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Leslie  I. Katzel

Leslie I. Katzel M.D., Ph.D.

Academic Title: Associate Professor
Primary Appointment: Medicine
Additional Title(s): Associate Director for Clinical of the Baltimore GRECC; Assistant Program Director University of Maryland GCRC
Location: Baltimore VA Medical Center, Room 4B-189
Phone: (410) 605-7248
Fax: (410) 605-7913

Research Interests:

Dr. Katzel's research examines the effect of candidate gene polymorphisms on the lipid and glucose metabolic and blood pressure response to exercise and weight loss interventions in older people. These collaborative studies are conducted with Drs. Hagberg, Ryan, Goldberg, and Shuldiner. Dr. Katzel  collaborates with Shari Waldstein, Ph.D. and Stephen Seliger, M.D. on studies that examine the effect of hypertension, insulin resistance syndrome, and chronic kidney disease on neurcognitive function and neurocognition. Dr. Katzel collaborates with Drs Kris Ann Oursler and Barbara Smith on the effects of exercise training on functional performance and metabolic function in older HIV-infected adults with the lipodystrophy syndrome. Dr. Katzel is also Core Director of the Clinical Physiology Core of the UMB Claude D. Pepper Older Americans Independence Center and collaborates with Drs. Ryan, Macko, Goldberg, and other Pepper Center Investigators on the effects of exercise training in hemiparetic stroke patients.

As Associate Director for Clinical of the Baltimore GRECC, Dr. Katzel oversees the GRECC Clinical Demonstration Projects.  Dr. Katzel attends on the general medical service at the Baltimore VA Medical Center and is director of the fourth year medical student clinical and research elective in geriatrics and gerontology, and director for the research elective in gerontology for medical housestaff. Dr. Katzel also plays an active role in mentoring geriatric medicine fellows, and is a co-investigator/mentor on two T32 training grants and the NIH K30.

Dr. Katzel is recognized for his contributions to the ethical oversight of research conducted at UMB. Dr. Katzel is a former chair and vice-chair of the UMB IRB and continues to serve on the IRB. As one of the Assistant Program Directors of the University of Maryland GCRC he works with Kathleen Palmer, the research subject advocate on protocol safety and data safety monitoring.  He lectures frequently on the ethical oversight of research and good clinical practice guidelines, and chairs several safety monitoring boards. At a national level, he serves as a consultant/site visitor for AAHRPP.


Most Recent Publications

Izquierdo-Porrera AM, Gardner AW, Bradham DD, Montgomery PS, Sorkin JD, Powell CC, Katzel LI. Relationship between objective measures of peripheral arterial disease severity to self-reported quality of life in older adults with intermittent claudication. J Vasc Surg 2005;41(4):625-630.

Waldstein SR, Katzel LI. Stress-Induced Blood Pressure Reactivity and Cognitive Function. Neurology 2005;64:1746-1749.

Macko RM, Forrester L, Katzel LI, Ivey F, Hanley D, Sorkin JD, Goldberg AP.  Treadmill Exercise Improves Ambulatory Function and Cardiovascular Fitness in Chronic Stroke Patients: A Randomized Controlled Trial. Stroke. 2005 Oct;36(10):2206-11. Epub 2005 Sep 8.

Joseph LO, Blumenthal J, Katzel LI, Goldberg AP. Exercise Training and Cardiovascular Health with Aging. Clinical Geriatrics 2005;13(4):40-46.

Waldstein SR, Pelletier Brown JR, Maier KJ, Katzel LI. Diagnosed Hypertension and High Blood Pressure Levels Negatively Affect Cognitive Function in Older Adults. Ann Behav Med 2005;29(3):174-180.

Brown JRP, Katzel LI, Neumann SA, Maier KJ, Waldstein SR. Silent myocardial ischemia and cardiovascular response to anger provocation in older adults. In press 2005.

Gardner AW, Montgomery PS, Flinn WR, Katzel LI. The effect of exercise intensity on the response to exercise rehabilitation in patients with intermittent claudication.. J Vasc Surg. 2005 Oct;42(4):702-9.

Waldstein SR, Katzel LI. Interactive relations of central versus total obesity and blood pressure to cognitive function. Int J Obes (Lond). 2005 Oct 4; [Epub ahead of print]

Neumann SA, Brown JRP, Waldstein SR, Katzel LI. Six-month walking program attenuates cardiovascular reactivity to mental stress in older adults with silent ischemia. In press Journal of Aging and Physical Activity 2005.

Gardner AW, Killewich LA, Flinn WR, Montgomery PS, Katzel LI.  The response to exercise rehabilitation in smoking and non-smoking patients with intermittent claudication. J Vasc Surg. 2004;39(3):531-8.

Waldstein SR, Katzel LI. Gender Differences in the Relation of Hypertension to Cognitive Function in Older Adults. Neurological Research 2004;26:502-506.

Waldstein, SR. Siegel EL, Lefkowitz D, Maier KJ, Brown JP, Obuchowski AB, Katzel LI Stress-Induced Blood Pressure Reactivity and Silent Cerebrovascular Disease. Stroke 2004;35:1294-1298.

Tankard CF, Waldstein SR, Siegel EL, Holder LE, Lefkowitz D, Anstett F, Katzel LI.  Cerebral blood flow and anxiety in older men:  An analysis of resting anterior asymmetry and prefrontal regions. Brain Cognition 2003;52:70-78.

Brendle DC, Joseph LJO, Sorkin JD, McNelly D, Katzel LI. Aging and marathon times in an 81 year old man who has competed in 591 marathons. Am J Cardiol 2003;91:1154-1156.

Waldstein SR, Tankard CF, Maier KJ, Pelletier R, Snow J, Gardner AW, Macko R, Katzel LI. Peripheral arterial disease and cognitive function. Psychosom Med. 2003;65(5):757-63.