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Edna F. Pereira Albuquerque

Edna F. Pereira Albuquerque Ph.D.

Academic Title: Associate Professor
Primary Appointment: Epidemiology & Public Health
Secondary Appointments: Pharmacology
Location: MSTF, 900F
Phone: (410) 706-3563

Personal History:

In 1987, Dr. Pereira graduated from the School of Pharmacy at the Universidade Federal do Rio de Janeiro, in Brazil. In 1989, she earned a master's degree from the Departmento de Farmacologia Basica e Clinica at the same University. During her training, Dr. Pereira received an in-depth education in classical pharmacology, and conducted experimental research aimed at evaluating the antiinflamatory and analgesic properties of novel compounds designed and synthesized at the Departamento de Tecnologia Farmaceutica at the Universidade Federal do Rio de Janeiro. In 1989, Dr. Pereira started a pre-doctoral training in electrophysiological techniques applied to the CNS at the Instituto de Biofisica Carlos Chagas Filho at the Universidade Federal do Rio de Janeiro. In 1993, Dr. Pereira began her doctoral studies at the University of Maryland School of Medicine. Under the advisorship of Dr. Edson Albuquerque at the University of Maryland School of Medicine and Dr. Alfred Maelicke at the University of Mainz, Dr. Pereira studied the modulation of neuronal nicotinic receptors by compounds now referred to as "nicotinic allosteric potentiating ligands" and approved to treat Alzheimer's disease. After completing her Ph.D. in 1996, Dr. Pereira received post-doctoral training from Drs. Albuquerque and Maelicke, and, in 2001, she joined the faculty of the Department of Pharmacology and Experimental Therapeutics at the University of Maryland School of Medicine. Currently, Dr. Pereira is pursuing a scientific career as an Associate Professor in the Division of Translational Toxicology of the Department of Epidemiology and Public Health.

Research Interests:

Dr. Pereira's research is focused on understanding the mechanisms by which nicotinic receptors regulate synaptic transmission and neuronal viability in the developing and the mature male and female brains with the ultimate goal of developing more effective treatments to halt the immediate and delayed neurotoxic effects of organophosphorus pesticides and nerve agents.

Lab Techniques and Equipment:

Various modalities of the patch-clamp technique, including the cell attached, the whole cell and the outside out, are used to characterize pharmacologically and functionally the activity of different receptors in neurons of the central nervous system. They are also used to study synaptic activity, integration and plasticity in preparations ranging from primary and organotypic cultures to fresh slices.

Molecular biology and biochemistry
Immunocytochemistry, western blots, binding and enzymatic assays are used primarily to complement the functional studies and to identify developmental or drug-induced changes in receptor expression and enzymatic activity associated with alterations in receptor function and synaptic integration.

Analyses of neuronal structures, including dendrites and dendritic spines, is performed in fresh slices and in whole brain using the Golgi technique, immunocytochemistry with Lucifer Yellow, or chemical processing of biocytin.

Grants and Contracts:

Search for my current funding in NIH Reporter under PI "Pereira, Edna."