- 1986: Graduated from Sun Yat-Sen University of Medical Sciences, Guangzhou, China
- 2003 - present: Faculty, Maryland Psychiatric Research Center (MPRC), Department of Psychiatry, University of Maryland School of Medicine
- Director, UM Center for Brain Imaging Research
- Director, First Episode Psychosis Clinic, MPRC
- Chief, Neuroimaging Research Program (NRP), MPRC
- Neurophysiology: Current interests on brain electral oscillations as biomarkers for genetic and translational studies. Eye movement and motion perception behavioral and imaging studies.
- Functional MRI: Current interests in fMRI of schizophrenia, nicotine addiction, and as clinical trial end-point measures.
- Genetic study: Association studies with clinical endophenotypes and in post-mortem tissue gene expression.
- Clinical trials of novel compounds for treating schizophrenia core biological deficits. Current interest in nicotinic and GABAergic receptor agents.
Lab Techniques and Equipment:
fMRI, 64-channel ERP, state-of-the-art eyetracking and motion percpetion equipments, eyetracking in MRI, PPI, rTMS, bistimTMS
Hong LE, Avila MT, Adami HM, Elliot A, Thaker GK. Components of the smooth pursuit function in deficit and non-deficit schizophrenia. Schizophr Res. 2003 Sep 1;63(1-2):39-48.
Hong LE, Avila MT, Thaker GK. Schizophrenia IV: defining the neurobiology of risk factors. Am J Psychiatry. 2003 Nov;160(11):1929.
Thaker GK, Avila MT, Hong LE, Medoff DR, Ross DE, Adami HM. A model of smooth pursuit eye movement deficit associated with the schizophrenia phenotype. Psychophysiology. 2003 Mar;40(2):277-84.
Avila MT, Sherr JD, Hong LE, Myers CS, Thaker GK. Effects of nicotine on leading saccades during smooth pursuit eye movements in smokers and nonsmokers with schizophrenia. Neuropsychopharmacology. 2003 Dec;28(12):2184-91.
Hong LE, Summerfelt A, McMahon RP, Adami H, Francis G, Elliott A, Buchanan RW, Thaker GK. Evoked Gamma Band Synchronization and the Liability for Schizophrenia. Schizophr Res. 2004 Oct 1;70(2-3):293-302.
Hong LE, Summerfelt A, McMahon RP, Thaker GK, Buchanan RW. Gamma / beta oscillation and sensory gating deficit in schizophrenia. NeuroReport 2004;15(1):155-164
Thaker GK, Wonodi I, Avila MT, Hong LE, Stine OC. Catechol-O-Methyltransferase polymorphism and eye tracking in schizophrenia: a preliminary report. Am J Psychiatry. 2004 Dec;161(12):2320-2.
Wonodi I, Adami HM, Sherr J, Avila MT, Hong LE, Thaker GK. Naltrexone treatment of tardive dyskinesia in patients with schizophrenia. J Clin Psychopharmacol. 2004 Aug;24(4):441-5.
Hong LE, Wonodi I, Avila MT, Buchanan RW, McMahon RP, Mitchell BD, Stine OC, Carpenter Jr. WT, Thaker GK. Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136(1):8-11.
Hong LE, Avila MT, Wonodi I, McMahon RP, Thaker GK. Reliability of a portable head-mounted eye tracking instrument for schizophrenia research. Behav Res Methods. 2005;37(1): 133-8.
Hong LE, Avila MT, Thaker GK. Response to unexpected target changes during sustained visual tracking in schizophrenic patients. Exp Brain Res. 2005 Aug;165(1):125-31.
Hong LE, Tagamets M, Avila MT, Wonodi I, Holcomb H, Thaker GK: Evidence of specific motion processing pathway deficit during pursuit eye movement in schizophrenia: a performance-matched fMRI study. Biol Psychiatry. 2005;57:726.
Wonodi I, Hong LE, Thaker GK. Psychopathological and cognitive correlates of tardive dyskinesia in patients treated with neuroleptics. Adv Neurol. 2005;96:336-49.
Wonodi I, Hong LE, Avila MT, Buchanan RW, Carpenter WT Jr., Stine OC, Mitchell BD & Thaker GK. Association between Polymorphism of the SNAP29 Gene Promoter Region and Schizophrenia. Schizophr Res. 2005 15;78:339-41
Hong LE, Mitchell BD, Avila MT, McMahon RP, Adami H, Thaker GK. Familial aggregation of eye tracking endophenotypes in schizophrenia families. Arch Gen Psychiatry. 2006 Mar;63(3):259-64.
Avila MT, Hong LE, Moates A, Turano KA, Thaker GK. Role of anticipation in schizophrenia-related pursuit initiation deficits. J Neurophysiol. 2006 Feb;95(2):593-601.
Avila MT, Robles O, Hong LE, Blaxton TA, Meyers C, Wonodi I, Gold J, Thaker GK. Attention and working memory performance across the schizophrenia spectrum and the mediating effects of familial risk. J Abnorm Psychol. 2006 Nov;115(4):771-8.
Wonodi I, Mitchell BD, Stine OC, Hong LE, Elliott A, Kirkpatrick B, Carpenter WT Jr, Thaker GK, Buchanan RW. Lack of association between COMT gene and deficit/nondeficit schizophrenia. Behav Brain Funct. 2006 Dec 15;2:42.
