Da-Wei Gong
M.D., Ph.D.
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| Academic Title:
Associate Professor |
| Primary Appointment:
Medicine |
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dgong@medicine.umaryland.edu |
| Location:
Howard Hall
Room 497 |
| Phone:
(410) 706-1672 |
| Fax:
(410) 706-1622 |
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Research Interests
I have a broad interest in the molecular and cellular mechanisms of endocrine and metabolism diseases. My current research focuses on the role of adipokines in the pathogenesis of obesity and its co-morbidities, such as type 2 diabetes and cardiovascular disease.
We use functional genomics techniques and bioinformatics to identify novel genes important for adipose biology and energy metabolism in general. As a result, we have identified two new adipokines, omentin and serum amyloid A (SAA), in human adipose tissue. In addition, we are the first to clone the gene of alanine transaminase 2 (ALT2), which is not only a key enzyme in gluconeogenesis and but also potentially a new serum marker for liver damage.
With my colleagues, we are taking approaches at the molecular, cellular, animal and human levels to tackle obesity and diabetes, the two major health problems in the nation.
Publications
View My Publications in Pub Med
HIGHLIGHTED PUBLICATIONS
Yang, R.Z., Blaileanu, G., Hansen, B.C., Shuldiner, A.R. and Gong, D.W. (2002) cDNA cloning, genomic structure, chromosomal mapping, and expression of a novel human alanine aminotransferase (ALT2). Genomics 79:445-450
Yang, R.Z., Huang, Q., Xu, A., McLenithan, J.C., Eisen, J.A., Shuldiner, A.R., Alkan, S. and Gong, D.W. (2003) Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem Biophys Res Commun. 301:927-935.
Jadhao, S.B., Yang, R.Z., Lin, Q., Hu, H., Anania, F.A., Shuldiner, A.R. and Gong, D.W. (2004) Murine Alanine Aminotransferase: cDNA Cloning, Functional Expression, and Differential Gene Regulation in Fatty Liver. Hepatology. 39:1297-1302.
You, T., Yang, R., Lyles, M.F., Gong, D.W and Nicklas, B.J. (2005) Abdominal Adipose Tissue Cytokine Gene Expression: Relationship to Obesity and Metabolic Risk Factors. Am J Physiol Endocrinol Metab. 288(4):E741-7.
Yang, R.Z., Lee, M.J., Hu, H., Pray, J., Wu, H.B., Hansen, B.C., Shuldiner, A.R., Fried, S.K., McLenithan, J. and Gong, D.W. (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 290: E1253-E1261.
Yang, R-Z., Lee, M-J., Hu, H., Pollin, T.I., Ryan, A.S., Nicklas, B.J., Snitker, S., Horenstein, R.B., Hull, K., Goldberg, N.H., Goldberg, A.P., Shuldiner, A.R., Fried, S.K. and Gong, D.W. (2006). Acute-phase protein serum amyloid protein A (SAA) is a pro-inflammatory adipocytokine in humans. PLoS/Medicine 2006 Jun;3(6):e287.
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