Dr. Scharf is Professor of Medicine at the University of Maryland. Throughout his career he has maintained a wide variety of laboratory and clinical interests. He is widely known for his work in heart-lung interactions and large-scale clinical trials in obstructive airway disease. The latter includes a leading role in the National Emphysema Treatment Trial for lung volume reduction surgery, Feasibility of Retinoids in the Treatment of Emphysema and Asthma Clinical Research Center network of the ALA. He is PI on the recently funded University of Maryland COPD Clinical Research Center Site for the NIH COPD Clinical Research Network. He is also Co-PI of the Mid-Atlantic Consortium for the NIH funded Long-Term Oxygen Treatment Trial.
Dr. Scharf has maintained a research and clinical interest in sleep disorders, especially sleep-disordered breathing. He founded the University of Maryland Sleep Disorders Center as a multi-disciplinary resource for the management of a variety of sleep disorders. This center manages a referral clinic, a sleep laboratory, and educational program in sleep medicine and has embarked on several clinical and laboratory studies, some in collaboration with other departments.
Research studies have used an animal model of sleep apnea to demonstrate oxidative stress and deterioration of myocardial function. We are currently investigating the source of reactive oxygen species and the possible role of antioxidants in preventing myocardial damage in this model.
Chronic Obstructive Pulmonary Disease (COPD), Sleep Apnea, Oxidant Stress
Pulmonary medicine, Critical Care, Sleep Disorders
Lab Techniques and Equipment
Chronic intermittent hypoxia, oxidative stress
Education & Experience:
- A.B., University of Rochester
- M.D., Johns Hopkins
- Ph.D., Johns Hopkins University School of Public Health
- 1973 - 1975: Medical House Officer, Internal Medicine, Peter Bent Brigham Hospital, Boston, MA
- 1975 - 1978: Pulmonary Diseases Fellowship, Peter Bent Brigham Hospital, Boston, MA
- 1978-1979: Instructor in Medicine, Harvard Medical School, Boston, MA
- Assistant Professor of Medicine, Harvard Medical School, Boston, MA
- 1980-1984: Senior Lecturer in Medicine, Ben-Gurion University of the Negev, Faculty of Health Sciences, Beersheba, Israel
- 1984-1988: Assistant Professor of Medicine, Harvard Medical School, Boston, MA
- 1989-1995: Associate Professor of Medicine, Albert Einstein College of Medicine, Bronx, NY
- 1996-2002: Professor of Medicine, Albert Einstein College of Medicine
- 2002-present: Professor of Medicine, University of Maryland, School of Medicine, and Medical Director, Sleep Disorders Center, University of Maryland Medical Center
Selected Publications From the Last Three Years
Scharf SM, Seiden L, DeMore J, Carter-Pokras O. Racial differences in clinical presentation of patients with sleep disordered breathing. Sleep and Breathing 2004; 8: 173-183.
Scharf SM, DeMore J, Landau T, Smale P. Comparison of Primary Care Practitioners and sleep specialists in the treatment of obstructive sleep apnea. Sleep and Breathing 2004; 8: 111 - 124.
Scharf SM, Tubman A, Smale P. Prevalence of Concomitant Sleep Disorders in Patients with Obstructive Sleep Apnea. Sleep and Breathing 2005; 9: 50-56. An editorial on this paper was published in the same issue.
Chen L, Einbinder E, Zhang Q, Hasday J, Balke WC, Scharf SM. Oxidative Stress and Left Ventricular Function with chronic intermittent hypoxia in rats. Am J Resp Crit Care Med 2005; 172: 915-920.
Finkelstein J, Shaya FT, Arora M, Joshi A, Samant N, Scharf SM. Automated Survey collector (ASC): A Universal Platform for Interactive Collection of Clinical Data. J Systemics, Cybernetics and Informatics 2006; Vol 3 (1). Online journal.
Roth MD, Connett JE, D'Armiento JM, Foronjy Rf, Friedman PJ, Goldin JG, Louis TA, Mao JT, Muindi JR, O'Connor GT, Ransdell JW, Ries AL, Scharf SM, Schluger NW, Sciurba FC, Skeans MA, Walter RE, Wendt CH, Wise RA. Feasibility of Retinoids for the Treatment of Emphysema (FORTE) Study. CHEST 2006; 130: 1334-1345.
Shaya FT, El Khoury AC, Samant ND, Scharf SM. Utilization of Health Care Resources in a high-risk Medicaid population with chronic obstructive pulmonary disease. P&T 2006; 31: 261-268. (online journal)
Shaya FT, Samant ND, Pradel FG, Mullins CD, Scharf SM, Britt EJ. Health-related quality of life as potential predictor in COPD patients. Expert Review of Pharmacoeconomics & Outcomes Research, April 2007; 7: 129-135.
Welch K, Scharf SM. Construct Validity for the Health Utilities Index in a Sleep Center. Sleep and Breathing 2007, in press.
Witting MD, Scharf SM. Diagnostic Room-Air Pulse Oximetry: Effects of Smoking, Race, and Gender. Am J Emerg Med 2007, in press.
Criner GJ , Scharf SM, Falk JA, Gaughan JP, Sternberg AL, Namrata PB, Fessler HE, Minai OA, Fishman AP. Effect of Lung Volume Reduction Surgery on Resting Pulmonary Hemodynamics in Severe Emphysema. Am J Resp Crit Care Med 2007, in press.
Fisher M, Criner GJ, Fishman AF, Hassoun PM, Minai OA, Scharf SM and Fessler HE. Estimating Pulmonary Artery Pressures by Echocardiography in Patients with Emphysema. European Respiratory Journal 2007, in press.
Falk J, Martin UJ, Scharf SM, Criner CJ. Lung Elastic Recoil Does Not Correlate with Pulmonary Hemodynamics in Severe Emphysema. Chest 2007; in press.
Lesage S, Scharf SM. Sleep! Beyond the usual suspects. J Gerontology 2007; 62:53 - 54.
Williams A, Scharf SM: Obstructive Sleep Apnea, Cardiovascular Disease, and Inflammation -- Is NF-kB the key? Sleep and Breathing 2007; 11: 69-76.
King DA, Cordova F, Scharf SM. Nutritional Aspects of COPD. Proc Am Thor Soc, in press.
Fessler HE, Scharf SM, Ingenito EP, McKenna RJ, Sharafkhaneh A. Physiologic basis for improved pulmonary function after lung volume reduction. Proc Am Thor Soc, in press.
Krachman S, Minai O, Scharf SM. Sleep abnormalities and Treatment in Emphysema. Proc Am Thor Soc, in press.