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Personal History
Education
1975: B.S., River Plate College, Entre Rios, Argentina, Biological Sciences
1982: M.D., National University of the Northeast, Corrientes, Argentina, Surgery
Residency
1987-1991: Pathology Resident, Univ. of Maryland Hospital, Baltimore, Maryland
1989-1991: Chief Resident, Pathology, Univ. of Maryland Hospital, Baltimore, Maryland
1991-1992: Surgical Pathology Fellowship, University of Maryland Hospital, with concurrent Renal Pathology Elective, Armed Forces Institute of Pathology, Washington, DC
Research Interests
Solid Organ Transplantation (Kidney, Pancreas, Liver), Acute Rejection, Chronic Rejection and Recurrence of Primary Diseases, Viral Infections in Organ Transplants
Grant Support:
Active
5/1/05-4/30/10
Dr. Drachenberg (GI Supervisor; 2.5%; PI Dr. R. Jones, P.I.)
NCI NO2-RC-57004-21
"A Resource for the Collection and Evaluation of Human Tissues and Cells from Donors with an Epidemiological Profile"
Total Directs Awarded: $2,909,338
Pending
7/1/07-6/30/12
Dr. Drachenberg (Collaborator, 5%; PI Dr. Agnes Azimzadeh)
"Immunomodulation for Kidney Allograft Tolerance"
NIH
Annual Direct Costs: $450,000
Total Direct Costs: $2,250,000
7/1/07-6/30/10
Dr. Drachenberg (Co-investigator, 5%; PI Dr. Abdolreza Haririan)
"Thiazolidinediones, PPAR-gamma Agonists, Improve Kidney Transplant Outcomes in Diabetics by Reducing the Risk of Chronic Allograft Hephropathy"
American Diabetes Assoc.
Annual Direct Costs: $173,913
Total Direct Costs: $521,739
Publications
In press
Rubio, L., et al., A multiplex real-time PCR method for quantification of BK and JC polyomaviruses in renal transplant patients. Diagn Mol Pathol. 19(2): p. 105-11.
Drachenberg, C.B. and J.C. Papadimitriou, "Now you see it, now you don't": morphologic variability is a confounder in chronic rejection/graft sclerosis. Transplantation. 89(8): p. 1040.
de Kort, H., et al., Pancreas Allograft Biopsies with Positive C4d Staining and Anti-Donor Antibodies Related to Worse Outcome for Patients. Am J Transplant.
Tervaert, T.W., et al., Pathologic classification of diabetic nephropathy. J Am Soc Nephrol. 21(4): p. 556-63.
Khurana, S., et al., Scopolamine treatment and muscarinic receptor subtype-3 gene ablation augment azoxymethane-induced murine liver injury. J Pharmacol Exp Ther. 333(3): p. 639-49.
Milicevic, N.M., et al., Stereologic analysis of tissue compartments of gunshot-injured and blunt-injured spleen. Pathol Oncol Res. 16(1): p. 69-73.
Munivenkatappa, R., et al., Tubular epithelial cell and podocyte apoptosis with de novo sirolimus based immunosuppression in renal allograft recipients with DGF. Histol Histopathol. 25(2): p. 189-96.
Sis, B., et al., Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant. 10(3): p. 464-71.
Selected Recent Publications (See CV for complete listing)
Kelley, W.E., et al., Washing platelets in neutral, calcium-free, Ringer's acetate. Transfusion, 2009. 49(9): p. 1917-23.
Nguyen, V., et al., TRAIL, DR4 and DR5 are upregulated in kidneys from patients with lupus nephritis and exert proliferative and proinflammatory effects. Clin Immunol, 2009. 132(1): p. 32-42.
Tavora, F., et al., Quantitation of T lymphocytes in posttransplant transbronchial biopsies. Hum Pathol, 2009. 40(4): p. 505-15.
Barth, R.N., et al., Prolonged survival of composite facial allografts in non-human primates associated with posttransplant lymphoproliferative disorder. Transplantation, 2009. 88(11): p. 1242-50.
Haririan, A., et al., Positive cross-match living donor kidney transplantation: longer-term outcomes. Am J Transplant, 2009. 9(3): p. 536-42.
