Personal HistoryDr. Streeten received her medical degree from Albany Medical College in Albany, NY. She completed her internship and residency in Internal Medicine and a fellowship in Medical Genetics at The Johns Hopkins Hospital. This was followed by a fellowship in Endocrinology at the NIH, in the Metabolic Diseases Branch of NIDDK. After completing her training in 1990, Dr. Streeten had a private practice of endocrinology and was on the part-time faculty in the Endocrinology division at Johns Hopkins. In 1998, she joined the faculty at UMMS in the division of Endocrinology, Diabetes & Nutrition, where she is to date. In 2005, she co-founded the Adult Genetics Clinic and received a secondary appointment in the Genetics Division of the Pediatric Department. Dr. Streeten is board-certified in Internal Medicine, Endocrinology and Clinical Genetics.
Dr. Streeten's research interests include the study of genetic factors contributing to bone health and vitamin D metabolism, primary and secondary hyperparathyroidism and treatment of Osteoporosis-pseudoglioma (OPPG) syndrome. She has been a co-investigator in the Amish Family Osteoporosis Study since 1998. Current research projects include (1) The Amish Family Osteoporosis Study (a study to look for genes related to bone health), (2) The "Sunshine Study" (a study to evaluate individual variability in Vitamin D production), (3) OPPG treatment, and (4) Myozyme Temporary Access Program (a study of Myozyme treatment for adults with Pompe disease).
Clinical SpecialityDr. Streeten's subspecialty within endocrinology is in metabolic bone and mineral diseases. She runs the Osteoporosis and Metabolic Bone Diseases clinics at both UMMS and the Baltimore VA. Adult patients seen in the metabolic bone clinics include those with osteoporosis, Paget disease of bone, renal osteodystrophy, parathyroid disorders, non-PTH mediated hypercalcemia, kidney stones, vitamin D disorders, osteogenesis imperfecta, hypophosphatemic rickets and oncogenic osteomalacia.
On the inpatient side, Dr. Streeten introduced a clinical initiative at UMMS in 11/01 to improve the recognition and treatment of osteoporosis in inpatients hospitalized for treatment of fragility fractures. This Osteoporosis Consultation program, in collaboration with the Orthopaedics department at UMMS, revealed that fracture patients who are started on treatment for osteoporosis during their inpatient stay generally remain on the treatment well after discharge.
Dr. Streeten also maintains a stronginterest in general endocrinology and sees patients in the UMMS Joslin Center for Diabetes.
Sparks A.B., Peterson S.N., Bell C., Loftus B.J., Hosckin L, Cahill D.P., Frassica F.J., Streeten E.A., Levine, M.A., Fraser C.M., Adams M.D., Broder S., Venter J.C., Kinzler K.W., Vogelstein B., Ralston S.H. Mutation Screening of the TNFRSF11A Gene Encoding Receptor Activator of NFkB (RANK) in Familial and Sporadic Paget’s Disease of Bone and Sarcoma. Calc. Tiss. Int. 68:151-155, 2001.
Jan de Beur S, Streeten, E.A., Sharon M., Civelek A.C., McCarthy E.F., Uribe L, Marx SJ, Onbrakpeya O, Raisz LG, Watts NB, Sharon M, Levine M.A. Localisation of mesenchymal tumours by somatostatin receptor imaging. Lancet. 359:761-763, 2002.
Streeten E.A., McBride D.J., Lodge A. L., Pollin T.I., Stinchcomb D.G., Argarwala R, Schaffer A.A., Shapiro J.A., Shuldiner A.R., Mitchell B.D. Reduced incidence of hip fracture in the Old Order Amish. J Bone Min Res 19:308-313, 2004.
