Dr. Regine received his medical degree from the State University of New York Health Science Center at Syracuse and served his residency at Thomas Jefferson University Hospital in Philadelphia. He was also a fellow in the Department of Radiation Oncology at Thomas Jefferson and at the University of Florida. From 1992 to 1994, Dr. Regine was assistant professor of radiation oncology at the University of Tennessee and served as the acting clinical chief of radiation oncology. Dr. Regine came to the University of Maryland from the University of Kentucky, where he was professor of radiation medicine and neurosurgery and vice chairman of the Department of Radiation Medicine. He was co-director of the gamma knife radiosurgery program and the former associate director for clinical research at the Markey Cancer Center at the University of Kentucky.
Research InterestsDr. Regine's research interests include the study and treatment of pancreas/gastrointestinal cancers, brain tumors and head and neck cancers. He is also Nationally recognized for his expertise in Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiation Therapy (SBRT).
Clinical SpecialityGastrointestinal Malignancies, Pancreatic cancer, Central Nervous System malignancies, Stereotactic Body Radiation Therapy (SBRT) Stereotactic Radiosurgery (SRS) and gamma knife radiosurgery.
Current Investigational Studies:
A feasibility study of neurocognitive evaluation in patients treated for brain metastases. RTOG Protocol #BR-0018 [ Principal Investigator/Study Chairman ] – Activated
A Phase II trial of conventional radiation therapy followed by intratumoral bleomycin delivered using a refillable, sustained release device (IND# 46,592) for the treatment of supratentorial glioblastoma. RTOG Protocol #BR-0013 [ Study Co-Chairman ] - Activated
A Phase I/II Postoperative Adjuvant Therapy with Gemcitabine and Gemcitabine and Irradiation Following Pancreaticoduodenectomy for Pancreatic Adenocarcinoma Resected with Curative Intent. RTOG Protocol #0414 [Study Co-Chairman]
Books and ChaptersKwok Y, Patchell RA, Regine WF. Palliation of Brain and Spinal Cord Metastases. In: Principles & Practice of Radiation Oncology, 5th Edition, Lippincott, Williams and Wilkins Publishing. 2008;1974-1985.
Suh JH, Barnett GH, Regine WF. Stereotactic Radiosurgery for Brain Metastases. In: Chin LC, Regine WF eds. Principles & Practice of Stereotactic Radiosurgery. Springer Publishing. 2008; 181-191.
Patchell RA, Regine WF. Whole Brain Radiation Therapy for Brain Metastases. In: Chin LC, Regine WF, eds. Principles & Practice of Stereotactic Radiosurgery. Springer Publishing 2008; 201-206.
Chin LS, Regine WF. Editors. Principles and Practice of Radiation Oncology, Springer Publishing, April, 2008.
Pandya N, Garofalo MC, Regine WF. The Case for Adjuvant Chemoradiation Therapy for Pancreatic Cancer. In: Handbook of Pancreatic Cancer. Abbruzzese J, Buchler M, Neoptolemos J, Urrutia R, eds(In Press).
Garofalo MC, Regine WF. Adjuvant Chemoradiation for Pancreatic Cancer: Past, Present, and Future. In: M.D. Anderson Solid Tumor Oncology Series. Pancreatic Cancer. Lowy, Leach, Philip, eds. 2008; 535-548.
Cohen AM, Garofalo MC, DeSimone PA, Hanna NN, Regine WF. Cancer of the Rectum. In: Clinical Oncology 4th Edition. Abeloff M, Armitage JO, Neiderhuber JE, Kastan MB, McKenna WG, eds. Churchill Livingstone, 2008; 1535-1556.
Yovino S, Kwok Y, Regine WF. Brain and Cranial Nerves. In: Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. (Springer-Verlag, 2010).
Kwok Y, Patchell RA, Regine WF. Management of Overt Central Nervous System Metastases: Brain and Spinal Cord. In: Principles and Practice of Lung Cancer, Fourth Edition. Pass, HI, Carbone DP, Johnson DH, Minna JD, Scagliotti GV, Turris III AT, eds. Lippincott Williams & Wilkins, 2010; 911-926.
Selected Recent Journal Articles
Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. The Proliferation of Primary Cancer Caregiving Stress to Secondary Stress. Cancer Nursing 31 (2): 1-8, 2008.
Balcer-Kubiczek EK, Attarpourl M, Wang Jiang Z, Regine WF. The Effect of Docetaxel (Taxotere®) on Human Gastric Cancer Cancer Cells Exhibiting Low-dose Radiation Hypersensitivity. Clinical Medicine: Oncology (2): 1-11, 2008.
Regine WF, Winter KA, Abrams RA, Safran H, Hoffman JP, Konski A, Benson AB, Macdonald JS, Kudrimoty MR, Fromm ML, Haddock MG, Schaefer P, Willett C, Rich TA. Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-based Chemoradiation Following Resection of Pancreatic Adenocarcinoma: A Randomized Controlled Trial [published correction appears in JAMA. 2008;299(18):JCX80010]. JAMA. 2008;299(9):1019-1026.
Flannery TW, Suntharalingam M, Regine WF, Chin LS, Krasna MJ, Shehata MK, Edelman MJ, Kremer M, Patchell RA, Kwok Y. Long-Term Survival in Patients with Synchronous, Solitary Brain metastasis from Non-Small-Cell Lung Cancer Treated with Radiosurgery. Int. Journal Radiation Oncology Biol. Phys. 72 (1): 19-23, 2008.
Berger AC, Garcia M, Hoffman JP, Regine WF, Abrams RA, Safran H, Konski A, Benson AB, MacDonald J, Willett C. Postresection CA 19-9 Predicts Overall Survival in Patients with Pancreatic Cancer Treated with Adjuvant Chemoradiation: A Prospective Validation by RTOG 9704. Journal of Clinical Oncology 26 (36): 5918-5922, December 2008.
Farrell, J, Regine WF, et.al. Human Equilibrative Nucleoside Transporter 1 Levels Predice Response to Gemcitabine in Patients with Pancreatic Cancer. Gastroenterology, 136(1): 187-95, January, 2009.
Dhople A, Adams JR, Maggio WW, Naqvi S, Regine WF, Kwok Y. Long Term Outcomes of Gamma- Knife Radiosurgery for Classic Trigeminal Neuralgia: Implications of Treatment and Critical Review of the Literature. Journal of Neurosurgery, March 2009.
Berlin J, Hoffman J, Regine WF. Editorial: Combined Modality Treatment of Resectable and Borderline Resectable Pancreas Cancer: Expert Consensus Statement. Annals of Surgical Oncology (16):1757-1759, April, 2009.
Crane CH, Winter K, Regine WF, Safran H, Rich TA, Curran WJ, Willett CG. Phase II Study of Bevacizumab with Concurrent Capecitabine and Radiation Followed by Maintenance Gemcitabine and Bevacizumab for Locally Advanced Pancreatic Cancer: RTOG 0411. Journal of Clinical Oncology 27 (25): 4089-4095, September, 2009.