS
Publications
• Qiu, Y., Ravi, L. and Kung, H-J. 1998. Requirement of erbB2 for activation of MAP kinase by Interleukin-6 in Prostate Cancer cells. Nature, 393: 83-85.
• Qiu, Y., Robinson, D., Pretlow, T. and Kung, H-J. 1998. Etk, a tyrosine kinase with a PH domain, is an effector of PI3 Kinase and involved in IL6 induced neuroendocrine differentiation of prostate cancer cells. Proc. Natl. Acad. Sci., 95: 3644-3649.
• Chen, R., Kim, O., Li, M., Xiong, X., Guan, J-L., Kung, H-J., Chen, H., Shimizu, Y. and Qiu, Y. 2001. Regulation of the PH-domain-containing tyrosine kinase Etk by Focal Adhesion Kinase through the FERM Domain. Nature Cell Biology, 3: 439-444.
• Jiang, T., Guo, Z., Dai, B., Kang, M., Ann, D. K., Kung, H-J. and Qiu, Y. 2004. Bi-directional Regulation between Tyrosine Kinase Etk/BMX and Tumor Suppressor p53 in Response to DNA Damage. J. Biol. Chem., 279: 50181 - 50189.
• Xie, Y., Xu, K., Dai, B., Guo, Z., Jiang, T., Chen, H. and Qiu, Y. 2006. The 44 kd Pim-1 Kinase Directly Interacts with Tyrosine Kinase Etk/BMX and Protects Human Prostate Cancer Cells from Apoptosis Induced by Chemotherapeutic Drugs. Oncogene 25, 70-78.
• Dai, B., Kim, O., Xie, Y., Guo, Z., Xu, K., Kong, X., Melamed, J., Chen, H., Bieberich, C.J., Borowsky, A.D., Kung, HJ, Wei, G., Ostrowski, M.C., Brodie, A., and Qiu, Y. 2006. Tyrosine Kinase Etk/Bmx Is Upregulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse. Cancer Research 66: 8058-8064.
• Guo, Z., Dai, B., Jiang, T., Xu, K., Xie, Y., Kim, O., Nesheiwat, I., Kong, X., Melamed, J., Handratta, V.D., Njar, V.C.O., Brodie, A.M.H., Yu, LR, Veenstra,T.D., Chen, H., and Qiu, Y. 2006. Regulation of the Androgen Receptor by Tyrosine Phosphorylation. Cancer Cell, in press.
Faculty members:
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