William F. Regine, M.D. is the Isadore and Fannie Schneider Foxman Chairman and Professor of Radiation Oncology at the University of Maryland, ranked top 5 in the country in published NIH rankings for research funding profile. Dr. Regine obtained his training at Thomas Jefferson University Hospital in Philadelphia where he also completed a Radiation Oncology Fellowship in Gastrointestinal and Head and Neck malignancies. Dr. Regine is considered a National and International expert in the area of GI and CNS malignancies, as well as in the use of Stereotactic Radiosurgery (SRS). His first faculty appointment was at St. Jude’s Children’s Cancer Research Hospital where as a Clinical Investigator he helped redefine new standards of care in children with rhabdomyosarcomas and in developing a pediatric SRS program. After 2 years at St. Jude he dedicated his career to clinical research in adult cancer patients. He has since served as Principal Investigator or Co-Principal Investigator in at least 4 national NCI sponsored cooperative group clinical trials (Radiation Therapy Oncology Group [RTOG] protocol 97-04,RTOG Protocol BR-0018, RTOG Protocol BR-0013, RTOG Protocol 08-48). He is a member of the GI and CNS Tumor steering committees for the RTOG and is the Chairman of the GI section of the National Oral Board examination for trainees in Radiation Oncology.
Dr. Regine served as the Principal Investigator of RTOG 9704 study evaluating adjuvant therapy in patients with pancreatic cancer published in the Journal of the American Medical Association in 2008 and the Annals of Surgical Oncology 2011(Regine). This study defined a new standard of care for patients with pancreatic cancer. He has also been the Radiation Oncology Principal Investigator/Study Chairman for 2 Institutional clinical trials published in JAMA (Patchell) and the Lancet (Patchell) which defined new standards of care for patients with brain metastases and malignant spinal cord compression. He is co-Editor of “Principles and Practices of Stereotactic Radiosurgery”, the first comprehensive textbook of its kind. More recently, Dr. Regine published the benefits of advanced imaging and treatment delivery (Yovino-2012) techniques in pancreatic cancer which are the basis for the current accruing RTOG Protocol 0848 for which Dr. Regine is a Study Chairman. Dr. Regine is also co-inventor of the first of its kind treatment device completely dedicated to the stereotactic radiation treatment of early stage breast cancer known as the GammaPod.
Dr. Regine's research interests include the study and treatment of pancreas/gastrointestinal cancers, brain metastases/ tumors and head and neck cancers. He is also Nationally recognized for his expertise in Stereotactic Radiosurgery (SRS).
Gastrointestinal Malignancies, Pancreatic cancer, Central Nervous System malignancies, Brain metastases, Head and Neck cancers, Stereotactic Body Radiation Therapy (SBRT), Stereotactic Radiosurgery (SBRT), Gamma Knife Radiosurgery and Proton Therapy.
Current Investigational Studies:
A Phase III Postoperative Adjuvant Therapy with Gemcitabine vs. Gemcitabine and Irradiation Following Pancreaticoduodenectomy for Pancreatic Adenocarcinoma Resected with Curative Intent. RTOG Protocol #0848 [Study Co-Chairman]