Dr. Gottlieb’s investigations center on the physiology of congestive heart failure. This has included a particular interest in neurohormonal activation in CHF patients. Dr. Gottlieb was United States principal investigator for MERIT, an international beta blocker survival trial in heart failure patients. He was also co-chairman of the mortality committee of BEST, an NIH and VA sponsored study of a different beta blocker. In addition, with the support of the local AHA, he is looking at the mechanism by which beta blockers may be effective. Other neurohormonal interests include investigation of vasopressin antagonists, adenosine antagonists and endothelin antagonists.
Dr. Gottlieb is particularly interested in the interaction of heart failure and renal dysfunction, having studied the impact of various medications on renal function and the physiology of renal function in heart failure patients. Similarly, he is investigating the best ways to treat fluid overload, a common problem in patients with heart failure.
He is actively involved in investigation of left ventricular assist devices, investigational agents and home telemonitoring in heart failure patients. In addition, he is evaluating sleep abnormalities in heart failure patients, funded by a grant from NIH.
Gottlieb SS, McCarter RJ, Vogel RA. Effect of beta-blockade on mortality in high-risk and low-risk patients after myocardial infarction. N Engl J Med 1998;339:489-497.
Gottlieb SS, Skettino SL, Wolff A, Beckman E, Fisher ML, Freudenberger R, Gladwell T, Marshall J, Cines M, Bennett D, Liittschwager E. The effects of BG9719 (CVT-124), an A1 adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in congestive heart failure patients. J Am Coll Cardiol 2000; 35:56-59.
Gottlieb SS, Fisher ML, Freudenberger R, Robinson S, Zietowski G, Alves L, Krichten C, Vaitkevicus P, McCarter R. Effects of exercise training on peak performance and quality of life in congestive heart failure patients. J Cardiac Failure 1999; 5: 188-194.
Khatta M, Alexander BS, Krichten CM, Fisher ML, Freudenberger R, Robinson S, Gottlieb SS. The impact of coenzyme Q10 in patients with congestive heart failure. Ann Int Med 2000; 132: 636-640.
Gottlieb SS, McCarter RJ. Comparative effects of three beta-blockers (atenolol, metoprolol, and propranolol) on survival after acute myocardial infarction. Am J Card 2001; 87:823-826.
Gottlieb SS, Fisher ML, Kjekshus J, Deedwania P, Gullestad L, Vitovec J, Wikstrand J, on behalf of the MERIT-HF Investigators. Tolerability of beta-blocker initiation and titration in MERIT-HF. Circulation 2002; 105:1182-88.
Gottlieb SS, Brater DC, Thomas I, et al. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 2002;105:1348-1353.
Bennett SK, Smith MF, Gottlieb SS, Fisher ML, Bacharach SL, Dilsizian V. Effect of metoprolol on absolute myocardial blood flow in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy. Am J Card 2002; 89:1431-1434.
Gottlieb SS, Abraham W, Butler J, Forman DE, Loh E, Massie BM, O’Connor CM, Rich MW, Stevenson LW, Young J, Krumholz HM. The prognostic importance of different definitions of worsening renal function in congestive heart failure. J Card Fail 2002, 8:136-41.
Blaustein MP, Robinson SW, Gottlieb SS, Balke CW, Hamlyn JM. Sex, digitalis, and the sodium pump. Molecular Interv 2003, 3(2):68-72.
Gottlieb SS, Khatta M, Friedmann E, Einbinder L, Katzen S, Baker B, Robinson S, Fisher ML, Potenza M, Sigler B, Baldwin C, Thomas SA The Influence of Age, Sex and Race on the Prevalence of Depression in Heart Failure Patients. J Am Coll Cardiol. 2004; 109:
Deedwania PC, Gottlieb S, Ghali JK, Waagstein F, Wikstrand JC, for the MERIT-HF Study Group. Efficacy, safety and tolerability of beta-adrenergic blockade with metoprolol CR/XL in elderly patients with heart failure. European Heart Journal 2004; 3:1-11.
Wang DJ, Dowling TC, Meadows D, Ayala T, Marshall J, Minshall S, Greenberg N, Thattassery E, Fisher ML, Rao K, Gottlieb SS. Nesiritide does not improve renal function in patients with chronic heart failure and worsening serum creatinine. Circulation 2004; 110(12): 1620-1625.
Wali RK, Wang GS, Gottlieb SS, et al. Effect of kidney transplantation on left ventricular systolic function and congestive heart failure in patients with end-stage renal disease. J Am Coll Cardiol 2005; 45:1051-1060.
Rogers RL, Feller ED, Gottlieb SS. Acute Congestive Heart Failure in the Emergency Department. Cardiol Clin. 2006 Feb;24(1):115-23.
Shah KB, Rao K, Sawyer R, Gottlieb SS. The adequacy of laboratory monitoring in patients treated with spironolactone for congestive heart failure. J Am Coll Cardiol 2005 46 (4); 845-84
Gottlieb SS, Pina IL. Enhanced external counterpulsation: What can we learn from the treatment of neurasthenia? J Am Coll Cardiol. 2006 Sep 19;48(6):1206-7.
Rao K, Fisher ML, Robinson S, Shorofsky S, Gottlieb SS. Effect of chronic changes in heart rate on congestive heart failure. J Card Fail. 2007;13:269-74.
Gottlieb SS, Kop WJ, Thomas SA, Katzen S, Vesely MR, Greenberg N, Marshall J, Cines M, Minshall S. A double-blind placebo-controlled pilot study of controlled-release paroxetine on depression and quality of life in chronic heart failure. Am Heart J. 2007;153:868-73.
Shah KB, Nolan MM, Rao K, Wang DJ, Christenson RH, Shanholtz CB, Mehra MR, Gottlieb SS. The characteristics and prognostic importance of NT-ProBNP concentrations in critically ill patients. Am J Med 2007;120:1071-1077.
Rogers HL, Marshall J, Bock J, Dowling TC, Feller E, Robinson, Gottlieb SS. A Randomized, Controlled Trial of the Renal Effects of Ultrafiltration Compared with Furosemide in Patients with Acute Decompensated Heart Failure. J Card Failure 2008;14:1-5.
Gottlieb SS. Adenosine A1 antagonists and the cardiorenal syndrome. Curr Heart Fail Rep. 2008 ;5:105-9
Thomas SA, Friedmann E, Gottlieb SS, Liu F, Morton PG, Chapa DW, Lee HJ, Nahm ES. Sudden Cardiac Death in Heart Failure Trial Investigators. Changes in psychosocial distress in outpatients with heart failure with implantable cardioverter defibrillators. Heart Lung. 2009;38:109-20.
Gottlieb SS, Kop WJ, Ellis SJ, Binkley P, Howlett J, O'Connor C, Blumenthal JA, Fletcher G, Swank AM, Cooper L. HF-ACTION Investigators. Relation of depression to severity of illness in heart failure (from Heart Failure And a Controlled Trial Investigating Outcomes of Exercise Training [HF-ACTION]). Am J Cardiol. 2009;103:1285-9.
Gottlieb SS. Prognostic indicators: useful for clinical care? J Am Coll Cardiol. 2009;53:343-4