Manitpisitkul, W., et al., Maintenance immunosuppressive agents as risk factors for BK virus nephropathy: a case-control study. Transplantation, 2009. 88(1): p. 83-8.
Wolff, J.H., E.M. Goldberg, and C.B. Drachenberg, Large solitary rectal ulcer as a complication of prostate brachytherapy. Gastrointest Endosc, 2009. 70(2): p. 389-90; discussion 390.
Munivenkatappa, R.B., et al., Interacinar c4d staining in pancreas allografts. Transplantation, 2009. 88(1): p. 145-6.
Haririan, A., et al., The impact of c4d pattern and donor-specific antibody on graft survival in recipients requiring indication renal allograft biopsy. Am J Transplant, 2009. 9(12): p. 2758-67.
Melis, M., et al., Full thickness transanal re-excision following endoscopic removal of malignant rectal polyps. Int J Colorectal Dis, 2009. 24(5): p. 531-6.
Nogueira, J.M., et al., The detrimental effect of poor early graft function after laparoscopic live donor nephrectomy on graft outcomes. Am J Transplant, 2009. 9(2): p. 337-47.
Ramos, E., et al., The decade of polyomavirus BK-associated nephropathy: state of affairs. Transplantation, 2009. 87(5): p. 621-30.
Barth, R.N., et al., Antibody-mediated rejection of renal allograft in combined liver-kidney transplant. Clin Transplant, 2009.
Gosert, R., et al., Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology. J Exp Med, 2008. 205(4): p. 841-52.
Munivenkatappa, R.B., et al., The Maryland aggregate pathology index: a deceased donor kidney biopsy scoring system for predicting graft failure. Am J Transplant, 2008. 8(11): p. 2316-24.
Raufman, J.P., et al., Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res, 2008. 68(10): p. 3573-8.
Carter-Monroe, N.L., et al., A comparison of the diffusion of two innovations -- a pilot study: telemicroscopy versus teleradiology. AMIA Annu Symp Proc, 2008: p. 891.
Hitti, W.A., et al., Cholesterol embolization syndrome induced by thrombolytic therapy. Am J Cardiovasc Drugs, 2008. 8(1): p. 27-34.
Drachenberg, C.B., et al., Banff schema for grading pancreas allograft rejection: working proposal by a multi-disciplinary international consensus panel. Am J Transplant, 2008. 8(6): p. 1237-49.
Cendales, L.C., et al., The Banff 2007 working classification of skin-containing composite tissue allograft pathology. Am J Transplant, 2008. 8(7): p. 1396-400.
Solez, K., et al., Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant, 2008. 8(4): p. 753-60.
Cheng, K., et al., Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol, 2008. 295(3): p. G591-7.
Hitti, W., et al., Xanthogranulomatous pyelonephritis in a renal allograft associated with xanthogranulomatous diverticulitis: report of the first case and review of the literature. Nephrol Dial Transplant, 2007. 22(11): p. 3344-7.
Kanner, W.A., et al., Urethral stromal tumor with pacemaker cell phenotype. Ultrastruct Pathol, 2007. 31(1): p. 63-71.
Alexiev, B.A., C.B. Drachenberg, and A.P. Burke, Thymomas: a cytological and immunohistochemical study, with emphasis on lymphoid and neuroendocrine markers. Diagn Pathol, 2007. 2: p. 13.
Drachenberg, C.B. and J.C. Papadimitriou, Spectrum of histopathological changes in pancreas allograft biopsies and relationship to graft loss. Transplant Proc, 2007. 39(7): p. 2326-8.
Drachenberg, C.B., et al., Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. Transplantation, 2007. 84(3): p. 323-30.
Alexiev, B.A., C.B. Drachenberg, and J.C. Papadimitriou, Endocrine tumors of the gastrointestinal tract and pancreas: grading, tumor size and proliferation index do not predict malignant behavior. Diagn Pathol, 2007. 2: p. 28.
Selaru, F.M., et al., Electronic clinical challenges and images in GI. Fibrolamellar carcinoma. Gastroenterology, 2007. 133(5): p. e1-3.
Wali, R.K., et al., Early withdrawal of calcineurin inhibitors and rescue immunosuppression with sirolimus-based therapy in renal transplant recipients with moderate to severe renal dysfunction. Am J Transplant, 2007. 7(6): p. 1572-83.