Hong LE, Summerfelt A, Wonodi I, Adami H, Buchanan RW, Thaker GK. Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval. Am J Psychiatry. 2007;164(1):61-5.
Wonodi I, Reeves G, Carmichael D, Verovsky I, Avila MT, Elliott A, Hong LE, Adami HM, Thaker GK. Tardive dyskinesia in children treated with atypical antipsychotic medications. Mov Disord. 2007 Sep 15;22(12):1777-82
Hong LE, Wonodi I, Stine OC, Mitchell BD, Thaker GK Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biol Psychiatry. 2008 Jan 1;63(1):17-23.
Hong LE, Buchanan RW, Thaker GK, Shepard PD, Summerfelt A. Beta (~16Hz) frequency neural oscillations mediate auditory sensory gating in humans. Psychophysiology. 2008 Mar;45(2):197-204.
Hong LE, Turano KA, O'Neil H, Lei H, Wonodi I, McMahon RP, Elliott A, Thaker GK. Refining the predictive pursuit endophenotype in schizophrenia. Biol Psychiatry. 2008 Mar 1;63(5):458-64.
Hong LE, Wonodi I, Lewis J, Thaker GK. Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients. Neuropsychopharmacology. 2008 Aug;33(9):2167-74.
Hong LE, Summerfelt A, Mitchell BD, McMahon RP, Wonodi I, Buchanan RW, Thaker GK. Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate. Arch Gen Psychiatry. 2008 Sep;65(9):1008-16.
Wonodi I, Hong LE, Stine OC, Mitchell BD, Elliot A, Roberts RC, Conley RR, McMahon RP, Thaker GK. Dopamine Transporter Polymorphism Modulates Oculomotor Function and DAT1 mRNA Expression in Schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2009 150B(2):282-9.
Hong LE, Gu, H, Yang YH, Ross TJ, Salmeron BJ, Buchholz B, Thaker GK, Stein EA. Nicotine addiction and Nicotine’s actions are associated with separate cingulate cortex functional circuits. Arch Gen Psychiatry. 2009 66(4):431-41.
Hong LE, Turano KA, O’Neil H, Lei H, Wonodi I, McMahon RP, Thaker GK. Is motion perception deficit in schizophrenia a consequence of eyetracking abnormality? Biol Psychiatry. 2009 65(12):1079-85.
Hong LE, Summerfelt A, Buchanan RW, O'Donnell P, Thaker GK, Weiler MA, Lahti AC. Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine. Neuropsychopharmacology. 2010 Feb;35(3):632-40.
Hong, LE, Hodgkinson CA, Yang Y, Sampath H, Ross TJ, Buchholz B, Salmeron BJ, Srivastava V, Thaker GK, Goldman D, Stein EA. A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13509-14
Hong LE, Schroeder, M, Ross TJ, Buchholz B, Salmeron BJ, Wonodi I, Thaker GK, Stein EA. Nicotine enhances but does not normalize visual sustained attention and the associated brain network in schizophrenia. Schizophr Bull. 2011 Mar;37(2):416-25.
Zhang XC, Stein EA, Hong LE. Smoking and schizophrenia independently and additively reduce white matter integrity between striatum and frontal cortex. Biol Psychiatry. 2010 Oct 1;68(7):674-7.
Moran, LV, Hong, LE. High vs. low frequency neural oscillations in schizophrenia. Schizophr Bull. 2011 37(4):659-63.
Wonodi I, Stine OC, Sathyasaikumar KV, Roberts RC, Mitchell BD, Hong LE, Kajii Y, Thaker GK, Schwarcz R. Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Arch Gen Psychiatry. 2011 Jul;68(7):665-74
Hong, LE, Yang X, Wonodi I, Hodgkinson CA, Goldman D, Stine OC, Stein EA, Thaker GK. A CHRNA5 allele related to nicotine addiction and schizophrenia. Genes Brain Behav. 2011 Jul;10(5):530-5.
Kochunov P, Glahn DC, Nichols TE, Winkler AM, Hong LE, Holcomb HH, Stein JL, Thompson PM, Curran JE, Carless MA, Olvera RL, Johnson MP, Cole SA, Kochunov V, Kent J, Blangero J. Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain. Front Neurosci. 2011;5:120.
Hong, LE, Thaker GK, McMahon RP, Summerfelt A, RachBeisel J, Fuller RL, Wonodi I, Buchanan RW, Myers C, Heishman SJ, Yang X, Nye A. Moderate dose varenicline treatment on neurobiological and cognitive biomarkers in schizophrenia smokers and non-smokers. Arch Gen Psychiatry. 2011 Dec;68(12):1195-206.
Hong, LE, Summerfelt A, Mitchell BD, O’Donnell P, Thaker GK A shared low-frequency oscillatory rhythm abnormality in resting and sensory gating in schizophrenia. Clin Neurophysiology. 2012 Feb;123(2):285-92.
Hong, LE, Moran LV, Du X, O'Donnell P, Summerfelt A. Mismatch negativity and low frequency oscillations in schizophrenia families. Clin Neurophysiology. 2012 Apr 25. [Epub ahead of print]
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