Dr. Jian-Ying Wang received his medical degree from Sun Yat-Sen University School of Medicine, China, in 1978 and Ph.D degree from Peking (Beijing) University School of Medicine in 1986. He then completed postdoctoral training at Kyoto Pharmaceutical University, Japan, and University of Texas School of Medicine at Houston.
In 1994, Dr. Wang joined the faculty of University of Maryland School of Medicine as an assistant professor. He was subsequently promoted to associate professor with tenure in 1998 and professor in 2002. Dr. Wang has been appointed as an associate chair for basic research of the Department of Surgery from 2005. Dr. Wang is also an investigator of Medical Research Service, US Department of Veterans Affairs, and he has been selected as an honor position as Senior Research Career Scientist from 2011.
Dr. Wang has published 131 original research articles, 19 review articles and book chapters, and 3 reference books on gut physiology and polyamine topics. Dr. Wang's research program has been continuously funded by multiple NIH grants and VA Merit-Review grants for more than twenty years. His service to the scientific community is also exceptional, as Dr. Wang serves as a member of multiple NIH study sections and VA-MERIT Review study sections, and is also on the editorial board for several scientific journals.
Dr. Wang's research focuses on understanding of how gut mucosa functions to repair itself after injury and how gut epithelial integrity is maintained under biological and critical pathological conditions, with specifically focusing on the importance of cellular polyamines in these processes. The natural polyamines (spermidine and spermine and their precursor putrescine) are organic cations found in all eukaryotic cells and are implicated in many aspects of cellular physiology. Studies in Dr. Wang's laboratory are to define the exact roles and mechanisms of polyamines and polyamine-regulated genes in the regulation of gut epithelial cell proliferation, apoptosis, migration, and cell-cell interaction.
He first reported that polyamines stimulate repair of damaged mucosa and are crucial for maintaining the gut epithelial integrity. His group further found that polyamines up-regulate expression of growth-promoting genes by increasing gene transcription but down-regulate growth-inhibiting genes through destabilization of mRNAs. His group has further elucidated critical mechanism underlying posttranscriptional gene regulation by polyamines, finding that polyamines regulate the stability and translation of mRNAs via RNA-binding proteins and microRNAs. Importantly, Dr. Wang's research projects are directly relevant to patients with trauma, hemorrhage, and massive surgical operations. The ongoing studies in Dr. Wang's group is to further define the link between the posttranscriptional gene regulation and mucosal injury/repair, inflammation, leaky gut, and sepsis.
In addition, Dr. Wang has successfully mentored young scientists and junior faculty. During the past five years, six trainees under Dr. Wang's mentorship received NIH grants, VA Career development Awards, and VA Merit-Review Awards. Dr. Wang's research program has added depth and a higher level of sophistication to our biomedical research community in general.
Lab Techniques and Equipment:
The Wang laboratory uses physiology, cell biology, biochemistry, molecular biology, and transgenic/knockout mouse models to study gut mucosal growth, injury/repair, and barrier function. This includes molecular cloning and expression of regulatory proteins, cellular transfection with cDNAs or microRNAs and infection with adenovirus, nuclear run-on transcription assays and gel shift assays, ribonucleoprotein and biotin pulldown assays, polysome profile analysis, promoter deletion and point mutations, and fluorescence measurement of intracellular Ca2+ concentration, and measurements of paracellular permeability and barrier functions.