Solez, K., et al., Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant, 2007. 7(3): p. 518-26.
Singh, H.K., et al., Urine cytology findings of polyomavirus infections. Adv Exp Med Biol, 2006. 577: p. 201-12.
Drachenberg, C.B. and J.C. Papadimitriou, Polyomavirus-associated nephropathy: update in diagnosis. Transpl Infect Dis, 2006. 8(2): p. 68-75.
Hirsch, H.H., et al., Polyomavirus-associated nephropathy in renal transplantation: critical issues of screening and management. Adv Exp Med Biol, 2006. 577: p. 160-73.
Peng, H.Q., et al., Liver metastases of pancreatic acinar cell carcinoma with marked nuclear atypia and pleomorphism diagnosed by EUS FNA cytology: a case report with emphasis on FNA cytological findings. Cytojournal, 2006. 3: p. 29.
Semple, K., J. Lovchik, and C. Drachenberg, Identification of polyoma BK virus in kidney transplant recipients by shell vial cell culture assay and urine cytology. Am J Clin Pathol, 2006. 126(3): p. 444-7.
Drachenberg, C.B., J.C. Papadimitriou, and E. Ramos, Histologic versus molecular diagnosis of BK polyomavirus-associated nephropathy: a shifting paradigm? Clin J Am Soc Nephrol, 2006. 1(3): p. 374-9.
Chan-Tack, K.M., et al., Acute renal failure and nephrotic range proteinuria due to amyloidosis in an HIV-infected patient. Am J Med Sci, 2006. 332(6): p. 364-7.
El-Asady, R., et al., TGF-{beta}-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J Exp Med, 2005. 201(10): p. 1647-57.
Crowder, C.D., et al., Successful outcome of progressive multifocal leukoencephalopathy in a renal transplant patient. Am J Transplant, 2005. 5(5): p. 1151-8.
Hirsch, H.H., et al., Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation, 2005. 79(10): p. 1277-86.
Ramos, E. and C. Drachenberg, Polyomavirus nephropathy. Saudi J Kidney Dis Transpl, 2005. 16(4): p. 514-9.
Drachenberg, C.B., et al., Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods. Hum Pathol, 2005. 36(12): p. 1245-55.
Drachenberg, C.B., et al., Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy. Transplantation, 2005. 80(2): p. 276-8.
Aggarwal, M., et al., The efficacy of real-time 3-dimensional echocardiography for right ventricular biopsy. J Am Soc Echocardiogr, 2005. 18(11): p. 1208-12.
Wali, R.K., et al., Effect of kidney transplantation on left ventricular systolic dysfunction and congestive heart failure in patients with end-stage renal disease. J Am Coll Cardiol, 2005. 45(7): p. 1051-60.
Yuan, R., et al., Critical role for CD103+CD8+ effectors in promoting tubular injury following allogeneic renal transplantation. J Immunol, 2005. 175(5): p. 2868-79.
Xie, G., et al., Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors. Am J Physiol Gastrointest Liver Physiol, 2005. 289(3): p. G521-9.
Kasamon, K.M., et al., Catastrophic antiphospholipid syndrome: atypical presentation in the setting of chronic graft versus host disease: case report and review of the literature. Haematologica, 2005. 90(3): p. ECR17.
Ramos, E., et al., Retransplantation in patients with graft loss caused by polyoma virus nephropathy. Transplantation, 2004. 77(1): p. 131-3.
Regev, A., et al., Reliability of histopathologic assessment for the differentiation of recurrent hepatitis C from acute rejection after liver transplantation. Liver Transpl, 2004. 10(10): p. 1233-9.
Crosse, K., et al., Racial differences in liver inflammation and fibrosis related to chronic hepatitis C. Clin Gastroenterol Hepatol, 2004. 2(6): p. 463-8.
Nahar, A., et al., Pyelonephritis and acute renal failure. Am J Med Sci, 2004. 328(2): p. 121-3.
Gobert, A.P., et al., Protective role of arginase in a mouse model of colitis. J Immunol, 2004. 173(3): p. 2109-17.
Kennedy, A.S., et al., Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol Biol Phys, 2004. 60(5): p. 1552-63.
