Research InterestsDr. Yang is interested in the molecular and cellular biology of the regulation of energy metabolism. By high throughput sequencing of cDNA libraries from adipose tissue and bioinformatics, his research team has identified several novel adipose tissue specific genes such as omentin, serum amyloid A. His current research is to further characterize these novel adipokines and to define their relevance to energy metabolism and inflammation by studying their gene expression, regulation and their functions using a variety of approaches including real time PCR, microarray, genomics, proteomic, gene over-expression and gene silence in cultured cells and in transgenic or knockout mouse models.
Yang RZ, Blaileanu G, Hansen BC, Shuldiner AR, Gong DW. cDNA cloning, genomic structure, chromosomal mapping, and expression of a novel human alanine aminotransferase (ALT2). Genomics 2002 79:445-450
Yang RZ, Huang Q, Xu A, McLenithan JC, Eisen JA, Shuldiner AR, Alkan S, Gong DW. Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem Biophys Res Commun. 2003 301:927-935.
Jadhao SB, Yang RZ, Lin Q, Hu H, Anania FA, Shuldiner AR, Gong DW. Murine Alanine Aminotransferase: cDNA Cloning, Functional Expression, and Differential Gene Regulation in Fatty Liver. Hepatology. 2004 39:1297-1302.
You T, Yang R, Lyles MF, Gong D, Nicklas BJ.. Abdominal Adipose Tissue Cytokine Gene Expression: Relationship to Obesity and Metabolic Risk Factors. Am J Physiol Endocrinol Metab. 2005 288(4):E741-7
Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan J, Gong DW.Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 2006 Mar 10;
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