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O Colin  Stine
 

O Colin Stine Ph.D.

Academic Title: Professor
Primary Appointment: Epidemiology & Public Health
Secondary Appointments: Pediatrics
ostin001@umaryland.edu
Location: Howard Hall 596
Phone: (410) 706-1607
Fax: (410) 706-1644
Lab: (410) 706-1609

Personal History:

Education

1976: B.A., Biology /Mathematics, Kalamazoo College
1983: M.S., Biophysics, University of Virginia
1986: Ph.D., Biophysics, University of Virginia

Professional Experience

1986-1989: Postdoctoral Fellow, Johns Hopkins University School of Medicine, with Kirby D. Smith.
1989-1990: Pew Fellow, Johns Hopkins School of Medicine, with Orest Hurko. 
1990-1997: Assistant Professor of Psychiatry, Johns Hopkins School of Medicine. 
1997-2002: Assistant Professor of Epidemiology and Public Health, University of Maryland Baltimore.
2000-present: Scientific Director of the Biopolymers/Genomics Core, University of Maryland Baltimore.
2002-present: Associate Professor of Epidemiology and Public Health, University of Maryland Baltimore.
2002-2004: Member, Advisory Committee to the National Drinking Water Advisory Committee to the EPA.
2002-present: External Review Board, Research Center at Minority Institutions Grant, Morgan State University.

Research Interests:

I have two research interests. The first is focused on the epidemiology of Vibrio cholerae and unrecognized diarrheal pathogens in low income countries. For V. cholerae, the bacterial cause of cholera outbreaks, I developed a novel method of genotyping . This method permits epidemiological tracing of related strains at finer resolution than has been previously possible. Our tracing of strains in human populations and the environment is producing new and unexpected results. In addition, I am using metagenomic methods (ones based on sequencing all of the bacteria, eukaryotes and viruses) in diarrheal and normal stools of children from low-income countries. Although many pathogens are known to cause diarrhea, 15 to 30% of diarrheal cases do not have a known etiology by gold standard microbiological techniques. We are comparing the DNA signatures of organism in diarrheal and normal samples to identify those associated with diarrhea and then testing them in tissue culture.

My second area of research interest is genotyping individuals in order to establish correlations between clinical phenotypes like early onset stroke (<50 years old). schizophrenia and single-nucleotide polymorphisms.



Publications:

Search My Publications in Pub Med

HIGHLIGHTED PUBLICATIONS

Wonodi I, Stine OC, Sathyasaikumar KV, Roberts RC, Mitchell BD, Hong LE, Kajii Y, Thaker GK, Schwarcz R. Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Archives of General Psychiatry 68:665-674, 2011. PMID: 21727251

Shurland SM, Stine OC, Venezia RA, Zhan M,. Furuno JP, Miller RR, Roghmann M: USA300 Methicillin-resistant S. aureus (USA300 MRSA) Colonization and the Risk of MRSA Infection in Residents of Extended Care Facilities. Epidemiology and Infection Jul 18:1-10, 2011. PMID: 21767453

Chen Y, Stine OC, Badger JH, Gil AI, Nair GB, Nishibuchi M, Fouts DE: Comparative Genomic Analysis of Vibrio parahaemolyticus: Serotype Conversion and Virulence. BMC Genomics 12:294, 2011. PMID: 21645368

Hong LE, Yang X, Wonodi I, Hodgkinson CA, Goldman D, Stine OC, Elliot S. Stein ES, Thaker GK: A CHRNA5 Allele Related to Nicotine Addiction and Schizophrenia. Genes, Brain and Behavior, 2011. Mar 18. PMID: 21418140

Lindsay BR, Ramamurthy T, Sen Gupta S, Takeda Y, Rajendran K, Nair GB, Stine OC: Diarrheagenic Pathogens in Polymicrobial Infections. Emerging Infectious Diseases 17:606-611, 2011. PMID: 21470448

Ali A, Chen Y, Johnson JA, Redden E, Mayette Y, Rashid MH, Stine OC, Morris JG: Cholera in Haiti: Further Evidence of Very Recent Clonal Origin, Emerging Infectious Diseases 17:699-701, 2011. PMID: 21470464

Wonodi I, Stine OC, Sathyasaikumar KV, Roberts RC, Mitchell BD, Hong LE, Kajii Y, Thaker GK, Schwarcz R. Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Archives of General Psychiatry. 2011

Antonina Aydanian A, Tang L, Morris JG, Johnson JA, Stine OC: Genetic Diversity of O-Antigen Biosynthetic Regions in Vibrio cholerae. Applied Environmental Microbiology. 77:2247-53, 2011, PMID: 21317260.

