Dr. Laureano D. Asico earned his Doctor in Veterinary Medicine from the University of the Philippines in 1981. He had a successful stint in clinical practice and the corporate world. He is presently an Assistant Professor at the University of Maryland - School of Medicine, Department of Medicine, Division of Nephrology, with a concurrent appointment of Assistant Professor at the George Washington University School of Medicine. His involvement in the research field started when he joined the group of Dr. Pedro A. Jose at Georgetown University in 1989 and he has been a senior member of the team since then. His interests are mainly on blood pressure regulation and the influence of hormones like dopamine and gastrin on G protein coupled receptors, renal hemodynamics, epithelial transport, reactive oxygen species as well as extra-renal influences. His activities involve in vivo studies of various animal models, mainly rodents. He has introduced surgical and procedural innovations to renal clearance studies in rats by developing a system which targets only one kidney and uses the other kidney as its own control. As an animal surgeon, he has further added to his expertise by scaling down his technique to involve mouse models as well. In 2004, he trained at the University of Western Ontario in London, Canada to perform cardiac and renal transplantation in rats and mice. He has utilized this specialized skill to discern the extent of regulation of the kidney vs. nervous system on blood pressure homeostasis. Lately, with the advent of the transgenic mouse, he was instrumental in conceptualizing and validating a novel technique of targeted gene silencing through the use of renal subcapsular implantation of mini-osmotic pumps infusing siRNA or AAV delivery systems. This would conceivably allow for a cheaper and more efficient method of gene silencing as well as gene replacement or rescue of specific and select tissues of interest.
Dr. Asico is an author or co-author of at least 57 peer-reviewed articles. He has been invited to train young upcoming students both here and abroad. He has also served as mentor to high school and college students interested in pursuing careers in the medical field.
Education and Training
- 1971 – 1977: University of the Philippines - B.S. Biological Sciences
- 1977 – 1981: University of the Philippines - Doctor of Veterinary Medicine
- 2004: University of Western Ontario - Training on Rodent Renal and Cardiac Transplantation
Tuchman S, Asico LD, Escano C, Bobb DA, Ray PE. Development of an animal model of nephrocalcinosis via selective dietary sodium and chloride depletion. Pediatr Res. 2012 Nov 22. doi: 10.1038/pr.2012.172. [Epub ahead of print] PMID:23174703[PubMed - as supplied by publisher]
Villar VA, Jones JE, Armando I, Asico LD, Escano CS Jr, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes-Saloma CP, Felder RA, Jose PA. Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem. 2012 Nov 14. [Epub ahead of print] PMID: 23152498 [PubMed - as supplied by publisher]
Zhang Y, Cuevas S, Asico LD, Escano C, Yang Y, Pascua AM, Wang X, Jones JE, Grandy D, Eisner G, Jose PA, Armando I. Deficient dopamine D2 receptor function causes renal inflammation independently of high blood pressure. PLoS One. 2012 7(6):e38745. Epub 2012 Jun 14. PMID: 22719934 [PubMed – in process] Free PMC Article
Yang Y, Zhang Y, Cuevas-Gonzalez S, Villar VA, Escano C, Asico L, Yu P, Grandy DK, Felder RA, Armando I, Jose PA. Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D (2) receptor-induced inhibition of NADPH oxidase. Free Radic Biol Med. 2012 May 23 [Epub ahead of print]
Huang H, Ren H, Chen C, Wang X, Yang J, Han Y, He D, Zhou L, Asico LD, Jose PA, Zeng C. D(3) dopamine receptor regulation of D(5) receptor expression and function in renal proximal tubule cells. Hypertens Res. 2012 Feb 2. doi: 10.1038/hr.2012.11. [Epub ahead of print]
Cuevas S, Zhang Y, Yang Y, Escano C, Asico L, Jones JE, Armando I, Jose PA. Role of renal DJ-1 in the pathogenesis of hypertension associated with increased reactive oxygen species production. Hypertension. 2012 Feb; 59(2):446-52. Epub 2012 Jan 3. Erratum in: Hypertension. 2012 Apr; 59(4):e38
Asico L, Zhang X, Jiang J, Cabrera D, Escano CS, Sibley DR, Wang X, Yang Y, Mannon R, Jones JE, Armando I, Jose PA. Lack of Renal Dopamine D5 Receptors Promotes Hypertension. J Am Soc Nephrol. 2011 Jan; 22(1):82-9. Epub 2010 Nov 4.
Wang X, Luo Y, Escano CS, Yang Z, Asico L, Li H, Jones JE, Armando I, Lu Q, Sibley DR., Eisner GM, Jose PA. Upregulation of Renal Sodium Transporters in D5 Dopamine Receptor Deficient Mice. Hypertension. 2010 Jun; 55(6):1431-7. Epub 2010 Apr 19.
Yang Z, Asico LD, Yu P, Wang Z, Jones JE, Escano CS, Quinn MT, Sibley DR, Felder RA, Jose PA. D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase and blood pressure. Am J Physiol 2005 Jan; 290(1): R96-R104.
Bhatti F, Mankhey RW, Asico LD, Quinn MT, Welch WJ, Maric C. Mechanisms of antioxidant and pro-oxidant effects of ά-lipoic acid in the diabetic and nondiabetic kidney. Kid. Int. 2005; 67:1371-1380.
Asico LD, Ladines CA, Fuchs S, Accili D, Carey RM, Semeraro C, Pocchiari F, Felder R, Eisner GM, Jose PA. Disruption of the D3 receptor gene produces renin-dependent hypertension. J Clin Invest 1998; 102: 493-8.
Asico LD, Eisner GM, Jose PA. Renal nerves and D1-dopamine receptor-mediated natriuresis. Clin Exp Hypertens 1998; 20: 259-71.
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