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William T. Regenold

William T. Regenold M.D.C.M.

Academic Title: Associate Professor
Primary Appointment: Psychiatry
Administrative Title: Division Head, Geriatric Psychiatry
Additional Title(s): Director, Division of Geriatric Psychiatry; Director, Electroconvulsive Therapy Service
Location: UMMC, S12A09
Phone: (410) 328-6511
Phone: (410) 328-4169
Fax: (410) 328-2672

Personal History:


  • Medical School: McGill University Faculty of Medicine, Montreal, Quebec, Canada
  • Psychiatry Residency: Francis Scott Key Hospital, the Johns Hopkins Hospital, Baltimore, MD and the Maudsley Hospital, London, UK

Research Interests:

Dr. Regenold's areas of interest include:

  • brain energy metabolism in neuropsychiatric disorders, including bipolar disorder, schizophrenia, major depression and multiple sclerosis;
  • white matter disease in neuropsychiatric disorders;
  • the therapeutic mechanisms of action of ECT and lithium; and
  • biological markers of neuropsychiatric disorders, including bipolar disorder and Alzheimer's disease.

Clinical Speciality:

Dr. Regenold is certified in psychiatry and has added qualifications in geriatric psychiatry from the American Board of Psychiatry and Neurology. His clinical work mostly involves older adults. Although he sees patients with a variety of psychiatric problems, he is particularly interested in patients whose psychiatric problems are associated with medical or neurological disorders. He also consults on patients of any age who are considering electroconvulsive therapy (ECT) and performs ECT at the University of Maryland Medical Center.


Search all of my publications in PubMed.

Selected Recent Publications

Regenold WT, Thapar RK, Marano C, Gavirneni S, Kondapavuluru PV: Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar 1 affective and schizoaffective disorders, Journal of Affective Disorders, 70: 19-26, 2002.  [Corrigendum: J Affect Disord. 2003 Feb;73(3):301-2].

Regenold WT, Phatak P, Kling MA, Hauser P:  Post-mortem evidence from human brain tissue of disturbed glucose metabolism in mood and psychotic disorders. Molec Psychiatry, 9(8):731-3, 2004.

Marano CM, Phatak P, Vemulapalli UR, Sasan A, Nalbandyan MR, Ramanujam S, Soekadar S, Demosthenous M, Regenold WT: Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression. J Clin Psychiatry 68, 512-7, 2007.

Regenold WT, Phatak P, Marano CM, Gearhart L, Viens CH, Hisley KC: Myelin staining of deep white matter in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and unipolar major depression. Psychiatry Res 151, 179-88, 2007.

Regenold WT, Phatak P, Makley MJ, Stone RD, Kling MA: Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression. J Neurol Sci  275(1-2): 106-12, 2008.

Regenold WT, Hisley KC, Phatak P, Marano CM, Obuchowski A,Lefkowitz DM, Sassan A,  Ohri S,  Phillips TL, Dosanjh N, Conley RR, and Gullapalli R: Relationship of Cerebrospinal Fluid Glucose Metabolites to MRI Deep White Matter Hyperintensities and Treatment Resistance in Bipolar Disorder Patients. Bipolar Disorders, 10, 753-64, 2008.

Regenold WT, Phatak P, Marano CM, Sassan A, Conley RR, Kling MA. Elevated Cerebrospinal Fluid Lactate Concentrations in Patients with Bipolar Disorder and Schizophrenia: Implications for the Mitochondrial Dysfunction Hypothesis. Biol Psychiatry  .65(6):489-94, 2009.

Regenold WT, Pratt M, Nekkalapu S, Shapiro PS, Kristian T, Fiskum G: Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: Implications for brain energy metabolism and neurotrophic signaling. J Psychiatr Res, 46 (1): 95-104, 2012.

Lachner C, Steinle N, Regenold WT: The Neuropsychiatry of Vitamin B12 Deficiency in the Elderly. J Neuropsychiatry Clin Neurosci, 24 (1): 5-15, 2012.

Lachner C, Martin C, John D, Nekkalapu S, Sasan A, Steinle N, Regenold WT: Older adult psychiatric inpatients with non-cognitive disorders should be screened for vitamin B12 deficiency. J Nutrition, Health and Aging, September 2013.

Klinedinst NJ and Regenold WT: A mitochondrial bioenergetic basis of depression.  J Bioenerg Biomembr, 47(1-2):155-71, 2015.

Adler L and Regenold WT: Valproate-related hyperammonemia in older adult psychiatric inpatients Primary Care Companion CNS Disord, 17(2). Doi: 10.4088/PCC.14l01737, 2015

Regenold WT, Noorani RJ, Piez D, Patel P: Nonconvulsive electrotherapy for treatment resistant unipolar and bipolar major depressive disorder: a proof-of-concept.trial .Brain Stimul, 8(5):855-61, 2015.