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Katja M Langen
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Katja M Langen Ph.D.

Academic Title: Associate Professor
Primary Appointment: Radiation Oncology
Administrative Title: Associate Chief
klangen@som.umaryland.edu
Location: UMMC/Gudelsky, GGJ-40
Phone: 410-328-0773
Fax: 410-328-2618

Personal History:

Dr. Katja Langen received her PhD from the University of Wisconsin. Dr. Langen trained as a post-doctoral fellow at the National Accelerator Centre in Faure, South Africa. In 2003, Dr. Langen completed her residency training at the University of California. Dr. Langen came to the University of Maryland from MD Anderson Cancer Center, in Orlando, Florida, where she was a Senior Medical Physicist. Dr. Langen leads the physics effort at the Maryland Proton Treatment Center.

Research Interests:

  • Proton Therapy

Clinical Speciality:

  • Adaptive Radiation Therapy
  • Organ motion and its impact on radiation therapy treatments
  • Helical tomotherapy

Publications:

Books and Chapters

Langen KM, Meeks SL, Kupelian PA, Ruchala R, Lu L, Haimerl J, Chen Q, Schnarr E and Olivera G. TomoTherapy’s implementation on IGART. In: AAPM Summer School 2006: Integrating new technologies into the clinic: Monte Carlo dose calculations/Image guided radiation therapy. Medical Physics Publishing, Madison, Wisconsin. 2006.

Kupelian PA  and Langen KM. Helical Tomotherapy, Image Guided and Adaptive Radiotherapy. In: Frontiers of Radiation Therapy and Oncology, Vol 43, Karger AG Basel Switzerland 2011.

Langen KM. Uncertainties in Adaptive Radiation Therapy. In: AAPM Summer School 2011: Uncertainties in External Beam Radiation Therapy. Medical Physics Publishing, Madison, Wisconsin. 2011.

Meeks SL, Willoughby TR, Langen KM, Kupelian PA. Optical and remote monitoring IGRT. In Image-Guided Radiation Therapy, D Bourland (ed), Taylor and Francis, 2012.

Selected Recent Journal Articles

Azimi-Garakani D, Langen KM, Wernli C, Pihet, P. The Response of various neutron dosimeters at high energy neutrons. Nuclear Instrum. Methods.  A320:368-374, 1992.

Azimi-Garakani D, Langen KM, Wernli C, Pihet P.  Further study of the characteristics of different proton-recoil track detectors at various energies.  Radiat. Meas. 23:241-245, 1994.

Langen KM, Jones D.  Organ motion and its management.  International Journal of Radiation Oncology, Biology and Physics.  50:265-278, 2001.

Buffer A, Brooks F, Allie M, Binns P, Dangendorf V, Langen KM, Nolte R, Schuhmacher.  Measurement of neutron energy spectra from 15 to 150 MeV using stacked liquid scintillators.  Nucl. Instrum. Methods. A476:181-185, 2002.

Langen KM, Binns P, Lennox A, Kroc T, Deluca, Jr. P.  Pileup correction of microdosimetric spectra.  Nucl. Instrum. Methods.  A484:595-612, 2002.

Pouliot J, Aubin M, Langen KM, Liu Y, Pickett B, Roach III M.  Non-migration of implanted prostate markers used for daily online verification.  International Journal of Radiation Oncology, Biology and Physics.  56:862-866, 2003.

Langen KM, Binns P, Schreuder A, Lennox A, Deluca, Jr. P.  Measurement of the tissue to A-150 tissue equivalent plastic kerma coefficient ratio at two p(66)Be neutron therapy facilities.  Phys. Med. Biol.  48:1345-1359, 2003.

Langen KM, Pouliot J, Anezinos C, Aubin M, Gottschalk A, Hsu I, Lowther D, Shinohara K, Weinberg V, Verhey L, Roach III M.  Evaluation of ultrasound-based prostate localization for image guided radiation therapy.  International Journal of Radiation Oncology, Biology and Physics.  57:635-644, 2003.

Liu Y, Ling S, Langen KM, Shinohara K, Weinberg V, Pouliot J, Roach III M.  Prostate movement during simulation resulting from retrograde urethrogram compared with “natural” prostate movement.  International Journal of Radiation Oncology, Biology and Physics.  60:470-475, 2004.

Bhengu KJ, Langen KM, Symons JE, Jones DTL. Thermoluminescence dosimetry on a fast neutron therapy beam. Radiation Physics and Chemistry, 71 (304):981-982, 2004.

