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Personal History
EducationMedical School: McGill University Faculty of Medicine, Montreal, Quebec, Canada
Psychiatry Residency: Francis Scott Key Hospital, the Johns Hopkins Hospital, Baltimore, MD and the Maudsley Hospital, London, UK
Research Interests
Dr. Regenold's areas of interest include: brain energy metabolism in neuropsychiatric disorders, including bipolar disorder, schizophrenia, major depression and multiple sclerosis; white matter disease in neuropsychiatric disorders; the therapeutic mechanisms of action of ECT and lithium; and biological markers of neuropsychiatric disorders, including bipolar disorder and Alzheimer's disease.Clinical Speciality
Dr. Regenold is certified in psychiatry and has added qualifications in geriatric psychiatry from the American Board of Psychiatry and Neurology. His clinical work mostly involves older adults. Although he sees patients with a variety of psychiatric problems, he is particularly interested in patients whose psychiatric problems are associated with medical or neurological disorders. He also consults on patients of any age who are considering electroconvulsive therapy (ECT) and performs ECT at the University of Maryland Medical Center.Publications
Peer-reviewed journal articlesRegenold W, Araujo DM, Quirion R: Quantitative autoradiographic distribution of [3H]AF-DX 116 muscarinic-M2 receptor binding sites in rat brain. Synapse, 4:115- 25, 1989.
Packard MG, Regenold W, Quirion R, White NM: Post-training injection of the acetylcholine M2 receptor antagonist AF-DX 116 improves memory. Brain Research, 524: 72-76, 1990.
Mayberg HS, Lewis PJ, Regenold W, Wagner HN Jr.: Paralimbic hypoperfusion in unipolar depression, Journal of Nuclear Medicine, 35: 929-934, 1994.
Regenold WT, Weintraub D, Taller A: Electroconvulsive therapy for epilepsy and major depression, The American Journal of Geriatric Psychiatry, 6: 180-183, 1998.
Regenold WT, Kling MA, Hauser P: Elevated sorbitol concentration in the cerebrospinal fluid of patients with mood disorders, Psychoneuroendocrinology, 25: 593-606, 2000.
Regenold WT, Prasad M: Uses of intravenous valproate in geriatric psychiatry, The American Journal of Geriatric Psychiatry, 9:306-8, 2001.
Regenold WT, Thapar RK, Marano C, Gavirneni S, Kondapavuluru PV: Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar 1 affective and schizoaffective disorders, Journal of Affective Disorders, 70: 19-26, 2002. [Corrigendum: .J Affect Disord. 2003 Feb;73(3):301-2].
Regenold WT, Phatak P, Kling MA, Hauser P: Post-mortem evidence from human brain tissue of disturbed glucose metabolism in mood and psychotic disorders. Molec Psychiatry, 9(8):731-3, 2004.
Carpenter LL, Moreno FA, Kling MA, Anderson GM, Regenold WT, Labiner DM, Price LH: Effect of Vagus Nerve Stimulation on CSF Monoamine Metabolites, Norepinephrine, and GABA Concentrations in Depressed Patients, Biol Psychiatry, 56(6):418-26, 2004.
Regenold WT, Hisley KC, Obuchowski A, Lefkowitz DM, Marano C, Hauser P: Relationship of white matter hyperintensities to cerebrospinal fluid glucose polyol pathway metabolitesâ?"a pilot study in treatment-resistant affective disorder patients. J Affect Disord, 285(3):341-50, 2005.
Regenold WT, D'Agostino CA, Ramesh N, Hasnain M, Roys S, Gullapalli RP: Diffusion-weighted magnetic resonance imaging of white matter in bipolar disorder: a pilot study, Bipolar Disord. 8(2):188-95, 2006
Phatak, P, Shaldivin A, King LS, Shapiro P and Regenold WT: Lithium and inositol: effects on brain water homeostasis in the rat, Psychopharmacol. 186(1):41-7, 2006.
Marano CM, Phatak P, Vemulapalli UR, Sasan A, Nalbandyan MR, Ramanujam S, Soekadar S, Demosthenous M, Regenold WT: Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression. J Clin Psychiatry 68, 512-7, 2007.
Regenold WT, Phatak P, Marano CM, Gearhart L, Viens CH, Hisley KC: Myelin staining of deep white matter in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and unipolar major depression. Psychiatry Res 151, 179-88, 2007.
Regenold WT: Lithium and Increased Cortical Gray Matter-More Tissue or More Water? Biol Psychiatry 63, e17, 2008.
Regenold WT, Phatak P, Makley MJ, Stone RD, Kling MA: Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression. J Neurol Sci 275(1-2): 106-12, 208.
Regenold WT, Hisley KC, Phatak P, Marano CM, Obuchowski A,Lefkowitz DM, Sassan A, Ohri S, Phillips TL, Dosanjh N, Conley RR, and Gullapalli R: Relationship of Cerebrospinal Fluid Glucose Metabolites to MRI Deep White Matter Hyperintensities and Treatment Resistance in Bipolar Disorder Patients. Bipolar Disorders, 10, 753-64, 2008.
Regenold, WT, Phatak P, Marano CM, Sassan A, Conley RR, Kling MA. Elevated Cerebrospinal Fluid Lactate Concentrations in Patients with Bipolar Disorder and Schizophrenia: Implications for the Mitochondrial Dysfunction Hypothesis. Biol Psychiatry .65(6):489-94, 2009.
Ogunmefun A, Hasnain M, Alam A, Osuala T, Regenold WT: Effect of donepezil on tardive dyskinesia. J Clin Psychopharmacol 29 (1):102-4, 2009.
Regenold WT, Pratt M, Nekkalapu S, Shapiro PS, Kristian T, Fiskum G: Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: Implications for brain energy metabolism and neurotrophic signaling. J Psychiatr Res. [Epub ahead of print] Oct 21, 2011
Book Chapters
Sherwin AL, Dyve S, Dubeau F, Regenold W, Guvremont D: Postictal compensatory changes in cortical alpha-1 receptors and adrenergic-mediated phophoinositol metabolism following repeated electroconvulsive seizures in rats, in Generalized Epilepsy: Neurobiological Approaches, Edited by Avoli M, Gloor P, Kostopoulos G, Naquet R. Birkhauser, Boston, Basel, Berlin, 1990.
Regenold WT, Marano C, Glucose metabolism in bipolar disorder, in Trends in Bipolar Disorder Research, Edited by Malcomb R. Brown. Nova Science Publishers, Hauppauge, NY, 2004.
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