Roghmann M, Johnson JK, Stine OC, Lydecker A, Ryan K, Mitchell BD, Shuldiner AR. Persistent Staphylococcus aureus colonization is not a strongly heritable trait in Amish families. PLoS One. Feb 28;6(2):e17368. PMID: 21386985

Kendall EA, Chowdhury F, Begum Y, Khan AI, Li S, Thierer JH, Bailey J, Kreisel K, Tacket CO, LaRocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB, Stine OC. Relatedness of Vibrio cholerae O1/O139 from patients and their household contacts, determined by multilocus variable number tandem repeat analysis (MLVA). Journal of Bacteriology 192:4367-4376. 2010 PMID: 20585059

Kreisel K, Lesse A, Gordin F, Climo M, Johnson JK, Shardell M, Perencevich E, Stine OC, Roghmann MC: Illicit Drug Use and the Risk of USA300 Methicillin-Resistant Staphylococcus aureus Bacteremia. Emerging Infectious Disease 16. 1419-1427, 2010. PMID: 20735927

Laufer MK, Takala-Harrison SL, Dzinjalamala FK, Stine OC, Taylor TE, Plowe CV. Chloroquine-susceptible malaria parasites in Malawi are a re-expansion of susceptible parasites that survived drug pressure. The Journal of Infectious Diseases. 801-808 2010. PMID: 20662717

Thom K, Hsiao W, Harris A, Stine OC, Rasko D, Johnson JK. Patients with Acinetobacter baumannii bloodstream infection are colonized in the gastrointestinal tract with the identical strains. American Journal of Infection Control, in press 2010. PMID: 20570393

Shurland SM, Stine OC, Venezia RA, Johnson JK, Zhan M, Furuno JP, Miller RR, Pelser C, Roghmann MC. Prolonged Colonization with USA300 MRSA in Extended Care Residents. Infection Control and Hospital Epidemiology 31:838-841, 2010. PMID: 20569116

Nalls MA, Biffi A, Matarin M, Anderson CD, Chasman DI, Bevan S, Spencer CCA, Gschwendtner A, Sale MM, Wu L, Saleheen D, Deary IJ, Langefeld C, Peddareddygari LR, Cole JW, Arapelli SK, Aucutt-Walter N, Brott TG, Broderick JP, Brown DL, Brown M, Brown RD, Buring JE, Cortellini L, Danesh J, Deka R, Elias GA, Ferrucci L, Frossard P, Furie K, Gibbs JR, Greenberg SM, Gul M, Hardy J, Harris SE, Hernandez DG, Hsu F-C, Indugula S, Jackson C, Kissela B, Liu L, Metter EJ, Mitchell BD, Murphy L, Mychaleckyj JC, O'Connell JR, Paré G, Parker AN, Patel RK, Poole D, Rasheed A, Richie A, Rothwell PM, Rose L, Ross OA, Rost NS, Schwab K, Sen S, Silliman SL, Soto-Ortolaza AI, Starr JM, Stine OC, Stamova B, Xu H, Wichmann HE, Young LE, Young W, Zaidi M, Zhang H, Kittner SJ, Grewal RP, Woo D, Sudlow C, Kamal AK, Wang X, Sharp FR, Worrall BB, Dichgans M, Markus HS, Ridker PM, de Bakker PIW, Wellcome Trust Case-Control Consortium 2, Singleton AB, Meschia JF, Rosand J: Failure to validate association between 12p13 Variants and Ischemic Stroke. New England Journal of Medicine 362:1547-1550, 2010. PMID: 20410525

Kreisel K, Roghmann MC, Shardell M, Stine OC, Perencevich E, Lesse A, Gordin F, Climo M, Johnson JK: Assessment of the 48-Hour Rule for Identifying Community-Associated Methicillin-Resistant Staphylococcus aureus Infections Complicated by Bacteremia. Infection Control and Hospital Epidemiology 31:657-659, 2010. PMID: 20412012

Mez JB, Cole JW, Howard TD, MacCellan LR, Stine OC, O’Connell JR, Wozniak MA, Stern BJ, Sorkin JD, Mitchell BD, Kittner SJ: Evaluation of Self-Reported Race in a Case-Control Population: The Stroke Prevention in Young Women Study. BMC Research Notes.2:260 2009. PMID: 20021678.