Langen KM, Zhang Y, Andrews R, Hurley M, Meeks S, Poole D, Willoughby T, Kupelian P.  Initial experience with Megavoltage (MV) CT-guidance for daily prostate alignments.  International Journal of Radiation Oncology, Biology and Physics.  62(5):1517-1524, 2005.

Kupelian P, Ramsey C, Meeks S, Willoughby T, Forbes A, Wagner T, Langen KM.  Serial megavoltage CT imagining during external beam radiotherapy for non-small cell lung cancer: Observations on tumor regression during treatment.  International Journal of Radiation Oncology, Biology and Physics. 63(4):1024-1028, 2005.

Langen KM, Meeks S, Poole D, Wagner T, Willoughby T, Kupelian P, Ruchala J, Haimerl J, Olivera G.  The use of megavoltage CT (MVCT) images for dose recomputations.  Phys. Med. Biol.  50(18):4259-4276, 2005.
Meeks S, Harmon J, Langen KM, Willoughby T, Wagner T, Kupelian P.  Performance characterization of megavoltage computed tomography imaging on a helical tomotherapy unit.  Medical Physics.  32(8):2673-2681, 2005.

Kupelian P, Willoughby T, Meeks S, Forbes A, Wagner T, Maach M, Langen KM.  Intraprostatic fiducials for localization of the prostate gland:  Monitoring intermarker distances during radiation therapy to test for marker stability.   International Journal of Radiation Oncology, Biology and Physics.  62(5):1291-1296, 2005.

Langen KM, Meeks S, Poole D, Wagner T, Willoughby T, Zeidan O, Kupelian P.  Evaluation of a diode array for QA measurements on a helical TomoTherapy unit.  Medical Physics, 32(11):3424-3430, 2005.

Ramsey C, Langen KM, Kupelian P, Scaperoth D, Meeks S, Mahan S.  A technique for adaptive image-guided helical tomotherapy for lung cancer.  International Journal of Radiation Oncology, Biology and Physics, 64(4):1237-44, 2006.

Gonzalez V, Buchholz D, Langen KM, Olivera G, Chauhan B, Meeks S, Ruchala K, Haimerl J, Kupelian P.  Evaluation of helical tomotherapy-based techniques for delivery of whole breast intensity modulated radiation therapy.  International Journal of Radiation Oncology, Biology and Physics, 65(1):284-290, 2006.

Willoughby TR, Forbes AR, Buchholz D, Langen KM, Wagner TH, Zeidan OA, Kupelian PA, Meeks SL. Evaluation of an infrared camera and x-ray system using implanted fiducials in patients with lung tumors for gated radiation therapy. International Journal of Radiation Oncology, Biology and Physics, 66(2):568-575, 2006.

Lu W, Olivera GH, Chen O, Ruchala KJ, Haimerl J, Meeks SL, Langen KM, Kupelian PA. Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy. Physics in Medicine and Biology, 51 (17): 4357-4374, 2006.

Kupelian PA, Langen KM, Willoughby TR, Wagner TH, Zeidan OA, Meeks SL. Daily variations  in the position of the prostate bed in patients with prostate cancer receiving postoperative external beam radiation therapy. International Journal of Radiation Oncology, Biology and Physics, 66(2):593-596, 2006.

Kupelian PA, Langen KM, Zeidan OA, Meeks SL. Willoughby TR, Wagner TH, Jeswani S, Ruchala KJ, Haimerl J, Olivera GH. Daily variations in delivered doses in patients treated with radiotherapy for localized prostate cancer. International Journal of Radiation Oncology, Biology and Physics, 66(3):876-882, 2006.

Zeidan OA, Stephenson SA, Meeks SL, Wagner TH, Willoughby TR, Kupelian PA, Langen KM. Characterization and use of EBT radiochromic film for IMRT dose verification. Medical Physics, 33(11):4064-4072, 2006.

Santhanam, AP, Fidopiastis CM, Davenport P, Langen K, Meeks S, Rolland, JP. Real-time simulation and visualization of subject-specific 3D lung dynamics. Proceedings –IEEE Symposium on Computer-Based Medical Systems: 629-634, 2006.

Seibert RM, Ramsey CR, Hines JW, Kupelian PA, Langen KM, Meeks SL, Scaperoth DD. A model for predicting lung cancer response to therapy. International Journal of Radiation Oncology, Biology and Physics, 67(2):601-609, 2007.

Zeidan OA, Langen KM, Meeks SL, Manon RR, Wagner TH, Willoughby TR, Jenkins DW, Kupelian PA. Evaluation of image-guidance protocols in the treatment of head and neck cancers. International Journal of Radiation Oncology, Biology and Physics, 67(3):670-677, 2007.

