Nanette I. Steinle
Dr. Steinle is Associate Professor of Medicine, University of Maryland and Interim Chief, Diabetes and Endocrine Section, Baltimore Veterans Administration Medical Center. Dr. Steinle completed undergraduate training in nutrition and was credentialed as a Registered Dietician/Nutritionist prior to completing her medical degree. She completed an internal medicine residency and endocrinology fellowship at the University of Maryland Baltimore.
Dr. Steinle's major research interests are directed at understanding the molecular and genetic aspects of blood-pressure regulation, obesity, metabolic syndrome and eating behavior. She published the first genome-wide scan of eating behavior traits, demonstrating that eating behavior is heritable and that there may be specific genetic loci that regulate eating behavior. Currently she is studying candidate genes that may regulate eating behavior. Her work focuses on the study of genetic variation in taste receptor genes and their role in eating behavior, nutrient intake, diabetes and obesity. She is currently collaborating with investigators in UMB’s Institute for Genome Sciences to uncover mechanisms whereby dietary fiber impact gut micro-organisms and the downstream impact on host energy and glucose metabolism. Additionally, Dr. Steinle is involved in diabetes prevention research, and leads a diabetes prevention program at the Baltimore Veterans Administration Medical Center.
Dr. Steinle is also involved in teaching nutrition in the medical curriculum. She is co-course director of the medical student year 1 Cell and Molecular Biology course and directs an interprofessional clinical nutrition training experience for medical students and residents. She is PI of an NIDDK funded medical student summer research training program. She is Director of Enrichment of the Mid Atlantic Nutrition and Obesity Research Center.
- Genetics of complex disease
- Taste receptors and metabolic disorders
- Genetics of blood-pressure regulation
Lab Techniques and Equipment:
- Genome-wide association studies
Search My Publications in Pub Med
- Steinle N and Shuldiner A. The Old Order Amish, a unique model to study ageing. Journal of the British Menopause Society 2000; 6 (4); 127.
- Steinle N, Hsueh W-C, Snitker S, Mitchell BD, Pollin T, Sakul H, St.Jean PL, Bell CJ, Shuldiner AR. Genetics of eating behavior in the Amish: A Genome Wide Scan and Heritability Study. Am J Clin Nutr 2002;75:1098-1106.
- Pollin T, Hsueh W-C, Steinle N, Snitker S, Shuldiner A, Mitchell B. A genome-wide scan of lipid levels in the Old Order Amish. Atherosclerosis 2004; 173: 89-96.
- Steinle N, Kazlauskaite R, Imumorin I, Hsueh W-C, Pollin T, O’Connell J, Mitchell B, Shuldiner A. Variation in the Lamin A/C (LMNA) Gene: Associations with metabolic syndrome. Arterioscler Thromb Vasc Biol; 2004;24(9):1708-13. Epub 2004 Jun 17.
- Steinle N, Pollin T, O’Connell J, Mitchell B, Shuldiner A. Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish. JClin Endocrinol Metab. 2005;90(12):6672-7. Epub 2005 Oct 4.
- Patrick F McArdle, Sue Rutherford, Braxton D Mitchell, Coleen M Damcott, Ying Wang, Vasan Ramachandran, Sandra Ott, Yen-Pei C Chang, Daniel Levy and Nanette Steinle. Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study. BMC Medical Genetics 2008, 9:67 (14 Jul 2008)
- Cedrick D. Dotson, Lan Zhang, Hong Xu, Yu-Kyong Shin, Stephan Vigues, Sandra H. Ott, Amanda E. T. Elson, Hyun Jin Choi, Hillary Shaw, Josephine M. Egan, Braxton D. Mitchell, Xiaodong Li, Nanette I. Steinle and Steven D. Munger. Bitter taste receptors influence glucose homeostasis. PlosOne December 2008 Vol 3 Issue 12.
- Ying Wang, Patrick F. McArdle, James B. Wade, Sarah E. Dorff, Sanjiv Sha, Xiaolian Shi, Evadnie Rampersaud, Arohan R. Subramanya, Haiqing Shen, James D. Kim, Nanette I. Steinle, Carole C. Ober, Paul A. Welling, Aravinda Chakravarti, Alan B. Weder, Richard R. Cooper, Braxton D. Mitchell, Alan R. Shuldiner, and Yen-Pei C. Chang. Whole-genome association study in the Old Order Amish identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):226-31. Epub 2008 Dec 29.
- Cedrick D. Dotson, Hillary L. Shaw, Braxton D. Mitchell, Steven D. Munger, Nanette I. Steinle. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. Appetite. 2010 Feb;54(1):93-9.
- Cedrick D. Dotson, Stephan Vigues, Nanette I. Steinle, Steven D. Munger. T1R and T2R receptors: The modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitus. Current Opinion in Investigational Drugs 2010 11(4):447-454.
- E Grimm and N Steinle. Genetics of Eating Behavior: Established and Emerging Concepts. Nutrition Reviews. Nutr Rev. 2011 Jan;69(1):52-60.
