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Andrew P. Goldberg
 

Andrew P. Goldberg M.D.

Academic Title: Professor
Primary Appointment: Medicine
Secondary Appointments: Family & Community Medicine
Administrative Title: Division Head, Gerontology & Geriatric Medicine
agoldber@medicine.umaryland.edu
Location: Howard Hall, 115
Phone: 410-706-6052
Fax: 410-706-6053
 

Personal History:

Dr. Goldberg received  his medical training at SUNY-Downstate Medical Center in Brooklyn NYC and did residency training in internal Medicine at NYU-Bellevue Medical center from 1972-74. He completed a fellowship in Endocrinology-Metabolism, Nutrition, and Gerontology at the University of Washington and Seattle VA from 1974-77 where he was mentored in the conduct of clinical investigation in nutrition and metabolism by Drs. John Brunzell and Edwin Bierman. He moved to Washington University in St. Louis Missouri as an Assistant Professor in the Departments of Medicine and Preventive Medicine to conduct research with Dr. John Holloszy in exercise, metabolism and nutrition research in chronic renal disease, obesity and diabetes. In 1983 he joined William Hazzard, MD as Director of Research in the Johns Hopkins University Division of Gerontology and Geriatric Medicine as PI of  the Johns Hopkins Academic Teaching Nursing Home Program Project, director of the  new Bayview-Johns Hopkins General Clinical Research Center, and  PI on RO1’s and  the T32 training grant in gerontology and geriatrics until 1990.

Dr. Goldberg was recruited to the University of Maryland in 1990, and established the Division of Gerontology and Geriatric Medicine, the Baltimore VA Geriatric Research Education and Clinical Center (GRECC) and the T32 NIA Training Grant in “The Biology of Exercise, Nutrition and Metabolism in Aging” in 1992, which have been continuously renewed through 2015. He received RO1 and VA grants, and in 1994 was awarded a Claude D. Pepper Older Americans Independence Center from the NIA,  which he renewed 3 times (1994- 2016). In 2005 a Clinical Nutrition Research Unit, and in 2010 the Nutrition Obesity Research Center were awarded to GRECC investigators Drs. Friedand Shuldiner with Dr. Goldberg as Co-Director, and in 2005-2015 a VA Rehabilitation Center of Excellence in Robotics and Neurological Diseases was awarded to Dr. Macko.

Dr. Goldberg has been continuously funded for 38 years by NIA and VA center grants and program projects, R01’s and VA Merit Awards, and has  published >200 peer-reviewed manuscripts and book chapters. He has extensive experience in research training, having mentored >55 pre- and  postdoctoral fellows on T32 and T35 training grants and 20 junior faculty on NIH/VA Career Development Awards in translational exercise rehabilitation, nutrition and metabolism clinical research in aging. He is currently PI of the UM Claude D. Pepper Older Americans Independence Center, NIA T32 Training Grant in Exercise, Nutrition and Metabolism in Aging, and Co-Director of the Mid-Atlantic Nutrition and Obesity Research Center and UM Center for Research on Aging.  These prestigious Research Centers, Training Grants, VA and RO1 Grants fostered the growth of translational bedside to bench research in the Division by coalescing the efforts of an interdisciplinary team of MD and PhD investigators, exercise physiologists, dietitians and nurses in the conduct of exercise, nutrition, metabolism and cardiovascular disease – related clinical research in aging.

Research Interests:

Dr. Goldberg leads research programs in the Baltimore VA GRECC, NIH RO1 grants and UMB Claude D. Pepper Older American Independence Center that investigate the hypothesis that some of the functional declines and medical diseases associated with aging in Western society are contributed to significantly by physical deconditioning and the development of obesity, i.e. lifestyle habits, as well as genetic and ethnic factors, not aging per se. Aging and obesity have many medically-related similarities, and there is a progressive relationship between obesity, physical deconditioning and risk for diabetes, hypertension, hyperlipidemia and their arteriosclerotic-thrombotic complications.