Herbert MS, Brooks FD, Allie MS, Buffler A, Nchodu MR, Makupula SA, Jones DTL, Langen KM. Determination of neutron energy spectra inside a water phantom irradiated by 64 MeV neutrons. Radiation Protection Dosimetry, 126 (1-4):346-9, 2007.

Kupelian PA, Langen KM, Willoughby TR, Zeidan OA, Meeks SL. Image-Guided Radiotherapy for Localized Prostate Cancer: Treating a moving Target.  Semin Radiat Oncol. 18(1):58-66, 2008.

Kupelian PA, Lee C, Langen KM, Zeidan OA, Mañon RR, Willoughby TR, Meeks SL. Evaluation of Image-Guidance Strategies in the Treatment of Localized Prostate Cancer.
International Journal of Radiation Oncology, Biology and Physics, 70(4):1151-7, 2008.

Langen KM, Buchholz DJ, Burch DR, Burkavage R, Limaye AU, Meeks SL, Kupelian PA, Ruchala KJ, Haimerl J, Henderson D, Olivera GH. Investigation of accelerated partial breast alignment and treatment with a helical tomotherapy unit.  International Journal of Radiation Oncology, Biology and Physics, 70(4):1272-80, 2008.

Langen KM, Meeks SL, Pouliot J. Quality Assurance of Onboard MVCT Imaging and Target Localization Systems for On- and Off-line Image Guided Radiation Therapy. International Journal of Radiation Oncology, Biology and Physics, 71(1):S62-S65, 2008.

Shah AP, Langen KM, Ruchala KJ, Cox A, Kupelian PA, Meeks SL. Patient dose from megavoltage computed tomography imaging. International Journal of Radiation Oncology, Biology and Physics, 70(5), 1579-87, 2008.

Newhauser WD, Giebeler A, Langen KM, Mirkovic D, Mohan R. Can megavoltage computed tomography reduce proton range uncertainties in treatment plans for patients with large metal implants. Physics in Medicine and Biology, 53(9):2327-44, 2008.

Langen KM, Willoughby TR, Meeks SL, Santhanam A, Levine L, Kupelian, PA. Observations on real-time prostate gland motion using electromagnetic tracking. International Journal of Radiation Oncology, Biology and Physics, 71(4):1084-90, 2008.

Lee C, Langen KM, Lu W, Haimerl J, Schnarr E, Ruchala KJ, Olivera GH, Meeks S, Kupelian PA, Shellenberger TD, Mañon RR. Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily MVCT and deformable image registration. International Journal of Radiation Oncology, Biology and Physics, 71(5): 1563-1571, 2008.

Poulson PR, Cho BC, Langen KM, Kupelian PA, Keall PJ. Three-dimensional prostate position estimation with a single x-ray imager utilizing spatial probability density. Physics in Medicine and Biology, 53(16):4331-4353, 2008.

Lee C, Langen KM, Lu W, Haimerl J, Schnarr E, Ruchala KJ, Olivera GH, Meeks S, Kupelian PA, Shellenberger TD, Mañon RR. Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration. Radiotherapy and Oncology, 89(1):81-88, 2008.

Lopatiuk-Tirpak O, Langen KM, Meeks SL, Kupelian PA, Zeidan OA, Maryanski MJ. Performance Evaluation of an Improved Optical Computed Tomography Gel Dosimeter System for 3-D Dose Verification of Static and Dynamic Phantom Deliveries. Medical Physics, 35(9):3847-3859, 2008.

Langen KM, Lu W, Ngwa W, Willoughby TR, Chauhan B, Meeks SL, Kupelian PA, Olivera G. Correlation of dosimetric effect and intrafraction motion during prostate treatments delivered with helical tomotherapy. Physics in Medicine and Biology, 53(24):7073-7086, 2008.

Langen KM, Lu W, Willoughby TR, Chauhan B, Meeks SL, Kupelian PA, Olivera G. Dosimetric effect of prostate motion during helical tomotherapy. International Journal of Radiation Oncology, Biology and Physics, 74(4): 1134-42, 2009.

Wagner TH, Langen KM, Meeks SL, Willoughby TR, Zeidan OA, Staton RJ, Shah AP, Manon RR, Kupelian PA. Megavoltage computed tomography image-based low-dose rate intracavitary brachytherapy planning for cervical carcinoma. Technol. Cancer Res Treat, 8(2):123-130, 2009.

