SOM Faculty Profile : Andrew P Goldberg

Andrew P Goldberg

Andrew P Goldberg M.D.

Academic Title: Professor

Primary Appointment: Medicine

Secondary Appointments: Family & Community Medicine

Administrative Title: Division Head

Additional Title(s): Director, Geriatric Research, Education and Clinical Center (GRECC); Chief, Geriatrics Service, Baltimore VA Medical Center

agoldber@grecc.umaryland.edu

Location: Baltimore VA Medical Center, Room 4B-186

Phone: (410) 605-7183

Fax: (410) 605-7116

Research Interests

Dr. Goldberg leads research programs in the Baltimore VA GRECC, NIH RO1 grants and UMB Claude D. Pepper Older American Independence Center that investigate the hypothesis that some of the functional declines and medical diseases associated with aging in Western society are contributed to significantly by physical deconditioning and the development of obesity, i.e. lifestyle habits, as well as genetic and ethnic factors, not aging per se. Aging and obesity have many medically-related similarities, and there is a progressive relationship between obesity, physical deconditioning and risk for diabetes, hypertension, hyperlipidemia and their arteriosclerotic-thrombotic complications.

The Goldberg laboratory examines the mechanisms by which exercise and weight loss affect obesity and its glucose and lipid metabolic complications. His studies show that the combined effects of exercise and weight loss are synergistic in reducing central obesity and raising VO2 max to reduce CVD risk factors associated with the metabolic syndrome. These and other studies confirm that exercise and weight loss increase insulin sensitivity and reduce lipid profiles, hyperinsulinemia and glucose intolerance more than either do independently in obese men and women. This work shows that mechanisms in both adipose tissue and muscle contribute to the metabolic complications associated with central obesity and are modifiable by exercise and weight loss. His current research assesses the cellular mechanisms by which weight loss and exercise improve the metabolic dysfunction associated with obesity. The addition of a moderate intensity exercise to weight loss seems to partition nutrients to muscle for oxidation, in contrast to weight loss alone which does not increase lipoprotein lipase, the rate limiting enzyme for lipid uptake by muscle. The influence of gene polymorphisms on metabolic and body fat responses to weight loss and exercise training are being studied to test the hypothesis that obese subjects with certain certain gene variants may respond better to exercise than weight loss.

Publications

Selected Publications

Luft AR, Macko RF, Forrester LW, Villagra F, Ivey F, Sorkin JD, Whitall J, McCombe-Waller S, Katzel L, Goldberg AP, Hanley DF. Treadmill exercise activates subcortical neural networks and improves walking after stroke: A randomized controlled trial. Stroke 2008;39:3341-3350.

Obisesan TO, Ferrell RE, Goldberg AP, Phares DA, Ellis TJ, Hagberg JM. APOE genotype affects black-white responses of high-density lipoprotein cholesterol subspecies to aerobic exercise training. Metabolism 2008;57:1669-1676.

Lynch NA, Ryan AS, Evans J, Katzel LI, Goldberg AP. Older elite football players have reduced cardiac and osteoporosis risk factors. Med Sci Sports Exerc 2007;39:1124-1130.

Halverstadt A, Phares DA, Wilund KR, Goldberg AP, Hagberg JM. Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women. Metabolism 2007;56:444-450.

Hinson HE, Patterson SL, Macko, RF, Goldberg AP. Reduced cardiovascular fitness and ambulatory function in black and white stroke survivors. Ethnicity & Disease 2007;17:682-685.

Ivey FM, Ryan AS, Hafer-Macko CE, Goldberg AP, Macko RF. Treadmill aerobic training improves glucose tolerance and indices of insulin sensitivity in disabled stroke survivors: A preliminary report. Stroke 2007;38:2752-2758.

Kopunek SP, Michael KM, Shaughnessy M, Resnick B, Nahm E-S, Whitall J, Goldberg A, Macko RF. Cardiovascular risk in survivors of stroke. Am J Prev Med 2007;32:408-412.

Lynch NA, Ryan AS, Evans J, Katzel LI, Goldberg AP. Older elite football players have reduced cardiac and osteoporosis risk factors. Med Sci Sports Exerc 2007;39:1124-1130.

Ferrara CM, Goldberg AP, Ortmeyer HK, Ryan AS. Effects of aerobic and resistive exercise training on glucose disposal and skeletal muscle metabolism in older men. J Gerontol 2006;61A:480-487.

Yang R-Z, Lee M-J, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH, Goldberg AP, Shuldiner AR, Fried SK, Gong D-W. Acute-phase serum amyloid A: An inflammatory adipokine and a potential link between obesity and its metabolic complications. PloS Medicine 2006;3(6):e287.

Kulaputana O, Ghiu I, Phares DA, Ferrell RE, Macko RF, Goldberg AP, Hagberg JM. Genetic markers of fibrinolytic responses of older persons to exercise training. Int J Sports Med 2006;27:617-622.

Ivey FM, Ryan AS, Hafer-Macko CE, Garrity BM, Sorkin JD, Goldberg AP, Macko RF. High prevalence of abnormal glucose metabolism and poor sensitivity of fasting plasma glucose in the chronic phase of stroke. Cardiovasc Dis 2006;22:368-371.

Ferrara CM, Goldberg AP, Ortmeyer HK, Ryan AS. Effects of aerobic and resistive exercise training on glucose disposal and skeletal muscle metabolism in older men. J Gerontol 2006;61A:480-487.

Joseph LJO, Blumenthal J, Katzel LI, Goldberg AP. Exercise training and cardiovascular health with aging. Clinical Geriatrics 2005;13(4):40-46.

Halverstadt A, Phares DA, Roth S, Ferrell RE, Goldberg AP, Hagberg JM. Interleukin-6 genotype is associated with high-density lipoprotein cholesterol responses to exercise training. Biochim Biophys Acta 2005;1734:143-151.

Macko RF, Ivey FM, Forrester L, Hanley DF, Sorkin JD, Katzel LI, Silver KH, Goldberg AP. Treadmill exercise rehabilitation improves ambulatory function and cardiovascular fitness in patients with chronic stroke: A randomized controlled trial. Stroke 2005;36:2206-2211.

Kulaputana O, Macko RF, Ghiu I, Phares DA, Goldberg AP, Hagberg JM. Human gender differences in fibrinolytic responses to exercise training and their determinants. Exp. Physiol. 2005;90:881-887.

Tittelbach TJ, Berman DM, Nicklas BJ, Ryan AS, Goldberg AP. Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women. Obesity Research 2004;12:990-998.

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