- Suzhou University School of Medicine, Bachelor of Medicine (M.D. equivalent)
- Zhejiang University School of Medicine, Master of Science
- Shanghai University School of Medicine, Ph.D.
I have a broad interest in the molecular and cellular mechanisms of endocrine and metabolism diseases. My current research focuses on the role of adipokines in the pathogenesis of obesity and its co-morbidities, such as type 2 diabetes and cardiovascular disease, and application of induced pluripotent stem (iPS) cells in research and treatment of endocrine and metabolic diseases.
We use functional genomics techniques and bioinformatics to identify novel genes important for adipose biology and energy metabolism in general. As a result, we have identified two new adipokines, omentin and serum amyloid A (SAA), in human adipose tissue. In addition, we are the first to clone the gene of alanine transaminase 2 (ALT2), which is not only a key enzyme in gluconeogenesis and but also potentially a new serum marker for liver damage.
We are establishing disease-specific or patient-specific iPS cells for disease mechanism study and cell-based therapy.
Lab Techniques and Equipment
We conduct studies at molecular, cellular, animal and human levels.
Yang, R.Z., Blaileanu, G., Hansen, B.C., Shuldiner, A.R. and Gong, D.W. (2002) cDNA cloning, genomic structure, chromosomal mapping, and expression of a novel human alanine aminotransferase (ALT2). Genomics 79:445-450
Yang, R.Z., Huang, Q., Xu, A., McLenithan, J.C., Eisen, J.A., Shuldiner, A.R., Alkan, S. and Gong, D.W. (2003) Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem Biophys Res Commun. 301:927-935.
Jadhao, S.B., Yang, R.Z., Lin, Q., Hu, H., Anania, F.A., Shuldiner, A.R. and Gong, D.W. (2004) Murine Alanine Aminotransferase: cDNA Cloning, Functional Expression, and Differential Gene Regulation in Fatty Liver. Hepatology. 39:1297-1302.
You, T., Yang, R., Lyles, M.F., Gong, D.W and Nicklas, B.J. (2005) Abdominal Adipose Tissue Cytokine Gene Expression: Relationship to Obesity and Metabolic Risk Factors. Am J Physiol Endocrinol Metab. 288(4):E741-7.
Yang, R.Z., Lee, M.J., Hu, H., Pray, J., Wu, H.B., Hansen, B.C., Shuldiner, A.R., Fried, S.K., McLenithan, J. and Gong, D.W. (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 290: E1253-E1261.
Yang, R-Z., Lee, M-J., Hu, H., Pollin, T.I., Ryan, A.S., Nicklas, B.J., Snitker, S., Horenstein, R.B., Hull, K., Goldberg, N.H., Goldberg, A.P., Shuldiner, A.R., Fried, S.K. and Gong, D.W. (2006). Acute-phase protein serum amyloid protein A (SAA) is a pro-inflammatory adipocytokine in humans. PLoS/Medicine 2006 Jun;3(6):e287.
Liu L, Zhong S, Yang R, Hu H, Yu D, Zhu D, Hua Z, Shuldiner AR, Goldstein R, Reagan WJ, Gong DW. 2008. Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells. Protein Expr Purif. 2008 60(2):225-31
Rong-Ze Yang, Soohyun Park, William J. Reagan, Rick Goldstein, Shao Zhong, Michael Lawton, Francis Rajamohan, Li Liu, and Da-Wei Gong. Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Hepatology, 2009 49(2):598-607.