Shurland SM, Stine OC, Venezia RA, Johnson JK, Zhan M, Furuno JP, Miller RR, Johnson T, Roghmann MC. Colonization Sites of USA300 Methicillin-Resistant Staphylococcus aureus in Extended Care Residents. Infection Control and Hospital Epidemiology 30: 313-318, 2009. PMID: 19239380

Wonodi I., Hong LE, Stine OC, Mitchell BD, Elliott A, Roberts RC, Conley RR, McMahon RP, Thaker GK, Dopamine Transporter Polymorphism Modulates Oculomotor Function and DAT1 mRNA Expression in Schizophrenia American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2009 Mar 5;150B(2):282-9. PMID: 18553389

Shebl F, Saleh D, Abdel-Hamid M, Mikhail N, Allam A, El-Arabi H, Elhenawy I, El-Kafrawy S, El-Daly M, Selim S, El-Wahab AA, Mostafa M, Sharaf S, El-Kamary S, Hashem M, Heyward S, Stine OC, Magder L, Stoszek S, Strickland GT. Study of mother-to-infant infecdtion and clearance of hepatitus C in rural Egyptian villages. Journal of Medical Virology 81:1024-1031, 2009. PMID: 19382251

Johnson, JK, Smith, G, Warren, MS, Venezia, RA, Stine, OC, Nataro, JP, Hsiao W, Harris, AD. The Role of Patient-to-Patient Transmission in the Acquisition of Imipenem-resistant Pseudomonas aeruginosa Colonization in the Intensive Care Unit. Journal of Infectious Disease 200:900-5, 2009. PMID:19673646.

MacClellan LR, Howard TD, Cole JW, Stine OC, Giles WH, O’Connell JR, Wozniak MA, Stern BJ, Mitchell BD, and Kittner SJ. Relation of Candidate Genes that Encode for Endothelial Function to Migraine and Stroke: The Stroke Prevention in Young Women Study. Stroke Aug 6. [Epub] PMID: 19661472

Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Nolte IM, van Diemen CC, Boezen HM, Timens W, Whittaker PA, Stine OC, Barton SJ, Holloway JW, Holgate ST, Graves PE, Martinez FD, van Oosterhout A, Bleecker ER, Postma DS: Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. American Journal of Respiration and Critical Care Medicine Sep 3 [Epub] 2009. PMID: 19729670

Stine OC, Alam M, Tang L, Nair GB, Siddique AK, Faruque SM, Huq A, Colwell RR, Sack RB, Morris JG: Seasonal cholera from multiple small outbreaks, rural Bangladesh. Emerging Infectious Diseases 14:831-833, http://www.cdc.gov/eid/content/14/5/pdfs/831.pdf. 2008.

González-Fraga S, Pichel M, Binsztein N, Johnson JA, Morris JG, Stine OC: Vibrio cholerae: Lateral gene transfer of O1 serotype encoding genes in isolates from Argentina. FEMS Microbiology Letters http://www3.interscience.wiley.com/cgi-bin/fulltext/120736452/PDFSTART
. 2008.

Boyd EF, Cohen ALV, Naughton LM, Ussery DW, Binnewies TT, Stine OC, Parent MA: Molecular analysis of the emergence of pandemic Vibrio parahaemolyticus. BMC Microbiology 8:110, http://www.biomedcentral.com/content/pdf/1471-2180-8-110.pdf
. 2008.

Ghosh R, Nair GB, Tang L, Morris JG, Sharma NC, Ballal M, Garg P, Ramamurthy T, Stine OC: Epidemiological study of Vibrio cholerae using variable number of tandem repeats. FEMS Microbiology Letters 288(2):196-201, 2008.

Cole JW, Brown DW, Giles WH, Stine OC, O'Connell JR, Mitchell BD, Sorkin JD, Wozniak MA, Stern BJ, Sparks MJ, Dobbins MT, Shoffner LT, Zappala NK, Reinhart LJ, Kittner SJ: Ischemic Stroke Risk, Smoking, and the Genetics of Inflammation in a Biracial Population: The Stroke Prevention in Young Women Study. Thrombosis Journal 6:11, 2008.

Shurland SM, Stine OC, Venezia RA, Johnson JK, Zhan M, Furuno JP, Miller RR, Johnson T, Roghmann MC. Colonization Sites of USA300 Methicillin-Resistant Staphylococcus aureus in Extended Care Residents Infection Control and Hospital Epidemiology. Infection Control and Hospital Epidemiology 2008.