Brown L.B., Streeten E.A., Shuldiner A.R., Almasy L.A., Peyser P.A., Mitchell B.D. Assessment of sex-specific genetic and environmental effects on bone mineral density. Genet Epidem 27:153-161, 2004
Streeten EA, Ryan KA, McBride DJ, Pollin TI, Shuldiner AR, Mitchell BD. The relationship between parity and bone mineral density in women characterized by a homogeneous lifestyle and high parity. J Clin Endo Metab 90(8): 4536-41, 2005.
Brown LB, Streeten EA, Shapiro JR, McBride D, Shuldiner AR, Peyser PA, Mitchell BD. Genetic and Environmental Influences on Bone Mineral Density in Pre- and Post-Menopausal Women. Osteoporosis International, 16(12):1849-56, 2005.
McArdle P, Sorkin J, Schaeffer A, O’Connell J, Pollin T, Streeten E, Shuldiner A, Pollin T, Mitchell B. Does Having Children Extend Lifespan? A Genealogical Study of Parity and Longevity in the Amish. The Journal of Gerontology: Medical Sciences. 61(2):190-5, 2006.
Streeten, EA, McBride DJ, Pollin TI, Ryan K, Shapiro J, Ott S, Mitchell BD, Shuldiner AR, O’Connell JR. Quantitative Trait Loci for Bone Mineral Density Identified by Genome-Wide Linkage Scan to Chromosomes 7q and 21q in Men from the Amish Family Osteoporosis Study. Journal of Bone and Mineral Research, March 2006.
Streeten, EA. Mohamed A, Gandhi A, Orwig D, Sack P, Sterling R, Pelligrini VD. The Inpatient Osteoporosis Consult Approach to Treating Osteoporosis in Fracture Patients: Automatic Consult Mechanism Needed? Journal of Bone and Joint Surgery, March 2006.
Shen H, Bielak LF, Streeten EA, Ryan KA, Rumberger JA, Sheedy PF 2nd, Shuldiner AR, Peyser PA, Mitchell BD. Relationship between vascular calcification and bone mineral density in the Old-order Amish. Calcified Tissue International, April 2007, 80(4):244
Streeten EA, Beck TJ, O'Connell JR, Rampersand E, McBride DJ, Takala SL, Pollin TI, Uusi-Rasi K, Mitchell BD, Shuldiner AR. Autosome-wide linkage analysis of hip structural phenotypes in the Old Order Amish. Bone, Sept 2008, 43(3):607.
Streeten EA, Munir K, Hines S, Mohamed A, Mangano C, Ryan KA, Post W. Coronary artery calcification in patients with primary hyperparathyroidism in comparison with control subjects from the multi-ethnic study of atherosclerosis. Endocrine Practice, March 2008, 14(2):155-161.
Streeten EA, Beck TJ, O'Connell JR, Evadnie Rampersand, McBride D, Takala SL, Pollin TI,Uusi-Rasi K, Mitchell BD, Shuldiner AR Autosome-Wide Linkage Analysis of Hip Structural Phenotypes in the Old Order Amish. Bone. 2008 Apr 25 [Epub ahead of print].
Streeten EA Daniel McBride, Eric Puffenberger, Marc E. Hoffman, Toni I. Pollin, Patrick Donnelly, Paul Sack, Holmes Morton. Osteoporosis-pseudoglioma Syndrome: Description of 9 New Cases and Beneficial Response to Bisphosphonates. Bone 2008 May 7 [Epub ahead of Print]
Badros A., Goloubeva O, Terpos E, Milliron T, Baer MR, Streeten EA. Prevalence Of vitamin D deficiency in multiple myeloma patients. Br. J Haematol 2008 May 15 [Epub ahead of print].
Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T,Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. 2009 Nat Genet May 17 [Epub ahead of print].
Michos ED, Streeten, EA Ryan KA, Rampersaud E, Peyser PA, Bielak LF, Shuldiner AR,Mitchell BD, Post W. Serum 25-hydroxyvitamin d levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish. 2009 Calcif Tissue Int.Mar;84(3):195-202. Epub Jan