SOM Faculty Profile : Frederick Ivey

Frederick Ivey

Frederick Ivey Ph.D.

Academic Title: Assistant Professor

Primary Appointment: Medicine

fivey@grecc.umaryland.edu

Location: Baltimore VA Medical Center, Room 4B-193A

Phone: (410) 605-7297

Fax: (410) 605-7913

Research Interests

Stroke is the leading cause of disability and third leading cause of death in the United States. As our adult population ages, the number of strokes in the United States is anticipated to double, reaching nearly 1.5 million annually by the year 2050. Following stroke, patients remain at continued high risk for recurrent stroke, as well as for myocardial infarction and cardiac death. Nearly a third of stroke patients experience recurrent stroke within five years, despite optimal medical management. Comorbid cardiovascular conditions are present in 75% of stroke patients, with annual cardiac mortality rates of 4-5%; the leading cause of death in stroke survivors. Current health care models rely upon best medical-pharmacological management, primarily antiplatelet agents, which have limited efficacy. Given the burgeoning numbers of chronically disabled elderly stroke patients and downsizing of health care services in both the public and private sectors, alternative strategies are needed to improve cardiovascular health and reduce atherothrombotic risk in this population. The majority of my research effort focuses on evaluating the efficacy of treadmill aerobic exercise as an adjunct therapy for improving cardiovascular risk profiles in the chronic stroke population. Specific outcome variables include resting fibrinolysis markers, post-stressor fibrinolytic response, and other markers of fibrin turnover and thrombin generation. In addition, we are studying vasomotor function in both the cerebral and peripheral vasculatures using Transcranial Doppler Ultrasonography and Venous Occlusion Strain Gauge Plethysmography. Whole body Nitric Oxide Metabolism is assessed using NO biomarkers in urine after a 12 hour fast. Finally, the metabolic status of the stroke patients is evaluated using the Oral Glucose Tolerance and Hyperglycemic Clamp tests. The latter testing is complimented by our efforts to study insulin signaling at the tissue level from bilateral vastus lateralis muscle biopsies. We hypothesize that stroke patients are capable of exercising at the level required to provoke adaptation in vascular function, glucose metabolism, and insulin action. A primary aim of this research is to determine the degree of association between changes in vascular parameters and glucose/insulin metabolism across an exercise intervention in stroke. This work is currently funded by an NIH K award (5K01AG019242-03 NIH/NIA) under the mentorship of Drs. Macko and Goldberg. Additionally, I have recently become involved with a Pepper Center Pilot study assessing the effects of strength training on function and metabolism in chronically disabled stroke patient.

Publications

Most Recent Publications
Martel GF, Roth SM, Ivey FM, Lemmer JT, Tracy BL, Hurlbut DE, Metter EJ, Hurley BF, Rogers MA, Age and Sex Affect Muscle Fibre Adaptations to Heavy Resistance Strength Training.Exp Physiol. 2006 Jan 11

Macko RF, Ivey FM, Forrester L, Hanley DF, Katzel LI, Sorkin JD, Silver K, Goldberg AP. Treadmill Exercise Rehabilitation Improves Cardiovascular Fitness and Ambulatory Function in Chronic Stroke Patients: A Randomized Controlled Trial. 2005 Stroke Oct 36(10): 2206-11.

Hafer-Macko CE, Yu S, Ryan AS, Ivey FM, Macko RF. Elevated tumor necrosis factor-alpha in skeletal muscle after stroke 2005 Stroke 2005 Sep;36(9):2021-3

Ivey, F.M., Macko, R.F., Ryan,A.S., Hafer-Macko, C.E. Cardiovascular Health and Fitness After Stroke. 2005 Topics in Stroke Rehabilitation, Winter, 12(1): 1-16.

Macko, R.F., Ivey,F.M., Forrester,L.W. Task-Oriented Aerobic Exercise in Chronic Hemiparetic Stroke: Training Protocols and Treatment Effects. 2005 Topics in Stroke Rehabilitation, Winter, 12(1): 45-57.

DeDeyne, P.G., Hafer-Macko, C.E., Ivey, F.M., Ryan, A.S., Macko, R.F. Altered muscle molecular phenotype after stroke and its relationship to gait deficit severity 2004 Muscle & Nerve Aug; 30(2): 209-215.

Ivey, F.M., Gardner,A.W.. Dobrovolny, C.L., Macko, R.F. 2004 Unilateral Impairment of Leg Blood Flow in Chronic Stroke Patients. 2004. Cerebrovasc Dis 18:283-289

Ryan, A.S., Ivey, F.M., Hurlbut, D.E., Martel, G.F., Lemmer, J.T., Metter, E.J.,Fleg, J.L., Hurley, B.F., 2004 Regional bone mineral density after Resistive Exercise in young and older men and women. Scand J Med Sci Sports 14:16-23.

Dobrovolny, L., Ivey, F.M., Rogers, M.A., Sorkin, J.D., Macko, R.F., 2003 Test-Retest reliability of open circuit spirometry treadmill testing in chronic hemiparetic stroke patients. Arch Phys Med Rehabil; 84: 2003.

Tracy, B.L., Ivey, F.M., Metter, E.J., Fleg, J.L., Hurley, B.F., 2003 MRI-based methods of muscle hypertrophy measurement in young and older men and women Med Sci Sports Exerc; 35(3):425-33.

Ivey, F.M., Womack, C.J., Tiyasangthong, O., Dobrovolny, C.L., Wiley,L., Macko, R.F., 2003 A single bout of walking exercise enhances endogenous fibrinolysis in chronic stroke patients. Med Sci Sports Exerc;35(2):193-

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