Pineiro SA, Williams HN, Stine OC: Phylogenetic relationships amongst saltwater Bacteriovorax using rpoB sequences and reclassification of Bacteriovorax stolpii as <<Bacteriolytic>> stolpii gen. nov., comb. nov. International Journal of Systematic and Evolutionary Microbiology 2008

Revazishvili T, Rajanna C, Bakanidze L, Kekelidze K, Tsertsvadze K, Mgeladze G, Shavishvili M, Beridze L, Velijanashvili I, O'Connell K, Kreger A, Stine OC, Morris JG, Sulakvelidze: A Characterization of Yersinia pestis Strains Isolated from Endemic Foci of Plague in the Republic of Georgia. Clinical Microbiology and Infection 2008

Stine OC, Johnson JA, Keefer-Norris A, Perry K, Tigno J, Qaiyumi S, Stine MS, Morris JG: Widespread distribution of tetracycline resistance genes in a concentrated animal feeding operation. International Journal of Antimicrobial Agents, 29:348-352 2007.
 
Chen Y, Johnson JA, Pusch GD, Morris JG, Stine OC: The genome of non-O1 Vibrio cholerae NRT36S demonstrates the presence of pathogenic mechanisms that are distinct from O1 V. cholerae.  Infection and Immunity, 75:2645-2647, 2007

Chen Y, Bystricky P, Adeyeye J, Panigrahi P, Ali A, Johnson JA, Bush, CA, Morris JG, Stine OC: The capsule polysaccharide structure and biogenesis for non-O1 Vibrio cholerae NRT36S: genes are embedded in the LPS region.  BMC Microbiology, 7:20 2007

Chen Y, Stine OC, Morris JG, Johnson, JA: Genetic variation of capsule/lipopolysaccharide biogenesis in two serogroup O31 Vibrio cholerae isolates.  FEMS Microbiology Letters 273:133-139,  2007.

Hong LE, Ikwunga Wonodi I, Stine OC, Mitchell BD, Thaker GK: Evidence of Missense Mutations on the Neuregulin 1 Gene Affecting Function of Prepulse Inhibition. Biological Psychiatry Jul 11 2007.

Pineiro S, Stine OC, Chauhan A, Styert SR, Smith R, Williams HN: Global Survey of Diversity Among Environmental Saltwater Bacteriovoracaceae. Environmental Microbiology 9:2441-2450, 2007.
 
Panigrahi P, Braileanu GT, Chen H, Stine OC: Probiotic bacteria change E. coli-induced gene expression in cultured colonocytes: implications in intestinal pathophysiology. World J. Gastroenterology 13(47):6370-6378, 2007.

Johnson JK, Arduino SM, Stine OC, Johnson JA, Harris AD: Multilocus Sequencing Typing (MLST) Compared to Pulsed-Field Gel Electrophoresis (PFGE) for Molecular Typing of Pseudomonas aeruginosa. Journal of Clinical Microbiology 45:3707-3712, 2007.

Johnson JK, Khoie T, Shurland S, Kreisel K, Stine OC, Roghmann MC. Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus USA300 clone. Emerg Infect Dis. 13:1195-200, 2007.

Cole JW, Naj AC, O'Connell JR, Stine OC, Sorkin J, Wozniak MA, Stern BJ, Yepes M, Lawrence DA, Reinhart LJ, Strickland DK, Mitchell BD, Kittner SJ:  Neuroserpin Polymorphisms and Stroke Risk in a Biracial Population: The Stroke Prevention in Young Women Study.  BMC Neurol. 7:37, 2007.

Crum, NF, Lee, RU, Thornton, SA, Stine, OC, Wallace, MR, Barrozo, C, Keefer-Norris, A, Judd, S, Russell, R: 15-Year Retrospective Study of the Changing Epidemiology of Methicillin-Resistant Staphylococcus aureus (MRSA).  American Journal of Medicine 119:943-51, 2006.

Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C, Clark CD, McInnis MG, Simpson SG,  Breschel TS, Vishio E, Riskin K, Feilotter H, Chen E, Shen S, Folstein S, Meyers DA, Botstein D, Marr TG, DePaulo JR: Evidence for linkage of bipolar disorder to chromosome 18 with a parent of origin effect.  Am  J Hum Gen 57:1384 1394, 1995. (over 185 citations)