Staton RJ, Langen KM, Kupelian PA, Meeks SL. Dosimetric effects of rotational output variation and x-ray target degradation on helical tomotherapy plans. Medical Physics, 36(7): 2881-8, 2009.

Lu W, Chen M, Ruchala KJ, Chen Q, Langen KM, Kupelian PA, Olivera GH. Real-time motion-adaptive-optimization (MAO) in TomoTherapy. Physics in Medicine and Biology, 54(14):4373-98, 2009.

Ngwa W, Meeks SL, Kupelian PA, Schnarr E, Langen KM. Validation of a computational method for assessing the impact of intra-fraction motion on helical tomotherapy plans, Physics in Medicine and Biology, 54(21):6611-21, 2009.

Zeidan OA, Huddleston AJ, Lee C, Langen KM, Kupelian PA, Meeks SL, Manon RR. A comparison of implanted soft-tissue markers and bony anatomy alignments for image-guided treatments of head and neck cancers. International Journal of Radiation Oncology, Biology, and Physics, 76(3):767-774, 2010

Waghorn BJ, Shah AP, Ngwa W, Meeks SL, Moore JA, Siebers, JV, Langen KM. A computational method for estimating the dosimetric effect of intra-fraction motion on Step-and-Shoot IMRT and compensator plans, Physics in Medicine and Biology, 55(14): 4187-4202, 2010.

Langen KM, Papanikolaou N, Balog J, Crilly R, Followill D, Goddu SM, Grant W, Olivera G, Ramsey CR, Shi C. QA for Helical Tomotherapy: Report of the AAPM Task Group 148, Medical Physics, Medical Physics, 37(9):4817-4853, 2010.

Shah AP, Kupelian PA, Willoughby TR, Langen KM, Meeks SL. An evaluation of intrafraction motion of the prostate in the prone and supine positions using electromagnetic tracking, Radiotherapy and Oncology 99(4):37–43, 2011.

Waghorn BJ, Meeks SL, Langen KM. Analyzing the impact of intrafraction motion: Correlation of different dose metrics with changes in target D95%. Medical Physics, 38(8):4505-4511, 2011.

Pukala J, Meeks SL, Bova FJ, Langen KM. The effect of temporal HU variations on the uncertainty of dose recalculations performed on MVCT images. Physics in Medicine and Biology, 56(24):7829-41, 2011.

Bissonnette J-P, Balter PA, Dong L, Langen KM, Lovelock DM, Miften M, Moseley DJ, Pouliot J, Sonke J-J, Yoo S.  Quality assurance for image-guided radiation therapy utilizing CT-based technologies: A report of the AAPM TG-179. Medical Physics, 39(4):1946-1963, 2012.

Smeenk RJ, Louwe RJW, Langen KM, Shah AP, Kupelian PA, van Lin ENJTh, Kaanders JHAM. An Endorectal Balloon Reduces Intrafraction Prostate Motion During Radiotherapy. International Journal of Radiation Oncology, Biology and Physics, 83(2):661-669, 2012.

Langen KM, Chauhan B, Siebers JV, Moore JA, Kupelian P. The dosimetric effect of intrafraction prostate motion on step-and-shoot IMRT plans – magnitude, correlation with motion parameters, and comparison with helical tomotherapy plans. International Journal of Radiation Oncology, Biology and Physics, 84(5):1220-1225, 2012.

Waghorn BJ, Staton RJ, Rineer JM, Meeks SL, Langen KM, A comparison of the dosimetric Effects of Intrafraction Motion on Step-and-Shoot, Compensator, and Helical Tomotherapy based IMRT, Journal of Applied Clinical Medical Physics, 14(3):121-132, 2013.

Jaffray DA, Langen KM, Mageras G, Dawson LA, Yan D, Adams R, Mundt AJ, Frass B, Safety consideration for IGRT: Executive Summary, Practical Radiation Oncology, Practical Radiation Oncology, 3(3):167-170, 2013.

De Los Santos J, Popple R, Agazaryan N, Bayouth J, Bissonnette J-P, Bucci MK, Dieterich S, Dong L, Forster KM, Indelicato D, Langen K, Lehman J, Mayr N, Parsai I, Salter W, Tomblyn M, Yuh WTC, Chetty IP. Image Guided Radiation Therapy (IGRT) Technologies for Radiation Therapy Localization and Delivery, International Journal of Radiation Oncology, Biology and Physics, 87(1):33-45, 2013.

Pukala J, Meeks SL, Staton RJ, Bova FJ, Langen KM, A virtual phantom Library for the quantifications of deformable image registration uncertainties with cancer of the head and neck, Medical Physics, In Press, 2013.