Drachenberg, C.B. and J.C. Papadimitriou, The inflamed pancreas transplant: histological differential diagnosis. Semin Diagn Pathol, 2004. 21(4): p. 255-9.
Drachenberg, C.B., et al., Improved outcome of polyoma virus allograft nephropathy with early biopsy. Transplant Proc, 2004. 36(3): p. 758-9.
Buckles, E.L., et al., Identification and characterization of a novel uropathogenic Escherichia coli-associated fimbrial gene cluster. Infect Immun, 2004. 72(7): p. 3890-901.
Drachenberg, C.B., et al., Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Am J Transplant, 2004. 4(12): p. 2082-92.
Drachenberg, C.B., et al., Histological findings in "incidental" intraoperative pancreas allograft biopsies. Transplant Proc, 2004. 36(3): p. 780-1.
6
Xie, X.Y., et al., Gastrointestinal stromal tumors: update. Arkh Patol, 2004. 66(2): p. 36-40.
Drachenberg, C., et al., Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. Transplant Proc, 2004. 36(10): p. 3028-31.
Arluk, G.M., C. Drachenberg, and P. Darwin, Colonic cystic lymphangioma. Gastrointest Endosc, 2004. 60(1): p. 98.
Wali, R.K., et al., BK virus-associated nephropathy in renal allograft recipients: rescue therapy by sirolimus-based immunosuppression. Transplantation, 2004. 78(7): p. 1069-73.
Armand, R., et al., Adrenal cortical adenoma with excess black pigment deposition, combined with myelolipoma and clinical Cushing's syndrome. Int J Surg Pathol, 2004. 12(1): p. 57-61.
Haririan, A., et al., Polyomavirus reactivation in native kidneys of pancreas alone allograft recipients. Transplantation, 2003. 75(8): p. 1186-90.
Papadimitriou, J.C., et al., Histological grading of chronic pancreas allograft rejection/graft sclerosis. Am J Transplant, 2003. 3(5): p. 599-605.
Papadimitriou, J.C., et al., Histologic features of mycophenolate mofetil-related colitis: a graft-versus-host disease-like pattern. Int J Surg Pathol, 2003. 11(4): p. 295-302.
Drachenberg, C.B., et al., BK polyoma virus allograft nephropathy: ultrastructural features from viral cell entry to lysis. Am J Transplant, 2003. 3(11): p. 1383-92.
Li, X., et al., Visualization of Proteus mirabilis within the matrix of urease-induced bladder stones during experimental urinary tract infection. Infect Immun, 2002. 70(1): p. 389-94.
Haririan, A., et al., Polyomavirus nephropathy in native kidneys of a solitary pancreas transplant recipient. Transplantation, 2002. 73(8): p. 1350-3.
Klassen, D.K., et al., Pancreas allograft biopsy: safety of percutaneous biopsy-results of a large experience. Transplantation, 2002. 73(4): p. 553-5.
Hankey, K.G., et al., MIC expression in renal and pancreatic allografts. Transplantation, 2002. 73(2): p. 304-6.
Nikitakis, N.G., C.B. Drachenberg, and J.C. Papadimitriou, MDM2 and CDK4 expression in carcinosarcoma of the esophagus: comparison with squamous cell carcinoma and review of the literature. Exp Mol Pathol, 2002. 73(3): p. 198-208.
Lustberg, A.M., et al., Hyperbaric oxygen treatment for intractable diarrhea caused by pneumatosis coli. Gastrointest Endosc, 2002. 56(6): p. 935-7.
Chapters
Drachenberg, C.B., Papadimitriou, J.C., & Klassen, D.K. Pathology of Kidney Allografts. In: Weir, M.R. (Ed.). Medical Management of Kidney Transplantation. Chapter 31. Baltimore: Lippincott, Williams & Wilkins, p. 473-484, 2005.
Singh, H.K., Bubendorf, L., Mihatsch, M.J., Drachenberg, C.B., & Nickeleit, V. Urine cytology findings of polyomavirus infections. Adv. Exp. Med. Biol., 577:201-12, 2006
Hirsch HH, Drachenberg CB, Steiger J, Ramos E. Polyomavirus-associated nephropathy in renal transplantation: critical issues of screening and management. Adv Exp Med Biol. 2006;577:160-73.