Matthew R Weir
View Curriculum Vitae 

Matthew R Weir M.D.

Academic Title: Professor
Primary Appointment: Medicine
Administrative Title: Division Head
MWEIR@medicine.umaryland.edu
Location: UMMS N3W143
Phone: 410-328-5720
Phone: 410-328-8717
Fax: 410-328-5685 (Fax)

Personal History

Matthew R. Weir, MD, is attending physician and Director of the Division of Nephrology in the Department of Medicine at the University of Maryland Hospital, Baltimore. He is also Professor of Medicine at the University of Maryland School Of Medicine.

Dr. Weir’s primary research interests include the use of antihypertensive therapy for the treatment of diabetic nephropathy, hypertensive renal injury in African Americans, and preventing allograft nephropathy in transplant recipients. He has written more than 400 manuscripts and book chapters about these topics. He has edited two books: “Medical Management of Kidney Transplantation” and “Hypertension”. He has presented at numerous international scientific association meetings, hospitals, and medical schools.

Dr. Weir currently reviews manuscripts for more than 20 major medical journals, including the American Journal of Kidney Disease, the Journal of the American Society of Nephrology, and Archives of Internal Medicine. He is on the editorial board of eight journals and is Section Editor of Current Hypertension Reports and Current Opinion in Hypertension and Nephrology. He has three active NIH supported grants from NIDDK. In addition, he is a member of numerous associations, including the American Society of Nephrology, the National Kidney Foundation, the American Heart Association, and the American Society of Transplantation.

Dr. Weir received his medical degree from the University of Virginia, Charlottesville. He completed his internship and residency programs in medicine at the Waterbury and Yale-New Haven Hospitals in Connecticut, and completed his nephrology training at the Brigham and Women’s Hospital, Harvard Medical School, in Boston, Massachusetts. He then moved to the University of Maryland where he has been a full time faculty member since 1983.

Research Interests

My primary research interest focus is on cardiovascular disease associated with chronic kidney disease.  Our group is involved in a series of clinical trials to evaluate biomeasures of cardiovascular disease in patients with chronic kidney disease as well as to better describe optimum levels of blood pressure and use of various antihypertensive medications in delaying progression of kidney disease.  These studies are ongoing in patients with non-diabetic as well as diabetic native kidney disease.  In addition, we have ongoing trials to evaluate the etiologies of cardiovascular disease and progressive loss of kidney function in patients who have received kidney transplants.  These data are important in order to evaluate optimal means of preventing cardiovascular disease in kidney transplant recipients, as well as better forms of immunosuppression to limit the development of allograft nephropathy and ultimately graft loss. 

Clinical Speciality

Cardiovascular disease associated with chronic kidney disease and prevention of progressive renal disease.

Publications

Search My Publications in Pub Med

HIGHLIGHTED PUBLICATIONS

Weir MR. Progressive renal and cardiovascular disease: Optimal treatment strategies.  Kidney Int 2002; 62:1482-1492.

Bakris GL, Weir MR, Shanifar S, Zhang Z, Douglas J, van Dijk DJ, Brenner BM: Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study. Arch.Intern.Med. 2003; 163:1555-1565.

Mange KC, Weir MR: Preemptive renal transplantation: why not? Am.J.Transplant 2003;3:1336-1340.

Weir MR. Microalbuminuria in Type 2 Diabetics: An Important, Overlooked Cardiovascular Risk Factor. J Clin Hypertens 2004; 6:134-141.

Weir MR: Blood Pressure Management in the Kidney Transplant Recipient. Adv.Chronic Kidney Dis. 2004; 11:172-183.

Bakris GL, Weir MR, Secic M, Brett C, Weir-McNulty A.  Differential effects of calcium antagonist subclasses on markers of nephropathy progression. Kidney Int. 2004;65:1991-2002.

Weir MR, Blahut S, Drachenburg C, Young C, Papademitriou J, Klassen DK, Cangro CB, Bartlett ST, Fink JC.  Late Calcineurin Inhibitor Withdrawal as a Strategy to Prevent Graft Loss in Patients with Suboptimal Kidney Transplant Function. Am J Nephrol 2004;24:379-386.

Weir MR: Albuminuria predicting outcome in diabetes: Incidence of microalbuminuria in Asia-Pacific Rim.  Kidney Int; 2004; 66:S38-S39.

Wu AY, Kong NC, de Leon FA, Pan CY, Tai TY, Yeung VT, Yoo SJ, Rouillon A, Weir MR: An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: the MicroAlbuminuria Prevalence (MAP) Study. Diabetologia 2005; 48:17-26.

Weir MR: Editorial Commentary. Reduction in Microalbuminuria: A Biomeasure of Therapeutic Success?  Hypertension.  2005; 45:181-182.

Weir MR, Fink JC.  Salt intake and progression of chronic kidney disease: an overlooked modifiable exposure?  A commentary.  Am J Kidney Disease 2005; 45(1): 176-188.

Weir MR, Ferdinand KC, Flack JM, Jamerson KA, Daley W, Zelenofske, AADVANCE investigators: A Noninferiority Comparison of Valsartan/Hydrochlorothiazide Combinations Versus Amlodipine in Black Hypertensives.  Hypertension.  2005; 46:508-513.

Wali, R.K.; Wang, G.S.; Gottlieb, S.S.; Bellumkonda, L.; Hansalia, R.; Ramos, E.; Drachenberg, C.; Papadimitriou, J.; Brisco, M.A.; Blahut, S.; Fink, J.C.; Fisher, M.L.; Bartlett, S.T.; Weir, M.R.: Effect of kidney transplantation on left ventricular systolic dysfunction and congestive heart failure in patients with end-stage renal disease.  J.Am.Coll.Cardiol. 2005; 45:7, 1051-1060.

Mishra SI, Jones-Burton C, Fink JC, Brown JB, Bakris GL, Weir MR:  Does Dietary Salt Increase the Risk for Progression on Kidney Disease?  Curr Hypertension Reports.  2005; 7:385-391.

Gotto Jr AM, Blackburn GL, Dailey III GE, Garber AJ, Grundy SM, Sobel BE, Weir MR:  The metabolic syndrome: a call to action.  Coronary Artery Disease 2006, (1) 17:77-80.

Jones-Burton C., Seliger SL, Scherer RW, Mishra, SI, Vessal G, Brown J, Weir MR, Fink JC. Cigarette Smoking and Incident Chronic Kidney Disease: A Systemic Review. Am J Nephrol 2007; 27:342-351.

Weir MR. Hypertension and Cardiovascular Risk. US Cardiovascular Disease 2007 (2): 64-66.

Weir MR. The Obesity Paradox: Impact of Obesity on the Prevalence and Prognosis of Cardiovascular Diseases. Practice Pearl. January 2009;121(1): 164-165.




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