- Charlene C. Quinn, Renee Royak-Schaler, Dan Lender, Nanette Steinle, Shahinaz Gadalla, Min Zhan. Patient understanding of Diabetes Self Management. Journal of Diabetes Science and Technology. May 2011, Volume 5, Issue 3: pages 723-730.
- Fox, ER, Young JH et al. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 1;20(11):2273-84.
- The International Consortium of Blood Pressure investigators. Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk. Nature. 2011 Sep 11;478(7367):103-9
- Christian Lachner, Nanette Steinle, and William Regenold. The Neuropsychiatry of Vitamin B12 Deficiency in the Elderly. Journal of Neuropsychiatry and Clinical Neurosciences 2012 Dec 1;24(1):5-15.
- Montasser ME, Douglas JA, Roy-Gagnon M-H, Van Hout CV, Weir MR, Vogel R, Parsa A, Steinle NI, Snitker S, Brereton HN, Chang YP, Shuldiner AR, Mitchell BD. Determinants of blood pressure response to low salt intake in a healthy adult population. J Clin Hyperten 2011 13(11):795-800.
- Patricia Sareh, MD; Mariaileen Sourwine, MD; Charmaine D. Rochester, PharmD; and Nanette I. Steinle, MD. Vitamin D and Calcium: Implications for healthy ageing. Clinical Geriatrics 2011 19(12): 29-34.
- Nicoleta Ionica, Mariaileen Sourwine, Charmaine D. Rochester, Nanette I. Steinle. Vitamin B12: Common Considerations in Maintaining Optimal Health in the Geriatric Patient. Clinical Geriatrics. 2012 20(1): 22-27.
- Kristen Hood Watson, Sruti Chandrasekran, Nanette I. Steinle. Popular Diets: Which Weight Loss Diet is best for Geriatric Patients? Clinical Geriatrics. 2012 20(2):25-31.
- Ellen Loreck, Roja Chimakurthi, Nanette Steinle. Nutritional Assessment of the Geriatric Patient: A comprehensive approach toward evaluating and managing nutritional health. Clinical Geriatrics. 2012 20(4): 20-26.
- Margaret L Zupancic, Brandi L Cantarel, Zhenqiu Liu, Elliott F Drabek, Kathleen A Ryan, Shana Cirimotich, Cheron Jones, Rob Knight, William A Walters, Daniel Knights, Emmanuel F Mongodin, Richard B Horenstein, Braxton D Mitchell, Nanette Steinle, Soren Snitker, Alan R Shuldiner, Claire M Fraser. Analysis of the gut microbiota in the old order amish and its relation to the metabolic syndrome. PLoS One. 2012;7(8):e43052. Epub 2012 Aug 15.
- Shawn Dotson, Jennifer Babich, Nanette Steinle. Genetic Predisposition and Taste Preference: Impact on Food Intake and Risk of Chronic Disease. Curr Nutr Rep 2012, 1:175–183. DOI 10.1007/s13668-012-0021-3.
- Richard B. Horenstein, Braxton D Mitchell, Wendy S. Post, D Leutjohann, K vonBergmann, Kathleen A Ryan, Michael Terrin, Alan R Shuldiner, and Nanette I Steinle. The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish. ATVB. 2013 Feb;33(2):413-9.
- Marie-Therese Gast, Anke Tönjes, Maria Keller, Annette Horstmann, Nanette Steinle, Markus Scholz, Ines Müller, Arno Villringer, Michael Stumvoll, Peter Kovacs, Yvonne Böttcher. The Role of rs2237781 in eating behavior. Brain and Behavior. 2013 Sept; 3(5): 495-601.
- Christian Lachner, Clinton Martin, Deby John, Sreenath Nekkalapu, Amritpal Sasan, Nanette Steinle, William T. Regenold. Older adult psychiatric inpatients with non-cognitive disorders should be screened for vitamin B12 deficiency. The Journal of Nutrition, Health and Aging. Published online Sept 2013 pp 1-4. DOI 10.1007/s12603-013-0378-z.
- Guoyun Bai, Nga Hong Brereton, Kathy Ryan, Michael Shapiro and Nanette Steinle. An NMR metabolomic study in the Old Order Amish to study increased dietary salt associated with elevation of organic osmolytes detected in urine. Current Metabolimics, 2014 Volume 2, pp 70-75.
- Reed RM, Reed AW, McArdle PF, Miller M, Pollin TI, Shuldiner AR, Steinle NI, Mitchell BD. Vitamin and Supplement Use among Old Order Amish: Sex-Specific Prevalence and Associations with Use. J Acad Nutr Diet. 2014 Oct 11. pii: S2212-2672(14)01353-7. doi: 10.1016/j.jand.2014.08.020. .
- Adam Clark, Cedrick Dotson, Amanda Elson, Anja Voigt, Ulrich Boehm, Wolfgang Myerhoff, Nanette Steinle, Steven Munger. TAS2R Bitter Taste Receptors Regulate Thyroid Function. FASEB Journal 2014 Oct 23. pii: fj.14-262246.