The Goldberg laboratory examines the mechanisms by which exercise and weight loss affect obesity and its glucose and lipid metabolic complications. His studies show that the combined effects of exercise and weight loss are synergistic in reducing central obesity and raising VO2 max to reduce CVD risk factors associated with the metabolic syndrome. These and other studies confirm that exercise and weight loss increase insulin sensitivity and reduce lipid profiles, hyperinsulinemia and glucose intolerance more than either do independently in obese men and women. This work shows that mechanisms in both adipose tissue and muscle contribute to the metabolic complications associated with central obesity and are modifiable by exercise and weight loss. His current research assesses the cellular mechanisms by which weight loss and exercise improve the metabolic dysfunction associated with obesity. The addition of a moderate intensity exercise to weight loss seems to partition nutrients to muscle for oxidation, in contrast to weight loss alone which does not increase lipoprotein lipase, the rate limiting enzyme for lipid uptake by muscle. The influence of gene polymorphisms on metabolic and body fat responses to weight loss and exercise training are being studied to test the hypothesis that obese subjects with certain gene variants may respond better to exercise than weight loss.


Publications:

Selected Publications

Luft AR, Macko RF, Forrester LW, Villagra F, Ivey F, Sorkin JD, Whitall J, McCombe-Waller S, Katzel L, Goldberg AP, Hanley DF.  Treadmill exercise activates subcortical neural networks and improves walking after stroke: A randomized controlled trial.  Stroke 2008;39:3341-3350.  PMCID: PMC2929142  

Fried SK, Tittelbach T, Blumenthal J, Sreenivassan U, Robey L, Yi J, Khan S, Hollender C, Ryan AS, Goldberg AP.  Resistance to the antilipolytic effect of insulin in adipocytes of African-Americans compared to Caucasian post-menopausal women.  J Lipid Res 2010;51:1193-1200.  PMCID:  PMC2853446

Joseph LJ, Prigeon RL, Blumenthal JB, Ryan AS, Goldberg AP.  Weight loss and low-intensity exercise for  the treatment and prevention of metabolic syndrome in obese postmenopausal women.  J Gerontol 2011;66A:M1022-M1029.  PMCID: PMC3156630

Brinkley TE, Halverstadt A, Phares DA, Ferrell RE, Prigeon RL, Hagberg JM, Goldberg AP.  Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase.  J Appl Physiol 2011;111:1871-1876. PMCID: PMC3233892

Supiano M, Alessi C, Chernoff R, Goldberg A, Morley J, Schmader K, Shay K.  VA Geriatric Research, Education and Clinical Centers: Translating aging research into clinical geriatrics; also Appendix S1.  J Amer Geriatr Soc 2012;60:1347-1356.

Hanson ED, Sheaff AK, Sood S, Ma L, Francis JD, Goldberg AP, Hurley BF.  Strength training induces muscle hypertrophy and functional gains in black prostate cancer patients despite androgen deprivation therapy.  J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):490-8. Epub 2012 Oct 22.  PMCID: PMC3593619.

Ryan AS, Katzel LI, Prior SJ, McLenithan JC, Goldberg AP, Ortmeyer HK.  Aerobic Exercise Plus Weight Loss Improves Insulin Sensitivity and Increases Skeletal Muscle Glycogen Synthase Activity in Older Men.  J Gerontol A Biol Sci Med Sci. 2013 Dec 19. [Epub ahead of print]  PMID:  24357038 [PubMed - as supplied by publisher]

Prior SJ, Ryan AS, Stevenson TG, Goldberg APMetabolic inflexibility during submaximal aerobic exercise is associated with glucose intolerance in obese older adults.  Obesity (Silver Spring). 2014 Feb;22(2):451-7. doi: 10.1002/oby.20609. Epub 2013 Oct 16.  PMID:  23983100 [PubMed - in process]

Prior SJ, Blumenthal JB, Katzel LI, Goldberg AP, Ryan AS.  Increased Skeletal Muscle Capillarization After Aerobic Exercise Training and Weight Loss Improves Insulin Sensitivity in Adults With IGT.  Diabetes Care. 2014 May;37(5):1469-75. doi: 10.2337/dc13-2358. Epub 2014 Mar 4. PMID: 24595633 [PubMed - in process]

Sorkin JD, Vasaitis TS, Streeten E, Ryan AS, Goldberg APEvidence for threshold effects of 25-hydroxyvitamin D on glucose tolerance and insulin resistance in black and white obese postmenopausal women.  J Nutr. 2014 May;144(5):734-42. doi: 10.3945/jn.114.190660. Epub 2014 Apr 9.  PMID: 24717362  [PubMed - in process]

Halter J,  Musi N, Horne , Crandall J, Goldberg A, Harkless L, Hazzard W, Huang E, Kirkman MS, Plutzky J, Schmader K, Zieman S, High K.  Diabetes Mellitus and Cardiovascular Disease in Older Adults: Current Status and Future Directions.  Diabetes 2014 ;63:2578-2589