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John  W Warren
 

John W Warren M.D.

Academic Title: Professor
Primary Appointment: Medicine
Secondary Appointments: Epidemiology & Public Health
JWARREN@medicine.umaryland.edu
Location: MSTF Room 9-00
Phone: (410) 706-2480
Fax: (410) 706-4200

Research Interests:

I have evolved from a long standing interest in urinary tract infections to interstitial cystitis (IC), which from all available evidence is NOT an infectious disease.  This is a disease comprising bladder pain, urinary urgency, urinary frequency, and nocturia, 90% of patients are women, and the etiology is unknown.

Funded by the National Institutes of Health, my colleagues and I have four objectives in our investigations of interstitial cystitis:

1) To determine risk factors for IC in a nation-wide case control study seeking exposures antecedent to onset of symptoms. 
2) To seek the alleles of susceptibility to IC in a, separate, nation-wide study of families with 2 or more IC patients.
3) To carefully study the onset of IC to reveal hints as to its etiology. 
4) To carefully investigate the symptoms of IC to develop a better case definition for this symptom-based disease.

In the process of investigating these aspects of IC, we are attempting to understand its relationship with several non-bladder diseases which appear to be epidemiologically associated with IC: systemic lupus erythematosis, panic attacks, fibromyalgia, irritable bowel syndrome, and inflammatory bowel disease.

Clinical Speciality:

I continue to be excited about the variety of infectious diseases patients encountered at University Hospital and attend, on an inpatient basis, two to three months a year.

Publications:

Trifillis, A.L., Cui, X., Jacobs, S., Warren, J.W.  Culture of bladder epithelium from cystoscopic biopsies of patients with interstitial cystitis.  J. Urol.  1995; 153:243-248.

Keay, S., Schwalbe, R.S., Trifillis, A.L., Lovchik, J.C., Jacobs, S., Warren, J.W.  A prospective study of microorganisms in urine and bladder biopsies from interstitial cystitis patients and controls.  Urology 1995; 45:223-229.

Johnson, D.E., Lockatell, C.V., Russell, R.G., Hebel, J.R., Island, M.D., Stapleton, A., Stamm, W.E., Warren, J.W.  Comparison of  Escherichia coli strains recovered from human cystitis and pyelonephritis infections in transurethrally challenged mice.  Infect. Immun. 1998; 66:3059-3065.

Warren, J.W., Abrutyn, E., Hebel, J.R., Johnson, J.R., Schaeffer, A.J., Stamm, W.E.  Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Clin. Infect. Dis. 1999; 29:745-758.

Warren, J.W., Horne, L.M., Hebel, J.R., Marvel, R.P., Keay, S.K., Chai, T.C.  Pilot study of sequential oral antibiotics in the treatment of interstitial cystitis.  J. Urol.  2000; 163:1685-1688.

Warren, J.W., Keay, S.K., Meyers, D., Xu, J.  Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs.  Urology 2001; 57:22-25.

Warren, J.W., Jackson T.L., Langenberg, P., Meyers, D.J., and Xu, J.  Prevalence of interstitial cystitis in first-degree relatives of patients with interstitial cystitis.  J Urol 2004; 63 (1): 17-21.

Warren, J.W., Diggs, C., Brown, V., Meyer, W.A., Markowitz, S., and Greenberg, P. Dysuria on onset of interstitial cystitis/painful bladder syndrome in women.  Urology. (accepted for publication).